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Author A Ryan

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Diverse viral proteases activate the NLRP1 inflammasome.

Brian V Tsu, Christopher Beierschmitt, Andrew P Ryan, Rimjhim Agarwal, Patrick S Mitchell, Matthew D Daugherty,

The NLRP1 inflammasome is a multiprotein complex that is a potent activator of inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial Lethal Toxin (LeTx) protease, resulting in degradation of the N-terminal domains of NLRP1B and liberation of the bioactive C-terminal domain, which includes the caspase activation ... Read more >>

Elife (eLife)
[2021, 10:]

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A 3D View of Colorectal Cancer Models in Predicting Therapeutic Responses and Resistance.

Eileen Reidy, Niamh A Leonard, Oliver Treacy, Aideen E Ryan,

Although there have been many advances in recent years for the treatment of colorectal cancer (CRC), it still remains the third most common cause of cancer-related deaths worldwide. Many patients with late stage CRC display resistance to multiple different therapeutics. An important aspect in developing effective therapeutics for CRC patients ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(2):]

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Development of novel in vitro human alveolar epithelial cell models to study distal lung biology and disease

Evelyn Tran, Tuo Shi, Xiuwen Li, Adnan Chowdhury, Du Jiang, Yixin Liu, Hongjun Wang, Chunli Yan, William Wallace, Rong Lu, Amy Ryan, Crystal Marconett, Beiyun Zhou, Zea Borok, Ite Offringa,

<h4>ABSTRACT</h4> Many acute and chronic lung diseases affect the distal lung alveoli. Although airway-derived human cell lines exist, alveolar epithelial cell (AEC)-derived lines are needed to better model these diseases. We have generated and characterized novel immortalized cell lines derived from human AECs. They grow as epithelial monolayers expressing lung ... Read more >>

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Molecular Screening Strategy to Identify a Non-invasive Delivery Mechanism for the Treatment of Middle Ear Disorders.

Arwa Kurabi, Molly Cooper, Meghan Spriggs, Yuge Xu, Daniel Schaerer, Allen F Ryan,

Middle ear ailments include a broad range of pathological conditions. Otitis media is the leading middle ear disease of childhood, which incurs significant health care resources in developed countries and, in developing countries, causes significant mortality and morbidity. Recurrent and chronic infections of the middle ear lead to the prolonged ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2020, 7:503819]

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Insulin Resistance in Skeletal Muscle of Chronic Stroke.

Alice S Ryan, Charlene Hafer-Macko, Heidi K Ortmeyer,

A stroke can lead to reduced mobility affecting skeletal muscle mass and fatty infiltration which could lead to systemic insulin resistance, but this has not been examined and the mechanisms are currently unknown. The objective was to compare the effects of in vivo insulin on skeletal muscle glycogen synthase (GS) ... Read more >>

Brain Sci (Brain sciences)
[2020, 11(1):]

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Radiological Assessment and Outcome of Local Disease Progression after Neoadjuvant Chemotherapy in Children and Adolescents with Localized Osteosarcoma.

Adriana Fonseca, Anne L Ryan, Paul Gibson, Eleanor Hendershot, Sevan Hopyan, Marilyn Ranson, Jennifer Stimec, Abha A Gupta,

<h4>Objective</h4>We examined the interobserver reliability of local progressive disease (L-PD) determination using two major radiological response evaluation criteria systems (Response evaluation Criteria in Solid Tumors (RECIST) and the European and American Osteosarcoma Study (EURAMOS)) in patients diagnosed with localized osteosarcoma (OS). Additionally, we describe the outcomes of patients determined to ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(12):]

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Avoidance of Nephrectomy and Percutaneous Extraction of Retroperitoneal Calculi Secondary to Xanthogranulomatous Pyelonephritis.

Jennifer Hennebry, Andreea Stroiescu, Mark Bolger, Caoimhe Byrne, Keith Cross, Anthony Ryan,

J Vasc Interv Radiol (Journal of vascular and interventional radiology : JVIR)
[2020, :]

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Assault Deterrents and Educators' Risk of Physical Assault: A Case-Control Study.

