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Author A Zarina Kraal

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Physical Activity in Early- and Mid-Adulthood are Associated with Longitudinal Memory Trajectories in Later-Life.

A Zarina Kraal, Hailey L Dotterer, Neika Sharifian, Emily P Morris, Ketlyne Sol, Afara B Zaheed, Jacqui Smith, Laura B Zahodne,

BACKGROUND:Physical activity (PA) in later-life may reduce dementia risk, but little is known regarding long-term cognitive effects of PA that occurred earlier in adulthood or mechanisms underlying associations. PA patterns at different ages may independently contribute to dementia risk, which would implicate multiple critical periods for intervention. The current study ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2020, :]

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Everyday discrimination and subsequent cognitive abilities across five domains.

Laura B Zahodne, Emily P Morris, Neika Sharifian, Afsara B Zaheed, A Zarina Kraal, Ketlyne Sol,

OBJECTIVE:Previous research suggests that everyday discrimination is associated with worse concomitant performance in several cognitive domains, as well as faster subsequent declines in episodic memory. This study aimed to extend knowledge on the specificity, durability, and mechanisms of associations between everyday discrimination and cognition by using a comprehensive neuropsychological battery ... Read more >>

Neuropsychology (Neuropsychology)
[2020, :]

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Longitudinal Associations Between Contact Frequency with Friends and with Family, Activity Engagement, and Cognitive Functioning.

Neika Sharifian, A Zarina Kraal, Afsara B Zaheed, Ketlyne Sol, Laura B Zahodne,

OBJECTIVES:Social engagement may be an important protective resource for cognitive aging. Some evidence suggests that time spent with friends may be more beneficial for cognition than time spent with family. Because maintaining friendships has been demonstrated to require more active maintenance and engagement in shared activities, activity engagement may be ... Read more >>

J Int Neuropsychol Soc (Journal of the International Neuropsychological Society : JINS)
[2020, 26(8):815-824]

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Psychological predictors of memory decline in a racially and ethnically diverse longitudinal sample of older adults in the United States.

Ketlyne Sol, Afsara B Zaheed, A Zarina Kraal, Neika Sharifian, Miguel Arce RenterĂ­a, Laura B Zahodne,

OBJECTIVES:In the United States, racial and ethnic disparities in memory dysfunction and Alzheimer disease are evident even after accounting for many risk factors. Psychological factors, such as psychological well-being, perceived control, depressive symptoms, and negative affect, may influence memory dysfunction, and associations may differ by race and ethnicity. This study ... Read more >>

Int J Geriatr Psychiatry (International journal of geriatric psychiatry)
[2020, 35(2):204-212]

Cited: 1 time

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Unique Effects of Perceived Neighborhood Physical Disorder and Social Cohesion on Episodic Memory and Semantic Fluency.

Afsara B Zaheed, Neika Sharifian, A Zarina Kraal, Ketlyne Sol, Alyssia Hence, Laura B Zahodne,

OBJECTIVE:Objective measures of neighborhood quality are associated with physical and mental health outcomes for older adults, but the relationship between perceived neighborhood quality and cognitive health has not been fully explored. Furthermore, positive and negative neighborhood characteristics may influence cognition through different mechanisms. The present study aimed to determine whether ... Read more >>

Arch Clin Neuropsychol (Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists)
[2019, 34(8):1346-1355]

Cited: 1 time

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Longitudinal socioemotional pathways between retrospective early life maternal relationship quality and episodic memory in older adulthood.

Neika Sharifian, A Zarina Kraal, Afsara B Zaheed, Ketlyne Sol, Laura B Zahodne,

Prior research suggests that social relations may play a role in explaining individual differences in cognitive functioning in older adulthood. In particular, early life maternal relationship quality (MRQ) has been shown to be a strong predictor of later-life socioemotional outcomes and may also contribute to later-life cognitive outcomes. The current ... Read more >>

Dev Psychol (Developmental psychology)
[2019, 55(11):2464-2473]

Cited: 1 time

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Metabolic syndrome is negatively associated with cognition among endothelial nitric oxide synthase (eNOS)- 786C carriers in schizophrenia-spectrum disorders.

