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Social Deprivation and Incident Diabetes-Related Foot Disease in Patients With Type 2 Diabetes: A Population-Based Cohort Study.

Jenny Riley, Christina Antza, Punith Kempegowda, Anuradhaa Subramanian, Joht Singh Chandan, Krishna Gokhale, Neil Thomas, Christopher Sainsbury, Abd A Tahrani, Krishnarajah Nirantharakumar,

<h4>Objective</h4>To investigate the relationship between social deprivation and incident diabetes-related foot disease (DFD) in newly diagnosed patients with type 2 diabetes.<h4>Research design and methods</h4>A population-based open retrospective cohort study using The Health Improvement Network (1 January 2005 to 31 December 2019) was conducted. Patients with type 2 diabetes free of ... Read more >>

Diabetes Care (Diabetes care)
[2021, :]

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Multivariable Association Discovery in Population-scale Meta-omics Studies

Himel Mallick, Ali Rahnavard, Lauren McIver, Siyuan Ma, Yancong Zhang, Long Nguyen, Timothy Tickle, George Weingart, Boyu Ren, Emma Schwager, Suvo Chatterjee, Kelsey Thompson, Jeremy Wilkinson, Ayshwarya Subramanian, Yiren Lu, Levi Waldron, Joseph Paulson, Eric Franzosa, Hector Corrada Bravo, Curtis Huttenhower,

It is challenging to associate features such as human health outcomes, diet, environmental conditions, or other metadata to microbial community measurements, due in part to their quantitative properties. Microbiome multi-omics are typically noisy, sparse (zero-inflated), high-dimensional, extremely non-normal, and often in the form of count or compositional measurements. Here we ... Read more >>

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Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes.

Evgeny Kiner, Elijah Willie, Brinda Vijaykumar, Kaitavjeet Chowdhary, Hugo Schmutz, Jodie Chandler, Alexandra Schnell, Pratiksha I Thakore, Graham LeGros, Sara Mostafavi, Diane Mathis, Christophe Benoist, ,

CD4<sup>+</sup> effector lymphocytes (T<sub>eff</sub>) are traditionally classified by the cytokines they produce. To determine the states that T<sub>eff</sub> cells actually adopt in frontline tissues in vivo, we applied single-cell transcriptome and chromatin analyses to colonic T<sub>eff</sub> cells in germ-free or conventional mice or in mice after challenge with a range ... Read more >>

Nat Immunol (Nature immunology)
[2021, :]

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Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review.

Anuradhaa Subramanian, Jan Idkowiak, Konstantinos A Toulis, Shakila Thangaratinam, Wiebke Arlt, Krishnarajah Nirantharakumar,

<h4>Context</h4>The incidence of gestational diabetes mellitus (GDM) has been on the rise, driven by maternal obesity. In parallel, pubertal tempo has increased in the general population, driven by childhood obesity.<h4>Objective</h4>To evaluate the available evidence on pubertal timing of boys and girls born to mothers with GDM.<h4>Data sources</h4>We searched MEDLINE, EMBASE, ... Read more >>

Eur J Endocrinol (European journal of endocrinology)
[2021, 184(1):51-64]

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Effect of vitamin D supplementation during pregnancy on mid-to-late gestational blood pressure in a randomized controlled trial in Bangladesh.

Anita Subramanian, Jill Korsiak, Kellie E Murphy, Abdullah Al Mahmud, Daniel E Roth, Alison D Gernand,

<h4>Objective</h4>To examine the dose-dependent effect of maternal vitamin D during pregnancy on blood pressure from mid-to-late gestation within the context of a randomized, placebo-controlled trial of vitamin D supplementation in Bangladesh (n = 1298).<h4>Methods</h4>Healthy women without hypertension were enrolled at 17-24 weeks gestation and randomized to one of four vitamin D doses ... Read more >>

J Hypertens (Journal of hypertension)
[2021, 39(1):135-142]

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Surface modified NIR magnetic nanoprobes for theranostic applications.

