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Auxin-independent depletion of degron-tagged proteins by TIR1.

Erin Schiksnis, Angela Nicholson, Matthew Modena, Makena Pule, Joshua Arribere, Amy Pasquinelli,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

Cited: 2 times

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Transitioning to Telemedicine During COVID-19: Impact on Perceptions and Use of Telemedicine Procedures for the Diagnosis of Autism in Toddlers.

Liliana Wagner, Amy S Weitlauf, Jeffrey Hine, Laura L Corona, Anna F Berman, Amy Nicholson, William Allen, Michelle Black, Zachary Warren,

The COVID-19 pandemic has increased the use of telemedicine as an avenue to address the need for diagnostic clarification in young children at risk for autism spectrum disorder (ASD). Although preliminary research has supported the use of telemedicine for identifying ASD in toddlers, little is known about the experiences of ... Read more >>

J Autism Dev Disord (Journal of autism and developmental disorders)
[2021, :]

Cited: 0 times

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Predictors of real-time fMRI neurofeedback performance and improvement - A machine learning mega-analysis.

Amelie Haugg, Fabian M Renz, Andrew A Nicholson, Cindy Lor, Sebastian J Götzendorfer, Ronald Sladky, Stavros Skouras, Amalia McDonald, Cameron Craddock, Lydia Hellrung, Matthias Kirschner, Marcus Herdener, Yury Koush, Marina Papoutsi, Jackob Keynan, Talma Hendler, Kathrin Cohen Kadosh, Catharina Zich, Simon H Kohl, Manfred Hallschmid, Jeff MacInnes, R Alison Adcock, Kathryn C Dickerson, Nan-Kuei Chen, Kymberly Young, Jerzy Bodurka, Michael Marxen, Shuxia Yao, Benjamin Becker, Tibor Auer, Renate Schweizer, Gustavo Pamplona, Ruth A Lanius, Kirsten Emmert, Sven Haller, Dimitri Van De Ville, Dong-Youl Kim, Jong-Hwan Lee, Theo Marins, Fukuda Megumi, Bettina Sorger, Tabea Kamp, Sook-Lei Liew, Ralf Veit, Maartje Spetter, Nikolaus Weiskopf, Frank Scharnowski, David Steyrl,

Real-time fMRI neurofeedback is an increasingly popular neuroimaging technique that allows an individual to gain control over his/her own brain signals, which can lead to improvements in behavior in healthy participants as well as to improvements of clinical symptoms in patient populations. However, a considerably large ratio of participants undergoing ... Read more >>

Neuroimage (NeuroImage)
[2021, 237:118207]

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Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial.

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<h4>Background</h4>Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19.<h4>Methods</h4>This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10289):2049-2059]

Cited: 1 time

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Comparison of Nuclear Grade, Necrosis, and Histologic Subtype Between Biopsy and Resection in Pleural Malignant Mesothelioma.

Jefree J Schulte, David B Chapel, Richard Attanoos, Luka Brcic, Juliet Burn, Kelly J Butnor, Nina Chang, Heather Chen, Sanja Dacic, Marc De Perrot, Junya Fukuoka, Francoise Galateau-Salle, Theresa Godschachner, Kenzo Hiroshima, Sonja Klebe, Thomas Krausz, Leslie Litzky, Alberto M Marchevsky, Jeffrey Mueller, Kazuki Nabeshima, Andrew G Nicholson, Prodipto Pal, Anja C Roden, Sara Rorvig, Eric Santoni-Rugiu, Henry Tazelaar, Ming-Sound Tsao, Ann E Walts, Birgit Weynand, Yoshiaki Zaizen, Yu Zhi Zhang, Aliya N Husain,

<h4>Objectives</h4>Numerous studies on malignant mesothelioma (MM) highlight the prognostic importance of histologic subtype, nuclear grade, and necrosis. This study compares these parameters in paired biopsy and resection specimens of pleural MM.<h4>Methods</h4>Histologic subtype, percentage of epithelioid morphology, nuclear grade, and the presence or absence of necrosis were compared in 429 paired ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2021, :]

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Modification and application of the proximal humerus ossification system to adolescent idiopathic scoliosis patients.

