Full Text Journal Articles by
Author A Curley

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Neonatal Platelet Transfusions: Starting Again.

Carmel Maria Moore, Anna E Curley,

Preterm neonates with severe thrombocytopenia are frequently prescribed prophylactic platelet transfusions despite no evidence of benefit. Neonatal platelet transfusion practice varies, both nationally and internationally. Volumes and rates of transfusion in neonatology are based on historic precedent and lack an evidence base. The etiology of harm from platelet transfusions is ... Read more >>

Transfus Med Rev (Transfusion medicine reviews)
[2021, :]

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Outcomes of Prophylactic Negative Pressure Wound Therapy in Multiligament Knee Reconstruction.

Edward Fakhre, Katherine M Connors, Andrew J Curley, Evan H Argintar,

Negative pressure wound therapy (NPWT) has shown promise in reducing postoperative complications in several applications in orthopedic surgery, including trauma and arthroplasty. To the authors' knowledge, no study has evaluated its use in multiligament knee reconstruction. Multiligament knee reconstruction is often fraught with arthrofibrosis and wound-healing complications. This retrospective study ... Read more >>

Orthopedics (Orthopedics)
[2021, 44(3):187-191]

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Labral Index-Controlling Femoral Size to Evaluate the Relationship Between Relative Labral Size and Acetabular Version.

Andrew J Curley, Arjun Minhas, Cooper B Ehlers, William F Postma,

<h4>Purpose</h4>To assess the relationship of acetabular version with the length of the anterior and posterior labrum and to introduce a developed metric, the labral index, as a means of controlling for femoral head size when measuring labral length.<h4>Methods</h4>One hundred forty-eight patients who underwent hip arthroscopies for femoroacetabular impingement from October ... Read more >>

Arthrosc Sports Med Rehabil (Arthroscopy, sports medicine, and rehabilitation)
[2021, 3(3):e791-e797]

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Impact of Sarcopenia on Degenerative Lumbar Spondylosis.

Denys Gibbons, Daniel P Ahern, Antoinette E Curley, Christopher K Kepler, Joseph S Butler,

Sarcopenia is characterized by progressive age-related and systematic loss of skeletal muscle mass, strength, and function. It was classified as an independent disease in 2016; thus, there is a sparsity of research on the association of sarcopenia with lower back pain and spinal diseases. Its prevalence is around 10% worldwide ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2021, 34(2):43-50]

Cited: 1 time

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Voluntary and involuntary admissions with schizoaffective disorder: do they differ from schizophrenia?

A Feeney, E Umama-Agada, A Curley, C Anamdi, M Asghar, B D Kelly,

<h4>Objectives</h4>Schizoaffective disorder and schizophrenia are common presentations to psychiatry services. Research to date has focussed on hypothesised biological differences between these two disorders. Little is known about possible variations in admission patterns. Our study compared demographic and clinical features of patients admitted voluntarily and involuntarily with diagnoses of schizoaffective disorder ... Read more >>

Ir J Psychol Med (Irish journal of psychological medicine)
[2020, :1-8]

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The Statistical Fragility of Hamstring Versus Patellar Tendon Autografts for Anterior Cruciate Ligament Reconstruction: A Systematic Review of Comparative Studies.

Cooper B Ehlers, Andrew J Curley, Nathan P Fackler, Arjun Minhas, Edward S Chang,

<h4>Background</h4>Evidence-based medicine utilizes data to inform clinical decision making, despite the ability of a small number of outcome reversals to change statistical significance. <i>P</i> values are common measurements of statistical significance that possess inherent flaws. The inclusion of the fragility index (FI) and fragility quotient (FQ) may provide a clearer ... Read more >>

Am J Sports Med (The American journal of sports medicine)
[2020, :363546520969973]

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Longitudinal assessment of cardiac function in infants with Down’s syndrome using novel echocardiography techniques – project protocol

Aisling Smith, Eleanor Molloy, Jan Miletin, Anna Curley, Joanne Balfe, Orla Franklin, Afif EL-Khuffash,

Background: Down’s syndrome (DS) is the most common chromosomal abnormality globally. Ireland has one of the highest rates of DS in the western world with an incidence of 1:444 live births. Congenital heart disease (CHD) and pulmonary hypertension (PH) are the commonest morbidities affecting the cardiovascular system in DS. PH ... Read more >>

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Police Involvement in Involuntary Psychiatry Admission: A Report From the Dublin Involuntary Admission Study.

