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Underreporting of mesothelioma, asbestosis and pleural plaques in Brazil.

V S Santana, L Salvi, F Cavalcante, F Campos, E Algranti,

<h4>Background</h4>Brazil has a long history of heavy asbestos consumption. However, the number of asbestos-related diseases (ARDs) falls far below the one expected compared with other asbestos consumer countries.<h4>Aims</h4>To examine underreporting of ARDs, that is mesothelioma, asbestosis and pleural plaques, in Brazil's Mortality Information System (SIM).<h4>Methods</h4>Health information systems (HIS) were mapped, ... Read more >>

Occup Med (Lond) (Occupational medicine (Oxford, England))
[2021, :]

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Increased Risk of Gastric Cancer in Asbestos-Exposed Workers: A Retrospective Cohort Study Based on Taiwan Cancer Registry 1980-2015.

Yi-Jen Fang, Hung-Yi Chuang, Chih-Hong Pan, Yu-Yin Chang, Yawen Cheng, Lukas Jyuhn-Hsiarn Lee, Jung-Der Wang,

Asbestos has been recognized as a human carcinogen associated with malignant mesothelioma, cancers of lung, larynx, and ovary. However, a putative association between gastric cancer and asbestos exposure remains controversial. In this study, we aimed to explore gastric cancer risk of workers potentially exposed to asbestos in Taiwan. The asbestos ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(14):]

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Interstitial Lung Abnormalities Detected by CT in Asbestos-Exposed Subjects Are More Likely Associated to Age.

François Laurent, Ilyes Benlala, Gael Dournes, Celine Gramond, Isabelle Thaon, Bénédicte Clin, Patrick Brochard, Antoine Gislard, Pascal Andujar, Soizick Chammings, Justine Gallet, Aude Lacourt, Fleur Delva, Christophe Paris, Gilbert Ferretti, Jean-Claude Pairon,

<h4>Objective</h4>the aim of this study was to evaluate the association between interstitial lung abnormalities, asbestos exposure and age in a population of retired workers previously occupationally exposed to asbestos.<h4>Methods</h4>previously occupationally exposed former workers to asbestos eligible for a survey conducted between 2003 and 2005 in four regions of France, underwent ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(14):]

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Int.-J.-Environ.-Res.-Public-Health-2021,-18,-2053".">Reply to Mirabelli et al. Is Mesothelioma Unrelated to the Lung Asbestos Burden? Comment on "Visonà et al. Inorganic Fiber Lung Burden in Subjects with Occupational and/or Anthropogenic Environmental Asbestos Exposure in Broni (Pavia, Northern Italy): An SEM-EDS Study on Autoptic Samples. Int. J. Environ. Res. Public Health 2021, 18, 2053".

Silvia Damiana Visonà, Silvana Capella, Sofia Bodini, Paola Borrelli, Simona Villani, Eleonora Crespi, Andrea Frontini, Claudio Colosio, Ruggero Vigliaturo, Elena Belluso,

We appreciate very much the interest of Mirabelli et al. [...]. ... Int.-J.-Environ.-Res.-Public-Health-2021,-18,-2053".">Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(13):]

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Int.-J.-Environ.-Res.-Public-Health-2021,-18,-2053".">View full text PDF listing >>



Risk of asbestosis, mesothelioma, other lung disease or death among motor vehicle mechanics: a 45-year Danish cohort study.

Reimar Wernich Thomsen, Anders Hammerich Riis, Esben Meulengracht Flachs, David H Garabrant, Jens Peter Ellekilde Bonde, Henrik Toft Sørensen,

<h4>Introduction</h4>The risk of asbestosis, malignant mesothelioma and lung cancer among motor vehicle mechanics is of concern because of potential exposure to chrysotile asbestos during brake, clutch and gasket repair and maintenance. Asbestos has also been used in insulation and exhaust systems.<h4>Methods</h4>We examined the long-term risk of incident mesothelioma, lung cancer, ... Read more >>

Thorax (Thorax)
[2021, :]

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Is Mesothelioma Unrelated to the Lung Asbestos Burden? Comment on Visonà et al. Inorganic Fiber Lung Burden in Subjects with Occupational and/or Anthropogenic Environmental Asbestos Exposure in Broni (Pavia, Northern Italy): An SEM-EDS Study on Autoptic Samples. Int. J. Environ. Res. Public Health 2021, 18, 2053.

