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Generation of sas-6::ha by CRISPR/Cas9 editing.

Mary Bergwell, Amy Smith, Holly Lakin, Rebecca Slay, Jyoti Iyer,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

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Gender Differences in Lifetime Prevalence and Onset Timing of Suicidal Ideation and Suicide Attempt Among Post-9/11 Veterans and Nonveterans.

Claire A Hoffmire, Lindsey M Monteith, Jeri E Forster, Paul A Bernhard, John R Blosnich, Dawne Vogt, Shira Maguen, Alexandra A Smith, Aaron I Schneiderman,

<h4>Background</h4>Rising US suicide rates are particularly notable among military veterans, especially women. It is unknown whether these differences extend to suicidal ideation (SI) and suicide attempts (SA), which are major predictors of suicide. Literature comparing SI and SA prevalence and timing of onset between veterans and nonveterans is limited.<h4>Objective</h4>The objective ... Read more >>

Med Care (Medical care)
[2021, 59:S84-S91]

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Genetic insights into the biological mechanisms governing human ovarian ageing

Katherine Ruth, Felix Day, Jazib Hussain, Ana Martínez-Marchal, Catherine Aiken, Ajuna Azad, Deborah Thompson, Hironori Abe, Jane Tarry-Adkins, Javier Martin Gonzalez, Annique Claringbould, Olivier Bakker, Patrick Sulem, Sandra Turon, Charlotte Onland-Moret, Emil Peter Trane Hertz, Pascal Timshel, Vallari Shukla, Rehannah Borup, Kristina Olsen, Mònica Ferrer-Roda, Yan Huang, Stasa Stankovic, Paul RHJ Timmers, Thomas Ahearn, Behrooz Alizadeh, Elnaz Naderi, Irene Andrulis, Alice Arnold, Kristan Aronson, Annelie Augustinsson, Stefania Bandinelli, Caterina Barbieri, Robin Beaumont, Heiko Becher, Matthias Beckmann, Stefania Benonisdottir, Sven Bergmann, Murielle Bochud, Eric Boerwinkle, Stig Bojesen, Manjeet Bolla, Dorret Boomsma, Nicholas Bowker, Jennifer Brody, Linda Broer, Julie Buring, Archie Campbell, Harry Campbell, Jose Castelao, Eulalia Catamo, Stephen Chanock, Georgia Chenevix-Trench, Marina Ciullo, Tanguy Corre, Fergus Couch, Angela Cox, Simon Cross, Francesco Cucca, Kamila Czene, George Davey-Smith, Eco JCN de Geus, Renée de Mutsert, Immaculata De Vivo, Ellen Demerath, Joe Dennis, Alison Dunning, Miriam Dwek, Mikael Eriksson, Tõnu Esko, Peter Fasching, Jessica Faul, Luigi Ferrucci, Nora Franceschini, Timothy Frayling, Manuela Gago-Dominguez, Massimo Mezzavilla, Montserrat García-Closas, Christian Gieger, Graham Giles, Harald Grallert, Daniel Gudbjartsson, Vilmundur Gudnason, Pascal Guénel, Christopher Haiman, Niclas Håkansson, Per Hall, Caroline Hayward, Chunyan He, Wei He, Gerardo Heiss, Miya Høffding, John Hopper, Jouke Hottenga, Frank Hu, David Hunter, Mohammad Ikram, Rebecca Jackson, Micaella DR Joaquim, Esther John, Peter Joshi, David Karasik, Sharon LR Kardia, Robert Karlsson, Cari Kitahara, Ivana Kolcic, Charles Kooperberg, Peter Kraft, Allison Kurian, Zoltan Kutalik, Martina La Bianca, Genevieve LaChance, Claudia Langenberg, Lenore Launer, Joop SE Laven, Deborah Lawlor, Loic Le Marchand, Jingmei Li, Annika Lindblom, Sara Lindstrom, Tricia Lindstrom, Martha Linet, YongMei Liu, Simin Liu, Jian’an Luan, Reedik Mägi, Patrik KE Magnusson, Massimo Mangino, Arto Mannermaa, Brumat Marco, Jonathan Marten, Nicholas Martin, Hamdi Mbarek, Barbara McKnight, Sarah Medland, Christa Meisinger, Thomas Meitinger, Cristina Menni, Andres Metspalu, Lili Milani, Roger Milne, Grant Montgomery, Dennis Mook-Kanamori, Antonella Mulas, Anna Mulligan, Alison Murray, Mike Nalls, Anne Newman, Raymond Noordam, Teresa Nutile, Dale Nyholt, Andrew Olshan, Håkan Olsson, Jodie Painter, Alpa Patel, Nancy Pedersen, Natalia Perjakova, Annette Peters, Ulrike Peters, Paul DP Pharoah, Ozren Polasek, Eleonora Porcu, Bruce Psaty, Iffat Rahman, Gad Rennert, Hedy Rennert, Paul Ridker, Susan Ring, Antonietta Robino, Lynda Rose, Frits Rosendaal, Jacques Rossouw, Igor Rudan, Rico Rueedi, Daniela Ruggiero, Cinzia Sala, Emmanouil Saloustros, Dale Sandler, Serena Sanna, Elinor Sawyer, Chloé Sarnowski, David Schlessinger, Marjanka Schmidt, Minouk Schoemaker, Katharina Schraut, Christopher Scott, Saleh Shekari, Amruta Shrikhande, Albert Smith, Blair Smith, Jennifer Smith, Rossella Sorice, Melissa Southey, Tim Spector, John Spinelli, Meir Stampfer, Doris Stöckl, Joyce BJ van Meurs, Konstantin Strauch, Unnur Styrkarsdottir, Anthony Swerdlow, Toshiko Tanaka, Lauren Teras, Alexander Teumer, Unnur Þorsteinsdottir, Nicholas Timpson, Daniela Toniolo, Michela Traglia, Melissa Troester, Thérèse Truong, Jessica Tyrrell, André Uitterlinden, Sheila Ulivi, Celine Vachon, Veronique Vitart, Uwe Völker, Peter Vollenweider, Henry Völzke, Qin Wang, Nicholas Wareham, Clarice Weinberg, David Weir, Amber Wilcox, Ko Willems van Dijk, Gonneke Willemsen, James Wilson, Bruce HR Wolffenbuttel, Alicja Wolk, Andrew Wood, Wei Zhao, Marek Zygmunt, Lude Franke, Stephen Burgess, Patrick Deelen, Tune Pers, Marie Louise Grønda,

