Full Text Journal Articles by
Author A Brennan

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Bridging the age gap in breast cancer. Impacts of omission of breast cancer surgery in older women with oestrogen receptor positive early breast cancer. A risk stratified analysis of survival outcomes and quality of life.

Lynda Wyld, Malcolm W R Reed, Jenna Morgan, Karen Collins, Sue Ward, Geoffrey R Holmes, Mike Bradburn, Stephen Walters, Maria Burton, Esther Herbert, Kate Lifford, Adrian Edwards, Alistair Ring, Thompson Robinson, Charlene Martin, Tim Chater, Kirsty Pemberton, Anne Shrestha, Alan Brennan, Kwok L Cheung, Annaliza Todd, Riccardo Audisio, Juliet Wright, Richard Simcock, Tracy Green, Deirdre Revell, Jacqui Gath, Kieran Horgan, Chris Holcombe, Matt Winter, Jay Naik, Rishi Parmeshwar, Julietta Patnick, Margot Gosney, Matthew Hatton, Alastair M Thomson,

BACKGROUND:Age-related breast cancer treatment variance is widespread with many older women having primary endocrine therapy (PET), which may contribute to inferior survival and local control. This propensity-matched study determined if a subgroup of older women may safely be offered PET. METHODS:Multicentre, prospective, UK, observational cohort study with propensity-matched analysis to ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2020, 142:48-62]

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Multiple deprivation and geographic distance to community physical activity events - achieving equitable access to parkrun in England.

P P Schneider, R A Smith, A M Bullas, H Quirk, T Bayley, S J Haake, A Brennan, E Goyder,

OBJECTIVES:To evaluate geographic access to free weekly outdoor physical activity events ('parkrun') in England, with a particular focus on deprived communities, and to identify optimal locations for future events to further maximise access. STUDY DESIGN:This study is a cross-sectional ecological analysis of the socio-economic disparities in geographic access to parkrun ... Read more >>

Public Health (Public health)
[2020, 189:48-53]

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Management of menopausal symptoms and ovarian function preservation in women with gynecological cancer.

Annabelle Brennan, Donal Brennan, Margaret Rees, Martha Hickey,

Gynecological cancers affect a growing number of women globally, with approximately 1.3 million women diagnosed in 2018. Menopausal symptoms are a significant health concern after treatment for gynecological cancers and may result from oncologic treatments such as premenopausal bilateral oophorectomy, ovarian failure associated with chemotherapy or radiotherapy, and anti-estrogenic effects ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2020, :]

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Dental Topics for Plastic Surgeons, Part Three: Infection and Trauma of the Dentition.

Jocelyn C Zajac, Monica Manrique, Christopher M Fleury, Jason Marrazzo, Esperanza Mantilla-Rivas, Joseph H Talbet, Ashleigh M Brennan, Marudeen Aivaz, Albert K Oh, Anupama R Tate, Gary F Rogers,

Conditions that affect dental and periodontal structures receive sparse coverage in the plastic surgery literature, yet a working knowledge of this subject matter is important in certain areas of clinical practice and a fundamental understanding is part of plastic surgery competency tested on the in-service and written board examinations. This ... Read more >>

J Craniofac Surg (The Journal of craniofacial surgery)
[2020, :]

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Outcomes of Percutaneous Coronary Intervention in Patients With Rheumatoid Arthritis.

Luke P Dawson, Diem Dinh, Jessica O'Brien, Stephen J Duffy, Emma Guymer, Angela Brennan, David Clark, Ernesto Oqueli, Chin Hiew, Melanie Freeman, Christopher M Reid, Andrew E Ajani, ,

Rheumatoid arthritis (RA) is the most common inflammatory arthritis and is associated with increased risk of cardiovascular events and mortality. Evidence regarding outcomes following PCI is limited. This study aimed to assess differences in outcomes following percutaneous coronary intervention (PCI) between patients with and without RA. The Melbourne Interventional Group ... Read more >>

Am J Cardiol (The American journal of cardiology)
[2020, :]

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Controlled observational study and economic evaluation of the effect of city-centre night-time alcohol intoxication management services on the emergency care system compared with usual care.

