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Silencing hsa_circ_PVT1 (circPVT1) suppresses the growth and metastasis of glioblastoma multiforme cells by up-regulation of miR-199a-5p.

Guonan Chi, Fuwei Yang, Donghui Xu, Weiming Liu,

Background: Glioblastoma multiforme (GBM) is one of the most prevailing primary brain tumours among adults and most aggressive cancers. Despite multiple developments in medical and surgical treatments, GBM is still a deadly disease with a high mortality rate. Here, this study was performed to investigate the function of circPVT1 on ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):188-196]

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Examination of sulfonamide-based inhibitors of MMP3 using the conditioned media of invasive glioma cells.

Alisha T Poole, Christopher A Sitko, Caitlin Le, Christian C Naus, Bryan M Hill, Eric A C Bushnell, Vincent C Chen,

Glioblastoma multiforme (GBM) is the deadliest and the most common primary malignant brain tumour. The median survival for patients with GBM is around one year due to the nature of glioma cells to diffusely invade that make the complete surgical resection of tumours difficult. Based upon the connexin43 (Cx43) model ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):672-681]

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Zika virus promotes CCN1 expression via the CaMKIIα-CREB pathway in astrocytes.

Jianhong Sun, Wanpo Zhang, Zhongyuan Tan, Caishang Zheng, Yan Tang, Xianliang Ke, Yuan Zhang, Yan Liu, Penghui Li, Qinxue Hu, Hanzhong Wang, Panyong Mao, Zhenhua Zheng,

Zika virus (ZIKV) infection in the human central nervous system (CNS) causes Guillain-Barre syndrome, cerebellum deformity, and other diseases. Astrocytes are immune response cells in the CNS and an important component of the blood-brain barrier. Consequently, any damage to astrocytes facilitates the spread of ZIKV in the CNS. Connective tissue ... Read more >>

Virulence (Virulence)
[2020, 11(1):113-131]

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c(RGDyk)-modified nanoparticles encapsulating quantum dots as a stable fluorescence probe for imaging-guided surgical resection of glioma under the auxiliary UTMD.

Qi-Long Wu, He-Lin Xu, Cui Xiong, Qing-Hua Lan, Ming-Ling Fang, Jin-Hua Cai, Hui Li, Shu-Ting Zhu, Jing-Hong Xu, Fang-Yi Tao, Cui-Tao Lu, Ying-Zheng Zhao, Bin Chen,

Surgical resection remains the preferred approach for some patients with glioblastoma (GBM), and eradication of the residual tumour niche after surgical resection is very helpful for prolonging patient survival. However, complete surgical resection of invasive GBM is difficult because of its ambiguous boundary. Herein, a novel targeting material, c(RGDyk)-poloxamer-188, was ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):143-158]

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The N-formyl peptide receptors: contemporary roles in neuronal function and dysfunction.

Peter J G Cussell, Margarita Gomez Escalada, Nathaniel G N Milton, Andrew W J Paterson,

N-formyl peptide receptors (FPRs) were first identified upon phagocytic leukocytes, but more than four decades of research has unearthed a plethora of non-myeloid roles for this receptor family. FPRs are expressed within neuronal tissues and markedly in the central nervous system, where FPR interactions with endogenous ligands have been implicated ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1191-1198]

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MRI Follow-up of Astrocytoma: Automated Coregistration and Color-Coding of FLAIR Sequences Improves Diagnostic Accuracy With Comparable Reading Time.

Simon Lennartz, David Zopfs, Anne Nobis, Stefanie Paquet, Ulrike Cornelia Isabel Hoyer, Charlotte Zäske, Lukas Goertz, Christoph Kabbasch, Kai Roman Laukamp, Nils Große Hokamp, Norbert Galldiks, Jan Borggrefe,

BACKGROUND:MRI follow-up is widely used for longitudinal assessment of astrocytoma, yet reading can be tedious and error-prone, in particular when changes are subtle. PURPOSE/HYPOTHESIS:To determine the effect of automated, color-coded coregistration (AC) of fluid attenuated inversion recovery (FLAIR) sequences on diagnostic accuracy, certainty, and reading time compared to conventional follow-up ... Read more >>

J Magn Reson Imaging (Journal of magnetic resonance imaging : JMRI)
[2020, :]

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Gross Total Resection of a Grade IV Astrocytoma Adjacent to the Precentral Gyrus With Nonawake Motor Mapping and Motor-Evoked Potential Monitoring: 3-Dimensional Operative Video.