Reproductive longevity is critical for fertility and impacts healthy ageing in women, yet insights into the underlying biological mechanisms and treatments to preserve it are limited. Here, we identify 290 genetic determinants of ovarian ageing, assessed using normal variation in age at natural menopause (ANM) in ∼200,000 women of European ... Read more >>

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Examination of individual and multiple comorbid conditions and health-related quality of life in older cancer survivors.

Elizabeth J Siembida, Ashley Wilder Smith, Arnold L Potosky, Kristi D Graves, Roxanne E Jensen,

<h4>Purpose</h4>Older cancer survivors (≥ 65 years at diagnosis) are at high-risk for multimorbidity (2 + comorbid conditions). However, few studies have utilized a generalizable sample of older cancer survivors to understand how individual comorbid conditions, as opposed to total comorbidity burden, are associated with health-related quality of life (HRQOL). We examined associations between HRQOL ... Read more >>

Qual Life Res (Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation)
[2021, :]

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Total laryngectomy and permanent tracheostomy in 6 dogs.

Brad M Matz, Ralph A Henderson, Stephanie S Lindley, Annette N Smith,

The objective of this report is to describe the surgical technique for total laryngectomy and outcome in 6 dogs. Laryngeal cancer is an uncommon and challenging clinical problem. Total laryngectomy can provide local disease control but is uncommonly performed. Detailed procedural descriptions are limited and similarly limited information is available ... Read more >>

Vet Comp Oncol (Veterinary and comparative oncology)
[2021, :]

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Consensus opinion on immune-mediated cytopenias after hematopoietic cell transplant for inherited metabolic disorders.

Ashish O Gupta, Jaap Jan Boelens, Christen L Ebens, Joanne Kurtzberg, Troy C Lund, Angela R Smith, John E Wagner, Robert Wynn, Bruce R Blazar, Paul J Orchard,

Hematopoietic stem cell transplantation (HCT) has been increasingly used for patients with inherited metabolic disorders (IMD). Immune mediated cytopenias (IMCs) after HCT, manifesting as hemolytic anemia, thrombocytopenia, and/or neutropenia, are recognized as a significant complication in this patient population, yet our understanding of the incidence, risk factors, and pathophysiology is ... Read more >>

Bone Marrow Transplant (Bone marrow transplantation)
[2021, :]

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Takeoff diversity in Diptera.