Simon Moore, Tracey Young, Andy Irving, Steve Goodacre, Alan Brennan, Yvette Amos,

BACKGROUND:Alcohol intoxication management services (AIMS) provide an alternative care pathway for alcohol-intoxicated adults otherwise requiring emergency department (ED) services and at times of high incidence. We estimate the effectiveness and cost-effectiveness of AIMS on ED attendance rates with ED and ambulance service performance indicators as secondary outcomes. METHODS:A controlled longitudinal ... Read more >>

Emerg Med J (Emergency medicine journal : EMJ)
[2020, :]

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The impact of promoting revised UK low-risk drinking guidelines on alcohol consumption: interrupted time series analysis

John Holmes, Emma Beard, Jamie Brown, Alan Brennan, Inge Kersbergen, Petra S Meier, Susan Michie, Abigail K Stevely, Penny Buykx,

BACKGROUND:The UK’s Chief Medical Officers revised the UK alcohol drinking guidelines in 2016 to ≤ 14 units per week (1 unit = 10 ml/8 g ethanol) for men and women. Previously, the guideline stated that men should not regularly consume more than 3–4 units per day and women should not regularly consume more than 2–3 ... Read more >>

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Machine Learning Can Improve Clinical Detection of Low BMD: The DXA-HIP Study.

Erjiang E, Tingyan Wang, Lan Yang, Mary Dempsey, Attracta Brennan, Ming Yu, Wing P Chan, Bryan Whelan, Carmel Silke, Miriam O'Sullivan, Bridie Rooney, Aoife McPartland, Gráinne O'Malley, John J Carey,

BACKGROUND:Identification of those at high risk before a fracture occurs is an essential part of osteoporosis management. This topic remains a significant challenge for researchers in the field, and clinicians worldwide. Although many algorithms have been developed to either identify those with a diagnosis of osteoporosis or predict their risk ... Read more >>

J Clin Densitom (Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry)
[2020, :]

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Hybrid Breeding for Restoration of Threatened Forest Trees: Evidence for Incorporating Disease Tolerance in Juglans cinerea.

Andrea N Brennan, James R McKenna, Sean M Hoban, Douglass F Jacobs,

Hybridization is a potential tool for incorporating stress tolerance in plants, particularly to pests and diseases, in support of restoration and conservation efforts. Butternut (Juglans cinerea) is a species for which hybridization has only recently begun being explored. This North American hardwood tree is threatened due to Ophiognomonia clavigignenti-juglandacearum (Ocj), ... Read more >>

Front Plant Sci (Frontiers in plant science)
[2020, 11:580693]

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Quantile regression of tobacco tax pass-through in the UK 2013-2019. How have manufacturers passed through tax changes for different tobacco products?

Luke Brian Wilson, Robert Pryce, Rosemary Hiscock, Colin Angus, Alan Brennan, Duncan Gillespie,

BACKGROUND:The effectiveness of tax increases relies heavily on the tobacco industry passing on such increases to smokers (also referred to as 'pass-through'). Previous research has found heterogeneous levels of tax pass-through across the market segments of tobacco products available to smokers. This study uses retail sales data to assess the ... Read more >>

Tob Control (Tobacco control)
[2020, :]

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Metastatic Right Ventricular Liposarcoma.

Anthony P Brennan, Andrew Newcomb, Louise Creati, Justin Mariani,

Heart Lung Circ (Heart, lung & circulation)
[2020, :]

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Vesicle Transport in Plants: A Revised Phylogeny of SNARE Proteins.

Xiaoyan Gu, Adrian Brennan, Wenbin Wei, Guangqin Guo, Keith Lindsey,

Communication systems within and between plant cells involve the transfer of ions and molecules between compartments, and are essential for development and responses to biotic and abiotic stresses. This in turn requires the regulated movement and fusion of membrane systems with their associated cargo. Recent advances in genomics has provided ... Read more >>

Evol Bioinform Online (Evolutionary bioinformatics online)
[2020, 16:1176934320956575]

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Incidence and Predictors of Unplanned Hospital Readmission after Percutaneous Coronary Intervention.

Sinjini Biswas, Diem Dinh, Mark Lucas, Stephen J Duffy, Angela L Brennan, Danny Liew, Nicholas Cox, Voltaire Nadurata, Christopher M Reid, Jeffrey Lefkovits, Dion Stub,

Unplanned readmissions to hospital after percutaneous coronary intervention (PCI) pose a significant burden to the healthcare system and are potentially preventable. In this study, we sought to determine the incidence of, and risk factors for, unplanned hospital readmissions within 30 days following PCI. We prospectively collected data on 28,488 patients ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(10):]

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The Impact of Including Costs and Outcomes of Dementia in a Health Economic Model to Evaluate Lifestyle Interventions to Prevent Diabetes and Cardiovascular Disease.

