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Identification and nomenclature of Albugo candida pathotypes of Indian origin causing white rust disease of rapeseed-mustard

Devanshu Dev, A K Tewari, Pooja Upadhyay, G R Daniel,

The highly variable nature of Albugo candida pathogen in terms of number of races/pathotypes poses a challenge in the proper identification. Therefore, in this study characterization and identification of 33 A. candida isolates of Indian origin have been done on the basis of molecular and host differentials studies. Molecular characterization ... Read more >>

Eur J Plant Pathol (European journal of plant pathology)
[2021, 158(4):987-1004]

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Anti-Ku positive Juvenile Dermatomyositis.

C Cotter, E Rudd, E Duarte Williamson, M Philippidou, A Tewari,

A 12-year-old atopic boy presented to our dermatology department in March 2020 with a cutaneous eruption affecting the face, the dorsum of the hands, the knees as well as generalised fatigue and fever. He had developed oral ulceration in the preceding week and had self-isolated with his mother who had ... Read more >>

Clin Exp Dermatol (Clinical and experimental dermatology)
[2021, :]

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Sodium sulphide promoted synthesis of fused quinoline at room temperature.

Rashmi Singh, Vishal Prasad Sharma, Priyanka Yadav, Priyanka Sonker, Radhey Mohan Singh, Ashish Kumar Tewari,

A novel, simple and eco-friendly strategy for the synthesis of thiopyrano[4,3-<i>b</i>]quinolin-1-ones and pyrrolo[3,4-<i>b</i>]quinolin-1-ones from 2-alkynylquinoline-3-carbonitriles and sodium sulphide (Na<sub>2</sub>S·9H<sub>2</sub>O) under catalyst-free conditions at room temperature has been described. In this reaction, a readily available inorganic salt (Na<sub>2</sub>S·9H<sub>2</sub>O) serves as the sulphur source and leads to the generation of diverse functionalized ... Read more >>

Org Biomol Chem (Organic & biomolecular chemistry)
[2021, :]

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Extracellular Vesicles Carry Distinct Proteo-Transcriptomic Signatures That are Different from Their Cancer Cell of Origin

Tzu-yi Chen, Edgar Gonzalez-Kozlova, Taliah Soleymani, Sabrina La Salvia, Natasha Kyprianou, Susmita Sahoo, Ash Tewari, Carlos Cordon-cardo, GUSTAVO Stolovitzky, Navneet Dogra,

Circulating extracellular vesicles (EVs) contain molecular footprints from their cell of origin and may provide potential non-invasive access for detection, characterization, and monitoring of numerous diseases. Despite their growing promise, the integrated proteo-transcriptomic landscape of EVs and their donor cells remain poorly understood. To assess their cargo, we conducted small ... Read more >>

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Molecular features of exceptional response to neoadjuvant anti-androgen therapy in high-risk localized prostate cancer.

Alok K Tewari, Alexander T M Cheung, Jett Crowdis, Jake R Conway, Sabrina Y Camp, Stephanie A Wankowicz, Dimitri G Livitz, Jihye Park, Rosina T Lis, Alice Bosma-Moody, Meng Xiao He, Saud H AlDubayan, Zhenwei Zhang, Rana R McKay, Ignaty Leshchiner, Myles Brown, Steven P Balk, Gad Getz, Mary-Ellen Taplin, Eliezer M Van Allen,

High-risk localized prostate cancer (HRLPC) is associated with a substantial risk of recurrence and disease mortality. Recent clinical trials have shown that intensifying anti-androgen therapies administered before prostatectomy can induce pathologic complete responses or minimal residual disease, called exceptional response, although the molecular determinants of these clinical outcomes are largely ... Read more >>

Cell Rep (Cell reports)
[2021, 36(10):109665]

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Environmental Toxicants and NAFLD: A Neglected yet Significant Relationship.

