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Author A Holmes

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Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence.

Moritz U G Kraemer, Verity Hill, Christopher Ruis, Simon Dellicour, Sumali Bajaj, John T McCrone, Guy Baele, Kris V Parag, Anya Lindström Battle, Bernardo Gutierrez, Ben Jackson, Rachel Colquhoun, Áine O'Toole, Brennan Klein, Alessandro Vespignani, , Erik Volz, Nuno R Faria, David Aanensen, Nicholas J Loman, Louis du Plessis, Simon Cauchemez, Andrew Rambaut, Samuel V Scarpino, Oliver G Pybus,

Understanding the causes and consequences of the emergence of SARS-CoV-2 variants of concern is crucial to pandemic control yet difficult to achieve, as they arise in the context of variable human behavior and immunity. We investigate the spatial invasion dynamics of lineage B.1.1.7 by jointly analyzing UK human mobility, virus ... Read more >>

Science (Science (New York, N.Y.))
[2021, :]

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Patient understanding of and participation in infection-related care across surgical pathways: a scoping review.

Oluchi Mbamalu, Candice Bonaconsa, Vrinda Nampoothiri, Surya Surendran, Pranav Veepanattu, Sanjeev Singh, Puneet Dhar, Vanessa Carter, Adam Boutall, Timothy Pennel, Mark Hampton, Alison Holmes, Marc Mendelson, Esmita Charani,

<h4>Objective</h4>To explore the existing evidence on patient understanding of and/or participation in infection-related care in surgical specialties.<h4>Method</h4>A scoping review of literature was conducted. PubMed, Web of Science, Scopus, and grey literature sources were searched using predefined search criteria for policies, guidelines and studies in English. Data synthesis was through content ... Read more >>

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2021, :]

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Evolving biological associations of upfront cytoreductive nephrectomy in metastatic renal cell carcinoma.

Andrew W Silagy, Ritesh R Kotecha, Stanley Weng, Arturo Holmes, Nirmish Singla, Roy Mano, Kyrollis Attalla, Kate L Weiss, Renzo G DiNatale, Sujata Patil, Jonathan A Coleman, Robert J Motzer, Paul Russo, Martin H Voss, A Ari Hakimi,

<h4>Background</h4>Systemic responses to cytoreductive nephrectomy (CN) in the management of metastatic renal cell carcinoma (mRCC) are variable and difficult to anticipate. The authors aimed to determine the association of CN with modifiable International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk factors and oncological outcomes.<h4>Methods</h4>Consecutive patients with mRCC referred for ... Read more >>

Cancer (Cancer)
[2021, :]

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More and Better: Reappraisal Quality Partially Explains the Effect of Reappraisal Use on Changes in Positive and Negative Affect

Matthew Southward, Anne Holmes, Daniel Strunk, Jennifer Cheavens,

<p>Background: A substantial body of research suggests that cognitive reappraisal is effective at improving momentary affect, but it remains unclear how reappraisal leads to these changes. We tested the quality of reappraisal as one potential mechanism. <h4>Methods:</h4> A sample of 314 participants (Mage = 36.30; 51.0% female; 69.4% White) recruited ... Read more >>

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Quantifying within-school SARS-CoV-2 transmission and the impact of lateral flow testing in secondary schools in England

Trystan Leng, Edward Hill, Alex Holmes, Emma Southall, Robin Thompson, Michael Tildesley, Matt Keeling, Louise Dyson,

<h4>Background</h4> To control within-school SARS-CoV-2 transmission in England, secondary school pupils have been encouraged to participate in twice weekly mass testing via lateral flow device tests (LFTs) from 8th March 2021, to complement an isolation of close contacts policy in place since 31st August 2020. Strategies involving the isolation of ... Read more >>

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Correction to: Diauxic Inhibition: Jacques Monod's Ignored Work.

Pierre Louis Blaiseau, Allyson M Holmes,

J Hist Biol (Journal of the history of biology)
[2021, :]

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Hospital-onset COVID-19 infection surveillance systems: a systematic review.

