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Full Text Journal Articles about
Aspergillosis

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Underlying Conditions and Clinical Spectrum of Chronic Pulmonary Aspergillosis (CPA): An Experience from a Tertiary Care Hospital in Karachi, Pakistan.

Nousheen Iqbal, Muhammad Irfan, Ammar Mushtaq, Kauser Jabeen,

The incidence of chronic pulmonary aspergillosis (CPA) is especially increasing in high tuberculosis (TB) burden countries. Despite a high estimated CPA burden in Pakistan, actual data on CPA are not available. The aim of the current study is to determine the underlying conditions and clinical spectrum of CPA at a ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2020, 6(2):]

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Interferon gamma replacement as salvage therapy in chronic pulmonary aspergillosis: effects on frequency of acute exacerbation and all-cause hospital admission.

Edward Jm Monk, Chris Harris, Rainer Döffinger, Gemma Hayes, David W Denning, Chris Kosmidis,

Chronic pulmonary aspergillosis (CPA) is often poorly responsive to antifungal treatment; secondary infections increase morbidity/mortality, particularly in progressive cases. Interferon gamma (IFNγ) has been implicated in not only Aspergillus control but also bacterial clearance. Clinical notes of patients with CPA treated with IFNγ (2011-2018) were retrospectively hand-searched. In patients treated ... Read more >>

Thorax (Thorax)
[2020, :]

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A Rare Presentation of Pulmonary Aspergillosis: Bronchial Stump Aspergillosis.

Oguz Karcioglu, Riza Dogan, Omrum Uzun, Fatma Tokat, Dolunay Gülmez, Sevtap Arikan-Akdagli, Ziya T Selcuk,

J Bronchology Interv Pulmonol (Journal of bronchology & interventional pulmonology)
[2020, 27(2):e28-e33]

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Knowledge of Infectious Disease Specialists Regarding Aspergillosis Complicating Influenza, United States.

Mitsuru Toda, Susan E Beekmann, Philip M Polgreen, Tom M Chiller, Brendan R Jackson, Karlyn D Beer,

In an online survey, we found that nearly one fifth of physicians in the United States who responded had seen or heard about a case of invasive pulmonary aspergillosis after severe influenza at their institution. However, <10% routinely used galactomannan testing to test for this fungus in patients with severe ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(4):809-811]

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Blockade Of PD-1 Attenuated Postsepsis Aspergillosis Via The Activation of IFN-γ and The Dampening of IL-10.

Chau Tran Bao Vu, Arsa Thammahong, Hideo Yagita, Miyuki Azuma, Nattiya Hirankarn, Patcharee Ritprajak, Asada Leelahavanichkul,

BACKGROUND:Nosocomial aspergillosis in patients with sepsis has emerged in the past few years. Blockade of PD-1/PD-L pathway has tended to become a promising therapeutic strategy as it improved the outcome of bacterial sepsis and postsepsis secondary fungal infection. Recently, the controversial effects of PD-1 blockade on infectious diseases, including aspergillosis, ... Read more >>

Shock (Shock (Augusta, Ga.))
[2020, 53(4):514-524]

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Usefulness of ICU criteria for diagnosis of invasive pulmonary aspergillosis in nonhematologic critically ill patients.

Song-I Lee, Heungsup Sung, Sang-Bum Hong, Chae-Man Lim, Younsuck Koh, Jin-Won Huh,

Invasive pulmonary aspergillosis (IPA) is a life-threatening disease in the intensive care unit (ICU). The ICU criteria were proposed to diagnose IPA in critically ill patients. This study aims to evaluate the usefulness of ICU criteria for diagnosis and treatment of IPA in nonhematologic patients in the ICU. We retrospectively ... Read more >>

Med. Mycol. (Medical mycology)
[2020, 58(3):275-281]

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Species identification, antifungal susceptibility, and clinical feature association of Aspergillus section Nigri isolates from the lower respiratory tract.