A Zarina Kraal, Allison C Moll, Nicole R Arvanitis, Kristen M Ward, Ryan J Dougherty, Tyler B Grove, Kyle J Burghardt, Vicki L Ellingrod,

Although metabolic syndrome and cognitive inefficiencies are well-described common complications of schizophrenia, their association remains inconsistent, potentially due to poorly understood mechanisms underlying their relationship. Variability in the endothelial nitric oxide synthase (eNOS) gene, specifically the T-786C variant, has been separately associated with cognition and metabolic syndrome, with worse outcomes ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2019, 117:142-147]

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Dimensions of Religious Involvement Represent Positive Pathways in Cognitive Aging.

A Zarina Kraal, Neika Sharifian, Afsara B Zaheed, Ketlyne Sol, Laura B Zahodne,

Older Black and Hispanic adults report more religious involvement, and religious involvement has been linked to better cognition. This study examined which aspects of religious involvement are associated with better longitudinal episodic memory and whether religious involvement offsets racial and ethnic inequalities in episodic memory. Using Health and Retirement Study ... Read more >>

Res Aging (Research on aging)
[2019, 41(9):868-890]

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Montreal Cognitive Assessment as a screening tool: Influence of performance and symptom validity.

Brigid Waldron-Perrine, Nicolette M Gabel, Katharine Seagly, A Zarina Kraal, Percival Pangilinan, Robert J Spencer, Linas Bieliauskas,

Background:We evaluated Montreal Cognitive Assessment (MoCA) performance in a veteran traumatic brain injury (TBI) population, considering performance validity test (PVT) and symptom validity test (SVT) data, and explored associations of MoCA performance with neuropsychological test performance and self-reported distress. Methods:Of 198 consecutively referred veterans to a Veterans Administration TBI/Polytrauma Clinic, ... Read more >>

(Neurology. Clinical practice)
[2019, 9(2):101-108]

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Longitudinal effects of race, ethnicity, and psychosocial disadvantage on systemic inflammation.

Laura B Zahodne, A Zarina Kraal, Afsara Zaheed, Penelope Farris, Ketlyne Sol,

Objective:Psychosocial factors likely contribute to racial and ethnic inequalities in cardiovascular diseases (CVDs). However, precise social, psychological, and physiological pathways linking race and ethnicity to the development of CVDs are not well understood. Systemic inflammation, commonly indexed by C-reactive protein (CRP), is a biomarker for CVD risk and progression. The ... Read more >>

(SSM - population health)
[2019, 7:100391]

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Could Dietary Glutamate Play a Role in Psychiatric Distress?

A Zarina Kraal, Nicole R Arvanitis, Andrew P Jaeger, Vicki L Ellingrod,

Glutamate is an amino acid that functions as an excitatory neurotransmitter. It has also been associated with somatic and psychiatric distress and is implicated in the pathophysiology of psychiatric disorders such as schizophrenia. Ingestion of dietary glutamate, such as monosodium glutamate (MSG), has been mechanistically linked with greater distress among ... Read more >>

Neuropsychobiology (Neuropsychobiology)
[2020, 79(1):13-19]

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Effects of Atypical Antipsychotic Treatment and Resistant Starch Supplementation on Gut Microbiome Composition in a Cohort of Patients with Bipolar Disorder or Schizophrenia.

Stephanie A Flowers, Nielson T Baxter, Kristen M Ward, A Zarina Kraal, Melvin G McInnis, Thomas M Schmidt, Vicki L Ellingrod,

STUDY OBJECTIVE:Previous studies identified shifts in gut microbiota associated with atypical antipsychotic (AAP) treatment that may link AAPs to metabolic burden. Dietary prebiotics such as resistant starch may be beneficial in obesity and glucose regulation, but little is known mechanistically about their ability to modify gut microbiota in AAP-treated individuals. ... Read more >>

Pharmacotherapy (Pharmacotherapy)
[2019, 39(2):161-170]

Cited: 2 times

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Inflammatory mechanisms underlying the effects of everyday discrimination on age-related memory decline.