Sangam Rajak, Sana Raza, Archana Tewari, Rohit A Sinha,

The liver is an organ of vital importance in the body; it is the center of metabolic activities and acts as the primary line of defense against toxic compounds. Exposure to environmental toxicants is an unavoidable fallout from rapid industrialization across the world and is even higher in developing countries. Technological ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, :]

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Unannotated small RNA clusters associated with circulating extracellular vesicles detect early stage liver cancer.

Johann von Felden, Teresa Garcia-Lezana, Navneet Dogra, Edgar Gonzalez-Kozlova, Mehmet Eren Ahsen, Amanda Craig, Stacey Gifford, Benjamin Wunsch, Joshua T Smith, Sungcheol Kim, Jennifer E L Diaz, Xintong Chen, Ismail Labgaa, Philipp Haber, Reena Olsen, Dan Han, Paula Restrepo, Delia D'Avola, Gabriela Hernandez-Meza, Kimaada Allette, Robert Sebra, Behnam Saberi, Parissa Tabrizian, Amon Asgharpour, Douglas Dieterich, Josep M Llovet, Carlos Cordon-Cardo, Ash Tewari, Myron Schwartz, Gustavo Stolovitzky, Bojan Losic, Augusto Villanueva,

<h4>Objective</h4>Surveillance tools for early cancer detection are suboptimal, including hepatocellular carcinoma (HCC), and biomarkers are urgently needed. Extracellular vesicles (EVs) have gained increasing scientific interest due to their involvement in tumour initiation and metastasis; however, most extracellular RNA (exRNA) blood-based biomarker studies are limited to annotated genomic regions.<h4>Design</h4>EVs were isolated ... Read more >>

Gut (Gut)
[2021, :]

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A patient-driven clinicogenomic partnership through the Metastatic Prostate Cancer Project

Jett Crowdis, Sara Balch, Lauren Sterlin, Beena Thomas, Sabrina Camp, Michael Dunphy, Elana Anastasio, Shahrayz Shah, Alyssa Damon, Rafael Ramos, Delia Sosa, Ilan Small, Brett Tomson, Colleen Nguyen, Mary McGillicuddy, Parker Chastain, Meng Xiao He, Alexander T.M. Cheung, Stephanie Wankowicz, Alok Tewari, Dewey Kim, Saud AlDubayan, Ayanah Dowdye, Benjamin Zola, Joel Nowak, Jan Manarite, Major Idola Henry Gunn, Bryce Olson, Eric Lander, Corrie Painter, Nikhil Wagle, Eliezer Van Allen,

<h4>ABSTRACT</h4> Molecular profiling studies have enabled numerous discoveries for metastatic prostate cancer (MPC), but they have mostly occurred in academic medical institutions focused on select patient populations. We developed the Metastatic Prostate Cancer Project (MPCproject, mpcproject.org ), a patient-partnered initiative to empower MPC patients living anywhere in the U.S. and ... Read more >>

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Post-Electroconvulsive Therapy Hyperthermia: A Case Report.

Priya Arora, Shivani Nagpal, Abhinav Tewari, Nimmi A Jose, Ved Pal Mahla, Ashutosh Tripathi, Poorva Gupta, Avi Siwatch, Ajay Ogha,

J ECT (The journal of ECT)
[2021, :]

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Role of α- and β-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease.

M Archer, N Dogra, Z Dovey, T Ganta, H-S Jang, J A Khusid, A Lantz, M Mihalopoulos, J A Stockert, A Zahalka, L Björnebo, S Gaglani, M R Noh, S A Kaplan, R Mehrazin, K K Badani, P Wiklund, K Tsao, D J Lundon, N Mohamed, F Lucien, B Padanilam, M Gupta, A K Tewari, N Kyprianou,

The urinary tract is highly innervated by autonomic nerves which are essential in urinary tract development, the production of growth factors, and the control of homeostasis. These neural signals may become dysregulated in several genitourinary (GU) disease states, both benign and malignant. Accordingly, the autonomic nervous system is a therapeutic ... Read more >>

Cell Commun Signal (Cell communication and signaling : CCS)
[2021, 19(1):78]

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An integrated nomogram combining deep learning, Prostate Imaging-Reporting and Data System (PI-RADS) scoring, and clinical variables for identification of clinically significant prostate cancer on biparametric MRI: a retrospective multicentre study.