Alexandra M Yarger, Katherine A Jordan, Alexa J Smith, Jessica L Fox,

The order Diptera (true flies) are named for their two wings because their hindwings have evolved into specialized mechanosensory organs called halteres. Flies use halteres to detect body rotations and maintain stability during flight and other behaviours. The most recently diverged dipteran monophyletic subsection, the Calyptratae, is highly successful, accounting ... Read more >>

Proc Biol Sci (Proceedings. Biological sciences)
[2021, 288(1942):20202375]

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Is Neck Posture Subgroup in Late Adolescence a Risk Factor for Persistent Neck Pain in Young Adults? A Prospective Study.

Karen V Richards, Darren J Beales, Anne L Smith, Peter B O'Sullivan, Leon M Straker,

<h4>Objective</h4>The purpose of this study was to determine whether sagittal neck sitting posture subgroup membership in late adolescence was a risk factor for persistent neck pain (PNP) in young adults.<h4>Methods</h4>There were 686 participants enrolled in the Raine study at the 17- and 22-year follow-ups. At 17 years of age, posture was ... Read more >>

Phys Ther (Physical therapy)
[2021, :]

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BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver.

Maya Z Springer, Logan P Poole, Lauren E Drake, Althea Bock-Hughes, Michelle L Boland, Alexandra G Smith, John Hart, Aparajita H Chourasia, Ivan Liu, Grazyna Bozek, Kay F Macleod,

Mitophagy formed the basis of the original description of autophagy by Christian de Duve when he demonstrated that GCG (glucagon) induced macroautophagic/autophagic turnover of mitochondria in the liver. However, the molecular basis of liver-specific activation of mitophagy by GCG, or its significance for metabolic stress responses in the liver is ... Read more >>

Autophagy (Autophagy)
[2021, :]

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Investigating Partner Involvement in Pregnancy and Identifying Barriers and Facilitators to Participating as a Couple in a Digital Healthy Eating and Physical Activity Intervention.

Alexandra Rhodes, Andrea Smith, Clare Llewellyn, Helen Croker,

<h4>Background: </h4> Maternal obesity and excessive gestational weight gain are associated with adverse maternal and foetal health outcomes. Interventions targeting dietary and physical activity behaviours during pregnancy have typically been directed at women only. A digital intervention targeting couples could encourage expectant parents to support each other in improving energy ... Read more >>

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Pilot Executive Functioning Intervention in Epilepsy: Behavioral and Quality of Life Outcomes.

Avani C Modi, Constance A Mara, Matthew Schmidt, Aimee W Smith, Luke Turnier, Shari L Wade,

<h4>Objective</h4>To examine changes in emotional and behavioral functioning and health-related quality of life (HRQOL) following a web-based executive functioning (EF) intervention open pilot trial (e.g., Epilepsy Journey) for adolescents with epilepsy.<h4>Methods</h4>Adolescents with an established diagnosis of epilepsy, EF deficits, and without developmental disorders participated in a single-arm trial of Epilepsy ... Read more >>

J Pediatr Psychol (Journal of pediatric psychology)
[2021, :]

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The pathway of starch synthesis in Arabidopsis thaliana leaves

Maximilian M.F.F. Fünfgeld, Wei Wang, Hirofumi Ishihara, Stéphanie Arrivault, Regina Feil, Alison Smith, Mark Stitt, John Lunn, Totte Niittylä,

Many plants accumulate transitory starch reserves in their leaves during the day to buffer their carbohydrate supply against fluctuating light conditions, and to provide carbon and energy for survival at night. It is universally accepted that transitory starch is synthesized from ADP-glucose (ADPG) in the chloroplasts. However, the consensus that ... Read more >>

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Research consent rates before and during a COVID-19 one-visitor policy in a children's hospital.

Sara L Van Driest, Sarita M Madell, Kimberly Crum, Andrew H Smith, David P Bichell, Prince J Kannankeril,

Pediatr Res (Pediatric research)
[2021, :]

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Post-traumatic stress disorder as a moderator of transdiagnostic, residential eating disorder treatment outcome trajectory.