Burak Ozaydin, Ihsan Dogan, Bryan J Wheeler, Mustafa K Baskaya,

Surgical treatment of the gliomas located in or adjacent to the eloquent areas poses significant challenge to neurosurgeons. The main goal of the surgery is to achieve maximal safe resection while preserving the neurological function. This might be possible with utilizing pre- and intraoperative adjuncts such as functional magnetic resonance ... Read more >>

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2020, 18(4):E127-E128]

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Low expression of FOSL1 is associated with favorable prognosis and sensitivity to radiation/pharmaceutical therapy in lower grade glioma.

Jin Zhu, Ya-Peng Zhao, Yu-Qi Zhang,

Objectives: FOSL1 is overexpressed in multiple cancers including malignant glioma and contributes to different cellular processes. However, little attention has been paid to the lower grade glioma (LGG).Methods: Cox coefficients were examined to compare FOSL1 expression among different tumors types using OncoLnc. The UCSC Xena browser was used to generate ... Read more >>

Neurol. Res. (Neurological research)
[2020, :1-6]

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Anaplastic Astrocytoma in a Child With Coffin-Siris Syndrome and a Germline SMARCE1 Mutation: A Case Report.

Beryl Lin, Chimene Kesserwan, Emily A Quinn, Stephanie L Einhaus, Karen D Wright, Elizabeth M Azzato, Brent A Orr, Santhosh A Upadhyaya,

Coffin-Siris syndrome (CSS) is a rare congenital disorder with variable clinical phenotype consisting of developmental delay and characteristic facial features. It is caused by mutations in the chromatin remodeling switch/sucrose nonfermenting complex. Although SWI/SNF genes are widely implicated in tumorigenesis, only 8 cases of neoplasm have been reported in patients ... Read more >>

J. Pediatr. Hematol. Oncol. (Journal of pediatric hematology/oncology)
[2020, 42(3):e177-e180]

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Glioblastoma chemotherapeutic agents used in the clinical setting and in clinical trials: nanomedicine approaches to improve their efficacy.

Juan Aparicio-Blanco, Lorena Sanz-Arriazu, Ricardo Lorenzoni, María J Blanco-Prieto,

Even though substantial advances in understanding glioma pathogenesis have prompted a more rational design of potential therapeutic strategies, glioblastoma multiforme remains an incurable disease with the lowest median overall survival among all malignant brain tumours. Therefore, there is a dire need to find novel drug delivery strategies to improve the ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2020, :119283]

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Small molecule tyrosine kinase inhibitors in glioblastoma.

Gayoung Kim, Young Tag Ko,

Glioblastoma (GBM) is the most common malignant primary brain tumor, with poor survival despite treatment with surgery, radiotherapy, and chemotherapy with temozolomide. Little progress has been made over the last two decades, and there remain unmet medical needs. Approximately 45% of patients with GBM carry EGFR mutations, and 13% of ... Read more >>

Arch. Pharm. Res. (Archives of pharmacal research)
[2020, :]

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Superficial siderosis associated with the long-term recurrence of pilocytic astrocytoma in an elderly person: A case report.

Kenji Yoshiki, Yasuo Sasagawa, Masashi Kinoshita, Takuya Furuta, Sho Tamai, Hemragul Sabit, Shingo Tanaka, Mitsutoshi Nakada,

BACKGROUND:Superficial siderosis is an irreversible disease in the central nervous system caused by the deposition of hemosiderin in the subpial tissue due to persistent bleeding in the subarachnoid space. The main symptoms include sensorineural hearing loss, cerebellar ataxia, and pyramidal tract disorder. Superficial siderosis is mainly idiopathic, but bleeding factors ... Read more >>

World Neurosurg (World neurosurgery)
[2020, :]

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Optimized Image-Based Surrogate Endpoints in Targeted Therapies for Glioblastoma: A Systematic Review and Meta-Analysis of Phase III Randomized Controlled Trials.