Amogh Hiremath, Rakesh Shiradkar, Pingfu Fu, Amr Mahran, Ardeshir R Rastinehad, Ashutosh Tewari, Sree Harsha Tirumani, Andrei Purysko, Lee Ponsky, Anant Madabhushi,

<h4>Background</h4>Biparametric MRI (comprising T2-weighted MRI and apparent diffusion coefficient maps) is increasingly being used to characterise prostate cancer. Although previous studies have combined Prostate Imaging-Reporting & Data System (PI-RADS)-based MRI findings with routinely available clinical variables and with deep learning-based imaging predictors, respectively, for prostate cancer risk stratification, none have ... Read more >>

Lancet Digit Health (The Lancet. Digital health)
[2021, 3(7):e445-e454]

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MTORC1 inhibition drives crinophagic degradation of glucagon.

Sangam Rajak, Sherwin Xie, Archana Tewari, Sana Raza, Yajun Wu, Boon-Huat Bay, Paul M Yen, Rohit A Sinha,

<h4>Objective</h4>Crinophagy is a secretory granule-specific autophagic process that regulates hormone content and secretion in endocrine cells. However, despite being one of the earliest described autophagic processes, its mechanism of action and regulation in mammalian cells remains unclear.<h4>Methods and results</h4>Here, we examined mammalian crinophagy and its modulation that regulate hormone secretion ... Read more >>

Mol Metab (Molecular metabolism)
[2021, 53:101286]

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Does Gender Matter in Academic Surgery? Author and Mentor Gender Impact Publication Citations in Surgical Research.

Devki C Shukla, Vannita Simma-Chiang, Natasha Kyprianou, Ashutosh K Tewari, Dara J Lundon,

<h4>Objective</h4>To examine female author representation within publications in the field of urology from the United States from 2000-2019.<h4>Methods</h4>All 25,787 articles with a U.S. correspondence address published in the two largest U.S. headquartered general urology journals, Urology and Journal of Urology, were analyzed from 2000-2019. Gender was assigned to each first ... Read more >>

Urology (Urology)
[2021, :]

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Comparative analysis of 1152 African-American and European-American men with prostate cancer identifies distinct genomic and immunological differences.

Walter Rayford, Alp Tuna Beksac, Jordan Alger, Mohammed Alshalalfa, Mohsen Ahmed, Irtaza Khan, Ugo G Falagario, Yang Liu, Elai Davicioni, Daniel E Spratt, Edward M Schaeffer, Felix Y Feng, Brandon Mahal, Paul L Nguyen, Robert B Den, Mark D Greenberger, Randy Bradley, Justin M Watson, Matthew Beamer, Lambros Stamatakis, Darrell J Carmen, Shivanshu Awasthi, Jonathan Hwang, Rachel Weil, Harri Merisaari, Nihal Mohamed, Leslie A Deane, Dimple Chakravarty, Kamlesh K Yadav, Kosj Yamoah, Sujit S Nair, Ashutosh K Tewari,

Racial disparities in prostate cancer have not been well characterized on a genomic level. Here we show the results of a multi-institutional retrospective analysis of 1,152 patients (596 African-American men (AAM) and 556 European-American men (EAM)) who underwent radical prostatectomy. Comparative analyses between the race groups were conducted at the ... Read more >>

Commun Biol (Communications biology)
[2021, 4(1):670]

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Clinical characteristics and oncological outcomes in negative multiparametric MRI patients undergoing robot-assisted radical prostatectomy.