Adela Scharff, Shelby N Ortiz, Lauren N Forrest, April R Smith, James F Boswell,

<h4>Objective</h4>Residential treatment for severe eating disorders (EDs) is associated with primarily positive outcomes. However, less is known about the moderators of treatment response. Comorbid post-traumatic stress disorder (PTSD) diagnosis is associated with increased ED symptom severity. This study investigated whether PTSD moderated outcomes of transdiagnostic, residential ED treatment based upon ... Read more >>

J Clin Psychol (Journal of clinical psychology)
[2021, :]

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Cabozantinib for neurofibromatosis type 1-related plexiform neurofibromas: a phase 2 trial.

Michael J Fisher, Chie-Schin Shih, Steven D Rhodes, Amy E Armstrong, Pamela L Wolters, Eva Dombi, Chi Zhang, Steven P Angus, Gary L Johnson, Roger J Packer, Jeffrey C Allen, Nicole J Ullrich, Stewart Goldman, David H Gutmann, Scott R Plotkin, Tena Rosser, Kent A Robertson, Brigitte C Widemann, Abbi E Smith, Waylan K Bessler, Yongzheng He, Su-Jung Park, Julie A Mund, Li Jiang, Khadijeh Bijangi-Vishehsaraei, Coretta Thomas Robinson, Gary R Cutter, Bruce R Korf, , Jaishri O Blakeley, D Wade Clapp,

Neurofibromatosis type 1 (NF1) plexiform neurofibromas (PNs) are progressive, multicellular neoplasms that cause morbidity and may transform to sarcoma. Treatment of Nf1<sup>fl/fl</sup>;Postn-Cre mice with cabozantinib, an inhibitor of multiple tyrosine kinases, caused a reduction in PN size and number and differential modulation of kinases in cell lineages that drive PN ... Read more >>

Nat Med (Nature medicine)
[2021, 27(1):165-173]

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The Role of Mitochondrial Dysfunction in Preeclampsia: Causative Factor or Collateral Damage?

Alex N Smith, Xi Wang, Daniel G Thomas, Robert E Tatum, George W Booz, Mark W Cunningham,

Preeclampsia, new onset hypertension in pregnancy, affects ~ 5 -10% of the world's population. Preeclampsia is the leading cause of morbidity and mortality for both the mother and fetus. As of today, there is no cure for this disease except for delivery of the fetal-placental unit. The exact causation and ... Read more >>

Am J Hypertens (American journal of hypertension)
[2021, :]

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Postoperative dysphagia immediately following pediatric endoscopic laryngeal cleft repair.

Patrick Kiessling, Alyssa Smith, Cassandra Puccinelli, Karthik Balakrishnan,

<h4>Objectives</h4>In pediatric patients undergoing endoscopic laryngeal cleft repair, immediate postoperative dysphagia is not well-characterized. This study examined whether worsened dysphagia is present in the immediate postoperative period as detected by clinical swallow evaluation, and evaluated how this relates to postoperative change in presenting symptoms and findings on swallow studies.<h4>Methods</h4>A retrospective ... Read more >>

Int J Pediatr Otorhinolaryngol (International journal of pediatric otorhinolaryngology)
[2021, 142:110625]

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Incidence of accidental awareness during general anaesthesia in obstetrics: a multicentre, prospective cohort study.

P M Odor, S Bampoe, D N Lucas, S R Moonesinghe, J Andrade, J J Pandit, ,

General anaesthesia for obstetric surgery has distinct characteristics that may contribute towards a higher risk of accidental awareness during general anaesthesia. The primary aim of this study was to investigate the incidence, experience and psychological implications of unintended conscious awareness during general anaesthesia in obstetric patients. From May 2017 to ... Read more >>

Anaesthesia (Anaesthesia)
[2021, :]

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RAISE study protocol: a cross-sectional, multilevel, neurobiological study of resilience after individual stress exposure.

Laura Moreno-López, Samantha N Sallie, Konstantinos Ioannidis, Muzaffer Kaser, Katja Schueler, Adrian Dahl Askelund, Lorinda Turner, Anne-Laura van Harmelen, ,

<h4>Introduction</h4>This paper describes the protocol for an ongoing project funded by the Royal Society, the Resilience After Individual Stress Exposure (RAISE) study; which aims to examine the factors and mechanisms that facilitate resilient functioning after childhood adversity (CA).<h4>Methods and analysis</h4>We aim to recruit up to 200 participants. We will use ... Read more >>

BMJ Open (BMJ open)
[2021, 11(1):e040394]

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Deriving Vignettes for the Rare Disease AADC Deficiency Using Parent, Caregiver and Clinician Interviews to Evaluate the Impact on Health-Related Quality of Life.

