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Expression of ASPN with Prognostic Values in Gastric Cancer: A Study Based on TCGA Data

wen chao li, Zhe Xu, Hui Chen, Zhen dong Wang, Yang Xu, Li Liu, Rui jiang Xu,

<h4>Objective: </h4> Gastric ancer is a common cancer with high cancer-related death in the world Although, ASPN has been reported as a potential biomarker in some cancers, the relationship of ASPN and clinical pathologic features in gastric cancer has not been investigated thoroughly. Thus, the aim of study is to ... Read more >>

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Asporin represses gastric cancer apoptosis via activating LEF1-mediated gene transcription independent of β-catenin.

Zheng Zhang, Li Min, Hengcun Li, Lei Chen, Yu Zhao, Si Liu, Qingdong Guo, Shengtao Zhu, Peng Li, Shutian Zhang,

Asporin (ASPN) presents in the tumor microenvironment and exhibits a cancer-promoting effect as a stroma protein. Even though ASPN has already been observed inside cancer cells, the functions of intracellular ASPN and its underlying mechanisms remain unknown. Here we reported that ASPN was upregulated in different stages of gastric cancer ... Read more >>

Oncogene (Oncogene)
[2021, :]

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H. William Schnaper - Life course journey of a true Mensch.

Laurence Greenbaum, Victoria Norwood, Eileen Brewer, William Smoyer, Marva Moxey-Mims, Joseph Flynn, Barbara Fivush, Patrick Brophy, Brad Warady, Sandra Watkins, Isidro Salusky, Rick Kaskel,

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2021, 36(6):1657-1659]

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Asporin Expression on Stromal Cells and/or Cancer Cells Might Be A Useful Prognostic Marker in Patients with Diffuse-Type Gastric Cancer.

Masakazu Yashiro, Tsuyoshi Hasegawa, Yurie Yamamoto, Gen Tsujio, Sadaaki Nishimura, Tomohiro Sera, Atsushi Sugimoto, Shuhei Kushiyama, Hiroaki Kasashima, Tatsunari Fukuoka, Katsunobu Sakurai, Takahiro Toyokawa, Naoshi Kubo, Masaichi Ohira,

<h4>Background</h4>Asporin (ASPN), a member of the proteoglycan family, has been shown to have a close correlation with cancer progression. It is not known whether ASPN is an oncogenic driver or a tumor suppressor in human gastric cancer. We sought herein to determine the relationship between ASPN expression and clinicopathological features ... Read more >>

Eur Surg Res (European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes)
[2021, 62(1):53-60]

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Identification of Five m6A-Relevant mRNAs Signature and Risk Score for The Prognostication of Gastric Cancer

Dongwei Sun, Xiaorong Hang, Jun Ren, Qiannan Sun, Zhu Liu, Yong Wang, Daorong Wang,

<h4>Introduction: </h4> N6-methyladenosine (m6A) is the most abundant form of methylation modification in eukaryotic cell mRNA. However, the role of m6A in gastric cancer is unclear, which is one of the most common gastrointestinal malignancies. The m6A-relevant mRNA signatures and risk scores are determined to predict the prognosis of gastric ... Read more >>

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A distinct repertoire of cancer-associated fibroblasts is enriched in cribriform prostate cancer.

Amanda B Hesterberg, Brenda L Rios, Elysa M Wolf, Colby Tubbs, Hong Yuen Wong, Kerry R Schaffer, Tamara L Lotan, Giovanna A Giannico, Jennifer B Gordetsky, Paula J Hurley,

Outcomes for men with localized prostate cancer vary widely, with some men effectively managed without treatment on active surveillance, while other men rapidly progress to metastatic disease despite curative-intent therapies. One of the strongest prognostic indicators of outcome is grade groups based on the Gleason grading system. Gleason grade 4 ... Read more >>

J Pathol Clin Res (The journal of pathology. Clinical research)
[2021, 7(3):271-286]

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Frequency of Growth Differentiation Factor 5 rs143383 and asporin D-repeat polymorphisms in patients with hand and knee osteoarthritis in Kurdistan province, Iran.