Don T Li, Eric Li, Jonathan J Cui, Joseph B Kahan, Logan Petit, Giscard J Adeclat, Maxwell Modrak, Ronan Talty, Janelle D Greene, Alana M Munger, Allen D Nicholson, Erin Cravez, Daniel R Cooperman, Brian G Smith,

<h4>Purpose</h4>We have previously demonstrated that proximal humeral ossification patterns are reliable for assessing peak height velocity in growing patients. Here, we sought to modify the system by including medial physeal closure and evaluate whether this system combined with the Cobb angle correlates with progression to surgery in patients with adolescent ... Read more >>

Spine Deform (Spine deformity)
[2021, :]

Cited: 0 times

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Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.

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<h4>Background</h4>In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation.<h4>Methods</h4>This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those ... Read more >>

Lancet (Lancet (London, England))
[2021, 397(10285):1637-1645]

Cited: 10 times

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Autistic Traits Moderate Reappraisal Success for Depression and Anxiety Symptoms.

Gretchen J Diefenbach, Kimberly T Stevens, Amanda Dunlap, Alycia M Nicholson, Olivia N Grella, Godfrey Pearlson, Michal Assaf,

Cognitive reappraisal is associated with reduced emotional distress; however, little is known about the nature of this relationship in autism. This study tested whether autistic traits moderate reappraisal success (i.e., the negative correlation between reappraisal use and emotional symptom severity). Emotional symptoms were assessed using measures of depression, anxiety, and ... Read more >>

J Autism Dev Disord (Journal of autism and developmental disorders)
[2021, :]

Cited: 0 times

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Restoring large scale brain networks in the aftermath of trauma: implications for neuroscientifically-informed treatments

R. A. Lanius, P. A. Frewen, A. N. Nicholson, M. C. McKinnon,

Abstract Background: Several intrinsic networks in the brain, including the default mode network, the salience network, and the central executive network, have shown to be critical to higher cognitive functioning. Importantly, these networks have been demonstrated to be compromised in psychopathology, including posttraumatic stress disorder (PTSD) (Akiki, Averill, & Abdallah, ... Read more >>

(European Journal of Psychotraumatology)
[0, 12(Suppl ):]

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A Diffusion-like Process Accommodates New Crypts During Clonal Expansion in Human Colonic Epithelium.

Cora Olpe, Doran Khamis, Maria Chukanova, Nefeli Skoufou-Papoutsaki, Richard Kemp, Kate Marks, Cerys Tatton, Cecilia Lindskog, Anna Nicholson, Roxanne Brunton-Sim, Shalini Malhotra, Rogier Ten Hoopen, Rachael Stanley, Douglas J Winton, Edward Morrissey,

<h4>Background & aims</h4>Colorectal cancer (CRC) is thought to arise when the cumulative mutational burden within colonic crypts exceeds a certain threshold that leads to clonal expansion and ultimately neoplastic transformation. Therefore, quantification of the fixation and subsequent expansion of somatic mutations in normal epithelium is key to understanding colorectal cancer ... Read more >>

Gastroenterology (Gastroenterology)
[2021, :]

Cited: 0 times

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Community-driven tree planting greens the neighbouring landscape

Joshua Buxton, Thomas Powell, John Ambler, Chris Boulton, Arwen Nicholson, Rudy Arthur, Kirsten Lees, Hywel Williams, Timothy Lenton,

Nature-based solutions to climate change are growing policy priorities yet remain hard to quantify. Here we use remote sensing to quantify direct and indirect benefits from community-led agroforestry by The International Small group and Tree planting program (TIST) in Kenya. Since 2005, TIST-Kenya has incentivised smallholder farmers to plant trees ... Read more >>

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Comparison of medical student performance in summative undergraduate paediatric examinations and a clinician-designed minimum accepted competency (MAC) assessment.

Patrick McCrossan, Dara O'Donoghue, Alf Nicholson, Naomi McCallion,

<h4>Background</h4>It is recognised that newly qualified doctors feel unprepared in many areas of their daily practice and that there is a gap between what students learn during medical school and their clinical responsibilities early in their postgraduate career. This study aimed to assess if undergraduate students and junior paediatric doctors ... Read more >>

BMC Med Educ (BMC medical education)
[2021, 21(1):197]

Cited: 0 times

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Effects of flock age, storage temperature, and short period of incubation during egg storage, on the albumen quality, embryonic development and hatchability of long stored eggs.

S Özlü, A Uçar, T Erkuş, S Yasun, A D Nicholson, O Elibol,

1. The effect of breeder flock age, storage temperature and a short period of incubation during egg storage (SPIDES) on albumen quality, development of blastoderm, and hatchability of long-stored eggs was evaluated.2. Hatching eggs were collected from 28-week-old (young) and 40-week-old (prime) Ross female line grandparent flocks and were stored ... Read more >>

Br Poult Sci (British poultry science)
[2021, :1-9]

Cited: 0 times

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Spectrum of childhood interstitial and diffuse lung diseases at a tertiary hospital in Egypt.

