Full Text Journal Articles by
Author A J Hughes

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New Light on the Mechanism of Phototransduction in Phototropin.

L Henry, O Berntsson, M R Panman, A Cellini, A J Hughes, I Kosheleva, R Henning, S Westenhoff,

Phototropins are photoreceptor proteins that regulate blue light-dependent biological processes for efficient photosynthesis in plants and algae. The proteins consist of a photosensory domain that responds to the ambient light and an output module that triggers cellular responses. The photosensory domain of phototropin from Chlamydomonas reinhardtii contains two conserved LOV ... Read more >>

Biochemistry (Biochemistry)
[2020, 59(35):3206-3215]

Cited: 0 times

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Auto-Decompression - Preserved Neurological Function in Bilateral Cervical Facet Dislocations.

T Ó Doinn, A J Hughes, D P Ahern, J McDonnell, E Kavanagh, S Morris, J S Butler,

Introduction Bilateral cervical facet dislocation (BCFD) is an uncommon injury with a high incidence of severe neurological impairment. We describe 4 cases of BCFD with preserved neurological function. Case 1: A 78-year-old female who suffered two ground level falls (GLFs). Pre-operative American Spinal Injury Association (ASIA) Score was C5D. Imaging ... Read more >>

Ir Med J (Irish medical journal)
[2020, 113(7):131]

Cited: 0 times

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Lipodermatosclerosis of the pendulous abdomen.

J Frewen, A J Hughes, J Denny, J Natkunarajah,

Clin Exp Dermatol (Clinical and experimental dermatology)
[2020, 45(5):626-627]

Cited: 0 times

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Giant scabetic plaques.

E Shuber, A J Hughes, J Natkunarajah,

Clin Exp Dermatol (Clinical and experimental dermatology)
[2020, 45(5):587-589]

Cited: 0 times

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Methotrexate for papuloerythroderma of Ofuji.

F Qureshi, A J Hughes, J Natkunarajah,

Clin Exp Dermatol (Clinical and experimental dermatology)
[2020, 45(2):241-243]

Cited: 0 times

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ASC acts in a caspase-1-independent manner to worsen acute pneumonia caused by Pseudomonas aeruginosa.

A J Hughes, C A Knoten, A R Morris, A R Hauser,

PURPOSE:Pseudomonas aeruginosa expresses a type III secretion system (T3SS) that activates the host inflammasome-mediated immune response. We examined the role of inflammasome activation in severe infection outcomes. METHODS:We infected C57BL/6 (B6) mice lacking inflammasome components ASC or caspase-1/11 with a highly virulent strain of P. aeruginosa, PSE9, using a mouse ... Read more >>

J Med Microbiol (Journal of medical microbiology)
[2018, 67(8):1168-1180]

Cited: 0 times

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Habitual condom use across partner type and sexual position among younger gay and bisexual men: findings from New Zealand HIV behavioural surveillance 2006-2011.

N J Lachowsky, C E Dewey, N P Dickson, P J W Saxton, A J Hughes, R R Milhausen, A J S Summerlee,

OBJECTIVES:Our objectives were to investigate demographic and behavioural factors associated with condom use and to examine how habitual condom use was across partner types and sexual positions among younger men who have sex with men (YMSM), aged 16-29, surveyed in New Zealand. METHODS:We analysed the 2006-2011 national HIV behavioural surveillance ... Read more >>

Sex Transm Infect (Sexually transmitted infections)
[2015, 91(6):445-450]

Cited: 6 times

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Temporal regularity determines the impact of electrical stimulation on tactile reactivity and response to capsaicin in spinally transected rats.

K M Baumbauer, K H Lee, D A Puga, S A Woller, A J Hughes, J W Grau,

Nociceptive plasticity and central sensitization within the spinal cord depend on neurobiological mechanisms implicated in learning and memory in higher neural systems, suggesting that the factors that impact brain-mediated learning and memory could modulate how stimulation affects spinal systems. One such factor is temporal regularity (predictability). The present paper shows ... Read more >>

Neuroscience (Neuroscience)
[2012, 227:119-133]

Cited: 8 times

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HIV prevalence among men who have sex with men in New Zealand 1985-2009: 25 years of public health monitoring.

