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Author A Sheahan

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Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

Sylvan Baca, David Takeda, Ji-Heui Seo, Justin Hwang, Sheng Yu Ku, Rand Arafeh, Taylor Arnoff, Supreet Agarwal, Connor Bell, Edward O’Connor, Xintao Qiu, Sarah Abou Alaiwi, Rosario Corona, Marcos Fonseca, Claudia Giambartolomei, Paloma Cejas, Klothilda Lim, Monica He, Anjali Sheahan, Amin Nassar, Jacob Berchuck, Lisha Brown, Holly Nguyen, Ilsa Coleman, Arja Kaipainen, Navonil De Sarkar, Peter Nelson, Colm Morrissey, Keegan Korthauer, Mark Pomerantz, Leigh Ellis, Bogdan Pasaniuc, Kate Lawrenson, Kathleen Kelly, Amina Zoubeidi, William Hahn, Himisha Beltran, Henry Long, Myles Brown, Eva Corey, Matthew Freedman,

Abstract Lineage plasticity, the ability of a cell to alter its identity, is an increasingly common mechanism of adaptive resistance to targeted therapy in cancer 1,2 . An archetypal example is the development of neuroendocrine prostate cancer (NEPC) after treatment of prostate adenocarcinoma (PRAD) with inhibitors of androgen signaling. NEPC ... Read more >>

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Epidemiology and Treatment of Patients with Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis in Germany: A Real-World Evidence Study.

Claudia Grellmann, Wojciech Dombrowsky, Volker Fabricius, Robert Suruki, Anna Sheahan, Lars Joeres,

INTRODUCTION:Rheumatoid arthritis (RA), psoriatic arthritis (PsA) and psoriasis (PSO) are chronic inflammatory diseases that have a substantial impact on patients' health. This retrospective database study aimed to assess the epidemiology, comorbidities, diagnosis and treatment patterns of RA, PsA and PSO in the German population. METHODS:Data were extracted from the Deutsche ... Read more >>

Adv Ther (Advances in therapy)
[2020, :]

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Covid-19: The Irish Public Health Experience.

C Ni Bhuachalla, N Murphy, M O'Sullivan, M O' Mahony, C Buckley, C Foley-Nolan, D Murray, A Brennan, A Sheahan,

Ir Med J (Irish medical journal)
[2020, 113(7):117]

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Measuring the effectiveness of an automated text messaging active surveillance system for COVID-19 in the south of Ireland, March to April 2020.

Peter M Barrett, Niamh Bambury, Louise Kelly, Rosalind Condon, Janice Crompton, Anne Sheahan, ,

We report the effectiveness of automated text messaging for active surveillance of asymptomatic close contacts of coronavirus disease (COVID-19) cases in the Cork/Kerry region of Ireland. In the first 7 weeks of the COVID-19 outbreak, 1,336 close contacts received 12,421 automated texts. Overall, 120 contacts (9.0%) reported symptoms which required ... Read more >>

Euro Surveill (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2020, 25(23):]

Cited: 1 time

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Targeting RET Kinase in Neuroendocrine Prostate Cancer.

Halena R VanDeusen, Johnny R Ramroop, Katherine L Morel, Song Yi Bae, Anjali V Sheahan, Zoi Sychev, Nathan A Lau, Larry C Cheng, Victor M Tan, Zhen Li, Ashley Petersen, John K Lee, Jung Wook Park, Rendong Yang, Justin H Hwang, Ilsa Coleman, Owen N Witte, Colm Morrissey, Eva Corey, Peter S Nelson, Leigh Ellis, Justin M Drake,

The increased treatment of metastatic castration-resistant prostate cancer (mCRPC) with second-generation antiandrogen therapies (ADT) has coincided with a greater incidence of lethal, aggressive variant prostate cancer (AVPC) tumors that have lost dependence on androgen receptor (AR) signaling. These AR-independent tumors may also transdifferentiate to express neuroendocrine lineage markers and are ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2020, 18(8):1176-1188]

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The effect of HIV infection and exposure on cognitive development in the first two years of life in Malawi.