Ramya Dhandapani, Ayyappan Sathya, Swaminathan Sethuraman, Anuradha Subramanian,

<b>Objectives</b>: Near-Infrared based imaging modalities integrated with thermotherapy can facilitate detection of cancer at early stages and mediate high-resolution image-guided hyperthermia. In this work, fluorescent iron oxide nanoparticles (FIO) have been developed possessing deep tissue penetrable NIR imaging and site-specific magnetic hyperthermia characteristics for the elimination of cancer cells. <b>Methods</b>: ... Read more >>

Expert Opin Drug Deliv (Expert opinion on drug delivery)
[2020, :1-10]

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Morquio Syndrome Presenting with Dural Band Pathology: A Case Report.

Saloni Gupta, Kangana Sengar, Arulselvi Subramanian, Gurudatta Satyarthee,

Morquio syndrome is caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS) enzyme, which is required for the catabolism of glycosaminoglycans (namely, chondroitin-6-sulfate and keratan sulfate). Pathogenic accumulation of these glycosaminoglycans occurs throughout the body. The various organs and tissues affected are bones, cartilage, tendon, teeth, trachea and lungs, heart, cornea, ... Read more >>

J Lab Physicians (Journal of laboratory physicians)
[2020, 12(4):285-288]

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Characterization of analytical errors in thromboelastography interpretation.

Tapasyapreeti Mukhopadhyay, Arulselvi Subramanian, Hara Prasad Pati, Renu Saxena,

<h4>Introduction</h4>Interpretation of Thromboelastography (TEG) curve involves correlating patient's clinical profile with TEG parameters and the tracing, keeping in mind the potential sources of errors, and hence requires expertise. We aimed to analyse the analytical errors in TEG interpretation due to paucity of literature in this regard.<h4>Material and methods</h4>The retrospective study ... Read more >>

Pract Lab Med (Practical laboratory medicine)
[2021, 23:e00196]

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A Fatal Case of Kaposi Sarcoma Immune Reconstitution Syndrome (KS-IRIS) Complicated by Kaposi Sarcoma Inflammatory Cytokine Syndrome (KICS) or Multicentric Castleman Disease (MCD): A Case Report and Review.

Igor Dumic, Milan Radovanovic, Oladapo Igandan, Ivana Savic, Charles W Nordstrom, Djordje Jevtic, Anand Subramanian, Poornima Ramanan,

BACKGROUND Kaposi Sarcoma Inflammatory Cytokine Syndrome (KICS) is a relatively new syndrome described in patients co-infected with Human Immunodeficiency Virus (HIV) and Kaposi Sarcoma (KS) Herpes Virus (KSHV). KICS clinically resembles Multicentric Castleman disease (MCD) and both present with various degrees of lymphadenopathy, pancytopenia, HIV and KSHV viremia, and signs ... Read more >>

Am J Case Rep (The American journal of case reports)
[2020, 21:e926433]

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Renin-Angiotensin System Inhibitors and Susceptibility to COVID-19 in Patients With Hypertension: A Propensity Score-Matched Cohort Study in Primary Care

Shamil Haroon, Anuradhaa Subramanian, Jennifer Cooper, Astha Anand, Krishna Gokhale, Nathan Byne, Samir Dhalla, Dionisio Acosta-Mena, Thomas Taverner, Kelvin Okoth, Jingya Wang, Joht Singh Chandan, Christopher Sainsbury, Dawit Tefra Zemedikun, Neil Thomas, Dhruv Parekh, Tom Marshall, Elizabeth Sapey, Nicola Adderley, Krishnarajah Nirantharakumar,

<h4>Introduction: </h4> Renin-angiotensin system (RAS) inhibitors have been postulated to influence susceptibility to Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). This study investigated whether there is an association between their prescription and the incidence of COVID-19 and all-cause mortality. <h4>Methods: </h4> We conducted a propensity-score matched cohort study comparing the incidence ... Read more >>

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Outcomes and implications of a single brain death examination policy on organ donation outcomes at a high-volume trauma center.