Denise M Feda, Susan G Gerberich, Andrew D Ryan, Nancy M Nachreiner, Patricia M McGovern,

The study purpose was to identify associations between assault deterrent presence in kindergarten through 12th (K-12) grade schools and physical assaults (PAs) against educators. Data collected through a two-phase study identified physical and nonphysical violent events and utilized a nested case-control study to identify PA risk/protective factors. Analyses included multivariable ... Read more >>

J Sch Nurs (The Journal of school nursing : the official publication of the National Association of School Nurses)
[2020, :1059840520976396]

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Completeness and accuracy of national cancer and death registration for outcome ascertainment in trials - an ovarian cancer exemplar

Jatinderpal Kalsi, Andy Ryan, Aleksandra Gentry-Maharaj, Danielle Crump, Naveena Singh, Matthew Burnell, Elizabeth Benjamin, Sophia Apostolidou, Mariam Habib, Susan Massingham, Karpinskyj Chloe, Robert Woolas, Martin Widschwendter, Lesley Fallowfield, Stuart Campbell, Steve Skates, Alistair McGuire, Max Parmar, Ian Jacobs, Usha Menon,

<h4>Background: </h4> There is a trend to increasing use of routinely collected health data to ascertain outcome measures in trials. We report on completeness and accuracy of national ovarian cancer and death registration in the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). <h4>Methods: </h4> Of the 202638 participants, ... Read more >>

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Intramuscular Fat Influences Neuromuscular Activation of the Gluteus Medius in Older Adults.

Marcel B Lanza, Alice S Ryan, Vicki Gray, William J Perez, Odessa Addison,

The amount of tissue between the muscle and surface electromyography (sEMG) electrode influences the sEMG signals. Increased intramuscular adipose tissue (IMAT) of the hip abductor muscles negatively impacts balance in older individuals, but it is unknown if this is related to the ability to activate the muscles. The aim of ... Read more >>

Front Physiol (Frontiers in physiology)
[2020, 11:614415]

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Palliative care nurses' experiences of clinical supervision: a qualitative evidence synthesis.

Sinéad Keane, Aoife Ryan, Niamh Adams, Maura Dowling,

<h4>Background</h4>Clinical supervision provides support and facilitates professional and personal development.<h4>Aim</h4>To identify and synthesise all available qualitative research on palliative care nurses' experiences of clinical supervision.<h4>Methods</h4>Guided by the 'enhancing transparency in reporting the synthesis of qualitative research' (ENTREQ) statement, eight databases were searched using a systematic search strategy (Cumulative Index to ... Read more >>

Int J Palliat Nurs (International journal of palliative nursing)
[2020, 26(8):413-423]

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Measures to support a safer drug supply.

Andrea Ryan, Andrea Sereda, Nadia Fairbairn,

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2020, 192(49):E1731]

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A Comprehensive Epithelial Tubo-Ovarian Cancer Risk Prediction Model Incorporating Genetic and Epidemiological Risk Factors

Andrew Lee, Xin Yang, Jonathan Tyrer, Aleksandra Gentry-Maharaj, Andy Ryan, Nasim Mavaddat, Alex Cunningham, Tim Carver, Stephanie Archer, Goska Leslie, Jatinderpal Kalsi, Faiza Gaba, Ranjit Manchanda, Simon Gayther, Susan Ramus, Fiona Walter, Marc Tischkowitz, Ian Jacobs, Usha Menon, Douglas Easton, Paul P.D. Pharoah, Antonis Antoniou,

<h4>Background</h4> Epithelial tubo-ovarian cancer (EOC) has high mortality partly due to late diagnosis. Prevention is available but may be associated with adverse effects. Several genetic and epidemiological risk factors (RFs) for EOC have been identified. A multifactorial risk model can help identify females at higher risk who could benefit from ... Read more >>

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'The Primacy of 'Home': An exploration of how older adults' transition to life in a care home towards the end of the first year.