Thomas Struyf, Queen Dube, Elizabeth A Cromwell, Anna D Sheahan, Robert S Heyderman, Annelies Van Rie,

OBJECTIVES:To assess longitudinal patterns and determinants of cognitive development in infants living with HIV, infants exposed to maternal HIV infection, and HIV-unexposed infants. METHODS:Prospective, community-based cohort study of 555 Malawian infants aged 8 weeks to 24 months, using multivariable linear mixed-effects regression models with random intercepts to analyze repeated measures ... Read more >>

Eur J Paediatr Neurol (European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society)
[2020, 25:157-164]

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Targeting EZH2 Increases Therapeutic Efficacy of Check-Point Blockade in Models of Prostate Cancer

Anjali Sheahan, Katherine Morel, Deborah Burkhart, Sylvan Baca, David Labbé, Kevin Roehle, Max Heckler, Carla Calagua, Huihui Ye, Phillip Galbo, Sukanya Panja, Antonina Mitrofanova, Anis Hamid, Adam Kibel, Atish Choudhury, Mark Pomerantz, Matthew Freedman, Christopher Sweeney, Stephanie Dougan, Adam Sowalsky, Massimo Loda, Brian Olson, Leigh Ellis,

Abstract Prostate cancers are considered immunologically ‘cold’ tumors given the very few patients who respond to checkpoint inhibitor therapy (CPI). Recently, enrichment of interferon (IFN) response genes predicts a favorable response to CPI across various disease sites. The enhancer of zeste homolog-2 (EZH2) is over-expressed in prostate cancer and is ... Read more >>

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Targeting RET Kinase in Neuroendocrine Prostate Cancer

Halena VanDeusen, Johnny Ramroop, Katherine Morel, Anjali Sheahan, Zoi Sychev, Nathan Lau, Larry Cheng, Victor Tan, Zhen Li, Ashley Petersen, John Lee, Jung Wook Park, Rendong Yang, Ilsa Coleman, Owen Witte, Colm Morrissey, Eva Corey, Peter Nelson, Leigh Ellis, Justin Drake,

Abstract Increased treatment of metastatic castration resistant prostate cancer (mCRPC) with second-generation anti-androgen therapies (ADT) has coincided with a greater incidence of lethal, aggressive variant prostate cancer (AVPC) tumors that have lost androgen receptor (AR) signaling. AVPC tumors may also express neuroendocrine markers, termed neuroendocrine prostate cancer (NEPC). Recent evidence ... Read more >>

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Opioid Use in Patients with Ankylosing Spondylitis Is Common in the United States: Outcomes of a Retrospective Cohort Study.

Victor S Sloan, Anna Sheahan, Jeffrey L Stark, Robert Y Suruki,

OBJECTIVE:To assess the prevalence of chronic opioid use in patients with ankylosing spondylitis (AS), and to compare the characteristics of patients with and without chronic opioid use. METHODS:This was a retrospective cohort study of patients with AS identified in the Truven Health MarketScan Research database between January 1, 2012, and ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2019, 46(11):1450-1457]

Cited: 1 time

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The Role of RB in Prostate Cancer Progression.

Deborah L Burkhart, Katherine L Morel, Anjali V Sheahan, Zachary A Richards, Leigh Ellis,

The RB tumor suppressor is one of the most commonly deleted/mutated genes in human cancers. In prostate cancer specifically, mutation of RB is most frequently observed in aggressive, metastatic disease. As one of the earliest tumor suppressors to be identified, the molecular functions of RB that are lost in tumor ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2019, 1210:301-318]

Cited: 1 time

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Assessing Collaboration in a National Research Partnership in Quality Improvement in Indigenous Primary Health Care: A Network Approach.

Frances C Cunningham, Veronica Matthews, Anna Sheahan, Jodie Bailie, Ross S Bailie,

Background: The ABCD National Research Partnership was formed in mid-2010 as a collaboration to harness the expertise, experiences and resources of Aboriginal and Torres Strait Islander community-controlled peak bodies, government and research organisations to improve the quality of Indigenous primary health care. The aim of this study was to apply ... Read more >>

Front Public Health (Frontiers in public health)
[2018, 6:182]

Cited: 4 times

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Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: a systematic review.

Anjali V Sheahan, Andrew V Biankin, Christopher R Parish, Levon M Khachigian,

Pancreatic cancer has a dismal prognosis particularly in patients presenting with unresectable tumors. We performed a bibliometric analysis of clinical trials for pancreatic cancer conducted between 2014-2016 focusing on patients that presented with unresectable (locally advanced or metastatic) tumors. We discuss a range of studies that employed FOLFIRINOX, the gemcitabine ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(30):21613-21627]

Cited: 9 times

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Epigenetic reprogramming: A key mechanism driving therapeutic resistance.