Abraham J Matar, Hannah Wichmann, Lisa Kenney, Anuradha Subramanian, Jonathan Ratcliff, Vishal Patel, Brett M Tracy, Rondi B Gelbard,

BACKGROUND:Despite current neurological guidelines that a single brain death examination (SBDE) is sufficient to determine brain death, a vast majority of hospitals still use a two brain death examination (TBDE) policy based on historical practice. The purpose of this study was to analyze the outcomes and implications of an SBDE ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2020, 89(6):1166-1171]

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An overview of the potential sources of diagnostic errors in (classic) thromboelastography curve interpretation and preventive measures.

Tapasyapreeti Mukhopadhyay, Arulselvi Subramanian,

Thromboelastography (TEG), a hemostatic point-of-care assay, provides global information about fibrin formation, platelet activation, and clot retraction in real-time. As it is an operator-dependent technique, error in any phase of the testing process can result in the misinterpretation of the thromboelastogram, and subsequently lead to mismanagement of the patient, wastage ... Read more >>

Pract Lab Med (Practical laboratory medicine)
[2020, 22:e00193]

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Non-steroidal anti-inflammatory drugs and susceptibility to COVID-19.

Joht Singh Chandan, Dawit Tefra Zemedikun, Rasiah Thayakaran, Nathan Byne, Samir Dhalla, Dionisio Acosta-Mena, Krishna M Gokhale, Tom Thomas, Christopher Sainsbury, Anuradhaa Subramanian, Jennifer Cooper, Astha Anand, Kelvin O Okoth, Jingya Wang, Nicola J Adderley, Thomas Taverner, Alastair K Denniston, Janet Lord, G Neil Thomas, Christopher D Buckley, Karim Raza, Neeraj Bhala, Krishnarajah Nirantharakumar, Shamil Haroon,

<h4>Objectives</h4>To identify whether active use of non-steroidal anti-inflammatory drugs (NSAIDs) increases susceptibility to developing suspected or confirmed COVID-19 compared to the use of other common analgesics.<h4>Methods</h4>We performed a propensity score-matched cohort study with active comparators using a large UK primary care dataset. The cohort consisted of adult patients aged ≥18 ... Read more >>

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2020, :]

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The Impact of Bariatric Surgery on Incident Microvascular Complications in Patients With Type 2 Diabetes: A Matched Controlled Population-Based Retrospective Cohort Study.

Pushpa Singh, Nicola Adderley, Anuradhaa Subramanian, Krishna Gokhale, Rishi Singhal, Konstantinos A Toulis, Srikanth Bellary, Krishnarajah Nirantharakumar, Abd A Tahrani,

<h4>Objective</h4>To assess the impact of bariatric surgery (BS) on incident microvascular complications of diabetes-related foot disease (DFD), sight-threatening diabetic retinopathy (STDR), and chronic kidney disease (CKD) in patients with type 2 diabetes and obesity.<h4>Research design and methods</h4>A retrospective matched, controlled population-based cohort study was conducted of adults with type 2 ... Read more >>

Diabetes Care (Diabetes care)
[2021, 44(1):116-124]

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Functional Outcomes and Temporal Profile of Recovery in Patients with Intradural Extramedullary Spinal Cord Tumors with Poor Nurick Grade.

Apoorva Subramanian, Bijesh Ravindran Nair, Vedantam Rajshekhar,

<h4>Background</h4>Patients with spinal intradural extramedullary (IDEM) tumors usually have a good functional outcome after tumor excision. However, the literature is sparse on the functional outcome in patients with poor Nurick grade (NG 4 and 5).<h4>Methods</h4>A retrospective review of 81 patients with IDEM tumors presenting with a poor NG was performed ... Read more >>

World Neurosurg (World neurosurgery)
[2020, :]

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Self-cleaning structural colors by TiO2/Ti nanostructures.

