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Aseptic Meningitis

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The cerebrospinal fluid changes and clinical characteristics of aseptic meningitis in Kawasaki disease

Kaiyu Zhou, Fan Hu, Xiaoqing Shi, Yang Fan, Hanmin Liu,

<title>Abstract</title> <p> Background: Aseptic meningitis is not a common feature in Kawasaki disease (KD). However, it could cause difficulty in making correct and in-time diagnosis Methods: We retrospectively investigated patients of KD and bacterial meningitis (BM). Totally 38 KD patients and 126 BM patients were brought into this ... Read more >>

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A case of CLCN2-related leukoencephalopathy with bright tree appearance during aseptic meningitis.

Ayami Ozaki, Masayuki Sasaki, Takuya Hiraide, Noriko Sumitomo, Eri Takeshita, Yuko Shimizu-Motohashi, Akihiko Ishiyama, Takashi Saito, Hirofumi Komaki, Eiji Nakagawa, Noriko Sato, Mitsuko Nakashima, Hirotomo Saitsu,

CLCN2-related leukoencephalopathy (CC2L) is a rare autosomal recessive disorder caused by variants in CLCN2. We report a boy whose brain MRI during an episode of aseptic meningitis at the age of 6 years revealed wide areas of restriction on diffusion-weighted images (DWI) in the cerebral subcortical white matter called bright tree ... Read more >>

Brain Dev. (Brain & development)
[2020, :]

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MOG antibody associated demyelinating syndrome presenting as aseptic meningitis in a 6-year-old boy.

Johanna Leinert, Eva Neumaier-Probst, Georg Kutschke, Tobias Tenenbaum,

We describe the case of a 6-year-old boy who developed myelin oligodendrocyte glycoprotein antibody (MOG-Ab) associated demyelinating syndrome, after initially presenting with aseptic meningitis. Magnetic resonance imaging showed cerebral and spinal lesions consistent with acute disseminating encephalomyelitis. Rapid clinical improvement occurred after intravenous high dose methylprednisolone. A small number of ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 41:102050]

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A Rare Case of Mollaret's Meningitis Complicated by Chronic Intractable Migraine and Papilledema: Case Report and Review of Literature.

Kinjal P Gadhiya, Vinod Nookala,

Mollaret's meningitis is characterized by recurrent episodes of aseptic meningitis that last two to seven days and resolve spontaneously without any residual neurological deficit or complication. Viruses are the most common cause of aseptic meningitis and herpes simplex virus (HSV) type 2 has been noted as the most commonly associated virus ... Read more >>

Cureus (Cureus)
[2020, 12(2):e7026]

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Aseptic meningitis as an atypical manifestation of neuromyelitis optica spectrum disorder flare.

Bingxin Shi, Wei Jiang, Mianwang He, Hui Sun, Xuan Sun, Yang Yang, Jiarui Yao, Lei Wu, Dehui Huang,

BACKGROUND:Inflammatory demyelinating disease of the central nervous system characterized by aseptic meningitis is rare and can be easily confused with intracranial infection. Here, we investigated the clinical features of neuromyelitis optica spectrum disorder (NMOSD) patients with a meningitis-like presentation. METHODS:From a total of six attacks, five patients were identified. Their ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 41:102013]

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Chemical meningitis in children as a risk factor following craniopharyngioma resection - a case report.

Magdalena Chrościńska-Krawczyk, Ewa Zienkiewicz, Arkadiusz Podkowiński, Maria Klatka,

BACKGROUND:Craniopharyngiomas are defined by the WHO as "benign" tumours, but their location and surgical treatment may be associated with major complications, one being chemical meningitis. Although rare, especially in children, it should be taken into account when worrying symptoms appear after surgery. CASE PRESENTATION:The aim of this study is to ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):56]

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Accuracy of cerebrospinal fluid ferritin for purulent meningitis.