Andria Hanbury, Adam B Smith, Katharina Buesch,

<h4>Purpose</h4>Aromatic l-amino acid decarboxylase (AADC) deficiency is a rare genetic condition, characterised by movement disorder, and speech and cognitive functioning impairment. To enable economic evaluation of treatments, health-related quality of life or utilities need to be derived. These are currently lacking in the literature. This is challenging, where patient numbers ... Read more >>

Patient Relat Outcome Meas (Patient related outcome measures)
[2021, 12:1-12]

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Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-a]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies.

Killian Oukoloff, Goodwell Nzou, Carmine Varricchio, Bobby Lucero, Thibault Alle, Jane Kovalevich, Ludovica Monti, Anne-Sophie Cornec, Yuemang Yao, Michael J James, John Q Trojanowski, Virginia M-Y Lee, Amos B Smith, Andrea Brancale, Kurt R Brunden, Carlo Ballatore,

Studies in tau and Aβ plaque transgenic mouse models demonstrated that brain-penetrant microtubule (MT)-stabilizing compounds, including the 1,2,4-triazolo[1,5-<i>a</i>]pyrimidines, hold promise as candidate treatments for Alzheimer's disease and related neurodegenerative tauopathies. Triazolopyrimidines have already been investigated as anticancer agents; however, the antimitotic activity of these compounds does not always correlate with ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2021, :]

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The relationship between the home environment and child adiposity: a systematic review.

Alice R Kininmonth, Andrea D Smith, Clare H Llewellyn, Louise Dye, Clare L Lawton, Alison Fildes,

<h4>Background</h4>Extensive research has demonstrated the role of the Home Environment (HE) in shaping children's energy balance behaviours. Less is known about direct relationships with bodyweight. This review examines associations between the social and physical aspects of three pre-defined Home Environment domains (food, physical activity and media) and adiposity measures in ... Read more >>

Int J Behav Nutr Phys Act (The international journal of behavioral nutrition and physical activity)
[2021, 18(1):4]

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Patient Factors Associated With Parathyroidectomy in Older Adults With Primary Hyperparathyroidism.

Carolyn D Seib, Insoo Suh, Tong Meng, Amber Trickey, Alexander K Smith, Emily Finlayson, Kenneth E Covinsky, Manjula Kurella Tamura, Electron Kebebew,

<h4>Importance</h4>Parathyroidectomy provides definitive management for primary hyperparathyroidism (PHPT), reducing the risk of subsequent fracture, nephrolithiasis, and chronic kidney disease (CKD), but its use among older adults in the US is unknown.<h4>Objective</h4>To identify patient characteristics associated with the use of parathyroidectomy for the management of PHPT in older adults.<h4>Design, setting, and ... Read more >>

JAMA Surg (JAMA surgery)
[2021, :]

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Prolonged Codelivery of Hemagglutinin and a TLR7/8 Agonist in a Supramolecular Polymer-Nanoparticle Hydrogel Enhances Potency and Breadth of Influenza Vaccination.

Gillie A Roth, Olivia M Saouaf, Anton A A Smith, Emily C Gale, Marcela Alcántara Hernández, Juliana Idoyaga, Eric A Appel,

The sustained release of vaccine cargo has been shown to improve humoral immune responses to challenging pathogens such as influenza. Extended codelivery of antigen and adjuvant prolongs germinal center reactions, thus improving antibody affinity maturation and the ability to neutralize the target pathogen. Here, we develop an injectable, physically cross-linked ... Read more >>

ACS Biomater Sci Eng (ACS biomaterials science & engineering)
[2021, :]

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Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.