Gaurav Shukla, Angappane Subramanian,

Structural colors are fascinating due to their stability in comparison with dyes and pigments; nevertheless, environmental pollutants contaminate surfaces and redefine structural colors. To overcome this problem, cleaning of the surface is necessary at regular intervals, which is cumbersome and costly. We have circumvented this issue in this article and ... Read more >>

Appl Opt (Applied optics)
[2020, 59(33):10483-10492]

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Sodium-glucose co-transporter-2 inhibitors and susceptibility to COVID-19: A population-based retrospective cohort study.

Christopher Sainsbury, Jingya Wang, Krishna Gokhale, Dionisio Acosta-Mena, Samir Dhalla, Nathan Byne, Joht Singh Chandan, Astha Anand, Jennifer Cooper, Kelvin Okoth, Anuradhaa Subramanian, Mansoor N Bangash, Thomas Taverner, Wasim Hanif, Sandip Ghosh, Parth Narendran, Kar K Cheng, Tom Marshall, Georgios Gkoutos, Konstantinos Toulis, Neil Thomas, Abd Tahrani, Nicola J Adderley, Shamil Haroon, Krishnarajah Nirantharakumar,

Sodium-glucose co-transporter-2 (SGLT2) inhibitors are widely prescribed in people with type 2 diabetes. We aimed to investigate whether SGLT2 inhibitor prescription is associated with COVID-19, when compared with an active comparator. We performed a propensity-score-matched cohort study with active comparators and a negative control outcome in a large UK-based primary ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2021, 23(1):263-269]

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Personnel scheduling during Covid-19 pandemic.

Giorgio Zucchi, Manuel Iori, Anand Subramanian,

This paper addresses a real-life personnel scheduling problem in the context of Covid-19 pandemic, arising in a large Italian pharmaceutical distribution warehouse. In this case study, the challenge is to determine a schedule that attempts to meet the contractual working time of the employees, considering the fact that they must ... Read more >>

Optim Lett (Optimization letters)
[2020, :1-12]

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561. Safety of Remdesivir vs Standard Care in Patients with Moderate Covid-19

Gerard J Criner, Gerard J Criner, Mi Young Ahn, Gregory Huhn, Aruna Subramanian, Carlos Lumbreras, Stefan Schmiedel, Robert H Hyland, Vithika Suri, Huyen Cao, Hongyuan Wang, Devi SenGupta, Anand Chokkalingam, Anu Osinusi, Diana M Brainard, Yao-Shen Chen, Yao-Shen Chen, Huldrych Günthard, D Jose Sanz-Moreno, Judith A Aberg, Emanuele Nicastri, Owen Tak-Yin Tsang, Owen Tak-Yin Tsang,

Abstract <h4>Background</h4> Remdesivir (RDV) has been shown to shorten recovery time and was well tolerated in patients with severe COVID-19. Here we report safety of RDV in patients with moderate COVID-19. <h4>Methods</h4> We conducted an open-label, phase 3 trial (NCT04252664) in hospitalized patients with confirmed SARS-CoV-2 infection, evidence of pulmonary ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(Suppl 1):S345-S346]

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Epidemiology, morbidity and mortality in Behçet's disease: a cohort study using The Health Improvement Network (THIN).

Tom Thomas, Joht Singh Chandan, Anuradhaa Subramanian, Krishna Gokhale, George Gkoutos, Lorraine Harper, Christopher Buckley, Priyanka Chandratre, Karim Raza, Deva Situnayake, Krishnarajah Nirantharakumar,

<h4>Objectives</h4>The epidemiology of Behçet's disease (BD) has not been well characterized in the UK. Evidence on the risk of cardiovascular disease, thromboembolic disease and mortality in patients with BD compared with the general population is scarce.<h4>Methods</h4>We used a large UK primary care database to investigate the epidemiology of BD. A ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2020, 59(10):2785-2795]

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Trends in Optic Neuritis Incidence and Prevalence in the UK and Association With Systemic and Neurologic Disease.