Dario Mirabelli, Alessia Angelini, Pietro Gino Barbieri, Roberto Calisti, Fabio Capacci, Paolo Girardi, Stefano Silvestri, Anna Benedetta Somigliana,

We read with interest the report by Visonà and coworkers on the lung asbestos fiber burden in an autopsy series of decedents from mesothelioma (MM: 59 cases) and individuals who "suffered from asbestosis and died of its complications" (13 cases) [...]. ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(13):]

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Effect of Asbestos Consumption on Malignant Pleural Mesothelioma in Italy: Forecasts of Mortality up to 2040.

Enrico Oddone, Jordy Bollon, Consuelo Rubina Nava, Dario Consonni, Alessandro Marinaccio, Corrado Magnani, Antonio Gasparrini, Francesco Barone-Adesi,

Statistical models used to forecast malignant pleural mesothelioma (MPM) trends often do not take into account historical asbestos consumption, possibly resulting in less accurate predictions of the future MPM death toll. We used the distributed lag non-linear model (DLNM) approach to predict future MPM cases in Italy until 2040, based ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(13):]

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Asbestos Exposure Level and the Carcinogenic Risk Due to Corrugated Asbestos-Cement Slate Roofs in Korea.

Eun-Soo Lee, Young-Ki Kim,

Asbestos-cement slate roofs are one of the most common environmental causes of asbestos exposure. However, few studies have examined residential asbestos-cement slate-related exposure and its effects on human health. This study was performed to evaluate cumulative asbestos exposure levels and to calculate the Excess Lifetime Cancer Risk (ELCR) of residents ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(13):]

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A Case of Pulmonary Embolism with Sarcomatoid Malignant Pleural Mesothelioma with Long-Term Pleural Effusion.

Rumeng Gu, Luxi Jiang, Ting Duan, Chun Chen, Shengchang Wu, Deguang Mu,

<h4>Background</h4>Malignant pleural mesothelioma (MPM) is a highly aggressive tumor that originates from pleural mesothelial cells. In recent years, with the development of asbestos-related industries and the increase in air pollution, its incidence has been increased. The incidence of pulmonary embolism combined with sarcomatoid MPM is very low and the prognosis ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2021, 14:4231-4237]

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Performance of Asbestos Enclosure Ventilation: Laboratory Evaluation of Complex Configuration.

Ilpo Kulmala, Markku Linnainmaa, Anna Kokkonen, Kimmo Heinonen, Tomi Kanerva, Arto Säämänen,

The aim of the study was to find out good practices for effective air distribution inside a complex shaped asbestos enclosure and for control of pressure differences between the enclosure and the surroundings. In addition, sufficient pressure difference for asbestos containment was tested. The effect of air distribution was studied ... Read more >>

Ann Work Expo Health (Annals of work exposures and health)
[2021, :]

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Occupational exposure to asbestos and risk of kidney cancer: an updated meta-analysis.

Carlotta Zunarelli, Alessandro Godono, Giovanni Visci, Francesco S Violante, Paolo Boffetta,

Limited information is available on carcinogenicity of asbestos on non-respiratory organs. We aimed at conducted an updated systematic review and meta-analysis of cohort studies on occupational exposure to asbestos and risk of kidney cancer. We searched through three databases, PubMed, Embase and Scopus for article published after 2000, and after ... Read more >>

Eur J Epidemiol (European journal of epidemiology)
[2021, :]

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Future Incidence of Malignant Mesothelioma in South Korea: Updated Projection to 2038.