Anna Feeney, Emmanuel Umama-Agada, Aoife Curley, Muhammad Asghar, Brendan D Kelly,

<h4>Objective</h4>The authors sought to compare diagnostic and demographic factors among patients who were involuntarily admitted to psychiatry care with or without police involvement.<h4>Methods</h4>All admissions to psychiatry units in two university hospitals in Ireland were studied over a 3.5-year period.<h4>Results</h4>Of 2,715 admissions, 443 (16%) were involuntary; complete data were available for ... Read more >>

Psychiatr Serv (Psychiatric services (Washington, D.C.))
[2020, 71(12):1292-1295]

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Longitudinal assessment of cardiac function in infants with Down's syndrome using novel echocardiography techniques - project protocol.

Aisling Smith, Eleanor Molloy, Jan Miletin, Anna Curley, Joanne Balfe, Orla Franklin, Afif El-Khuffash,

<b>Background:</b> Down's syndrome (DS) is the most common chromosomal abnormality globally. Ireland has one of the highest rates of DS in the western world with an incidence of 1:444 live births. Congenital heart disease (CHD) and pulmonary hypertension (PH) are the commonest morbidities affecting the cardiovascular system in DS. PH ... Read more >>

HRB Open Res (HRB open research)
[2020, 3:77]

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Diagnostic Limitations in Congenital Zika Virus Infection.

M Flanagan, H Hughes, E B Forman, D O'Rourke, B Paturi, A Curley, S J Knowles, C De Gascun, D Sweetman,

This is the first documented case of an infant with congenital Zika virus infection (ZVI) born in Ireland. A term infant was delivered with an antenatal diagnosis of severe microcephaly. First trimester bloods confirmed maternal ZVI and although the infant did not have Zika virus RNA or Zika-specific IgM in ... Read more >>

Ir Med J (Irish medical journal)
[2020, 113(6):101]

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Impact of Socioeconomic Status on Concomitant Injuries and Access to Care following Anterior Cruciate Ligament Rupture

Caroline Fryar, David Wang, Christine Conroy, Mark Hopkins, Brian McCormick, Blake Bodendorfer, Edward Chang, Andrew Curley,

Objectives: The primary aim of this study was to further define the impact of socioeconomic factors on the timing of ACL reconstruction. The secondary goal was to determine if these variables were associated with bucket handle tears of the meniscus at the time of surgery. Methods: All patients undergoing ACL ... Read more >>

Orthop J Sports Med (Orthopaedic journal of sports medicine)
[2020, 8(7 suppl6):]

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Preterm neonates benefit from low prophylactic platelet transfusion threshold despite varying risk of bleeding or death.

Susanna F Fustolo-Gunnink, Karin Fijnvandraat, David van Klaveren, Simon J Stanworth, Anna Curley, Wes Onland, Ewout W Steyerberg, Ellen de Kort, Esther J d'Haens, Christian V Hulzebos, Elise J Huisman, Willem P de Boode, Enrico Lopriore, Johanna G van der Bom, ,

The Platelets for Neonatal Thrombocytopenia (PlaNeT-2) trial reported an unexpected overall benefit of a prophylactic platelet transfusion threshold of 25 × 109/L compared with 50 × 109/L for major bleeding and/or mortality in preterm neonates (7% absolute-risk reduction). However, some neonates in the trial may have experienced little benefit or ... Read more >>

Blood (Blood)
[2019, 134(26):2354-2360]

Cited: 3 times

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Platelet transfusion thresholds in neonatal medicine.