Penny Breeze, Chloe Thomas, Praveen Thokala, Louise Lafortune, Carol Brayne, Alan Brennan,

OBJECTIVES:Economic evaluations of lifestyle interventions, which aim to prevent diabetes/cardiovascular disease (CVD), have not included dementia. Lifestyle interventions decrease dementia risk and extend life expectancy, leading to competing effects on health care costs. We aim to demonstrate the feasibility of including dementia in a public health cost-effectiveness analysis and quantify ... Read more >>

Med Decis Making (Medical decision making : an international journal of the Society for Medical Decision Making)
[2020, 40(7):912-923]

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Attenuating the Selection of Vancomycin Resistance Among Enterococci through the Development of Peptide-Based Vancomycin Antagonists.

Ryan W Mull, Alec A Brennan, Brittany R Russ, Yftah Tal-Gan,

The emergence and spread of multidrug resistant (MDR) pathogens with acquired resistance to almost all available antimicrobial agents has severely threatened the international healthcare community over the last two decades. The last resort antibiotic vancomycin is critical for treatment of several of these pathogens; howeverc vancomycin resistance is spreading due ... Read more >>

ACS Infect Dis (ACS infectious diseases)
[2020, 6(11):2913-2925]

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ESC Core Curriculum for the Cardiologist.

Felix C Tanner, Nicolas Brooks, Kevin F Fox, Lino Gonçalves, Peter Kearney, Lampros Michalis, Agnès Pasquet, Susanna Price, Eric Bonnefoy, Mark Westwood, Chris Plummer, Paulus Kirchhof, ,

Eur Heart J (European heart journal)
[2020, 41(38):3605-3692]

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Impact of limited English proficiency on presentation and clinical outcomes of patients undergoing primary percutaneous coronary intervention.

Sinjini Biswas, Diem Dinh, Mark Lucas, Stephen J Duffy, Angela Brennan, Danny Liew, Nicholas Cox, Karen Smith, Emily Andrew, Ziad Nehme, Christopher M Reid, Jeffrey Lefkovits, Dion Stub,

AIMS:To evaluate the association of limited English proficiency (LEP) with reperfusion times and outcomes in patients undergoing primary percutaneous coronary intervention (PPCI) for ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS:This cohort study included 5385 patients who underwent PPCI in 2013-2017 and were prospectively enrolled in the Victorian Cardiac Outcomes Registry. ... Read more >>

Eur Heart J Qual Care Clin Outcomes (European heart journal. Quality of care & clinical outcomes)
[2020, 6(4):254-262]

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Guest Removal and External Pressure Variation Induce Spin Crossover in Halogen-Functionalized 2-D Hofmann Frameworks.

Ashley T Brennan, Katrina A Zenere, Helen E A Brand, Jason R Price, Mohan M Bhadbhade, Gemma F Turner, Stephen A Moggach, Francisco J Valverde-Muñoz, Jose A Real, Jack K Clegg, Cameron J Kepert, Suzanne M Neville,

The effect of halogen functionalization on the spin crossover (SCO) properties of a family of 2-D Hofmann framework materials, [FeIIPd(CN)4(thioX)2]·2H2O (X = Cl and Br; thioCl = (E)-1-(5-chlorothiophen-2-yl)-N-(4H-1,2,4-triazol-4-yl)methanimine) and thioBr = (E)-1-(5-bromothiophen-2-yl)-N-(4H-1,2,4-triazol-4-yl)methanimine)), is reported. Inclusion of both the chloro- and bromo-functionalized ligands into the Hofmann-type frameworks (1Cl·2H2O and 2Br·2H2O) results ... Read more >>

Inorg Chem (Inorganic chemistry)
[2020, 59(19):14296-14305]

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Individual Response Variation in the Effects of Weight Loss and Exercise on Insulin Sensitivity and Cardiometabolic Risk in Older Adults.

Andrea M Brennan, Robert A Standley, Fanchao Yi, Elvis A Carnero, Lauren M Sparks, Bret H Goodpaster,

Weight loss induced by decreased energy intake (diet) or exercise generally has favorable effects on insulin sensitivity and cardiometabolic risk. The variation in these responses to diet-induced weight loss with or without exercise, particularly in older obese adults, is less clear. The objectives of our study were to (1) examine ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2020, 11:632]

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What are the cost-savings and health benefits of improving detection and management for six high cardiovascular risk conditions in England? An economic evaluation.