M Abbas, N J Zhu, S Mookerjee, F Bolt, J A Otter, A H Holmes, J R Price,

Hospital-onset COVID-19 infections (HOCIs) are associated with excess morbidity and mortality in patients and healthcare workers. The aim of this review was to explore and describe the current literature in HOCI surveillance. Medline, EMBASE, the Cochrane Database of Systematic Reviews, the Cochrane Register of Controlled Trials, and MedRxiv were searched ... Read more >>

J Hosp Infect (The Journal of hospital infection)
[2021, 115:44-50]

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An Ageing Population Creates New Challenges Around Consent to Medical Treatment.

Alice L Holmes, Joseph E Ibrahim,

Obtaining consent for medical treatment in older adults raises a number of complex challenges. Despite being required by ethics and the law, consent for medical treatment is not always validly sought in this population. The dynamic nature of capacity, particularly in individuals who have dementia or other cognitive impairments, adds ... Read more >>

J Bioeth Inq (Journal of bioethical inquiry)
[2021, :]

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International Journal of Infectious Diseases: from the past quarter-century to the next.

E Petersen, S S Lee, L Blumberg, L D Kramer, C Obiero, S Al-Abri, A Abubakar, T C A Pinto, B R Yapi, P A Tambyah, A H Holmes,

Int J Infect Dis (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2021, 109:36-37]

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Changing patterns of bloodstream infections in the community and in acute care across two COVID-19 epidemic waves: a retrospective analysis

Nina Zhu, Timothy Rawson, Siddharth Mookerjee, James Price, Frances Davies, Jonathan Otter, Paul Aylin, Russell Hope, Mark Gilchrist, Yeeshika Shersing, Alison Holmes,

<h4>Introduction: </h4> We examined the epidemiology of community- and hospital-acquired bloodstream infections (BSIs) in COVID-19 and non-COVID-19 patients across two epidemic waves. <h4>Methods: </h4> We analysed blood cultures, SARS-CoV-2 tests, and hospital episodes of patients presenting and admitted to a London hospital group between January 2020 and February 2021. We ... Read more >>

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Shifting gradients of macroscale cortical organization mark the transition from childhood to adolescence.

Hao-Ming Dong, Daniel S Margulies, Xi-Nian Zuo, Avram J Holmes,

The transition from childhood to adolescence is marked by pronounced shifts in brain structure and function that coincide with the development of physical, cognitive, and social abilities. Prior work in adult populations has characterized the topographical organization of the cortex, revealing macroscale functional gradients that extend from unimodal (somatosensory/motor and ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(28):]

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Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study.

Thomas M Drake, Aya M Riad, Cameron J Fairfield, Conor Egan, Stephen R Knight, Riinu Pius, Hayley E Hardwick, Lisa Norman, Catherine A Shaw, Kenneth A McLean, A A Roger Thompson, Antonia Ho, Olivia V Swann, Michael Sullivan, Felipe Soares, Karl A Holden, Laura Merson, Daniel Plotkin, Louise Sigfrid, Thushan I de Silva, Michelle Girvan, Clare Jackson, Clark D Russell, Jake Dunning, Tom Solomon, Gail Carson, Piero Olliaro, Jonathan S Nguyen-Van-Tam, Lance Turtle, Annemarie B Docherty, Peter Jm Openshaw, J Kenneth Baillie, Ewen M Harrison, Malcolm G Semple, ,

<h4>Background</h4>COVID-19 is a multisystem disease and patients who survive might have in-hospital complications. These complications are likely to have important short-term and long-term consequences for patients, health-care utilisation, health-care system preparedness, and society amidst the ongoing COVID-19 pandemic. Our aim was to characterise the extent and effect of COVID-19 complications, ... Read more >>

Lancet (Lancet (London, England))
[2021, 398(10296):223-237]

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Macro level factors influencing strategic responses to emergent pandemics: A scoping review.