Carmel Maria Moore, Anna Curley,

Thrombocytopenia is common in preterm neonates. Thresholds for prophylactic platelet transfusion vary widely due to lack of evidence. The results of the PlaNet-2/MATISSE Study identified harm in the form of mortality and major bleed in babies prophylactically transfused below a platelet count of 50 × 10<sup>9</sup>/L compared to 25 × 10<sup>9</sup>/L. Neonatal platelet transfusions ... Read more >>

Early Hum Dev (Early human development)
[2019, 138:104845]

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Platelet and red cell transfusions for neonates: lifesavers or Trojan horses?

Suzanne F Fustolo-Gunnink, Charles C Roehr, Lani Lieberman, Robert D Christensen, Johanna G Van Der Bom, Christof Dame, Antonio Del Vecchio, Amy K Keir, Anna Curley, Simon J Stanworth, Enrico Lopriore,

Expert Rev Hematol (Expert review of hematology)
[2019, 12(10):797-800]

Cited: 1 time

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Age, psychiatry admission status and linear mental capacity for treatment decisions.

Aoife Curley, Ruth Murphy, Sean Fleming, Brendan D Kelly,

The relationship between age and mental capacity among psychiatry inpatients is not fully understood. We aimed to assess mental capacity for treatment decisions in voluntary and involuntary psychiatry inpatients in Ireland and, in this analysis of our data-set, to elucidate the linear relationship, if any, between linear (as opposed to ... Read more >>

Int J Law Psychiatry (International journal of law and psychiatry)
[2019, 66:101469]

Cited: 1 time

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Convergence or Divergence? Comparing Mental Capacity Assessments Based on Legal and Clinical Criteria in Medical and Surgical Inpatients.

Ruth Murphy, Sean Fleming, Aoife Curley, Richard M Duffy, Brendan D Kelly,

Despite the high prevalence of mental incapacity for treatment decisions in hospitals (27.7%), there is little information about the relationship, if any, between mental capacity assessments based on clinical and legal criteria. We performed a cross-sectional study of mental incapacity for treatment decisions in 300 hospital inpatients in two hospitals ... Read more >>

J Leg Med (The Journal of legal medicine)
[2019, 39(3):213-227]

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Concordance of mental capacity assessments based on legal and clinical criteria: A cross-sectional study of psychiatry inpatients.

Aoife Curley, Ruth Murphy, Róisín Plunkett, Brendan D Kelly,

This study aimed to compare assessments of mental capacity based on legal criteria with assessments based on clinical criteria among psychiatry inpatients to establish the concordance, if any, between these two approaches to assessing mental capacity. We assessed mental capacity for treatment decisions in 215 psychiatry inpatients (176 voluntary and ... Read more >>

Psychiatry Res (Psychiatry research)
[2019, 276:160-166]

Cited: 3 times

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A Randomized Trial of Neonatal Platelet Transfusion Thresholds. Reply.

Anna Curley, Simon J Stanworth, Helen New,

N Engl J Med (The New England journal of medicine)
[2019, 380(16):1584-1585]

Cited: 0 times

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Flow cytometry for near-patient testing in premature neonates reveals variation in platelet function: a novel approach to guide platelet transfusion.

Amie K Waller, Lajos Lantos, Audrienne Sammut, Burak Salgin, Harriet McKinney, Holly R Foster, Neline Kriek, Jonathan M Gibbins, Simon J Stanworth, Stephen F Garner, Vidheya Venkatesh, Anna Curley, Gusztav Belteki, Cedric Ghevaert,

<h4>Background</h4>Neonatal haemorrhaging is often co-observed with thrombocytopenia; however, no evidence of a causal relationship with low platelet count has been reported. Regardless, the administration of a platelet transfusion is often based upon this parameter. Accurate measurement of platelet function in small volumes of adult blood samples by flow cytometry is ... Read more >>

Pediatr Res (Pediatric research)
[2019, 85(6):874-884]

Cited: 2 times

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Categorical mental capacity for treatment decisions among psychiatry inpatients in Ireland.