Chloe Thomas, Alan Brennan, Edward Goka, Hazel Y Squires, Gilly Brenner, David Bagguley, Helen Buckley Woods, Michael Gillett, Joanna Leaviss, Mark Clowes, Laura Heathcote, Katy Cooper, Penny Breeze,

OBJECTIVES:To estimate the cost savings and health benefits of improving detection of individuals at high risk of cardiovascular disease (CVD) in England, to determine to which patient subgroups these benefits arise, and to compare different strategies for subsequent management. DESIGN:An economic analysis using the School for Public Health Research CVD ... Read more >>

BMJ Open (BMJ open)
[2020, 10(9):e037486]

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Selective antagonism of cJun for cancer therapy.

Andrew Brennan, James T Leech, Neil M Kad, Jody M Mason,

The activator protein-1 (AP-1) family of transcription factors modulate a diverse range of cellular signalling pathways into outputs which can be oncogenic or anti-oncogenic. The transcription of relevant genes is controlled by the cellular context, and in particular by the dimeric composition of AP-1. Here, we describe the evidence linking ... Read more >>

J Exp Clin Cancer Res (Journal of experimental & clinical cancer research : CR)
[2020, 39(1):184]

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Patient Perspectives of Quality of the Same-Day Antiretroviral Therapy Initiation Process in Gauteng Province, South Africa: Qualitative Dominant Mixed-Methods Analysis of the SLATE II Trial.

Nancy A Scott, Mhairi Maskew, Rachel M Fong, Ingrid E Olson, Alana T Brennan, Matthew P Fox, Lungisile Vezi, Peter D Ehrenkranz, Sydney Rosen,

BACKGROUND:HIV patients in South Africa continue to report operational barriers to starting antiretroviral therapy (ART). In the Simplified Algorithm for Treatment Eligibility (SLATE) II trial, same-day initiation (SDI) of ART increased the number of patients commencing ART and achieving HIV viral suppression by using a screening tool to distinguish between ... Read more >>

Patient (The patient)
[2020, :]

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Surface texture limits transfer of S. aureus, T4 Bacteriophage, Influenza B virus and Human coronavirus.

Qi Liu, Lindsey Brookbank, Angela Ho, Jenna Coffey, Anthony Brennan, Christopher Jones,

Spread of pathogens on contaminated surfaces plays a key role in disease transmission. Surface technologies that control pathogen transfer can help control fomite transmission and are of great interest to public health. Here, we report a novel bead transfer method for evaluating fomite transmission in common laboratory settings. We show ... Read more >>

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Interpretative characteristics and case features associated with the performances of radiologists in reading mammograms: A study from a non-screening population in Asia.

Phuong Dung Yun Trieu, Louise Puslednik, Brooke Colley, Anna Brennan, Veruska Cediel Rodriguez, Nicholas Cook, Kaitlin Dean, Sarah Dryburgh, Hayden Lowe, Charlotte Mahon, Saxon McGowan, Joshua O'Brien, William Moog, Jorja Whale, Dennis Wong, Tong Li, Patrick C Brennan,

AIMS:To explore radiologist characteristics and case features associated with diagnostic performances in cancer detection on mammograms in a South East Asian population. METHODS:Fifty-three radiologists reported 60 mammographic examinations which consisted of 40 normal and 20 cancer-containing cases at the BREAST workshops. Radiologists were asked to examine each mammogram using the ... Read more >>

Asia Pac J Clin Oncol (Asia-Pacific journal of clinical oncology)
[2020, :]

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Relation of Timing of Percutaneous Coronary Intervention on Outcomes in Patients With Non-ST Segment Elevation Myocardial Infarction.

Riley J Batchelor, Diem Dinh, Angela Brennan, Nathan Wong, Jeffrey Lefkovits, Christopher Reid, Stephen J Duffy, William Chan, Nicholas Cox, Danny Liew, Dion Stub, ,

International guidelines suggest revascularization within 24 hours in non-ST segment elevation myocardial infarction (NSTEMI). Within a large population cohort study, we aimed to explore clinical practice regarding timing targets for percutaneous coronary intervention (PCI) in NSTEMI. The Victorian Cardiac Outcomes Registry was established in 2013 as a state-wide clinical quality ... Read more >>

Am J Cardiol (The American journal of cardiology)
[2020, 136:15-23]

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