Anjali V Sheahan, Leigh Ellis,

Prostate cancer initiation, development and progression is driven by androgen receptor (AR) signaling. Androgen deprivation therapy is the primary treatment for patients that present with locally advanced or metastatic disease. However, androgen deprivation therapy is not curative, and patients will progress to castrate-resistant disease (CRPC). Although most patient's progress to ... Read more >>

Urol. Oncol. (Urologic oncology)
[2018, 36(8):375-379]

Cited: 6 times

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Early Antiretroviral Therapy Initiation and Mortality Among Infants Diagnosed With HIV in the First 12 Weeks of Life: Experiences From Kinshasa, DR Congo and Blantyre, Malawi.

Anna Sheahan, Lydia Feinstein, Queen Dube, Andrew Edmonds, Chawanangwa Mahebere Chirambo, Emily Smith, Frieda Behets, Robert Heyderman, Annelies Van Rie,

BACKGROUND:Based on clinical trial results, the World Health Organization recommends infant HIV testing at age 4-6 weeks and immediate antiretroviral therapy (ART) initiation in all HIV-infected infants. Little is known about the outcomes of HIV-infected infants diagnosed with HIV in the first weeks of life in resource-limited settings. We assessed ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2017, 36(7):654-658]

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Performance of HIV Rapid Tests Among Breastfeeding, Malawian Infants.

Emily R Smith, Anna D Sheahan, Robert S Heyderman, William C Miller, Stephanie Wheeler, Michael Hudgens, Julie A E Nelson, Queen Dube, Annelies Van Rie,

Timely, accurate and affordable testing algorithms at point-of-care are critical for early infant HIV diagnosis and initiation of antiretroviral therapy in the postpartum period. We aimed to assess the utility of HIV rapid tests for young, breast-fed HIV-exposed infants in resource limited, high HIV burden settings.We collected data on the ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2017, 36(4):405-411]

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Timing of HIV Seroreversion Among HIV-Exposed, Breastfed Infants in Malawi: Type of HIV Rapid Test Matters.

Emily R Smith, Michael Hudgens, Anna D Sheahan, William C Miller, Stephanie Wheeler, Julie A E Nelson, Queen Dube, Annelies Van Rie,

Introduction Rapid HIV serological tests are a cost-effective, point-of-care test among HIV exposed infants but cannot distinguish between maternal and infant antibodies. The lack of data on the timing of decay of maternal antibodies in young infants hinders the potential use of rapid tests in exposed infants. We aimed to ... Read more >>

Matern Child Health J (Maternal and child health journal)
[2017, 21(2):248-252]

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A molecular imaging biosensor detects in vivo protein folding and misfolding.

Anjali V Sheahan, Thillai V Sekar, Kai Chen, Ramasamy Paulmurugan, Tarik F Massoud,

Aberrant protein folding represents the molecular basis of many important human diseases. Although the discovery of new anti-misfolding drugs is a major priority in molecular therapeutics, there is currently no generalizable protein folding assay for use in cell-based high throughput screening (HTS) of chemical libraries, or for in vivo imaging. ... Read more >>

J Mol Med (Berl) (Journal of molecular medicine (Berlin, Germany))
[2016, 94(7):799-808]

Cited: 2 times

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Norovirus in Transplantation.

Michael P Angarone, Anna Sheahan, Mini Kamboj,

Noroviruses are among the most common cause of diarrhea in transplant recipients. The clinical spectrum of norovirus infection after transplant is increasingly being recognized. As substantial morbidity is now associated with norovirus infections in this population; the quest for rapid diagnostic modalities and newer therapies has expanded. Transplant recipients with ... Read more >>

Curr Infect Dis Rep (Current infectious disease reports)
[2016, 18(6):17]

Cited: 5 times

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Comparison of respiratory virus shedding by conventional and molecular testing methods in patients with haematological malignancy.

L Richardson, J Brite, M Del Castillo, T Childers, A Sheahan, Y-T Huang, E Dougherty, N E Babady, K Sepkowitz, M Kamboj,

Respiratory viruses (RV) are a leading cause of infection-related morbidity and mortality for patients undergoing treatment for cancer. This analysis compared duration of RV shedding as detected by culture and PCR among patients in a high-risk oncology setting (adult patients with haematological malignancy and/or stem cell transplant and all paediatric ... Read more >>

Clin Microbiol Infect (Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases)
[2016, 22(4):380.e1-380.e7]

Cited: 9 times

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Transmission of Clostridium difficile During Hospitalization for Allogeneic Stem Cell Transplant.