P J W Saxton, N P Dickson, S M McAllister, A J Hughes, K Sharples,

Annual population-based estimates of the number of men who have sex with men (MSM) with diagnosed HIV infection (HIV prevalence pool), and the proportion of all MSM this represents (HIV prevalence), have been insufficiently described over the long term. We investigated the dynamic effects of ongoing HIV diagnoses, lower mortality ... Read more >>

Int J STD AIDS (International journal of STD & AIDS)
[2012, 23(4):274-279]

Cited: 3 times

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Rotational drift of mandibular third molar teeth: a series of four cases.

A J Hughes, S T Vudiniabola, B D McMillan, A C Smith,

Rotational drift of mandibular third molar teeth is a challenge for clinicians to predict and manage. Evidence on the incidence and degree of rotation is sparse. As the factors influencing rotation are not defined, prediction is impossible. A series of four cases with lower third molar rotation are presented and ... Read more >>

Aust Dent J (Australian dental journal)
[2009, 54(1):54-56]

Cited: 1 time

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Timing in the absence of supraspinal input I: variable, but not fixed, spaced stimulation of the sciatic nerve undermines spinally-mediated instrumental learning.

K M Baumbauer, K C Hoy, J R Huie, A J Hughes, S A Woller, D A Puga, B Setlow, J W Grau,

Rats with complete spinal transections are capable of acquiring a simple instrumentally trained response. If rats receive shock to one hind limb when the limb is extended (controllable shock), the spinal cord will learn to hold the leg in a flexed position that minimizes shock exposure. If shock is delivered ... Read more >>

Neuroscience (Neuroscience)
[2008, 155(4):1030-1047]

Cited: 25 times

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Successful control of an outbreak of invasive aspergillosis in a regional haematology unit during hospital construction works.

C C Chang, A C Cheng, B Devitt, A J Hughes, P Campbell, K Styles, J Low, E Athan,

We report the successful control of an outbreak of six cases of nosocomial invasive aspergillosis (IA) in our haematology unit coinciding with major hospital construction works. Infection control changes included unit relocation, impermeable barriers at construction site, face-masking and voriconazole prophylaxis of 18 further high-risk patients, none of which developed ... Read more >>

J. Hosp. Infect. (The Journal of hospital infection)
[2008, 69(1):33-38]

Cited: 15 times

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Diagnosis of Mycobacterium tuberculosis infection using ESAT-6 and intracellular cytokine cytometry.

A J Hughes, P Hutchinson, T Gooding, N J Freezer, S R Holdsworth, P D R Johnson,

Diagnosis of infection with Mycobacterium tuberculosis (MTB) using tuberculin skin testing (TST) is often hampered by prior Bacille Calmette-Guérin (BCG) vaccination. ESAT-6 is a protein that is expressed by MTB but absent in BCG. It has been postulated that it might be useful in distinguishing MTB-specific immune responses. This study ... Read more >>

Clin. Exp. Immunol. (Clinical and experimental immunology)
[2005, 142(1):132-139]

Cited: 29 times

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Lewy body cortical involvement may not always predict dementia in Parkinson's disease.

C Colosimo, A J Hughes, L Kilford, A J Lees,

BACKGROUND:The presence of Lewy bodies (LB) in the neocortex and limbic system in patients with Parkinson's disease (PD) is commonly thought to be linked with cognitive impairment. The authors present here a series of patients with diagnosis of PD in life and no significant cognitive impairment who, at necropsy, satisfied ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2003, 74(7):852-856]

Cited: 90 times

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Parasitic worms of the central nervous system: an Australian perspective.

A J Hughes, B A Biggs,

The diagnosis and management of parasitic diseases of the central nervous system (CNS) is difficult, even for infectious diseases physicians and neurologists. Furthermore, few overviews of the spectrum of causative helminths and clinical syndromes have been published. In the present study, we review the seven most common parasitic diseases of ... Read more >>

Intern Med J (Internal medicine journal)
[2002, 32(11):541-553]

Cited: 21 times

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What features improve the accuracy of clinical diagnosis in Parkinson's disease: a clinicopathologic study. 1992.

A J Hughes, Y Ben-Shlomo, S E Daniel, A J Lees,

Neurology (Neurology)
[2001, 57(10 Suppl 3):S34-8]

Cited: 78 times

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Polymyositis as a cause of total gut failure.