Nina J Zhu, Ewan B Ferlie, Enrique Castro-Sánchez, Gabriel Birgand, Alison H Holmes, Rifat A Atun, Hailey Kieltyka, Raheelah Ahmad, ,

<h4>Background</h4>Strategic planning is critical for successful pandemic management. This study aimed to identify and review the scope and analytic depth of situation analyses conducted to understand their utility, and capture the documented macro-level factors impacting pandemic management.<h4>Methods</h4>To synthesise this disparate body of literature, we adopted a two-step search and review ... Read more >>

J Glob Health (Journal of global health)
[2021, 11:05012]

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Corrigendum to: Spatial Topography of Individual-Specific Cortical Networks Predicts Human Cognition, Personality and Emotion.

Ru Kong, Jingwei Li, Csaba Orban, Mert R Sabuncu, Hesheng Liu, Alexander Schaefer, Nanbo Sun, Xi-Nian Zuo, Avram J Holmes, Simon B Eickhoff, B T Thomas Yeo,

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2021, 31(8):3974]

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Macro level influences on strategic responses to the COVID-19 pandemic - an international survey and tool for national assessments.

Raheelah Ahmad, Rifat A Atun, Gabriel Birgand, Enrique Castro-Sánchez, Esmita Charani, Ewan B Ferlie, Izhar Hussain, Andrew Kambugu, Jaime Labarca, Gabriel Levy Hara, Martin McKee, Marc Mendelson, Sanjeev Singh, Jay Varma, Nina J Zhu, Walter Zingg, Alison H Holmes, ,

<h4>Background</h4>Variation in the approaches taken to contain the SARS-CoV-2 (COVID-19) pandemic at country level has been shaped by economic and political considerations, technical capacity, and assumptions about public behaviours. To address the limited application of learning from previous pandemics, this study aimed to analyse perceived facilitators and inhibitors during the ... Read more >>

J Glob Health (Journal of global health)
[2021, 11:05011]

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SARS-CoV-2 lineage B.1.1.7 is associated with greater disease severity among hospitalised women but not men

Oliver Stirrup, Florencia Boshier, Cristina Venturini, José Afonso Guerra-Assunção, Adela Alcolea-Medina, Angela Becket, Themoula Charalampous, Ana da Silva Filipe, Sharon Glaysher, Tabassum Khan, Raghavendran Kulasegara-Shylini, Beatrix Kele, Irene Monahan, Guy Mollett, Matthew Parker, Emanuela Pelosi, Paul Randell, Sunando Roy, Joshua Taylor, Sophie Weller, Eleri Wilson-Davies, Phillip Wade, Rachel Williams, Andrew Copas, Teresa Cutino-Moguel, Nick Freemantle, Andrew Hayward, Alison Holmes, Joseph Hughes, Tabitha Mahungu, Gaia Nebbia, David Partridge, Cassie Pope, James Price, Samuel Robson, Kordo Saeed, Thushan de Silva, Luke Snell, Emma Thomson, Adam Witney, Judith Breuer, , ,

<h4>Background</h4> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage B.1.1.7 has been associated with an increased rate of transmission and disease severity among subjects testing positive in the community. Its impact on hospitalised patients is less well documented. <h4>Methods</h4> We collected viral sequences and clinical data of patients admitted with ... Read more >>

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Optimizing antimicrobial use: challenges, advances and opportunities.

Timothy M Rawson, Richard C Wilson, Danny O'Hare, Pau Herrero, Andrew Kambugu, Mohammed Lamorde, Matthew Ellington, Pantelis Georgiou, Anthony Cass, William W Hope, Alison H Holmes,

An optimal antimicrobial dose provides enough drug to achieve a clinical response while minimizing toxicity and development of drug resistance. There can be considerable variability in pharmacokinetics, for example, owing to comorbidities or other medications, which affects antimicrobial pharmacodynamics and, thus, treatment success. Although current approaches to antimicrobial dose optimization ... Read more >>

Nat Rev Microbiol (Nature reviews. Microbiology)
[2021, :]

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Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial.