Mini Kamboj, Anna Sheahan, Janet Sun, Ying Taur, Elizabeth Robilotti, Esther Babady, Genovefa Papanicolaou, Ann Jakubowski, Eric Pamer, Kent Sepkowitz,

OBJECTIVE To determine the role of unit-based transmission that accounts for cases of early Clostridium difficile infection (CDI) during hospitalization for allogeneic stem cell transplant. SETTING Stem cell transplant unit at a tertiary care cancer center. METHODS Serially collected stool from patients admitted for transplant was screened for toxigenic C. ... Read more >>

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2016, 37(1):8-15]

Cited: 11 times

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Control of norovirus outbreak on a pediatric oncology unit.

Anna Sheahan, Gretchen Copeland, Lauren Richardson, Shelley McKay, Alexander Chou, N Esther Babady, Yi-Wei Tang, Farid Boulad, Janet Eagan, Kent Sepkowitz, Mini Kamboj,

Patients undergoing treatment for cancer with chemotherapy and hematopoietic stem cell recipients are at risk for severe morbidity caused by norovirus (NV).We describe a NV outbreak on the Memorial Sloan Kettering Cancer Center's pediatric oncology unit. Stool testing for diagnosis of NV was performed by real-time polymerase chain reaction (PCR).Twelve ... Read more >>

Am J Infect Control (American journal of infection control)
[2015, 43(10):1066-1069]

Cited: 9 times

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Clostridium difficile infection after allogeneic hematopoietic stem cell transplant: strain diversity and outcomes associated with NAP1/027.

Mini Kamboj, Kun Xiao, Anna Kaltsas, Yao-Ting Huang, Janet Sun, Dick Chung, Saliangi Wu, Anna Sheahan, Kent Sepkowitz, Ann A Jakubowski, Genovefa Papanicolaou,

Allogeneic hematopoietic stem cell transplantation (HSCT) recipients are at high risk for developing Clostridium difficile infection (CDI). We studied the incidence, risk factors, NAP1/027 prevalence, and clinical outcomes, including acute lower gastrointestinal graft-versus-host disease (GI GVHD), associated with early CDI in this population. A retrospective review was conducted of patients ... Read more >>

Biol Blood Marrow Transplant (Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation)
[2014, 20(10):1626-1633]

Cited: 21 times

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The impact of observation units on the rate of hospital-acquired infection.

Anna Dow Sheahan, Kent A Sepkowitz,

Using Clostridium difficile as an example, we calculated the impact that reduced inpatient-day denominators resulting from implementation of hospital observation units would have on hospital-acquired infection rates. Using proposed scenarios of reduced inpatient-days, we estimated an increase in the hospital-acquired C. difficile infection rate of up to 12%. ... Read more >>

Infect Control Hosp Epidemiol (Infection control and hospital epidemiology)
[2013, 34(12):1318-1320]

Cited: 0 times

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Carbohydrate supplements and their effects on pasture dry matter intake, feeding behavior, and blood factors associated with intake regulation.

A J Sheahan, J K Kay, J R Roche,

Supplementary feeds are offered to grazing dairy cows to increase dry matter (DM) and metabolizable energy (ME) intakes; however, offering feed supplements reduces pasture DM intake, a phenomenon known as substitution. The objective of the study was to investigate changes in blood factors associated with intake regulation in monogastric species ... Read more >>

J. Dairy Sci. (Journal of dairy science)
[2013, 96(12):7818-7829]

Cited: 2 times

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Technical note: Nitrogen isotopic fractionation can be used to predict nitrogen-use efficiency in dairy cows fed temperate pasture.

L Cheng, A J Sheahan, S J Gibbs, A G Rius, J K Kay, S Meier, G R Edwards, R J Dewhurst, J R Roche,

The objective of this study was to investigate the relationship between nitrogen isotopic fractionation (δ(15)N) and nitrogen-use efficiency (milk nitrogen/nitrogen intake; NUE) in pasture-fed dairy cows supplemented with increasing levels of urea to mimic high rumen degradable protein pastures in spring. Fifteen cows were randomly assigned to freshly cut pasture ... Read more >>

J. Anim. Sci. (Journal of animal science)
[2013, 91(12):5785-5788]

Cited: 11 times

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