Salma G Abdelhady, Eman M Fouda, Malak A Shaheen, Faten A Ghazal, Ahmed M Mostafa, Ahmed M Osman, Andrew G Nicholson, Heba M Hamza,

<h4>Background</h4>Childhood interstitial and diffuse lung diseases (chILD) encompass a broad spectrum of rare pulmonary disorders. In most developing Middle Eastern countries, chILD is still underdiagnosed. Our objective was to describe and investigate patients diagnosed with chILD in a tertiary university hospital in Egypt.<h4>Methods</h4>We analysed data of consecutive subjects (aged <18 years) ... Read more >>

ERJ Open Res (ERJ open research)
[2021, 7(2):]

Cited: 0 times

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Spectrum of childhood interstitial and diffuse lung diseases at a tertiary hospital in Egypt

Salma G. Abdelhady, Eman M. Fouda, Malak A. Shaheen, Faten A. Ghazal, Ahmed M. Mostafa, Ahmed M. Osman, Andrew G. Nicholson, Heba M. Hamza,

<h4>Background</h4> Childhood interstitial and diffuse lung diseases (chILD) encompass a broad spectrum of rare pulmonary disorders. In most developing Middle Eastern countries, chILD is still underdiagnosed. Our objective was to describe and investigate patients diagnosed with chILD in a tertiary university hospital in Egypt. <h4>Methods</h4> We analysed data of consecutive ... Read more >>

ERJ Open Res (ERJ open research)
[2021, 7(2):]

Cited: 0 times

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The concept of mesothelioma in situ, with consideration of its potential impact on cytology diagnosis.

Sonja Klebe, Yukio Nakatani, Katalin Dobra, Kelly J Butnor, Anja C Roden, Andrew G Nicholson, Alberto M Marchevsky, Aliya N Husain, Amanda Segal, Ann E Walts, Birgit Weynand, Claire W Michael, Sanja Dacic, David Godbolt, Richard Attanoos, Eric Santoni-Rugiu, Françoise Galateau-Salle, Kenzo Hiroshima, Andre L Moreira, Juliet Burn, Kazuki Nabeshima, Allen R Gibbs, Andrew Churg, Leslie A Litzky, Luka Brcic, Ming Sound Tsao, Mari Mino-Kenudson, Sara B Rørvig, Henry D Tazelaar, Thomas Krausz, Yu Zhi Zhang, Lucian R Chirieac, Mary B Beasley, Anders Hjerpe,

Diffuse malignant mesothelioma (MM) is an incurable tumour of the serosal membranes, which is often caused by exposure to asbestos and commonly diagnosed at advanced stage. Malignant mesothelioma in situ (MMIS) is now included as diagnostic category by the World Health Organization (WHO). However, our international survey of 34 pulmonary ... Read more >>

Pathology (Pathology)
[2021, 53(4):446-453]

Cited: 0 times

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Fructose 1,6-bisphosphatase deficiency as a cause of childhood interstitial lung disease.

Rebecca Devaney, Timothy Simpson, Andrew Bush, Sumit Jagani, Andrew G Nicholson, Thomas Semple, Jayesh Mahendra Bhatt,

Pediatr Pulmonol (Pediatric pulmonology)
[2021, :]

Cited: 0 times

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Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits.

Rosa Rademakers, Alexandra M Nicholson, Yingxue Ren, Shunsuke Koga, Hung Phuoc Nguyen, Mieu Brooks, Wenhui Qiao, Zachary S Quicksall, Billie Matchett, Ralph B Perkerson, Aishe Kurti, Monica Castanedes-Casey, Virginia Phillips, Ariston L Librero, Cristhoper H Fernandez De Castro, Matthew C Baker, Shanu F Roemer, Melissa E Murray, Yan Asmann, John D Fryer, Guojun Bu, Dennis W Dickson, Xiaolai Zhou,

TMEM106B has been recently implicated in multiple neurodegenerative diseases. Here, Rademakers et al. report a late-onset cerebellar Purkinje cell loss and progressive decline in motor function and gait deficits in a conventional Tmem106b-/- mouse model. By using high-power microscopy and bulk RNA sequencing, the authors further identify lysosomal and immune ... Read more >>

Brain Pathol (Brain pathology (Zurich, Switzerland))
[2021, 31(3):e12945]

Cited: 0 times

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Predicting fear and perceived health during the COVID-19 pandemic using machine learning: A cross-national longitudinal study.