Aoife Curley, Ruth Murphy, Róisín Plunkett, Brendan D Kelly,

This study aimed to assess mental capacity for treatment decisions among psychiatry inpatients in Ireland and explore the relationship, if any, between mental capacity and various demographics and clinical variables. We assessed mental capacity for treatment decisions in 215 psychiatry inpatients in four psychiatry admission units. Almost half of the ... Read more >>

Int J Law Psychiatry (International journal of law and psychiatry)
[2019, 64:53-59]

Cited: 2 times

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Randomized Trial of Platelet-Transfusion Thresholds in Neonates.

Anna Curley, Simon J Stanworth, Karen Willoughby, Susanna F Fustolo-Gunnink, Vidheya Venkatesh, Cara Hudson, Alison Deary, Renate Hodge, Valerie Hopkins, Beatriz Lopez Santamaria, Ana Mora, Charlotte Llewelyn, Angela D'Amore, Rizwan Khan, Wes Onland, Enrico Lopriore, Karin Fijnvandraat, Helen New, Paul Clarke, Timothy Watts, ,

<h4>Background</h4>Platelet transfusions are commonly used to prevent bleeding in preterm infants with thrombocytopenia. Data are lacking to provide guidance regarding thresholds for prophylactic platelet transfusions in preterm neonates with severe thrombocytopenia.<h4>Methods</h4>In this multicenter trial, we randomly assigned infants born at less than 34 weeks of gestation in whom severe thrombocytopenia ... Read more >>

N Engl J Med (The New England journal of medicine)
[2019, 380(3):242-251]

Cited: 35 times

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Operative Positioning Technique for an Intertrochanteric Fracture in a Patient with an Ipsilateral Below-the-Knee Amputation: A Case Report.

Andrew J Curley, Edward S Chang,

<h4>Case</h4>A 56-year-old man with a remote history of a left below-the-knee amputation (BKA) presented to the emergency department with an ipsilateral intertrochanteric fracture (IT). This case produced an operative challenge because commonly used intraoperative traction methods could not be applied to a patient with a BKA.<h4>Conclusion</h4>We describe a rarely utilized ... Read more >>

JBJS Case Connect (JBJS case connector)
[2019, 9(1):e1]

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Mental Incapacity for Treatment Decisions: Where do Doctors Stand?

B D Kelly, R Murphy, A Curley, R M Duffy, S Fleming,

Ir Med J (Irish medical journal)
[2018, 111(10):833]

Cited: 0 times

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Who can decide? Prevalence of mental incapacity for treatment decisions in medical and surgical hospital inpatients in Ireland.

R Murphy, S Fleming, A Curley, R M Duffy, B D Kelly,

<h4>Background</h4>The prevalence of mental incapacity for treatment decisions among medical and surgical hospital inpatients is poorly understood or not known in many countries, including Ireland.<h4>Aim</h4>To assess the prevalence of mental incapacity in hospital inpatients in Ireland.<h4>Design</h4>Cross-sectional observational study of mental incapacity for treatment decisions.<h4>Methods</h4>We assessed mental capacity in 300 randomly ... Read more >>

QJM (QJM : monthly journal of the Association of Physicians)
[2018, 111(12):881-885]

Cited: 0 times

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Outcomes of Prophylactic Negative Pressure Wound Therapy in Knee Arthroplasty.

Andrew J Curley, Elizabeth B Terhune, Anthony T Velott, Evan H Argintar,

Negative pressure wound therapy is becoming more commonly used to prevent wound complications in joint arthroplasty, although few studies have assessed its outcomes compared with those of a traditional dry sterile dressing. This retrospective study assessed complications that required return to the operating room in a cohort of patients who ... Read more >>

Orthopedics (Orthopedics)
[2018, 41(6):e837-e840]

Cited: 1 time

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