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68Ga-FAPI PET/CT Versus 18F-FDG PET/CT for the Evaluation of Disease Activity in Takayasu Arteritis.

Simin Wu, Yizhen Pang, Liang Zhao, Long Zhao, Haojun Chen,

<h4>Abstract</h4>Evaluation of disease activity in Takayasu arteritis (TA) is challenging because clinical, biological, and imaging data do not always correlate. In this case, a 19-year-old woman with TA underwent 18F-FDG PET/CT for evaluating disease activity. However, no abnormal 18F-FDG uptake was observed in the large arteries. Follow-up with 68Ga-FAPI PET/CT ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(10):847-849]

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First case of childhood Takayasu arteritis from Syria: a case report.

Wafa Alwattar, Rawan Al Khudari, Judy Naameh, Jia Batha, Raghad Almajzoub, Basheer Khalil,

<h4>Background</h4>Takayasu arteritis is a systemic granulomatous inflammation affecting the large- and medium-sized vessels such as aorta, its main branches, and pulmonary and renal arteries. Childhood Takayasu arteritis is a subtype of Takayasu arteritis that affects the age group ranging from young infants to late adolescents.<h4>Case presentation</h4>We report the first childhood ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2021, 15(1):469]

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Application of Deep Learning Image Reconstruction (DLIR) Algorithm to Improve Image Quality in CT Angiography of Children with Takayasu Arteritis

Jihang Sun, Haoyan Li, Jianying Li, Haiyun Li, Michelle Li, Zuofu Zhou, Yun Peng,

purpose: To evaluate the image quality improvement in CTA of children with Takayasu arteritis (TAK) using a Deep learning image reconstruction (DLIR) in comparison to other reconstruction algorithms. <h4>Methods: </h4>: 32 patients (9.14±4.51 years old) with TAK underwent neck, chest and abdominal CTA with 100kVp were enrolled. Images were reconstructed ... Read more >>

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HLA-B52 allele in giant cell arteritis may indicate diffuse large-vessel vasculitis formation: a retrospective study.

Kazuo Kushimoto, Masahiro Ayano, Keisuke Nishimura, Miki Nakano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro,

<h4>Background</h4>This study aimed to identify new characteristics of elderly onset large-vessel vasculitis (EOLVV) by focusing on human leucocyte antigen (HLA) genotype, polymyalgia rheumatica (PMR), and affected vascular lesions observed on positron emission tomography/computed tomography (PET/CT) imaging.<h4>Methods</h4>We retrospectively studied 65 consecutive Japanese patients with large-vessel vasculitis (LVV) who had extracranial vasculitis ... Read more >>

Arthritis Res Ther (Arthritis research & therapy)
[2021, 23(1):238]

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Vascular imaging of patients with refractory Takayasu arteritis treated with tocilizumab: post hoc analysis of a randomized controlled trial.

Yoshikazu Nakaoka, Masahiro Yanagawa, Akinori Hata, Katsuhisa Yamashita, Norihiro Okada, Shinji Yamakido, Hiromitsu Hayashi, David Jayne,

<h4>Objectives</h4>Tocilizumab, an anti-interleukin-6 receptor antibody, was investigated in patients with refractory Takayasu arteritis (TAK) in a phase 3 randomized controlled trial. In this post hoc analysis, we investigated whether tocilizumab treatment inhibited the progression of vascular lesions caused by TAK in these patients.<h4>Methods</h4>Included patients received at least one dose of ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2021, :]

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Fecal S100A12 in Takayasu arteritis predicts disease activity and intestinal involvement.

Simsek Cem, Armagan Berkan, Sari Alper, Emet Abdulsamer, Kilic Levent, Akdogan Ali,

Gastrointestinal involvement in Takayasu Arteritis (TA) requires invasive or expensive diagnostic studies. Instead a fecal biomarker can be used as an initial screening test. In this context, S100A12 is promising as an established biomarker in intestinal inflammation and its role in TA pathogenesis. As such we aimed to test the ... Read more >>

Rheumatol Int (Rheumatology international)
[2021, :]

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Takayasu arteritis-associated pulmonary hypertension.

Yoshihiro Fukumoto,

Eur Heart J (European heart journal)
[2021, :]

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Neurosyphilis in a suspected case of giant cell arteritis.

Annalisa Montebello, Daniela Harmsworth, Paul John Cassar, Sandro Vella,

A 67-year-old man had a few month history of deteriorating visual acuity. He had originally presented to ophthalmology with right-sided visual blurring. This subsequently progressed to involve the left eye. At this point, he was empirically treated with high-dose glucocorticoids, both orally and intravenously, with the suspicion that giant cell ... Read more >>

BMJ Case Rep (BMJ case reports)
[2021, 14(9):]

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Giant cell arteritis during COVID-19 pandemic.