Nasrin Moghimi, Sherko Nasseri, Farzad Ghafouri, Ali Jalili,

<h4>Aim</h4>Osteoarthritis (OA) is the most common chronic joint disorder, resulting from the breakdown of joint cartilage. It occurs in the knees, hands, and hips, leading to pain, stiffness, inflammation, and swelling.<h4>Methods</h4>In this study, 100 hand and knee OA patients, meeting the American College of Rheumatology criteria were included in the ... Read more >>

Int J Rheum Dis (International journal of rheumatic diseases)
[2021, 24(5):694-700]

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Fibroma of tendon sheath is defined by a USP6 gene fusion-morphologic and molecular reappraisal of the entity.

Jože Pižem, Alenka Matjašič, Andrej Zupan, Boštjan Luzar, Daja Šekoranja, Katarina Dimnik,

Fibroma of tendon sheath (FTS) is an uncommon benign myofibroblastic neoplasm that arises in association with tenosynovial tissue. Fusions of the USP6 gene have been recently documented in a proportion of so-called "cellular FTS" but not in "classic FTS". It remains unknown whether FTS can be defined by a USP6 ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2021, :]

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Differential Expression of Insulin-Like Growth Factor 1 and Wnt Family Member 4 Correlates With Functional Heterogeneity of Human Dermal Fibroblasts.

Oliver J Culley, Blaise Louis, Christina Philippeos, Bénédicte Oulès, Matthieu Tihy, Joe M Segal, Della Hyliands, Gail Jenkins, Ranjit K Bhogal, Richard C Siow, Fiona M Watt,

Although human dermis contains distinct fibroblast subpopulations, the functional heterogeneity of fibroblast lines from different donors is under-appreciated. We identified one commercially sourced fibroblast line (c64a) that failed to express α-smooth muscle actin (α-SMA), a marker linked to fibroblast contractility, even when treated with transforming growth factor-β1 (TGF-β1). Gene expression ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2021, 9:628039]

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Alcohol consumption and dependence is linked to the extent that people experience need satisfaction while drinking alcohol in two Aboriginal and Torres Strait Islander communities.

James H Conigrave, Emma L Bradshaw, Katherine M Conigrave, Richard M Ryan, Scott Wilson, Jimmy Perry, Michael F Doyle, K S Kylie Lee,

<h4>Background</h4>Unhealthy alcohol use is a key concern for Aboriginal and Torres Strait Islander ('Indigenous Australian') communities. Due to systematic disadvantage and inter-generational trauma, Indigenous Australians may be less likely to have satisfied basic psychological needs (autonomy, competence, and relatedness). When people are need-thwarted, they may engage in compensatory behaviours to ... Read more >>

Addict Sci Clin Pract (Addiction science & clinical practice)
[2021, 16(1):23]

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Identification and Functional Annotation of Genes Related to Bone Stability in Laying Hens Using Random Forests.

Simon Jansen, Ulrich Baulain, Christin Habig, Faisal Ramzan, Jens Schauer, Armin Otto Schmitt, Armin Manfred Scholz, Ahmad Reza Sharifi, Annett Weigend, Steffen Weigend,

Skeletal disorders, including fractures and osteoporosis, in laying hens cause major welfare and economic problems. Although genetics have been shown to play a key role in bone integrity, little is yet known about the underlying genetic architecture of the traits. This study aimed to identify genes associated with bone breaking ... Read more >>

Genes (Basel) (Genes)
[2021, 12(5):]

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Chlorogenic Acid Promotes Osteogenic Differentiation of Human Dental Pulp Stem Cells Through Wnt Signaling.

Xiaoping Hu, Li Wang, Yuanqiao He, Minli Wei, Huilin Yan, Hongshui Zhu,

Periodontal disease (PD) is one of the main causes of periodontal bone resorption and tooth loss in adults. How to repair the alveolar bone effectively has always been a challenge. This study was designed to clarify the effects and the underlying molecular mechanisms of chlorogenic acid (CGA) on osteogenic differentiation ... Read more >>

Stem Cells Dev (Stem cells and development)
[2021, 30(12):641-650]

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Asporin is a Potential Promising Biomarker for Common Heart Failure.