Vinayak G Wagaskar, Parita Ratnani, Micah Levy, Kate Moody, Mariely Garcia, Adriana M Pedraza, Sneha Parekh, Krunal Pandav, Bhavya Shukla, Stanislaw Sobotka, Kenneth Haines, Peter Wiklund, Ash Tewari,

<h4>Background</h4>Efforts are ongoing to try and find ways to reduce the number of unnecessary prostate biopsies without missing clinically significant prostate cancers (csPCa). The utility of multiparametric magnetic resonance imaging (mpMRI) in detecting prostate cancer (PCa) shows promise to be used as triage test for systematic prostate biopsy. Our aim ... Read more >>

Prostate (The Prostate)
[2021, 81(11):772-777]

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Metastatic Prostate Cancer: In Search of More Granularity.

Alok K Tewari, Silke Gillessen, Christopher J Sweeney,

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2021, 39(26):2968-2969]

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Development and Validation of Confirmatory Foot-and-Mouth Disease Virus Antibody ELISAs to Identify Infected Animals in Vaccinated Populations.

Anuj Tewari, Helen Ambrose, Krupali Parekh, Toru Inoue, Javier Guitian, Antonello Di Nardo, David James Paton, Satya Parida,

In foot-and-mouth disease (FMD)-endemic countries, vaccination is commonly used to control the disease, whilst in FMD-free countries, vaccination is considered as an option, in addition to culling the infected and in contact animals. FMD vaccines are mainly comprised of inactivated virions and stimulate protective antibodies to virus structural proteins. In ... Read more >>

Viruses (Viruses)
[2021, 13(5):]

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Screening for Asymptomatic Coronary Artery Disease in People With Type2 Diabetes Mellitus in a Tertiary Care Center

Ajoy Tewari,

Abstract Cardiovascular disease is the biggest driver of mortality in people with diabetes. Cardiovascular disease and diabetes share the same risk factors, the so-called “common soil” hypothesis. Asians and more specifically Indians are predisposed to cardiovascular disease, that too at an earlier age. The cost of management of cardiovascular disease ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2021, 5(Suppl 1):A419-A419]

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Computer extracted gland features from H&E predicts prostate cancer recurrence comparably to a genomic companion diagnostic test: a large multi-site study.

Patrick Leo, Andrew Janowczyk, Robin Elliott, Nafiseh Janaki, Kaustav Bera, Rakesh Shiradkar, Xavier Farré, Pingfu Fu, Ayah El-Fahmawi, Mohammed Shahait, Jessica Kim, David Lee, Kosj Yamoah, Timothy R Rebbeck, Francesca Khani, Brian D Robinson, Lauri Eklund, Ivan Jambor, Harri Merisaari, Otto Ettala, Pekka Taimen, Hannu J Aronen, Peter J Boström, Ashutosh Tewari, Cristina Magi-Galluzzi, Eric Klein, Andrei Purysko, Natalie Nc Shih, Michael Feldman, Sanjay Gupta, Priti Lal, Anant Madabhushi,

Existing tools for post-radical prostatectomy (RP) prostate cancer biochemical recurrence (BCR) prognosis rely on human pathologist-derived parameters such as tumor grade, with the resulting inter-reviewer variability. Genomic companion diagnostic tests such as Decipher tend to be tissue destructive, expensive, and not routinely available in most centers. We present a tissue ... Read more >>

NPJ Precis Oncol (NPJ precision oncology)
[2021, 5(1):35]

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A COVID-19 Test Triage Tool, Predicting Negative Results and Reducing the Testing Burden on Healthcare Systems During a Pandemic.

Dara J Lundon, Brian D Kelly, Sujit Nair, Damien M Bolton, Gopi Patel, David Reich, Ashutosh Tewari,

<b>Background:</b> Detecting and isolating cases of COVID-19 are amongst the key elements listed by the WHO to reduce transmission. This approach has been reported to reduce those symptomatic with COVID-19 in the population by over 90%. Testing is part of a strategy that will save lives. Testing everyone maybe ideal, ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:563465]

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Clinical Utility of Negative Multiparametric Magnetic Resonance Imaging in the Diagnosis of Prostate Cancer and Clinically Significant Prostate Cancer.

