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Neuronal expression of Ca2+ oscillation initiator is linked to rapid neonatal growth in mice.

Woojin Kang, Kenji Yamatoya, Kenji Miyado, Mami Miyado, Yoshitaka Miyamoto,

MicroPubl Biol (microPublication biology)
[2020, 2020:]

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Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury.

Yi-Xin Wang, Jin-Zhu Bai, Zhen Lyu, Guang-Hao Zhang, Xiao-Lin Huo,

Oscillating field stimulation (OFS) is a potential method for treating spinal cord injury. Although it has been used in spinal cord injury (SCI) therapy in basic and clinical studies, its underlying mechanism and the correlation between its duration and nerve injury repair remain poorly understood. In this study, we established ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1318-1323]

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HOXA11-AS aggravates microglia-induced neuroinflammation after traumatic brain injury.

Xiang-Long Li, Bin Wang, Fu-Bing Yang, Li-Gang Chen, Jian You,

Long noncoding RNAs (lncRNAs) participate in many pathophysiological processes after traumatic brain injury by mediating neuroinflammation and apoptosis. Homeobox A11 antisense RNA (HOXA11-AS) is a member of the lncRNA family that has been reported to participate in many inflammatory reactions; however, its role in traumatic brain injury remains unclear. In ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1096-1105]

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M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury.

Shui-Sheng Yu, Zi-Yu Li, Xin-Zhong Xu, Fei Yao, Yang Luo, Yan-Chang Liu, Li Cheng, Mei-Ge Zheng, Jue-Hua Jing,

After spinal cord injury (SCI), astrocytes gradually migrate to and surround the lesion, depositing chondroitin sulfate proteoglycan-rich extracellular matrix and forming astrocytic scar, which limits the spread of inflammation but hinders axon regeneration. Meanwhile, microglia gradually accumulate at the lesion border to form microglial scar and can polarize to generate ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1072-1079]

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Significance of intercellular communication for neurodegenerative diseases.

Hilal Cihankaya, Carsten Theiss, Veronika Matschke,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1015-1017]

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Non-cell autonomous role of astrocytes in axonal degeneration of cortical projection neurons in hereditary spastic paraplegias.

Xue-Jun Li,

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1265-1266]

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Preliminary examination of early neuroconnectivity features in the R6/1 mouse model of Huntington's disease by ultra-high field diffusion MRI.

Rodolfo G Gatto, Carina Weissmann,

During the last decades, advances in the understanding of genetic, cellular, and microstructural alterations associated to Huntington's disease (HD) have improved the understanding of this progressive and fatal illness. However, events related to early neuropathological events, neuroinflammation, deterioration of neuronal connectivity and compensatory mechanisms still remain vastly unknown. Ultra-high field ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):983-986]

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APOE4 expression is associated with impaired autophagy and mitophagy in astrocytes.

Schmukler Eran, Pinkas-Kramarski Ronit,

Neural Regen Res (Neural regeneration research)
[2022, 17(4):777-778]

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Potential use of lactate for the treatment of neonatal hypoxic-ischemic encephalopathy.

Isadora D'Ávila Tassinari, Luciano Stürmer de Fraga,

Neural Regen Res (Neural regeneration research)
[2022, 17(4):788-790]

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Involvement of glucose transporter overexpression in the protection or damage after ischemic stroke.

Iván Alquisiras-Burgos, Penélope Aguilera,

Neural Regen Res (Neural regeneration research)
[2022, 17(4):783-784]

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Colony stimulating factor 1: friend or foe of neurons?

Lorna Bo, Xuenong Bo,

Neural Regen Res (Neural regeneration research)
[2022, 17(4):773-774]

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Glial decline and loss of homeostatic support rather than inflammation defines cognitive aging.

Alexei Verkhratsky, Natalia Lazareva, Alexey Semyanov,

Neural Regen Res (Neural regeneration research)
[2022, 17(3):565-566]

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Estimation of the density of neural, glial, and endothelial lineage cells in the adult mouse dentate gyrus.

Joshua D Rieskamp, Patricia Sarchet, Bryon M Smith, Elizabeth D Kirby,

The dentate gyrus subregion of the mammalian hippocampus is an adult neural stem cell niche and site of lifelong neurogenesis. Hypotheses regarding the role of adult-born neuron synaptic integration in hippocampal circuit function are framed by robust estimations of adult-born versus pre/perinatally-born neuron number. In contrast, the non-neurogenic functions of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(6):1286-1292]

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Downregulation of EphB2 by RNA interference attenuates glial/fibrotic scar formation and promotes axon growth.