Pedro Celiny Ramos Garcia, Andrea Lucia Machado Barcelos, Cristian Tedesco Tonial, Humberto Holmer Fiori, Paulo Roberto Einloft, Caroline Abud Drumond Costa, Janete L Portela, Francisco Bruno, Ricardo Garcia Branco,

OBJECTIVE:To evaluate the use of cerebrospinal fluid (CSF) ferritin levels in the diagnosis of purulent meningitis (PM). METHOD:We studied 81 children between 28 days and 12 years of age who presented with clinical suspicion of meningitis to the emergency department. CSF ferritin levels were measured and compared between diagnostic groups ... Read more >>

Arch. Dis. Child. (Archives of disease in childhood)
[2020, :]

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Tricuspid valve infective endocarditis associated with aseptic meningitis: a rare presentation in a child.

Gülsüm Alkan, Melike Emiroğlu, Ahmet Sert, Ayşe Kartal, Mehmet Öc,

Infective endocarditis (IE) is a rare but a potentially life-threatening infectious disease. Atypical presentations cause delays in the diagnosis. Neurological involvement such as meningitis or meningismus, are especially common in mitral valve endocarditis, but unusual in tricuspid valve endocarditis. Although few cases of right-sided IE have been reported with neurological ... Read more >>

Arch Argent Pediatr (Archivos argentinos de pediatria)
[2020, 118(1):e22-e25]

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Cerebrospinal fluid cytokines and chemokines in children with Lyme neuroborreliosis; pattern and diagnostic utility.

Bjørn Barstad, Anna J Henningsson, Dag Tveitnes, Anastasia Ushakova, Sølvi Noraas, Ingvild S Ask, Franziskus J Bosse, Knut Øymar,

BACKGROUND:Lyme neuroborreliosis (LNB) is characterized by cerebrospinal fluid (CSF) inflammation with several cytokines/chemokines and B-lymphocytes. Clinically, LNB in children may be difficult to discriminate from non-Lyme aseptic meningitis (NLAM). We aimed to identify CSF cytokine/chemokine patterns in children with LNB, NLAM and controls and elucidate the diagnostic value of these ... Read more >>

Cytokine (Cytokine)
[2020, 130:155023]

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Acupuncture in the Management of Medication Overuse and Drug-Induced Aseptic Meningitis Headache.

Renuka T Rudra, Vitaly Gordin, Lihua Xu,

Headache disorders are burdensome, both in terms of the number of people they affect, and in terms of associated healthcare spending. This report presents a 36-year-old female admitted to a tertiary university hospital with a primary complaint of intractable headache, caused by a combination of Medication Overuse Headache (MOH), and ... Read more >>

J Acupunct Meridian Stud (Journal of acupuncture and meridian studies)
[2020, :]

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Drug-induced aseptic meningitis to ibuprofen: The first case confirmed by positive patch test.

Leonardo Bianchi, Rossella Marietti, Katharina Hansel, Marta Tramontana, Cataldo Patruno, Maddalena Napolitano, Luca Stingeni,

Contact Derm. (Contact dermatitis)
[2020, :]

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[Relationship between Echovirus Epidemics and Incidence of Aseptic Meningitis following Mumps Vaccination Based on Previous Japanese Reports: Possibility of Misclassification of Echovirus Infection in Previous Reports].

Hideaki Kumihashi, Munehide Kano, Hiroyasu Iso,

OBJECTIVES:In Japan, the vaccination for mumps has been on a voluntary basis since 1993 because of safety concerns arising from the high incidence of aseptic meningitis associated with Japanese mumps vaccine strains. However, recent reports on the voluntary mumps vaccination have described the decreased incidence of postvaccination aseptic meningitis for ... Read more >>

Nihon Eiseigaku Zasshi (Nihon eiseigaku zasshi. Japanese journal of hygiene)
[2020, 75(0):]

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Drug-Induced Aseptic Meningitis Following Spinal Anesthesia.

Ricardo Paquete Oliveira, Mafalda Teixeira, Sofia Cochito, Ana Furtado, Bruno Grima, José Delgado Alves,

Meningitis is a very uncommon complication of spinal anesthesia, and drug-induced aseptic meningitis (DIAM) is even rarer. We present two cases of DIAM following spinal anesthesia with bupivacaine and ropivacaine, respectively. The patients presented shortly after the procedure with typical meningitis symptoms. Since CSF (cerebrospinal fluid) analysis could not initially ... Read more >>

Eur J Case Rep Intern Med (European journal of case reports in internal medicine)
[2020, 7(1):001334]

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Recent advances in the diagnosis of leptospirosis.