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<h4>Background</h4>Respiratory complications are an important cause of postoperative morbidity. We aimed to investigate whether continuous positive airway pressure (CPAP) administered immediately after major abdominal surgery could prevent postoperative morbidity.<h4>Methods</h4>PRISM was an open-label, randomised, phase 3 trial done at 70 hospitals across six countries. Patients aged 50 years or older who ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, :]

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The quantra hemostasis analyzer compared to thromboelastography (TEG) in the surgical oncologic population: A prospective observational trial.

Olakunle Idowu, Ifey Ifeanyi-Pillette, Pascal Owusu-Agyemang, Allen Holmes, Piotr Kwater, Timothy Jackson, Gabriel Mena, Javier Lasala, Jagtar Singh Heir,

<h4>Background</h4>Management of coagulopathy during major oncologic surgery can be multifactorial and challenging. Viscoelastic assays (VEAs) can be useful in providing vital data about the mechanism of coagulopathy in these dynamic circumstances.<h4>Objectives</h4>A prospective nonrandomized observational study with the aim of describing the coagulation parameters of patients undergoing major oncologic surgery using ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2021, :]

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"Collaboration Toward One Collective Goal": A Mixed-Methods Study of Short-Term Learning Outcomes and Long-Term Impacts Among Students Participating in an Undergraduate Community-Based Participatory Research (CBPR) Course.

Seblewongel Yigletu, Karen C Kosinski, Alison Kuah, Kenia Alfaro, Ashley C Holmes, Shalini A Tendulkar,

<b>Background:</b> Research shows positive learning outcomes for students participating in service learning. However, the impacts of undergraduate student participation in Community-Based Participatory Research (CBPR) courses are minimally studied. <b>Methods:</b> We used a triangulation mixed-methods design approach to analyze short- and long-term (1-5 years post-course) data collected from 59 undergraduate students ... Read more >>

Front Public Health (Frontiers in public health)
[2021, 9:694840]

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Brain charts for the human lifespan

R.A.I. Bethlehem, Seidlitz, S.R. White, J.W. Vogel, K.M. Anderson, Adamson, Adler, G.S. Alexopoulos, Anagnostou, Areces-Gonzalez, D.E. Astle, Auyeung, Ayub, Ball, Baron-Cohen, Beare, S.A. Bedford, Benegal, Beyer, Bin Bae, Blangero, Blesa Cábez, J.P. Boardman, Borzage, J.F. Bosch-Bayard, Bourke, V.D. Calhoun, M.M. Chakravarty, Chen, Chertavian, Chetelat, Y.S. Chong, J.H. Cole, Corvin, Courchesne, Crivello, V.L. Cropley, Crosbie, Crossley, Delarue, Desrivieres, Devenyi, M.A. Di Biase, Dolan, K.A. Donald, Donohoe, Dunlop, A.D. Edwards, J.T. Elison, C.T. Ellis, J.A. Elman, Eyler, D.A. Fair, P.C. Fletcher, Fonagy, C.E. Franz, Galan-Garcia, Gholipour, Giedd, J.H. Gilmore, D.C. Glahn, Goodyer, P.E. Grant, N.A. Groenewold, F.M. Gunning, R.E. Gur, R.C. Gur, C.F. Hammill, Hansson, Hedden, Heinz, Henson, Heuer, Hoare, Holla, A.J. Holmes, Holt, Huang, Im, Ipser, C.R. Jack, A.P. Jackowski, Jia, K.A. Johnson, P.B. Jones, D.T. Jones, Kahn, Karlsson, Karlsson, Kawashima, E.A. Kelley, Kern, Kim, M.G. Kitzbichler, W.S. Kremen, Lalonde, Landeau, Lee, Lerch, J.D. Lewis, Li, Liao, D.P. Linares, Liston, M.V. Lombardo, Lv, Lynch, T.T. Mallard, Marcelis, R.D. Markello, Mazoyer, McGuire, M.J. Meaney, Mechelli, Medic, Misic, S.E. Morgan, Mothersill, Nigg, M.Q.W. Ong, Ortinau, Ossenkoppele, Ouyang, Palaniyappan, Paly, P.M. Pan, Pantelis, M.M. Park, Paus, Pausova, Pichet Binette, Pierce, Qian, Qiu, Qiu, Raznahan, Rittman, C.K. Rollins, Romero-Garcia, Ronan, M.D. Rosenberg, D.H. Rowitch, G.A. Salum, T.D. Satterthwaite, H.L. Schaare, R.J. Schachar, A.P. Schultz, Schumann, Schöll, Sharp, R.T. Shinohara, Skoog, C.D. Smyser, R.A. Sperling, D.J. Stein, Stolicyn, Suckling, Sullivan, Taki, Thyreau, Toro, K.A. Tsvetanov, N.B. Turk-Browne, J.J. Tuulari, Tzourio, Vachon-Presseau, M.J. Valdes-Sosa, P.A. Valdes-Sosa, S.L. Valk, van Amelsvoort, S.N. Vandekar, Vasung, L.W. Victoria, Villeneuve, Villringer, P.E. Vértes, Wagstyl, Y.S. Wang, S.K. Warfield, Warrier, Westman, M.L. Westwater, H.C. Whalley, A.V. Witte, Yang, B.T.T. Yeo, H.J. Yun, Zalesky, H.J. Zar, Zettergren, J.H. Zhou, Ziauddeen, Zugman, X.N. Zuo, A.F. Alexander-Bloch, , , , , , , , , , , , , , , , , ,