Keita Takeda, Junko Suzuki, Akira Watanabe, Mei Matsuki, Katsuyuki Higa, Eri Inoue, Shunsuke Akashi, Masahiro Shimada, Masahiro Kawashima, Nobuharu Ohshima, Takeshi Fukami, Kimihiko Masuda, Akira Yamane, Atsuhisa Tamura, Hideaki Nagai, Hirotoshi Matsui, Shigeto Tohma, Katsuhiko Kamei,

Species of Aspergillus section Nigri are generally identified by molecular genetics approaches, whereas in clinical practice, they are classified as A. niger by their morphological characteristics. This study aimed to investigate whether the species of Aspergillus section Nigri isolated from the respiratory tract vary depending on clinical diagnosis. Forty-four Aspergillus ... Read more >>

Med. Mycol. (Medical mycology)
[2020, 58(3):310-314]

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The utility of the basophil activation test in differentiating asthmatic subjects with and without allergic bronchopulmonary aspergillosis.

Kuruswamy Thurai Prasad, Valliappan Muthu, Inderpaul Singh Sehgal, Sahajal Dhooria, Pawan Singh, Man Updesh Singh Sachdeva, Arunaloke Chakrabarti, Ashutosh N Aggarwal, Ritesh Agarwal,

BACKGROUND:Asthma with Aspergillus sensitization (ASA) and allergic bronchopulmonary aspergillosis (ABPA) are distinct clinical conditions, with different management strategies. OBJECTIVE:To determine the utility of the basophil activation test (BAT) in differentiating between asthmatic subjects with and without ABPA. METHODS:We performed the BAT using flow cytometry for the basophil activation markers CD63, ... Read more >>

Mycoses (Mycoses)
[2020, :]

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Accuracy of serological tests for diagnosis of chronic pulmonary aspergillosis: A systematic review and meta-analysis.

Cláudia Elizabeth Volpe Chaves, Sandra Maria do Valle Leone de Oliveira, James Venturini, Antonio Jose Grande, Tatiane Fernanda Sylvestre, Rinaldo Poncio Mendes, Anamaria Mello Miranda Paniago,

Chronic pulmonary aspergillosis (CPA) is a slow and progressive disease that develops in preexisting lung cavities of patients with tuberculosis sequelae, and it is associated with a high mortality rate. Serological tests such as double agar gel immunodiffusion test (DID) or counterimmunoelectrophoresis (CIE) test have been routinely used for CPA ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0222738]

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Prevalence and mechanisms of azole resistance in clinical isolates of Aspergillus section Fumigati species in a Canadian tertiary care centre, 2000 to 2013.

Maxime Parent-Michaud, Philippe J Dufresne, Eric Fournier, Benjamin Folch, Christine Martineau, Sandrine Moreira, Nicolas Doucet, Louis De Repentigny, Simon F Dufresne,

OBJECTIVES:Azole resistance among Aspergillus fumigatus isolates is a growing concern worldwide. Induction of mutations during azole therapy, environment-acquired mutations caused by azole fungicides and intrinsic resistance of cryptic Fumigati species all contribute to the burden of resistance. However, there is a lack of data in Canada on this emerging threat. ... Read more >>

J. Antimicrob. Chemother. (The Journal of antimicrobial chemotherapy)
[2020, 75(4):849-858]

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Current burden of serious fungal infections in Republic of Congo.

Fructueux M Amona, David W Denning, Donatien Moukassa, Christophe Hennequin,

BACKGROUND:The Republic of Congo (RoC) is characterized by a high prevalence of tuberculosis and HIV/AIDS, which largely drive the epidemiology of serious fungal infections. OBJECTIVE:We aimed to estimate the current burden of serious fungal infections in RoC. MATERIAL AND METHODS:Using local, regional, or global data and estimates of population and ... Read more >>

Mycoses (Mycoses)
[2020, :]

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Characterization of clinical and genetic spectrum of Chinese patients with cystic fibrosis

Yaping Liu, Keqiang Liu, Wenshuai Xu, Meng xiao, Xinyue Zhao, Chun New, Qianli Zhang, Jiaxing Song, Keqi Chen, Xinlun Tian, Kai-Feng Xu, Xue Zhang,

<title>Abstract</title> <p> Background Cystic fibrosis (CF) is a rare autosomal recessive disorder caused by biallelic mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The clinical features and mutation spectrum of CF have been well characterized in Caucasians, while limited studies were conducted in Chinese patients. ... Read more >>

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Combination Therapy with Ibrexafungerp (formerly SCY-078), a First-in-Class Triterpenoid Inhibitor of (1→3)-β-D-Glucan Synthesis, and Isavuconazole for Treatment of Experimental Invasive Pulmonary Aspergillosis.