Vivek Verma, Mehendi Goyal, Deepak Kala, Shagun Gupta, Dinesh Kumar, Ankur Kaushal,

Leptospirosis can be found in virtually all tropical and temperate areas of the world and is presumed to be the widely spread zoonotic infection in the world. Because of the variety of clinical symptoms seen in the symptomatic cases, leptospirosis at its onset is often misdiagnosed as aseptic meningitis, influenza, ... Read more >>

Front Biosci (Landmark Ed) (Frontiers in bioscience (Landmark edition))
[2020, 25:1655-1681]

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Incidence and characteristics of neurotoxicity in immune checkpoint inhibitors with focus on neuromuscular events: Experience beyond the clinical trials.

Jordi Bruna, Andreas A Argyriou, Garifallia G Anastopoulou, Montse Alemany, Ernest Nadal, Foteini Kalofonou, Josep M Piulats, Marta Simó, Roser Velasco, Haralabos P Kalofonos,

Immune checkpoint inhibitors (ICIs) are associated with various neurological adverse events (NAEs). We herein explored the incidence and clinical phenotype of immune-related NAEs in cancer patients. Medical records of ICI-treated cancer patients were reviewed between the years 2010 and 2018, with an aim to characterize immuno-related NAEs. A total of ... Read more >>

J. Peripher. Nerv. Syst. (Journal of the peripheral nervous system : JPNS)
[2020, :]

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Multifocal Gorham-Stout disease associated with Chiari I malformation and recurrent aseptic meningitis: Case report and review of literature.

Sean Stephens, Lisa Squires, Robert Campbell, Janene Davies, Raymond Chaseling,

Gorham-Stout disease is a rare condition of uncertain aetiology characterised by lymphatic proliferation within osseous structures and subsequent massive osteolysis. This report describes the index case of a patient with multifocal Gorham-Stout disease involving the skull base with Chiari I malformation and recurrent aseptic meningitis without fistula. A five-year-old male ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, 72:486-492]

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Neurological manifestations of autoinflammatory diseases in Chinese adult patients.

Wenyi Qin, Di Wu, Yi Luo, Mengzhu Zhao, Yi Wang, Xiaochun Shi, Lixin Zhou, Weihong Yu, Yang Sun, Rongrong Wang, Wen Zhang, Mengqi Liu, Min Shen,

OBJECTIVE:Systemic autoinflammatory diseases (SAIDs) are a group of disorders characterized by a dysregulation of innate immune system leading to multi-systemic inflammation. We aim to assess the neurological manifestations of Chinese adult patients with SAIDs. METHODS:Eighty adult patients (≥16 years) were diagnosed as SAIDs from April 2015 to June 2019, at ... Read more >>

Semin. Arthritis Rheum. (Seminars in arthritis and rheumatism)
[2020, :]

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Trimethoprim-Sulfamethoxazole-Induced Aseptic Meningitis: A Rare Presentation of Commonly Used Antibiotic.

Salem Agabawi,

Drug-induced aseptic meningitis is a rare medical condition with trimethoprim-sulfamethoxazole being one of the most common antimicrobial agents associated with it. Here, I report a case of a 56-year-old male who presented to a health care facility with shock and meningitis-like syndrome in two occasions, one year apart following an ... Read more >>

Case Rep Infect Dis (Case reports in infectious diseases)
[2019, 2019:4289502]

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Case Report of Kikuchi-Fujimoto Disease from Sub-Saharan Africa: An Important Mimic of Tuberculous Lymphadenitis.

Karishma Sharma, Fredrick Otieno, Reena Shah,

Kikuchi-Fujimoto disease (KFD) is a rare form of painful lymphadenopathy, usually cervical, which is more common in Southeast Asia and rarely reported from Africa. Symptoms are usually nonspecific (fever, night sweats, etc.), and can mimic more common diseases such as tuberculosis (TB) in endemic areas. We report a case of ... Read more >>

Case Rep Med (Case Reports in Medicine)
[2020, 2020:4385286]

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Acute HIV Infection Masquerading as Idiopathic Intracranial Hypertension: A Case Report and Literature Review.