Chong Hyun Suh, Ho Sung Kim, Seung Chai Jung, Choong Gon Choi, Sang Joon Kim, Kyung Won Kim,

OBJECTIVE:We aimed to determine the optimized image-based surrogate endpoints (IBSEs) in targeted therapies for glioblastoma through a systematic review and meta-analysis of phase III randomized controlled trials (RCTs). MATERIALS AND METHODS:A systematic search of OVID-MEDLINE and EMBASE for phase III RCTs on glioblastoma was performed in December 2017. Data on ... Read more >>

Korean J Radiol (Korean journal of radiology)
[2020, 21(4):471-482]

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Correlation between IDH, ATRX, and TERT promoter mutations in glioma.

Shigeo Ohba, Kiyonori Kuwahara, Seiji Yamada, Masato Abe, Yuichi Hirose,

According to the 2016 World Health Organization (WHO) classification of central nervous system tumors, diffuse astrocytic and oligodendroglial tumors are differentiated by the presence of isocitrate dehydrogenase 1 or 2 (IDH1/2) mutation and the combined loss of the short arm of chromosome 1 and the long arm of chromosome 19 ... Read more >>

Brain Tumor Pathol (Brain tumor pathology)
[2020, :]

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lncRNA and mRNA signature for prognosis prediction of glioblastoma.

Guohong Liu, Yunbao Pan, Yueying Li, Haibo Xu,

Aims: We aimed to find out potential novel biomarkers for prognosis of glioblastoma (GBM). Materials & methods: We downloaded mRNA and lncRNA expression profiles of 169 GBM and five normal samples from The Cancer Genome Atlas and 129 normal brain samples from genotype-tissue expression. We use R language to perform ... Read more >>

Future Oncol (Future oncology (London, England))
[2020, :]

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Major Contribution of Caspase-9 to Honokiol-Induced Apoptotic Insults to Human Drug-Resistant Glioblastoma Cells.

Gong-Jhe Wu, Sun-Ta Yang, Ruei-Ming Chen,

Temozolomide (TMZ)-induced chemoresistance to human glioblastomas is a critical challenge now. Our previous studies showed that honokiol, a major bioactive constituent of Magnolia officinalis (Houpo), can kill human glioblastoma cells and suppresses glioblastoma growth. This study was further aimed to evaluate the effects of honokiol on human drug-resistant glioblastoma cells ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(6):]

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LCK expression is a potential biomarker for distinguishing primary central nervous system lymphoma from glioblastoma multiforme.

Le Ge, Lixia Xu, Shan Lu, Hua Yan,

Glioblastoma multiforme (GBM) and primary central nervous system lymphoma (PCNSL) are both malignant cerebral tumors; however, their treatments are vastly different. Early and precise diagnosis is vital for subsequent adequate treatment to improve prognosis. Reliable biomarkers that can easily distinguish GBM and PCNSL are urgently needed. We evaluated the diagnostic ... Read more >>

FEBS Open Bio (FEBS open bio)
[2020, :]

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The molecular characteristics of spinal cord gliomas with or without H3 K27M mutation.

Rui-Chao Chai, Yao-Wu Zhang, Yu-Qing Liu, Yu-Zhou Chang, Bo Pang, Tao Jiang, Wen-Qing Jia, Yong-Zhi Wang,

Due to the rare incidence of spinal cord astrocytomas, their molecular features remain unclear. Here, we characterized the landscapes of mutations in H3 K27M, isocitrate dehydrogenase 1 (IDH1) R132H, BRAF V600E, and the TERT promoter in 83 diffuse spinal cord astrocytic tumors. Among these samples, thirty-five patients had the H3 ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2020, 8(1):40]

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Tumoral and immune heterogeneity in an anti-PD-1-responsive glioblastoma: a case study.

Paula Restrepo, Raymund Yong, Ilaria Laface, Nadejda Tsankova, Kambiz Nael, Guray Akturk, Robert Sebra, Sacha Gnjatic, Adilia Hormigo, Bojan Losic,

Clinical benefit of immune checkpoint blockade in glioblastoma (GBM) is rare, and we hypothesize that tumor clonal evolution and the immune microenvironment are key determinants of response. Here, we present a detailed molecular characterization of the intratumoral and immune heterogeneity in an IDH wild-type, MGMT-negative GBM patient who plausibly benefited ... Read more >>

Cold Spring Harb Mol Case Stud (Cold Spring Harbor molecular case studies)
[2020, 6(2):]

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[A rare differential diagnosis of "atraumatic" shoulder pain].