Kyeongmin Kwak, Sung-Il Cho, Domyung Paek,

Malignant mesothelioma (MM) is a cancer that is largely caused by exposure to asbestos. Although asbestos is no longer used in South Korea, the incidence of MM continues to increase due to its long latent period. We aimed to update the previous prediction of MM incidence until 2038. We predicted ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(12):]

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Malignant Mesothelioma.

Daniel L Pouliquen, Joanna Kopecka,

Malignant mesothelioma (MM) is a rare and aggressive cancer, related to chronic inflammation and oxidative stress caused mainly by exposure to asbestos [...]. ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(14):]

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Significance of secretory leukocyte peptidase inhibitor in pleural fluid for the diagnosis of benign asbestos pleural effusion.

Takumi Kishimoto, Yoko Kojima, Nobukazu Fujimoto,

Secretory leukocyte peptidase inhibitor (SLPI) is a biomarker present in the respiratory tract that protects against tissue destruction and aids in wound healing. We examined whether SLPI in pleural effusion can be used to distinguish benign asbestos pleural effusion (BAPE) from early-stage malignant pleural mesothelioma (MPM) and other diseases. We ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):12965]

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Integrating data from multidisciplinary Management of Malignant Pleural Mesothelioma: a cohort study.

Laura Saracino, Chandra Bortolotto, Stefano Tomaselli, Elia Fraolini, Matteo Bosio, Giulia Accordino, Francesco Agustoni, David M Abbott, Emma Pozzi, Dimitrios Eleftheriou, Patrizia Morbini, Pietro Rinaldi, Cristiano Primiceri, Andrea Lancia, Patrizia Comoli, Andrea R Filippi, Giulia M Stella,

<h4>Background</h4>Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy that most commonly affects the pleural layers. MPM has a strong association with asbestos, mainly caused by exposure to its biopersistent fibers in at least 80% of cases. Individuals with a chronic exposure to asbestos might develop disease with a ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):762]

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Fiber burden and asbestos-related diseases: an umbrella review.

José María Ramada Rodilla, Beatriz Calvo Cerrada, Consol Serra Pujadas, George L Delclos, Fernando G Benavides,

<h4>Objective</h4>What are the levels of asbestos exposure that cause each type of health effect? The objective of this study was to review the available scientific evidence on exposure levels for asbestos and their relationship to health effects.<h4>Method</h4>An umbrella review of English-language reviews and meta-analyses, from 1980 to March 2021 was ... Read more >>

Gac Sanit (Gaceta sanitaria)
[2021, :]

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The minimum standard of care for managing malignant pleural mesothelioma in developing nations within the Asia-Pacific Region.

Helen Ke, Steven Kao, Kenneth Lee, Ken Takahashi, Hui Poh Goh, Anthony Linton,

Malignant pleural mesothelioma (MPM) is an incurable malignancy associated with high symptom burden and poor prognosis. The relationship between asbestos exposure and MPM incidence is well-established. The incidence rate of MPM in Australia and New Zealand is among the highest globally. Matching the experience of other nations with legal restrictions ... Read more >>

Asia Pac J Clin Oncol (Asia-Pacific journal of clinical oncology)
[2021, :]

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Asbestos Diseases Research Institute - A New WHO Collaborating Center.

Ken Takahashi,

Ind Health (Industrial health)
[2021, :]

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Association of Mesothelioma Deaths With Cumulated Neighborhood Exposures Due to a Large-Scale Asbestos Cement Plant in Amagasaki City, Japan: A Nested Case-control Study

Yuri Kitamura, Ling Zha, Rong Liu, Masayuki Shima, Tomoki Nakaya, Norio Kurumatani, Shinji Kumagai, Junko Goji, Tomotaka Sobue,

<h4>Background: </h4> Although a causal relationship between mesothelioma and asbestos exposure is well known, few studies have shown a relationship to non-occupational exposure, including neighborhood exposure, most likely because of the large effect size of occupational exposure. The aim of this study was to quantify the risk of malignant mesothelioma ... Read more >>

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Asbestos exposure and tuberculous pleurisy as developmental causes of progressive unilateral upper-lung field pulmonary fibrosis radiologically consistent with pleuroparenchymal fibroelastosis.