Over the past 25 years, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, there are no reference standards against which to anchor measures of individual differences in brain morphology, in contrast to growth charts for traits such as height and weight. ... Read more >>

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Theoretical demonstration of a capacitive rotor for generation of alternating current from mechanical motion.

Ehud Haimov, Aidan Chapman, Fernando Bresme, Andrew S Holmes, Tom Reddyhoff, Michael Urbakh, Alexei A Kornyshev,

Innovative concepts and materials are enabling energy harvesters for slower motion, particularly for personal wearables or portable small-scale applications, hence contributing to a future sustainable economy. Here we propose a principle for a capacitive rotor device and analyze its operation. This device is based on a rotor containing many capacitors ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):3678]

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Distinctive Microbiome Type Distribution in a Young Adult Balinese Cohort May Reflect Environmental Changes Associated with Modernization.

Clarissa A Febinia, Safarina G Malik, Ratna Djuwita, I Wayan Weta, Desak Made Wihandani, Rizka Maulida, Herawati Sudoyo, Andrew J Holmes,

An important public health question is understanding how changes in human environments can drive changes in the gut microbiota that influence risks associated with human health and wellbeing. It is well-documented that the modernization of societies is strongly correlated with intergenerational change in the frequency of nutrition-related chronic diseases in ... Read more >>

Microb Ecol (Microbial ecology)
[2021, :]

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The impact of device-assisted therapies on the gut microbiome in Parkinson's disease.

Michal Lubomski, Xiangnan Xu, Andrew J Holmes, Jean Y H Yang, Carolyn M Sue, Ryan L Davis,

<h4>Background</h4>Microbiome feedbacks are proposed to influence Parkinson's disease (PD) pathophysiology. A number of studies have evaluated the impact of oral medication on the gut microbiome (GM) in PD. However, the influence of PD device-assisted therapies (DATs) on the GM remains to be investigated.<h4>Objectives</h4>To profile acute gut microbial community alterations in ... Read more >>

J Neurol (Journal of neurology)
[2021, :]

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An analysis of school absences in England during the COVID-19 pandemic.

Emma Southall, Alex Holmes, Edward M Hill, Benjamin D Atkins, Trystan Leng, Robin N Thompson, Louise Dyson, Matt J Keeling, Michael J Tildesley,

<h4>Background</h4>The introduction of SARS-CoV-2, the virus that causes COVID-19 infection, in the UK in early 2020, resulted in the introduction of several control policies to reduce disease spread. As part of these restrictions, schools were closed to all pupils in March (except for vulnerable and key worker children), before re-opening ... Read more >>

BMC Med (BMC medicine)
[2021, 19(1):137]

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