Tasanee Braithwaite, Anuradhaa Subramanian, Axel Petzold, James Galloway, Nicola J Adderley, Susan P Mollan, Gordon T Plant, Krishnarajah Nirantharakumar, Alastair K Denniston,

<h4>Importance</h4>Epidemiologic data on optic neuritis (ON) incidence and associations with immune-mediated inflammatory diseases (IMIDs) are sparse.<h4>Objective</h4>To estimate 22-year trends in ON prevalence and incidence and association with IMIDs in the United Kingdom.<h4>Design, setting, and participants</h4>This cohort study analyzed data from The Health Improvement Network from January 1, 1995, to September ... Read more >>

JAMA Neurol (JAMA neurology)
[2020, :]

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Ethnicity-based differences in the incident risk of allergic diseases and autoimmune disorders: A UK-based retrospective cohort study of 4.4 million participants.

Anuradhaa Subramanian, Nicola J Adderley, Georgios V Gkoutos, Krishna Margadhamane Gokhale, Krishnarajah Nirantharakumar, Mamidipudi Thirumala Krishna,

Clin Exp Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2021, 51(1):144-147]

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Personnel scheduling during Covid-19 pandemic

Giorgio Zucchi, Manuel Iori, Anand Subramanian,

This paper addresses a real-life personnel scheduling problem in the context of Covid-19 pandemic, arising in a large Italian pharmaceutical distribution warehouse. In this case study, the challenge is to determine a schedule that attempts to meet the contractual working time of the employees, considering the fact that they must ... Read more >>

Optim Lett (Optimization letters)
[2020, :1-12]

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Sodium‐glucose‐co‐transporter‐2 inhibitors and susceptibility to COVID‐19: a population‐based retrospective cohort study

Christopher Sainsbury, Jingya Wang, Krishna Gokhale, Dionisio Acosta‐Mena, Samir Dhalla, Nathan Byne, Joht Singh Chandan, Astha Anand, Jennifer Cooper, Kelvin Okoth, Anuradhaa Subramanian, Mansoor N Bangash, Thomas Taverner, Wasim Hanif, Sandip Ghosh, Parth Narendran, Kar Keung Cheng, Tom Marshall, Georgios Gkoutos, Konstantinos Toulis, Neil Thomas, Abd Tahrani, Nicola J Adderley, Shamil Haroon, Krishnarajah Nirantharakumar,

Abstract Sodium/glucose co‐transporter‐2 inhibitors (SGLT2i) are widely prescribed in people with type 2 diabetes. We aimed to investigate whether SGLT2i prescription is associated with COVID‐19, when compared with an active comparator. We performed a propensity score‐matched cohort study with active comparators and a negative control outcome in a large UK‐based ... Read more >>

Diabetes Obes Metab (Diabetes, obesity & metabolism)
[2020, :]

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Quantifying infection risks in incompatible living donor kidney transplant recipients.

Robin K Avery, Jennifer D Motter, Kyle R Jackson, Robert A Montgomery, Allan B Massie, Edward S Kraus, Kieren A Marr, Bonnie E Lonze, Nada Alachkar, Mary J Holechek, Darin Ostrander, Niraj Desai, Madeleine M Waldram, Shmuel Shoham, Seema Mehta Steinke, Aruna Subramanian, Janet M Hiller, Julie Langlee, Sheila Young, Dorry L Segev, Jacqueline M Garonzik Wang,

Desensitization has enabled incompatible living donor kidney transplantation (ILDKT) across HLA/ABO barriers, but added immunomodulation might put patients at increased risk of infections. We studied 475 recipients from our center from 2010 to 2015, categorized by desensitization intensity: none/compatible (n = 260), low (0-4 plasmaphereses, n = 47), moderate (5-9, n = 74), and high ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2020, :]

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