Vidmantas Petraitis, Ruta Petraitiene, Aspasia Katragkou, Bo Bo Win Maung, Ethan Naing, Povilas Kavaliauskas, Stephen Barat, Katyna Borroto-Esoda, Nkechi Azie, David Angulo, Thomas J Walsh,

Ibrexafungerp (formerly SCY-078) is a semisynthetic triterpenoid and potent (1→3)-β-D-glucan synthase inhibitor. We investigated the in vitro activity, pharmacokinetics, and in vivo efficacy of ibrexafungerp (SCY) alone and in combination with anti-mould triazole isavuconazole (ISA) against invasive pulmonary aspergillosis (IPA). The combination of ibrexafungerp and isavuconazole in in vitro studies ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2020, :]

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Potential value of serum Aspergillus IgG antibody detection in the diagnosis of invasive and chronic pulmonary aspergillosis in non-agranulocytic patients

Haiying Peng, Qihong Yu, Jingdong He, Bin Xing, Xin Li, Hongyu Qian, Hong Zhang, Meilin Xu,

<title>Abstract</title> <p> <bold>Background:</bold> At present, serum <italic>Aspergillus</italic> IgG and IgM antibody detection is mainly used in the diagnosis of chronic pulmonary aspergillosis (CPA), but its value in the diagnosis of invasive pulmonary aspergillosis (IPA) in non-agranulocytic patients is still unclear. IgM can be used as a marker of ... Read more >>

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Aspergillus niger fungemia secondary to chronic pulmonary aspergillosis in a patient with invasive squamous cell carcinoma.

Caitlyn Hollingshead, Kelly Luttmann, Emad Abu Sitta, Hend Elsaghir,

BMJ Case Rep (BMJ case reports)
[2020, 13(3):]

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International survey on influenza-associated pulmonary aspergillosis (IAPA) in intensive care units: responses suggest low awareness and potential underdiagnosis outside Europe.

Karin Thevissen, Cato Jacobs, Michelle Holtappels, Mitsuru Toda, Paul Verweij, Joost Wauters,

Crit Care (Critical Care)
[2020, 24(1):84]

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Role of serum periostin in the management of asthma and its comorbidities.

Hisako Matsumoto,

Type-2 airway inflammation is a major characteristic of asthma. Assessing its degree of severity is, therefore, essential in asthma management. Periostin, a matricellular protein belonging to the fasciclin family, is a key molecule linking type-2 airway inflammation and airway remodeling. Fortunately, periostin can be detected in the blood and used ... Read more >>

Respir Investig (Respiratory investigation)
[2020, :]

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Molecular allergen sensitization of Aspergillus fumigatus in allergic bronchopulmonary aspergillosis in Guangzhou, Southern China

Haisheng Hu, Wenting Luo, Zehong Wu, Nili Wei, Huimin Huang, Peiyan Zheng, Baoqing Sun, Yong Liu,

<title>Abstract</title> <p> Background Few studies have assessed the sensitization of mycotic allergens and Aspergillus fumigatus molecular allergen. This study aimed to investigate the connection between A.fumigatus components and mycotic allergens between allergic bronchopulmonary aspergillosis (ABPA) patients and A. fumigatus (Af)-sensitized asthma. Methods Serum Penicillium chrysogenum , Cladosporium herbarum ... Read more >>

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Treating Allergic Bronchopulmonary Aspergillosis with Short-Term Prednisone and Itraconazole in Cystic Fibrosis.

Florian Gothe, Alessa Schmautz, Kurt Häusler, Nguyen-Binh Tran, Matthias Kappler, Matthias Griese,

BACKGROUND:Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity reaction to Aspergillus fumigatus contributing to cystic fibrosis (CF) lung disease. OBJECTIVE:To evaluate the combination of oral prednisone for 18 days together with itraconazole therapy for at least 12 months in CF-related ABPA with regard to long-term pulmonary function and side effects. METHODS:Sixty-five ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2020, :]

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Diagnostic Value of Galactomannan in Bronchoalveolar Lavage Fluid for Chronic Respiratory Disease with Pulmonary Aspergillosis.