Luciano Simão, André Messias,

Arq Bras Oftalmol (Arquivos brasileiros de oftalmologia)
[2021, 84(5):515-516]

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Giant Cell (Temporal) Arteritis: The Rate and Clinical Predictors of Histopathological Diagnosis

Ozlem Eski Yucel, Semih Murat Yucel, Seda Gun, Inci Gungor,

<h4>Purpose: </h4> To determine the rate of histopathological diagnosis by temporal artery (TA) biopsy (TAB) and the predictive clinical features of TAB positivity in patients with giant cell arteritis (GCA). Methods The records of patients who underwent TAB with pre-diagnosis of GCA between January 2006 and May 2020 were ... Read more >>

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Glucocorticoid dosing and relapses in giant cell arteritis-a single center cohort study.

Laura Felten, Nicolai Leuchten, Martin Aringer,

<h4>Objective</h4>To investigate the relationship between real life glucocorticoid (GC) dosing and relapse rates in patients with new onset giant cell arteritis (GCA) in a single center.<h4>Methods</h4>Complete clinical data taken from the inpatient and outpatient records of consecutive GCA patients followed beyond stopping GC were retrospectively analyzed for GC doses, other ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2021, :]

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Rho Kinase Expression in Giant Cell Arteritis Validating pERM Intensity Score as a Method of Increasing Sensitivity of Temporal Artery Biopsy

Lindsay Lally, Navneet Narula, Nicola Goodfellow, Raashid Luqmani, David Pisapia, Robert Spiera,

<h4>Background: </h4> Aberrant rho-kinase (ROCK) activity is implicated in pathogenesis of several vascular and immunologic disorders. We previously demonstrated evidence of increased ROCK activity in histopathologically negative temporal artery biopsies (TAB) of subjects with clinical Giant Cell Arteritis (GCA) compared to those without GCA. This study aimed to examine ROCK ... Read more >>

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A Case of Post-COVID-19-Associated Paracentral Acute Middle Maculopathy and Giant Cell Arteritis-Like Vasculitis.

Go L Jonathan, Fair M Scott, Kay D Matthew,

<h4>Abstract</h4>A 47-year-old man with a history of COVID-19 infection 2 months before presentation, presented with a scotoma of the paracentral visual field of the right eye. After thorough testing and evaluation, a diagnosis of paracentral acute middle maculopathy (PAMM) was established. Two months later, the patient developed temporal headache and ... Read more >>

J Neuroophthalmol (Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society)
[2021, 41(3):351-355]

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Aortic Calcification in Takayasu Arteritis: Risk Factors and Relationship With Activity and Vascular Lesion. It Is Not Only an Aging Question.

Gabriela Meléndez-Ramírez, Maria Elena Soto, Aloha Meave, Luis Alberto Ruiz-Elizondo, Eric Kimura, Erick Alexanderson,

<h4>Introduction</h4>Aortic calcification is a frequent finding in Takayasu arteritis (TA). The aim of this study was to evaluate the risk factors for aortic calcification in TA and its relationship with disease activity and the presence and type of vascular lesion.<h4>Methods</h4>Nineteen patients with TA underwent nonenhanced computed tomography to measure the ... Read more >>

J Clin Rheumatol (Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases)
[2021, 27(6S):S265-S273]

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Highly cited papers in Takayasu arteritis on Web of Science and Scopus: cross-sectional analysis.

Durga Prasanna Misra, Vikas Agarwal, Armen Yuri Gasparyan, Olena Zimba, Aman Sharma,

<h4>Background</h4>Takayasu arteritis (TAK) is a large vessel vasculitis affecting relatively younger population. Since literature on bibliometric analysis of TAK is scarce, we analyzed top-cited articles in TAK to address this knowledge gap.<h4>Methods</h4>We analyzed the top hundred cited articles in TAK on Web of Science and Scopus for time of publication, ... Read more >>

Clin Rheumatol (Clinical rheumatology)
[2021, :]

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Therapeutic options for cutaneous polyarteritis nodosa: a systematic review.

Eleni Papachristodoulou, Loukas Kakoullis, Eleni Tiniakou, Konstantinos Parperis,

<h4>Objective</h4>Cutaneous polyarteritis nodosa (CPAN) is a necrotizing vasculitis of the middle-size vessels, confined to the skin. We conducted a systematic review in order to identify studies evaluating the different treatment modalities used in CPAN.<h4>Methods</h4>This systematic review was conducted according to PRISMA guidelines, registered in PROSPERO: CRD42020222195. PubMed/Medline databases were searched ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2021, 60(9):4039-4047]

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Epidemiology of major relapse in giant cell arteritis: A study-level meta-analysis.

Marie Aussedat, Hervé Lobbes, Maxime Samson, Romain Euvrard, Jean-Christophe Lega, Sabine Mainbourg,

<h4>Objective</h4>The relapse rate of giant cell arteritis (GCA) is around 48%. Major relapse of GCA is defined by the European League Against Rheumatism as severe ischemic or aortic (stenosis, aneurysm, or aortic dissection) disease of GCA. The objective of the present study was to determine the prevalence and incidence, as ... Read more >>

Autoimmun Rev (Autoimmunity reviews)
[2021, :102930]

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Giant cell arteritis diagnosis.