Vinayak G Wagaskar, Micah Levy, Parita Ratnani, Kate Moody, Mariely Garcia, Adriana M Pedraza, Sneha Parekh, Krunal Pandav, Bhavya Shukla, Sonya Prasad, Stanislaw Sobotka, Kenneth Haines, Sanoj Punnen, Peter Wiklund, Ash Tewari,

<h4>Background</h4>Multiparametric magnetic resonance imaging (MRI) is increasingly used to diagnose prostate cancer (PCa). It is not yet established whether all men with negative MRI (Prostate Imaging-Reporting and Data System version 2 score <3) should undergo prostate biopsy or not.<h4>Objective</h4>To develop and validate a prediction model that uses clinical parameters to ... Read more >>

Eur Urol Open Sci (European urology open science)
[2021, 28:9-16]

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Molecular features of exceptional response to neoadjuvant anti-androgen therapy in high-risk localized prostate cancer

Alok Tewari, Alexander T.M. Cheung, Jett Crowdis, Jake Conway, Sabrina Camp, Stephanie Wankowicz, Dimitri Livitz, Jihye Park, Rosina Lis, Alice Boosma-Moody, Meng Xiao He, Saud AlDubayan, Zhenwei Zhang, Rana McKay, Ignaty Leshchiner, Myles Brown, Steve Balk, Gad Getz, Mary-Ellen Taplin, Eliezer Van Allen,

<h4>ABSTRACT</h4> High-risk localized prostate cancer (HRLPC) is associated with a substantial risk of recurrence and prostate cancer-specific mortality 1 . Recent clinical trials have shown that intensifying anti-androgen therapies administered prior to prostatectomy can induce pathologic complete responses (pCR) or minimal residual disease (MRD) (<5 mm), together termed exceptional response, ... Read more >>

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Simultaneous injection of 18F-BF3- Cy3-ACUPA and non-radioactive Cy7-ACUPA probes: a promising pre-biopsy PET and ex vivo fluorescence imaging approach to evaluate prostate cancer.

Omer Aras, Cetin Demirdag, Harikrishna Kommidi, Ina Pavlova, Vitaly Boyko, Dara J Lundon, Richard Ting, Ashutosh Tewari, Oguz Akin, Haluk B Sayman,

Eur J Nucl Med Mol Imaging (European journal of nuclear medicine and molecular imaging)
[2021, 48(11):3732-3733]

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Impact of chronic elevated ozone exposure on photosynthetic traits and anti-oxidative defense responses of Leucaena leucocephala (Lam.) de wit tree under field conditions.

Pratiksha Singh, Rekha Kannaujia, Shiv Narayan, Ashish Tewari, Pramod A Shirke, Vivek Pandey,

In this study, the impact of long term exposure of elevated ozone (+20 ppb above ambient) on photosynthetic traits and anti-oxidative defense system of Leucaena leucocephala, a tree of great economic importance, was studied in a Free Air Ozone Concentration Enrichment (O<sub>3</sub>-FACE) facility at different time intervals (6, 12, 18, ... Read more >>

Sci Total Environ (The Science of the total environment)
[2021, 782:146907]

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Small Molecule, Multimodal, [18F]-PET and Fluorescence Imaging Agent Targeting Prostate-Specific Membrane Antigen: First-in-Human Study.

Omer Aras, Cetin Demirdag, Harikrishna Kommidi, Hua Guo, Ina Pavlova, Aslan Aygun, Emre Karayel, Hüseyin Pehlivanoglu, Nami Yeyin, Natasha Kyprianou, Nandi Chen, Stefan Harmsen, Kerim Sonmezoglu, Dara J Lundon, Rahmi Oklu, Richard Ting, Ashutosh Tewari, Oguz Akin, Haluk B Sayman,

<h4>Background</h4>A first-in-human study of [<sup>18</sup>F]-BF3-Cy3-ACUPA, a small-molecule contrast agent that can be unimolecularly both positron emitting and fluorescent, is conducted to determine its: its safety, biodistribution, radiation dosimetry, feasibility in tumor detection by preoperative positron emission tomography (PET), as well as its intraoperative fluorescence imaging utility in patients with prostate-specific ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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