Guangbin Lai, Chao Zeng, Jianming Mo, Wei-Dong Song, Ping Xu,

The objective of this study was to explore the diagnostic value of the bronchoalveolar lavage fluid galactomannan (BALF GM) test for chronic respiratory disease with pulmonary aspergillosis and to establish the optimal cutoff value. Samples from a total of 309 chronic respiratory disease patients seen at the respiratory medicine department ... Read more >>

J. Clin. Microbiol. (Journal of clinical microbiology)
[2020, 58(3):]

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Invasive Pulmonary Aspergillosis in Patients With Severe Fever With Thrombocytopenia Syndrome.

Seongman Bae, Hye Jeon Hwang, Mi Young Kim, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim,

Sixteen of 45 patients with severe fever with thrombocytopenia (36%) were admitted to an intensive care unit; 9 (56%) developed invasive pulmonary aspergillosis (IPA) within a median of 8 days (range, 2-11). Mortality was higher in the IPA vs non-IPA patients and in those without vs with antifungal therapy. ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 70(7):1491-1494]

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Invasive Pulmonary Aspergillosis in Adults With Avian Influenza A (H7N9) Pneumonia in China: A Retrospective Study.

Pengfei Zou, Chen Wang, Shufa Zheng, Feifei Guo, Li Yang, Yan Zhang, Peng Liu, Yinzhong Shen, Yiming Wang, Xuan Zhang, Lingling Tang, Hainv Gao, Lanjuan Li,

Cases of severe influenza with Aspergillus infection are commonly reported in patients with severe influenza. However, the epidemiology, risk factors, and outcomes of invasive pulmonary aspergillosis (IPA) in patients with avian influenza A (H7N9) infection remain unclear. We performed a retrospective multicenter cohort study. Data were collected from patients with ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2020, 221(Supplement_2):S193-S197]

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Successful treatment of allergic bronchopulmonary aspergillosis with posaconazole in a child with cystic fibrosis: Case report and review of the literature.

Nurhayat Yakut, Eda Kepenekli Kadayifci, Ela Erdem Eralp, Yasemin Gokdemir,

Allergic bronchopulmonary aspergillosis (ABPA) is recognized as a rare, progressive, allergic disorder in patients with cystic fibrosis (CF) and asthma. Treatment of ABPA mainly includes systemic corticosteroids (CSs) and antifungal agents. Here, we report posaconazole treatment in a 9-year-old male child with ABPA and also review the literature on antifungal ... Read more >>

Lung India (Lung India : official organ of Indian Chest Society)
[2020, 37(2):161-163]

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Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with the Risk of Developing Invasive Aspergillosis.

C B Lupiañez, M Martínez-Bueno, J M Sánchez-Maldonado, J Badiola, C Cunha, J Springer, M Lackner, J Segura-Catena, L M Canet, L Alcazar-Fuoli, M A López-Nevot, L Fianchi, J M Aguado, L Pagano, E López-Fernández, M Alarcón-Riquelme, L Potenza, S M Gonçalves, M Luppi, L Moratalla, C Solano, A Sampedro, P González-Sierra, M Cuenca-Estrella, K Lagrou, J A Maertens, C Lass-Flörl, H Einsele, L Vazquez, , J Loeffler, R Ríos-Tamayo, A Carvalho, M Jurado, J Sainz,

Invasive aspergillosis (IA) is a life-threatening infection that affects an increasing number of patients undergoing chemotherapy or allo-transplantation, and recent studies have shown that genetic factors contribute to disease susceptibility. In this two-stage, population-based, case-control study, we evaluated whether 7 potentially functional single nucleotide polymorphisms (SNPs) within the ARNT2 and ... Read more >>

Infect. Immun. (Infection and immunity)
[2020, 88(4):]

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Prospective evaluation of the turbidimetric β-D-glucan assay and two lateral flow assays on serum in invasive aspergillosis.

Toine Mercier, Ellen Guldentops, Katrien Lagrou, Johan Maertens,

BACKGROUND:Invasive aspergillosis (IA) remains a potentially lethal disease and requires timely diagnosis and initiation of antifungal therapy. Recently, the IMMY lateral flow assay (LFA), the OLM Diagnostics lateral flow device (LFD) and the Wako turbidimetric beta-D-glucan assay have been approved for use as a diagnostic aid. However, their performance in ... Read more >>

Clin. Infect. Dis. (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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