Laura B Zahodne, A Zarina Kraal, Neika Sharifian, Afsara B Zaheed, Ketlyne Sol,

BACKGROUND/OBJECTIVES:Previous research suggests that everyday discrimination is associated with worse episodic memory and partially mediates Black-White disparities in memory aging. The biological mechanisms underlying the link between everyday discrimination and memory are unclear but may involve inflammatory processes. This study aimed to determine whether systemic inflammation, indexed by blood levels ... Read more >>

Brain Behav. Immun. (Brain, behavior, and immunity)
[2019, 75:149-154]

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Subjective Social Status Predicts Late-Life Memory Trajectories through Both Mental and Physical Health Pathways.

Laura B Zahodne, A Zarina Kraal, Afsara Zaheed, Ketlyne Sol,

BACKGROUND:Subjective social status (SSS) is associated with mental and physical health, independent of objective socioeconomic status (SES), but its association with late-life cognitive decline is unknown. OBJECTIVE:This study characterizes the association between SSS and late-life memory trajectories in a large, nationally representative sample of older adults in the United States. ... Read more >>

Gerontology (Gerontology)
[2018, 64(5):466-474]

Cited: 2 times

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Atypical Antipsychotic Exposure May Not Differentiate Metabolic Phenotypes of Patients with Schizophrenia.

Kristen M Ward, Larisa Yeoman, Cora McHugh, A Zarina Kraal, Stephanie A Flowers, Amy E Rothberg, Alla Karnovsky, Arun K Das, Vicki L Ellingrod, Kathleen A Stringer,

STUDY OBJECTIVE:Patients with schizophrenia are known to have higher rates of metabolic disease than the general population. Contributing factors likely include lifestyle and atypical antipsychotic (AAP) use, but the underlying mechanisms are unknown. The objective of this study was to identify metabolomic variability in adult patients with schizophrenia who were ... Read more >>

Pharmacotherapy (Pharmacotherapy)
[2018, 38(6):638-650]

Cited: 1 time

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Sex Differences in Antipsychotic Related Metabolic Functioning in Schizophrenia Spectrum Disorders.

A Zarina Kraal, Kristen M Ward, Vicki L Ellingrod,

The adverse metabolic risks associated with second generation antipsychotics (SGAs) are well known, and likely contribute to the high rate of premature mortality due to cardiovascular disease in schizophrenia. Female schizophrenia patients appear to be diagnosed with metabolic diseases at higher rates than males, which may reflect disparate adverse responses ... Read more >>

Psychopharmacol Bull (Psychopharmacology bulletin)
[2017, 47(2):8-21]

Cited: 2 times

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Cardiovascular Pharmacogenomics and Cognitive Function in Patients with Schizophrenia.

Kristen M Ward, A Zarina Kraal, Stephanie A Flowers, Vicki L Ellingrod,

The authors sought to examine the impact of multiple risk alleles for cognitive dysfunction and cardiovascular disease risk on cognitive function and to determine if these relationships varied by cognitive reserve (CR) or concomitant medication use in patients with schizophrenia. They conducted a cross-sectional study in ambulatory mental health centers. ... Read more >>

Pharmacotherapy (Pharmacotherapy)
[2017, 37(9):1122-1130]

Cited: 2 times

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Oxytocin Receptor (OXTR) Methylation and Cognition in Psychotic Disorders.

Tyler B Grove, Kyle J Burghardt, A Zarina Kraal, Ryan J Dougherty, Stephan F Taylor, Vicki L Ellingrod,

Previous reports have identified an association between cognitive impairment and genetic variation in psychotic disorders. In particular, this association may be related to abnormal regulation of genes responsible for broad cognitive functions such as the oxytocin receptor (OXTR). Within psychotic disorders, it is unknown if OXTR methylation, which can have ... Read more >>

(Molecular neuropsychiatry)
[2016, 2(3):151-160]

Cited: 3 times

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Affect and psychiatric symptoms in a veteran polytrauma clinic.

A Zarina Kraal, Brigid Waldron-Perrine, Percival H Pangilinan, Linas A Bieliauskas,

Although the relationship between negative affect and psychiatric symptoms has been well-demonstrated in research, less is known about positive affect relative to negative affect, and its relationship to psychiatric symptoms, especially among veterans. This study examined how levels of positive and negative affect are associated with symptoms of depression, anxiety, ... Read more >>

Rehabil Psychol (Rehabilitation psychology)
[2015, 60(1):36-42]

Cited: 2 times

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