Awyshah M Alqahtani, Zaid F Alsaaran, Naif H AlOtaibi, Mazin Barry, Khaldoon AlJerian, Mohammed H Alanazy, Taim A Muayqil,

We describe a previously healthy 21-year-old man who presented acutely with signs and symptoms of raised intracranial pressure (ICP). Lumbar puncture yielded an elevated opening pressure and an acellular CSF analysis. Radiological images showed bilateral flattening of the posterior eye globes and an empty sella turcica. His serum HIV antigen/antibody ... Read more >>

Case Rep Neurol (Case reports in neurology)
[2020, 12(1):56-62]

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Immunological biomarkers in neuropsychiatric systemic lupus erythematosus: a comparative cross-sectional study from a tertiary care center in South India.

G Seth, A Sundaresh, C M Mariaselvam, G Kumar, K G Chengappa, M B Adarsh, R Tamouza, V S Negi,

INTRODUCTION:The prevalence of various immunological biomarkers in neuropsychiatric systemic lupus erythematosus (NPSLE) differs among various patients with varied neuropsychiatric manifestations and different populations. We studied the prevalence of these biomarkers; especially the neuron specific autoantibodies in patients with systemic lupus erythematosus (SLE) and compared them among patients with and without ... Read more >>

Lupus (Lupus)
[2020, :961203320908940]

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Transclival Approach for Resection of a Pontine Cavernous Malformation: 2-Dimensional Operative Video.

Dennis London, Seth Lieberman, Omar Tanweer, Donato Pacione,

Cerebral cavernous malformations are common vascular anomalies consisting of a cluster of capillaries without intervening brain tissue.1 A variety of approaches for resection have been undertaken,2 and a handful of case reports have described the endoscopic, endonasal, transclival approach.3 We present a case of a 51-yr-old woman with lupus and ... Read more >>

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2020, :]

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Spontaneous trans-anal extrusion of caudally migrated ventriculo-peritoneal shunt tip in a child: a case report.

Sabyasachi Bakshi,

BACKGROUND:Bowel perforation caused by the ventriculo-peritoneal shunt is a rare occurrence with an estimated incidence rate of 0.1% to 1.0% among all cases of VP shunt displacement. This is an unusual report of spontaneous trans-anal extrusion of caudally migrated ventriculo-peritoneal shunt tip in a child. Literature was reviewed to find ... Read more >>

Surg Case Rep (Surgical case reports)
[2020, 6(1):50]

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Genetic characterization of a novel recombinant echovirus 30 strain causing a regional epidemic of aseptic meningitis in Hokkaido, Japan, 2017.

Masahiro Miyoshi, Akiko Goto, Rika Komagome, Hiroki Yamaguchi, Yuji Maruo, Masanori Nakanishi, Setsuko Ishida, Hideki Nagano, Takahisa Sugisawa, Motohiko Okano,

A regional epidemic of aseptic meningitis caused by echovirus 30 (E30) occurred in Hokkaido, Japan, during the period of August-December 2017. To investigate their phylogenetic relationship to other human enteroviruses, we determined the complete genomic nucleotide sequences of isolates from this outbreak. Phylogenetic analysis of the viral capsid protein 1 ... Read more >>

Arch. Virol. (Archives of virology)
[2020, 165(2):433-438]

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Meningitis gone viral: description of the echovirus wave 2013 in Germany.

Jonas Graf, Christian J Hartmann, Helmar C Lehmann, Carolin Otto, Ortwin Adams, Michael Karenfort, Christian Schneider, Klemens Ruprecht, Hans Martin Bosse, Sabine Diedrich, Sindy Böttcher, Alfons Schnitzler, Hans-Peter Hartung, Orhan Aktas, Philipp Albrecht,

BACKGROUND:Aseptic meningitis epidemics may pose various health care challenges. METHODS:We describe the German enterovirus meningitis epidemics in the university hospital centers of Düsseldorf, Cologne and Berlin between January 1st and December 31st, 2013 in order to scrutinize clinical differences from other aseptic meningitis cases. RESULTS:A total of 72 enterovirus (EV-positive) ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2019, 19(1):1010]

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