Diana Prieto-Peña, Miguel A González-Gay,

Med Clin (Barc) (Medicina clinica)
[2021, 157(6):285-287]

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The role of CD8+ Granzyme B+ T cells in the pathogenesis of Takayasu's arteritis.

Taotao Li, Na Gao, Wei Cui, Limin Zhao, Juan Du, Xuemei Shi, Junming Zhu, Zhiyu Qiao, Shichao Guo, Lili Pan,

<h4>Objective</h4>T cell-mediated immune response plays a key role in Takayasu arteritis (TAK). Although previous studies have showed the roles of CD4<sup>+</sup>T cell and its subsets in TAK, the change of CD8<sup>+</sup> T cell subsets remains unclear. This study investigated the role of CD8<sup>+</sup> T cell subsets in TAK.<h4>Methods</h4>The study consisted ... Read more >>

Clin Rheumatol (Clinical rheumatology)
[2021, :]

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The Cost-Effectiveness of Tocilizumab (Actemra) Therapy in Giant Cell Arteritis.

Arjun V Jogimahanti, Ashwini T Kini, Lauren E Irwin, Andrew G Lee,

<h4>Background</h4>Tocilizumab (Actemra) is a humanized anti-interleukin-6 receptor antibody that has been used as a steroid-sparing agent in giant cell arteritis (GCA). Although the clinical effects are well described in GCA, the cost-effectiveness of the use of tocilizumab in GCA is ill defined. The purpose of this study was to determine ... Read more >>

J Neuroophthalmol (Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society)
[2021, 41(3):342-350]

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Contextualizing temporal arterial magnetic resonance angiography in the diagnosis of giant cell arteritis: a retrospective cohort study.

Mats Junek, Angela Hu, Stephanie Garner, Ryan Rebello, Kim Legault, Karen Beattie, Nader Khalidi,

<h4>Objectives</h4>Imaging modalities have become common in evaluating patients for a possible diagnosis of GCA. This study seeks to contextualize how temporal arterial magnetic resonance angiography (TA-MRA) can be used in facilitating the diagnosis of GCA.<h4>Methods</h4>A retrospective cohort study was performed on patients who had been previously referred to a rheumatologist ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2021, 60(9):4229-4237]

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Targeted RNA Sequencing of Formalin-Fixed, Paraffin-Embedded Temporal Arteries From Giant Cell Arteritis Cases Reveals Viral Signatures.

Andrew N Bubak, Teresa Mescher, Michael Mariani, Seth E Frietze, James E Hassell, Christy S Niemeyer, Christina N Como, Anna M Burnet, Prem S Subramanian, Randall J Cohrs, Ravi Mahalingam, Maria A Nagel,

<h4>Background and objectives</h4>Varicella zoster virus (VZV) antigen has been detected in temporal arteries (TAs) of individuals with giant cell arteritis (GCA), the most common systemic vasculitis in older adults. Thus, we explored the contribution of VZV to GCA pathogenesis.<h4>Methods</h4>Formalin-fixed, paraffin-embedded TA sections from biopsy-positive GCA participants with VZV antigen (GCA/VZV-positive; ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2021, 8(6):]

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Pulmonary Vein Stenosis in a Patient With Takayasu Arteritis.

Arun Sharma, Niraj Nirmal Pandey, Manish Shaw, Sanjiv Sharma,

J Clin Rheumatol (Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases)
[2021, 27(6):e213-e214]

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Use of 18F-fluorodeoxyglucose positron emission tomography to monitor tocilizumab effect on vascular inflammation in giant cell arteritis.

Kaitlin A Quinn, Himanshu Dashora, Elaine Novakovich, Mark A Ahlman, Peter C Grayson,

<h4>Objectives</h4>To evaluate the time-dependent effects of tocilizumab on vascular inflammation as measured by 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in GCA.<h4>Methods</h4>Patients with GCA treated with tocilizumab were selected from a prospective, observational cohort. Patients underwent FDG-PET at the baseline visit prior to initiation of tocilizumab and at subsequent follow-up visits performed ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2021, 60(9):4384-4389]

Cited: 1 time

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Vascular Uptake on 18F-FDG PET/CT During the Clinically Inactive State of Takayasu Arteritis Is Associated with a Higher Risk of Relapse.

Oh Chan Kwon, Tae Joo Jeon, Min Chan Park,

<h4>Purpose</h4>To evaluate whether vascular uptake on <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) during the clinically inactive state of Takayasu arteritis (TAK) is associated with disease relapse.<h4>Materials and methods</h4>Patients with TAK who underwent <sup>18</sup>F-FDG PET/CT during the clinically inactive state of the disease between 2006 and 2019 were included. Clinically ... Read more >>

Yonsei Med J (Yonsei medical journal)
[2021, 62(9):814-821]

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