Kai Zhang, Min Wu, Xianyu Qin, Pengju Wen, Yueheng Wu, Jian Zhuang,

Heart failure (HF) is the end-stage of various diseases, especially ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM). We aimed to investigate the common molecular mechanism of ICM and DCM. Differentially expressed genes (DEGs) of ICM or DCM samples compared with control were identified in GSE1869, GSE5406, GSE57338, GSE79962, GSE116250, and ... Read more >>

DNA Cell Biol (DNA and cell biology)
[2021, 40(2):303-315]

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Impact of an Antibiotic Stewardship Program on the Incidence of Resistant Escherichia coli: A Quasi-Experimental Study.

Elad Ziv-On, Michael D Friger, Lisa Saidel-Odes, Abraham Borer, Orly Shimoni, Anna Nikonov, Lior Nesher,

Infections caused by multidrug-resistant Gram-negative bacteria increase hospitalizations and mortality rates; antibiotic pressure increases resistance rates. We evaluated the impact of the antibiotics stewardship program (ASP) on <i>Escherichia coli</i> resistance rates, evaluating all antibiotic use and patients with positive cultures hospitalized between 2011 and 2018. Data on antibiotics were collected ... Read more >>

Antibiotics (Basel) (Antibiotics (Basel, Switzerland))
[2021, 10(2):]

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Race as a Contributor to Stromal Modulation of Tumor Progression.

Mamatha Kakarla, Sathyavathi ChallaSivaKanaka, Simon W Hayward, Omar E Franco,

Stromal cells play crucial roles in tumor development and are increasingly attractive targets for therapy. There are considerable racial disparities in the incidence and progression of many tumors, reflecting both environmental exposure and genetic differences existing between races. Tumorigenesis and tumor progression are linked to both the propensity to suffer ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(11):]

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scRNA-seq of ovarian follicle granulosa cells from different fertility goats reveals distinct expression patterns.

Zengkuan Li, Junjie Wang, Yong Zhao, Dongxue Ma, Minghui Zhao, Na Li, Yuhao Men, Yuan Zhang, Huimin Chu, Chuzhao Lei, Wei Shen, Othman El-Mahdy Othman, Lingjiang Min,

The new technology of high-throughput single-cell RNA sequencing (10 × scRNA-seq) was developed recently with many advantages. However, it was not commonly used in farm animal research. There are few reports for the gene expression of goat ovarian follicle granulosa cells (GCs) during different developmental stages. In the current investigation, the gene ... Read more >>

Reprod Domest Anim (Reproduction in domestic animals = Zuchthygiene)
[2021, 56(5):801-811]

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Asporin inhibits collagen matrix-mediated intercellular mechanocommunications between fibroblasts during keloid progression.

Longwei Liu, Hongsheng Yu, Yi Long, Zhifeng You, Rei Ogawa, Yanan Du, Chenyu Huang,

Keloids are fibrotic lesions that grow unceasingly and invasively and are driven by local mechanical stimuli. Unlike other fibrotic diseases and normal wound healing, keloids exhibit little transformation of dermal fibroblasts into α-SMA<sup>+</sup> myofibroblasts. This study showed that asporin is the most strongly expressed gene in keloids and its gene-ontology ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21705]

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A new risk stratification system of prostate cancer to identify high-risk biochemical recurrence patients.

Xiangkun Wu, Daojun Lv, Md Eftekhar, Aisha Khan, Chao Cai, Zhijian Zhao, Di Gu, Yongda Liu,

<h4>Background</h4>Biochemical recurrence (BCR) is considered a decisive risk factor for clinical recurrence and the metastasis of prostate cancer (PCa). Therefore, we developed and validated a signature which could be used to accurately predict BCR risk and aid in the selection of PCa treatments.<h4>Methods</h4>A comprehensive genome-wide analysis of data concerning PCa ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(6):2572-2586]

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Cribriform Prostate Cancer: Clinical Pathologic and Molecular Considerations.