E Deibel, P Rossbach, O Distler,

A 30-year-old patient presented with bilateral shoulder pain, hematoma of the upper arm and livid discoloration of the tongue. Blood analysis showed an increase in creatine kinase and inflammatory markers. Screening for immunological and infection markers were negative. Under the suspicion of systemic vasculitis, a positron emission tomography-computed tomography (PET-CT) scan ... Read more >>

Z Rheumatol (Zeitschrift fur Rheumatologie)
[2020, 79(3):286-290]

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Spider venom administration impairs glioblastoma growth and modulates immune response in a non-clinical model.

Amanda Pires Bonfanti, Natália Barreto, Jaqueline Munhoz, Marcus Caballero, Gabriel Cordeiro, Thomaz Rocha-E-Silva, Rafael Sutti, Fernanda Moura, Sérgio Brunetto, Celso Dario Ramos, Rodolfo Thomé, Liana Verinaud, Catarina Rapôso,

Molecules from animal venoms are promising candidates for the development of new drugs. Previous in vitro studies have shown that the venom of the spider Phoneutria nigriventer (PnV) is a potential source of antineoplastic components with activity in glioblastoma (GB) cell lines. In the present work, the effects of PnV ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5876]

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Ursodeoxycholic acid inhibits glioblastoma progression via endoplasmic reticulum stress related apoptosis and synergizes with the proteasome inhibitor bortezomib.

Zhong Yao, Xun Zhang, Feihu Zhao, Shuai Wang, Anjing Chen, Bin Huang, Jian Wang, Xingang Li,

Ursodeoxycholic acid (UDCA) has demonstrated cancer suppressive potential in several tumors. Here, we investigated the antitumor potential and biochemical mechanism of UDCA on glioblastoma multiforme (GBM), the deadliest form of brain cancer with a median survival of 15 months. Cell viability was assessed using the CCK-8 and colony forming assays. ... Read more >>

ACS Chem Neurosci (ACS chemical neuroscience)
[2020, :]

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Efficacy and safety of dendritic cell vaccines for patients with glioblastoma: A meta-analysis of randomized controlled trials.

Li Lv, Jiangchao Huang, Haipeng Xi, Xiangyang Zhou,

BACKGROUND:Dendritic cell (DC)-based vaccination has been suggested to be promising for glioblastoma. However, the evidence in randomized controlled trials (RCTs) is inconsistent. We aimed to systematically evaluate the efficacy and safety of DC vaccine for glioblastoma via a meta-analysis of RCTs. METHODS:Related randomized controlled trials (RCTs) were identified via a ... Read more >>

Int. Immunopharmacol. (International immunopharmacology)
[2020, 83:106336]

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Growth inhibitory activity of bone morphogenetic protein 4 in human glioblastoma cell lines is heterogeneous and dependent on reduced SOX2 expression.

Erika Dalmo, Patrik Johansson, Mia Niklasson, Ida Gustavsson, Sven Nelander, Bengt Westermark,

Glioblastoma multiforme (GBM) continues to have a dismal prognosis. Even though detailed information on the genetic aberrations in cell signaling and cell cycle checkpoint control is available, no effective targeted treatment has been developed. Despite the advanced molecular defects, glioblastoma cells may have remnants of normal growth inhibitory pathways, such ... Read more >>

Mol. Cancer Res. (Molecular cancer research : MCR)
[2020, :]

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Personalized Neoantigen Vaccines: A Glimmer of Hope For Glioblastoma.

Vaishali Y Londhe, Varada Date,

Introduction: Glioblastoma Multiforme (GBM) is the most prevalent primary brain tumor. In spite of the rigorous multimodal treatment involving surgery and radiochemotherapy, GBM has a dismal prognosis and rapid relapsing potential. Hence, search for novel therapeutic agents still continues. Neoantigens are the tumor-specific antigens which arise due to somatic mutations ... Read more >>

Expert Rev Vaccines (Expert review of vaccines)
[2020, :]

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