Marie O'Neill, Assumpta Ryan, Anne Tracey, Liz Laird,

This grounded theory study sought to explore how older adults' experience the transition from living at home to a care home with a specific focus on the latter part of the first year of the move. The study was carried out within a large Health Trust in the UK between ... Read more >>

Health Soc Care Community (Health & social care in the community)
[2020, :]

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Coping with Discrimination from Peers and Adults: Implications for Adolescents' School Belonging.

Jessica P Montoro, Jessica E Kilday, Deborah Rivas-Drake, Allison M Ryan, Adriana J Umaña-Taylor,

School belonging is a key indicator of students' academic well-being that is threatened by adults' and peers' transgressions of discrimination. Moreover, the hierarchical power structure at school enables adults and peers to enact ethnic-racial discrimination differently, which is also more or less salient among Black, Asian American, and Latinx youth. ... Read more >>

J Youth Adolesc (Journal of youth and adolescence)
[2020, :]

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Alzheimer's Disease and Related Dementias and Episode Spending Under Medicare's Bundled Payment for Care Improvements Advanced (BPCI-A).

Geoffrey J Hoffman, Ushapoorna Nuliyalu, Julie Bynum, Andrew M Ryan,

J Gen Intern Med (Journal of general internal medicine)
[2020, :]

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Physical performance measures in older women with urinary incontinence: pelvic floor disorder or geriatric syndrome?

Tatiana V D Sanses, Sharee Pearson, Derik Davis, Chi Chiung Grace Chen, Soren Bentzen, Jack Guralnik, Holly E Richter, Alice S Ryan,

<h4>Introduction and hypothesis</h4>To evaluate physical performance measures of mobility and functional impairments and assess their association with urinary incontinence (UI) severity and impact on quality of life among older women with UI.<h4>Methods</h4>In a cross-sectional pilot study, 20 women aged ≥ 70 years with UI completed UI questionnaires (Global Impression of Severity, ... Read more >>

Int Urogynecol J (International urogynecology journal)
[2020, :]

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A Multimodal Sepsis Quality-Improvement Initiative Including 24/7 Screening and a Dedicated Sepsis Response Team-Reduced Readmissions and Mortality.

Muhtadi H Alnababteh, Sean Shenghsiu Huang, Andrea Ryan, Kevin M McGowan, Seife Yohannes,

<h4>Objectives</h4>To evaluate if a hospitalwide sepsis performance improvement initiative improves compliance with the Centers for Medicare and Medicaid Services-mandated sepsis bundle interventions and patient outcomes.<h4>Study design</h4>Retrospective analysis comparing 6 months before and 14 months after intervention.<h4>Setting</h4>Tertiary teaching hospital in Washington, DC.<h4>Subjects</h4>Patients admitted with a diagnosis of sepsis to a tertiary ... Read more >>

Crit Care Explor (Critical care explorations)
[2020, 2(12):e0251]

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UKCTOCS Update: Applying insights of delayed effects in cancer screening trials to the long-term follow-up mortality analysis

Matthew Burnell, Aleksandra Gentry-Maharaj, Steven Skates, Andy Ryan, Chloe Karpinskyj, Jatinderpal Kalsi, Sophia Apostolidou, Naveena Singh, Anne Dawnay, Robert Woolas, Lesley Fallowfield, Stuart Campbell, Alistair McGuire, Ian Jacobs, Mahesh Parmar, Usha Menon,

<h4>Background</h4> During trials that span decades, new evidence including progress in statistical methodology, may require revision of original assumptions. An example is the continued use of a constant-effect approach to analyse the mortality reduction which is often delayed in cancer-screening trials. The latter led us to re-examine our approach for ... Read more >>

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Relationship between Depression and Disease Activity in United States Veterans with Early Rheumatoid Arthritis Receiving Methotrexate.