Vasiliki Lagou, Reedik Mägi, Jouke- Jan Hottenga, Harald Grallert, John R B Perry, Nabila Bouatia-Naji, Letizia Marullo, Denis Rybin, Rick Jansen, Josine L Min, Antigone S Dimas, Anna Ulrich, Liudmila Zudina, Jesper R Gådin, Longda Jiang, Alessia Faggian, Amélie Bonnefond, Joao Fadista, Maria G Stathopoulou, Aaron Isaacs, Sara M Willems, Pau Navarro, Toshiko Tanaka, Anne U Jackson, May E Montasser, Jeff R O'Connell, Lawrence F Bielak, Rebecca J Webster, Richa Saxena, Jeanette M Stafford, Beate St Pourcain, Nicholas J Timpson, Perttu Salo, So-Youn Shin, Najaf Amin, Albert V Smith, Guo Li, Niek Verweij, Anuj Goel, Ian Ford, Paul C D Johnson, Toby Johnson, Karen Kapur, Gudmar Thorleifsson, Rona J Strawbridge, Laura J Rasmussen-Torvik, Tõnu Esko, Evelin Mihailov, Tove Fall, Ross M Fraser, Anubha Mahajan, Stavroula Kanoni, Vilmantas Giedraitis, Marcus E Kleber, Günther Silbernagel, Julia Meyer, Martina Müller-Nurasyid, Andrea Ganna, Antti-Pekka Sarin, Loic Yengo, Dmitry Shungin, Jian'an Luan, Momoko Horikoshi, Ping An, Serena Sanna, Yvonne Boettcher, N William Rayner, Ilja M Nolte, Tatijana Zemunik, Erik van Iperen, Peter Kovacs, Nicholas D Hastie, Sarah H Wild, Stela McLachlan, Susan Campbell, Ozren Polasek, Olga Carlson, Josephine Egan, Wieland Kiess, Gonneke Willemsen, Johanna Kuusisto, Markku Laakso, Maria Dimitriou, Andrew A Hicks, Rainer Rauramaa, Stefania Bandinelli, Barbara Thorand, Yongmei Liu, Iva Miljkovic, Lars Lind, Alex Doney, Markus Perola, Aroon Hingorani, Mika Kivimaki, Meena Kumari, Amanda J Bennett, Christopher J Groves, Christian Herder, Heikki A Koistinen, Leena Kinnunen, Ulf de Faire, Stephan J L Bakker, Matti Uusitupa, Colin N A Palmer, J Wouter Jukema, Naveed Sattar, Anneli Pouta, Harold Snieder, Eric Boerwinkle, James S Pankow, Patrik K Magnusson, Ulrika Krus, Chiara Scapoli, Eco J C N de Geus, Matthias Blüher, Bruce H R Wolffenbuttel, Michael A Province, Goncalo R Abecasis, James B Meigs, G Kees Hovingh, Jaana Lindström, James F Wilson, Alan F Wright, George V Dedoussis, Stefan R Bornstein, Peter E H Schwarz, Anke Tönjes, Bernhard R Winkelmann, Bernhard O Boehm, Winfried März, Andres Metspalu, Jackie F Price, Panos Deloukas, Antje Körner, Timo A Lakka, Sirkka M Keinanen-Kiukaanniemi, Timo E Saaristo, Richard N Bergman, Jaakko Tuomilehto, Nicholas J Wareham, Claudia Langenberg, Satu Männistö, Paul W Franks, Caroline Hayward, Veronique Vitart, Jaakko Kaprio, Sophie Visvikis-Siest, Beverley Balkau, David Altshuler, Igor Rudan, Michael Stumvoll, Harry Campbell, Cornelia M van Duijn, Christian Gieger, Thomas Illig, Luigi Ferrucci, Nancy L Pedersen, Peter P Pramstaller, Michael Boehnke, Timothy M Frayling, Alan R Shuldiner, Patricia A Peyser, Sharon L R Kardia, Lyle J Palmer, Brenda W Penninx, Pierre Meneton, Tamara B Harris, Gerjan Navis, Pim van der Harst, George Davey Smith, Nita G Forouhi, Ruth J F Loos, Veikko Salomaa, Nicole Soranzo, Dorret I Boomsma, Leif Groop, Tiinamaija Tuomi, Albert Hofman, Patricia B Munroe, Vilmundur Gudnason, David S Siscovick, Hugh Watkins, Cecile Lecoeur, Peter Vollenweider, Anders Franco-Cereceda, Per Eriksson, Marjo-Riitta Jarvelin, Kari Stefansson, Anders Hamsten, George Nicholson, Fredrik Karpe, Emmanouil T Dermitzakis, Cecilia M Lindgren, Mark I McCarthy, Philippe Froguel, Marika A Kaakinen, Valeriya Lyssenko, Richard M Watanabe, Erik Ingelsson, Jose C Florez, Josée Dupuis, Inês Barroso, Andrew P Morris, Inga Prokopenko, ,

Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):24]

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