Akimasa Sekine, Eri Hagiwara, Tae Iwasawa, Ryota Otoshi, Tabata Erina, Ryota Shintani, Hiroko Okabayashi, Satoshi Ikeda, Tsuneyuki Oda, Ryo Okuda, Hideya Kitamura, Tomohisa Baba, Shigeru Komatsu, Takashi Ogura,

<h4>Background</h4>Unilateral upper-lung field pulmonary fibrosis (upper-PF), which is radiologically consistent with pleuroparenchymal fibroelastosis, develops after thoracic surgery. In most patients with unilateral upper-PF, aberrant intra-/extra thoracic air commonly emerges and an autopsy shows chronic pleuritis, which indicates that pleural involvement is associated with upper-PF development. If so, there may be ... Read more >>

Respir Investig (Respiratory investigation)
[2021, :]

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Biological basis for novel mesothelioma therapies.

Joanna Obacz, Henry Yung, Marie Shamseddin, Emily Linnane, Xiewen Liu, Arsalan A Azad, Doris M Rassl, David Fairen-Jimenez, Robert C Rintoul, Marko Z Nikolić, Stefan J Marciniak,

Mesothelioma is an aggressive cancer that is associated with exposure to asbestos. Although asbestos is banned in several countries, including the UK, an epidemic of mesothelioma is predicted to affect middle-income countries during this century owing to their heavy consumption of asbestos. The prognosis for patients with mesothelioma is poor, ... Read more >>

Br J Cancer (British journal of cancer)
[2021, :]

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"The Natural Reduction of Threat in Selected Systems of Old Buildings Containing Asbestos"

Andrzej Obmiński,

The aim of the research was measure changes asbestos dust concentration over long period of use in old building systems. Buildings from different systems during their exploitation and after asbestos removal were tested. Asbestos dust concentration decreasing in some building systems is due to air exchange and other phenomena, if ... Read more >>

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How to Better Understand the Influence of Host Genetics on Developing an Effective Immune Response to Thoracic Cancers.

Kiarash Behrouzfar, Kimberley Burton, Steve E Mutsaers, Grant Morahan, Richard A Lake, Scott A Fisher,

Thoracic cancers pose a significant global health burden. Immune checkpoint blockade therapies have improved treatment outcomes, but durable responses remain limited. Understanding how the host immune system interacts with a developing tumor is essential for the rational development of improved treatments for thoracic malignancies. Recent technical advances have improved our ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:679609]

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Molecular Fingerprints of Malignant Pleural Mesothelioma: Not Just a Matter of Genetic Alterations.

Eugenia Lorenzini, Alessia Ciarrocchi, Federica Torricelli,

Malignant pleural mesothelioma (MPM) is a clinical emergency of our time. Being strongly associated with asbestos exposure, incidence of this cancer is ramping up these days in many industrialized countries and it will soon start to increase in many developing areas where the use of this silicate derivate is still ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(11):]

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NOX4 regulates macrophage apoptosis resistance to induce fibrotic progression.

Jennifer L Larson-Casey, Linlin Gu, Jungsoon Kang, Ashish Dhyani, A Brent Carter,

Pulmonary fibrosis is a progressive lung disease often occurring secondary to environmental exposure. Asbestos exposure is an important environmental mediator of lung fibrosis and remains a significant cause of disease despite strict regulations to limit exposure. Lung macrophages play an integral role in the pathogenesis of fibrosis induced by asbestos ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2021, 297(1):100810]

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