Alan M Rathbun, Bryant R England, Ted R Mikuls, Alice S Ryan, Jennifer L Barton, Michelle D Shardell, Marc C Hochberg,

<h4>Objective</h4>Depression is common in rheumatoid arthritis (RA) patients, exacerbates disease activity, and may decrease response to first-line disease-modifying antirheumatic drugs. This study aimed to determine if depression affects disease activity among Veterans with early RA prescribed methotrexate (MTX).<h4>Methods</h4>Participants included Veterans enrolled in the Veterans Affairs Rheumatoid Arthritis registry with early ... Read more >>

J Rheumatol (The Journal of rheumatology)
[2020, :]

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Comparative Safety of Sleeve Gastrectomy and Gastric Bypass: An Instrumental Variables Approach.

Karan R Chhabra, Dana A Telem, Grace F Chao, David E Arterburn, Jie Yang, Jyothi R Thumma, Andrew M Ryan, Blanche Blumenthal, Justin B Dimick,

<h4>Objective</h4>To compare the safety of sleeve gastrectomy and gastric bypass in a large cohort of commercially insured bariatric surgery patients from the IBM MarketScan claims database, while accounting for measurable and unmeasurable sources of selection bias in who is chosen for each operation.<h4>Summary of background data</h4>Sleeve gastrectomy has rapidly become ... Read more >>

Ann Surg (Annals of surgery)
[2020, :]

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Ribosome quality control activity potentiates vaccinia virus protein synthesis during infection

Elayanambi Sundaramoorthy, Andrew Ryan, Amit Fulzele, Marilyn Leonard, Matthew Daugherty, Eric Bennett,

Ribosomes are highly abundant cellular machines that perform the essential task of translating the genetic code into proteins. Cellular translation activity is finely tuned and proteostasis insults, such as those incurred upon viral infection, activate stress signaling pathways that result in translation reprogramming. Viral infection selectively shuts down host mRNA ... Read more >>

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Bariatric Surgery in Medicare Patients: Examining Safety and Healthcare Utilization in the Disabled and Elderly.

Grace F Chao, Karan R Chhabra, Jie Yang, Jyothi R Thumma, David E Arterburn, Andrew M Ryan, Dana A Telem, Justin B Dimick,

<h4>Objective</h4>To compare safety and healthcare utilization after sleeve gastrectomy versus Roux-en-Y gastric bypass in a national Medicare cohort.<h4>Summary background data</h4>Though bariatric surgery is increasing among Medicare beneficiaries, no long-term, national studies examining comparative effectiveness between procedures exist. Bariatric outcomes are needed for shared decision-making and coverage policy concerns identified by ... Read more >>

Ann Surg (Annals of surgery)
[2020, :]

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Long-term outcomes of psychological interventions on children and young people's mental health: A systematic review and meta-analysis.

Stephen Pilling, Peter Fonagy, Elizabeth Allison, Phoebe Barnett, Chloe Campbell, Matthew Constantinou, Tessa Gardner, Nicolas Lorenzini, Hannah Matthews, Alana Ryan, Sofia Sacchetti, Alexandra Truscott, Tamara Ventura, Kate Watchorn, Craig Whittington, Tim Kendall,

<h4>Background</h4>Over 600 RCTs have demonstrated the effectiveness of psychosocial interventions for children and young people's mental health, but little is known about the long-term outcomes. This systematic review sought to establish whether the effects of selective and indicated interventions were sustained at 12 months.<h4>Method</h4>We conducted a systematic review and meta-analysis ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0236525]

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Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress.

Katharine J Herbert, Rathi Puliyadi, Remko Prevo, Gonzalo Rodriguez-Berriguete, Anderson Ryan, Kristijan Ramadan, Geoff S Higgins,

T-LAK-originated protein kinase (TOPK) overexpression is a feature of multiple cancers, yet is absent from most phenotypically normal tissues. As such, TOPK expression profiling and the development of TOPK-targeting pharmaceutical agents have raised hopes for its future potential in the development of targeted therapeutics. Results presented in this paper confirm ... Read more >>

Cell Death Differ (Cell death and differentiation)
[2020, :]

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