A J Hughes, I Ferguson, E Rankin, K Kane,

BACKGROUND:Gastrointestinal manifestations are seen in systemic sclerosis and mixed connective tissue disorders but are rare in pure polymyositis. CASE REPORT:A 44 year old woman with polymyositis who developed total gut failure requiring treatment with total parenteral nutrition is described. RESULTS:The patient's polymyositis is now fully controlled biochemically, but her gastrointestinal ... Read more >>

Ann Rheum Dis (Annals of the rheumatic diseases)
[2002, 61(4):305-306]

Cited: 6 times

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Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease.

A J Hughes, S E Daniel, A J Lees,

The authors studied the accuracy of clinical diagnosis of idiopathic PD (IPD) in 100 consecutive clinically diagnosed cases that came to neuropathological examination. Ninety fulfilled pathologic criteria for IPD. Ten were misdiagnosed: multiple system atrophy (six), progressive supranuclear palsy (two), post-encephalitic parkinsonism (one), and vascular parkinsonism (one). Assessment of the ... Read more >>

Neurology (Neurology)
[2001, 57(8):1497-1499]

Cited: 380 times

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Motor imagery in Parkinson's disease: a PET study.

R Cunnington, G F Egan, J D O'Sullivan, A J Hughes, J L Bradshaw, J G Colebatch,

We used positron emission tomography (PET) with 15O-labelled water to record patterns of cerebral activation in six patients with Parkinson's disease (PD), studied when clinically "off" and after turning "on" as a result of dopaminergic stimulation. They were asked to imagine a finger opposition movement performed with their right hand, ... Read more >>

Mov. Disord. (Movement disorders : official journal of the Movement Disorder Society)
[2001, 16(5):849-857]

Cited: 37 times

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New dopaminergic neurons in Parkinson's disease striatum.

M J Porritt, P E Batchelor, A J Hughes, R Kalnins, G A Donnan, D W Howells,

A new population of dopaminergic neurons has been identified in Parkinson's disease striatum. These neurons are sufficiently numerous to have an important effect on dopaminergic function in the striatum. ... Read more >>

Lancet (Lancet (London, England))
[2000, 356(9223):44-45]

Cited: 77 times

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Voice characteristics in the progression of Parkinson's disease.

R J Holmes, J M Oates, D J Phyland, A J Hughes,

This study examined the acoustic and perceptual voice characteristics of patients with Parkinson's disease according to disease severity. The perceptual and acoustic voice characteristics of 30 patients with early stage PD and 30 patients with later stage PD were compared with data from 30 normal control subjects. Voice recordings consisted ... Read more >>

Int J Lang Commun Disord (International journal of language & communication disorders)
[2000, 35(3):407-418]

Cited: 50 times

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Response of parkinsonian swallowing dysfunction to dopaminergic stimulation.

P C Hunter, J Crameri, S Austin, M C Woodward, A J Hughes,

OBJECTIVES:To determine the degree of dopaminergic response of swallowing dysfunction in Parkinson's disease. METHODS:Fifteen patients with idiopathic Parkinson's disease and symptomatic dysphagia were studied. All had motor fluctuations in response to long term levodopa therapy. On two separate days, after overnight withdrawal of all antiparkinsonian medication, a modified barium swallow ... Read more >>

J. Neurol. Neurosurg. Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[1997, 63(5):579-583]

Cited: 73 times

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Apomorphine responses in Parkinson's disease and the pathogenesis of motor complications.

C Colosimo, M Merello, A J Hughes, K Sieradzan, A J Lees,

Neurology (Neurology)
[1998, 50(2):573-574]

Cited: 5 times

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Clinicopathological aspects of Parkinson's disease.

A J Hughes,

Clinicopathological studies have shown that the accuracy of a clinical diagnosis of Parkinson's disease (PD) is less than 80%. More selected diagnostic criteria can increase the proportion of true PD cases identified to more than 90%. However, by using these criteria almost a third of pathologically confirmed cases may be ... Read more >>

Eur. Neurol. (European neurology)
[1997, 38 Suppl 2:13-20]

Cited: 10 times

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Drug treatment of Parkinson's disease in the 1990s. Achievements and future possibilities.

A J Hughes,

Advances in the medical treatment of Parkinson's disease have improved the disability related to complications of long term levodopa therapy, including motor fluctuations, dyskinesias and neuropsychiatric toxicity. A range of new dopamine agonists are in various stages of preclinical and clinical development. Cabergoline appears to be effective in improving moderate ... Read more >>

Drugs (Drugs)
[1997, 53(2):195-205]

Cited: 6 times

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