Jian Wu, Zhen-Yu Zhu, Zhi-Wei Fan, Ying Chen, Ri-Yun Yang, Yi Li,

The rapid formation of a glial/fibrotic scar is one of the main factors hampering axon growth after spinal cord injury. The bidirectional EphB2/ephrin-B2 signaling of the fibroblast-astrocyte contact-dependent interaction is a trigger for glial/fibrotic scar formation. In the present study, a new in vitro model was produced by coculture of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):362-369]

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The emerging world of subcellular biological medicine: extracellular vesicles as novel biomarkers, targets, and therapeutics.

Leon G Coleman,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1020-1022]

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Retinal microglial activation in glaucoma: evolution over time in a unilateral ocular hypertension model.

José A Fernandez-Albarral, Ana I Ramírez, Rosa de Hoz, Juan J Salazar,

Neural Regen Res (Neural regeneration research)
[2022, 17(4):797-799]

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Diabetic retinopathy: neurovascular disease requiring neuroprotective and regenerative therapies.

Toshiyuki Oshitari,

Neural Regen Res (Neural regeneration research)
[2022, 17(4):795-796]

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From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease?

Rita Caridade Silva, Helena Sofia Domingues, António J Salgado, Fábio G Teixeira,

Parkinson's disease is the second most prevalent neurodegenerative disorder worldwide. Clinically, it is characterized by severe motor complications caused by progressive degeneration of dopaminergic neurons. Current treatment is focused on mitigating the symptoms through the administration of levodopa, rather than on preventing dopaminergic neuronal damage. Therefore, the use and development ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):933-936]

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Metabolic reprogramming of glial cells as a new target for central nervous system axon regeneration.

Erin L Walden, Shuxin Li,

Neural Regen Res (Neural regeneration research)
[2022, 17(5):997-998]

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Transcranial magnetic stimulation in animal models of neurodegeneration.

Mohammad Uzair, Turki Abualait, Muhammad Arshad, Woo-Kyoung Yoo, Ali Mir, Reem Fahd Bunyan, Shahid Bashir,

Brain stimulation techniques offer powerful means of modulating the physiology of specific neural structures. In recent years, non-invasive brain stimulation techniques, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation, have emerged as therapeutic tools for neurology and neuroscience. However, the possible repercussions of these techniques remain unclear, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):251-265]

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The short form of the SUR1 and its functional implications in the damaged brain.

Iván Alquisiras-Burgos, Javier Franco-Pérez, Moisés Rubio-Osornio, Penélope Aguilera,

Sulfonylurea receptor (SUR) belongs to the adenosine 5'-triphosphate (ATP)-binding cassette (ABC) transporter family; however, SUR is associated with ion channels and acts as a regulatory subunit determining the opening or closing of the pore. Abcc8 and Abcc9 genes code for the proteins SUR1 and SUR2, respectively. The SUR1 transcript encodes ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(3):488-496]

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Down-regulating Circular RNA Prkcsh suppresses the inflammatory response after spinal cord injury.

Jia-Nan Chen, Yi-Ning Zhang, Li-Ge Tian, Ying Zhang, Xin-Yu Li, Bin Ning,

Circular RNAs (circRNAs) are a class of conserved, endogenous non-coding RNAs that are involved in transcriptional and post-transcriptional gene regulation and are highly enriched in the nervous system. They participate in the survival and differentiation of multiple nerve cells, and may even promote the recovery of neurological function after stroke. ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):144-151]

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Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury.

Rui Zhao, Xue Wu, Xue-Yuan Bi, Hao Yang, Qian Zhang,

Baicalin is a natural active ingredient isolated from Scutellariae Radix that can cross the blood-brain barrier and exhibits neuroprotective effects on multiple central nervous system diseases. However, the mechanism behind the neuroprotective effects remains unclear. In this study, rat models of spinal cord injury were established using a modified Allen's ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(5):1080-1087]

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Promise of metformin for preventing age-related cognitive dysfunction.

Leelavathi N Madhu, Maheedhar Kodali, Ashok K Shetty,

The expanded lifespan of people, while a positive advance, has also amplified the prevalence of age-related disorders, which include mild cognitive impairment, dementia, and Alzheimer's disease. Therefore, competent therapies that could improve the healthspan of people have great significance. Some of the dietary and pharmacological approaches that augment the lifespan ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(3):503-507]

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Rapid GFAP and Iba1 expression changes in the female rat brain following spinal cord injury.

Mawj Mandwie, Jordan A Piper, Catherine A Gorrie, Kevin A Keay, Giuseppe Musumeci, Ghaith Al-Badri, Alessandro Castorina,

Evidence suggests that rapid changes to supporting glia may predispose individuals with spinal cord injury (SCI) to such comorbidities. Here, we interrogated the expression of astrocyte- and microglial-specific markers glial fibrillary acidic protein (GFAP) and ionized calcium binding adaptor molecule 1 (Iba1) in the rat brain in the first 24 ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(2):378-385]

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