Stephanie Josephine Eder, David Steyrl, Michal Mikolaj Stefanczyk, Michał Pieniak, Judit Martínez Molina, Ondra Pešout, Jakub Binter, Patrick Smela, Frank Scharnowski, Andrew A Nicholson,

During medical pandemics, protective behaviors need to be motivated by effective communication, where finding predictors of fear and perceived health is of critical importance. The varying trajectories of the COVID-19 pandemic in different countries afford the opportunity to assess the unique influence of 'macro-level' environmental factors and 'micro-level' psychological variables ... Read more >>

PLoS One (PloS one)
[2021, 16(3):e0247997]

Cited: 0 times

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The International Association for the Study of Lung Cancer Global Survey on Programmed Death-Ligand 1 Testing for NSCLC.

Mari Mino-Kenudson, Nolwenn Le Stang, Jillian B Daigneault, Andrew G Nicholson, Wendy A Cooper, Anja C Roden, Andre L Moreira, Erik Thunnissen, Mauro Papotti, Giuseppe Pelosi, Noriko Motoi, Claudia Poleri, Elisabeth Brambilla, Mary Redman, Deepali Jain, Sanja Dacic, Yasushi Yatabe, Ming Sound Tsao, Fernando Lopez-Rios, Johan Botling, Gang Chen, Teh-Ying Chou, Fred R Hirsch, Mary Beth Beasley, Alain Borczuk, Lukas Bubendorf, Jin-Haeng Chung, David Hwang, Dongmei Lin, John Longshore, Masayuki Noguchi, Natasha Rekhtman, Lynette Sholl, William Travis, Akihiko Yoshida, Murry W Wynes, Ignacio I Wistuba, Keith M Kerr, Sylvie Lantuejoul,

<h4>Introduction</h4>Programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) is required to determine the eligibility for pembrolizumab monotherapy in advanced NSCLC worldwide and for several other indications depending on the country. Four assays have been approved/ Communauté Européene-In vitro Diagnostic (CV-IVD)-marked, but PD-L1 IHC seems diversely implemented across regions and laboratories with the application ... Read more >>

J Thorac Oncol (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer)
[2021, 16(4):686-696]

Cited: 0 times

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Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.

, Anthony C Gordon, Paul R Mouncey, Farah Al-Beidh, Kathryn M Rowan, Alistair D Nichol, Yaseen M Arabi, Djillali Annane, Abi Beane, Wilma van Bentum-Puijk, Lindsay R Berry, Zahra Bhimani, Marc J M Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Adrian Buzgau, Allen C Cheng, Michelle A Detry, Eamon J Duffy, Lise J Estcourt, Mark Fitzgerald, Herman Goossens, Rashan Haniffa, Alisa M Higgins, Thomas E Hills, Christopher M Horvat, Francois Lamontagne, Patrick R Lawler, Helen L Leavis, Kelsey M Linstrum, Edward Litton, Elizabeth Lorenzi, John C Marshall, Florian B Mayr, Daniel F McAuley, Anna McGlothlin, Shay P McGuinness, Bryan J McVerry, Stephanie K Montgomery, Susan C Morpeth, Srinivas Murthy, Katrina Orr, Rachael L Parke, Jane C Parker, Asad E Patanwala, Ville Pettilä, Emma Rademaker, Marlene S Santos, Christina T Saunders, Christopher W Seymour, Manu Shankar-Hari, Wendy I Sligl, Alexis F Turgeon, Anne M Turner, Frank L van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J Lewis, Derek C Angus, Colin J McArthur, Scott Berry, Steve A Webb, Lennie P G Derde,

<h4>Background</h4>The efficacy of interleukin-6 receptor antagonists in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear.<h4>Methods</h4>We evaluated tocilizumab and sarilumab in an ongoing international, multifactorial, adaptive platform trial. Adult patients with Covid-19, within 24 hours after starting organ support in the intensive care unit (ICU), were randomly assigned to ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(16):1491-1502]

Cited: 53 times

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Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19.