Amanda B Hesterberg, Jennifer B Gordetsky, Paula J Hurley,

Intraductal cribriform (IDC) and invasive cribriform morphologies are associated with worse prostate cancer outcomes. Limited retrospective studies have associated IDC and cribriform morphology with germline mutations in DNA repair genes, particularly BRCA2. These findings, which prompted the National Comprehensive Cancer Network® (NCCN) Guidelines for Prostate Cancer and Genetic/Familial High- Risk ... Read more >>

Urology (Urology)
[2021, :]

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The American Society of Pain and Neuroscience (ASPN) Practical Guidelines to Study Design and Scientific Manuscript Preparation in Neuromodulation.

Yashar Eshraghi, Krishnan Chakravarthy, Natalie H Strand, Prasad Shirvalkar, Nathaniel M Schuster, Rany T Abdallah, Ricardo Vallejo, Dawood Sayed, David Kim, Chong Kim, Kathleen Meacham, Timothy Deer, ,

<h4>Background</h4>Healthcare clinical and even policy decisions are progressively made based on research-based evidence. The process by which the appropriate trials are developed and well-written manuscripts by means of evidence-based medicine recommendations has resulted in unprecedented necessity in evidence-based medicine in neuromodulation.<h4>Methods</h4>The essential considerations in the planning of neuromodulation research are ... Read more >>

J Pain Res (Journal of pain research)
[2021, 14:1027-1041]

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Towards comprehensive plasma proteomics by orthogonal protease digestion

Andrea Fossati, Alicia Richards, Kuei-Ho Chen, Devan Jaganath, Adithya Cattamanchi, Joel Ernst, Danielle Swaney,

Rapid and consistent protein identification across large clinical cohorts is an important goal for clinical proteomics. With the development of data-independent technologies (DIA/SWATH-MS), it is now possible to analyze hundreds of samples with great reproducibility and quantitative accuracy. However, this technology benefits from empirically derived spectral libraries that define the ... Read more >>

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Scouting the receptor-binding domain of SARS coronavirus 2: a comprehensive immunoinformatics inquisition

Zaira Rehman, Ammad Fahim, Muhammad Faraz Bhatti,

Aim: December 2019 witnessed the emergence of a worldwide outbreak of a novel strain of coronavirus (CoV) termed SARS-CoV-2. Several preventive strategies are being developed, such as vaccines, to stop the spread of infection. Materials & methods: A comprehensive immunoinformatics approach was used to map conserved peptide sequences on the receptor binding ... Read more >>

Future Virol (Future virology)
[2021, :]

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Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity.

Amber M Paul, Eliah G Overbey, Willian A da Silveira, Nathaniel Szewczyk, Nina C Nishiyama, Michael J Pecaut, Sulekha Anand, Jonathan M Galazka, Xiao Wen Mao,

Using a ground-based model to simulate spaceflight [21-days of single-housed, hindlimb unloading (HLU) combined with continuous low-dose gamma irradiation (LDR, total dose of 0.04 Gy)], an in-depth survey of the immune and hematological systems of mice at 7-days post-exposure was performed. Collected blood was profiled with a hematology analyzer and ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):11452]

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Bioinformatics Analysis and Identification of Genes and Pathways in Ischemic Cardiomyopathy

Jing Cao, Zhaoya Liu, Jie Liu, Chan Li, Guogang Zhang, Ruizheng Shi,

<h4>Background: </h4> Ischemic cardiomyopathy (ICM) is considered to be the common cause of heart failure, which has high prevalence and mortality. This study aimed to investigate the different expressed genes (DEGs) and pathways in the pathogenesis of ICM using bioinformatics analysis. <h4>Methods: </h4> The control and ICM datasets GSE116250,GSE46224 and ... Read more >>

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A novel immuno-oncology algorithm measuring tumor microenvironment to predict response to immunotherapies.

Tyler J Nielsen, Brian Z Ring, Robert S Seitz, David R Hout, Brock L Schweitzer,

Immune checkpoint inhibitor (ICI) therapies can improve clinical outcomes for patients with solid tumors, but relatively few patients respond. Because ICI therapies support an adaptive immune response, patients with an active tumor microenvironment (TME) may be more likely to respond, and thus biomarkers capable of discerning an active from a ... Read more >>

Heliyon (Heliyon)
[2021, 7(3):e06438]

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