Francisco J Salguero, Andrew D White, Gillian S Slack, Susan A Fotheringham, Kevin R Bewley, Karen E Gooch, Stephanie Longet, Holly E Humphries, Robert J Watson, Laura Hunter, Kathryn A Ryan, Yper Hall, Laura Sibley, Charlotte Sarfas, Lauren Allen, Marilyn Aram, Emily Brunt, Phillip Brown, Karen R Buttigieg, Breeze E Cavell, Rebecca Cobb, Naomi S Coombes, Alistair Darby, Owen Daykin-Pont, Michael J Elmore, Isabel Garcia-Dorival, Konstantinos Gkolfinos, Kerry J Godwin, Jade Gouriet, Rachel Halkerston, Debbie J Harris, Thomas Hender, Catherine M K Ho, Chelsea L Kennard, Daniel Knott, Stephanie Leung, Vanessa Lucas, Adam Mabbutt, Alexandra L Morrison, Charlotte Nelson, Didier Ngabo, Jemma Paterson, Elizabeth J Penn, Steve Pullan, Irene Taylor, Tom Tipton, Stephen Thomas, Julia A Tree, Carrie Turner, Edith Vamos, Nadina Wand, Nathan R Wiblin, Sue Charlton, Xiaofeng Dong, Bassam Hallis, Geoffrey Pearson, Emma L Rayner, Andrew G Nicholson, Simon G Funnell, Julian A Hiscox, Mike J Dennis, Fergus V Gleeson, Sally Sharpe, Miles W Carroll,

A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of the current COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to understand the pathogenesis of emerging diseases and to assess the safety and efficacy of novel vaccines and therapeutics. Here, we show that SARS-CoV-2 replicates ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):1260]

Cited: 0 times

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The Monash Autism-ADHD Genetics and Neurodevelopment (MAGNET) Project Design and Methodologies: A dimensional approach to understanding neurobiological and genetic aetiology.

Rachael Knott, Beth Johnson, Jeggan Tiego, Olivia Mellahn, Amy Finlay, Kathryn Kallady, Maria Kouspous, Vishnu Priya Mohankuma Sindhu, Ziarih Hawi, Aurina Arnatkeviciute, Tracey Chau, Dalia Maron, Emily-Clare Mercieca, Kirsten Furley, Katrina Harris, Katrina Williams, Alexandra Ure, Alex Fornito, Kylie Gray, David Coghill, Ann Nicholson, Dinh Phuong, Eva Loth, Luke Mason, Declan Murphy, Jan Buitelaar, Mark Bellgrove,

<h4>Background: </h4> ASD and ADHD are prevalent neurodevelopmental disorders that frequently co-occur and have strong evidence for a degree of shared genetic aetiology. Behavioural and neurocognitive heterogeneity in ASD and ADHD has hampered attempts to map the underlying genetics and neurobiology, predict intervention response, and improve diagnostic accuracy. Moving away ... Read more >>

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A Plan-Do-Study-Act Approach to the Development, Implementation and Evaluation of a Patient Navigation Program to Reduce Breast Cancer Screening Disparities in Un- and Under-Insured, Racially and Ethnically Diverse Urban Women.

Carmen E Guerra, Emily Verderame, Andrea Nicholson, LiYea Wan, Ari D Brooks,

<b>Introduction:</b> For the over 28 million Americans without health insurance, there is a great need to develop programs that help meet the health needs of the uninsured population. <b>Materials and Methods:</b> We applied the Plan-Do-Study-Act (PDSA) quality improvement framework to the development, implementation, and evaluation of a breast cancer screening ... Read more >>

Front Public Health (Frontiers in public health)
[2021, 9:595786]

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Multicenter Evaluation of 434 Hospital Deaths From COVID-19: How Can We Improve End-of-Life Care During a Pandemic?

Felicity Dewhurst, Hannah Billett, Lauri Simkiss, Charlotte Bryan, Julie Barnsley, Max Charles, Elizabeth Fleming, Jennifer Grieve, Sade Hacking, Kate Howorth, Amy Huggin, Emily Kavanagh, Rachel Kiltie, Lucy Lowery, Dene Miller, Alex Nicholson, Lucy Nicholson, Ann Paxton, Anna Porteous, Grace Rowley, Kaly Snell, Elizabeth Woods, Elizabeth Zabrocki, Katherine Frew, Leena Srivastava,

<h4>Context</h4>The pandemic has substantially increased the workload of hospital palliative care providers, requiring them to be responsive and innovative despite limited information on the specific end of life care needs of patients with COVID-19. Multi-site data detailing clinical characteristics of patient deaths from large populations, managed by specialist and generalist ... Read more >>

J Pain Symptom Manage (Journal of pain and symptom management)
[2021, 61(5):e7-e12]

Cited: 0 times

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