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Large-Scale Transient Production in ExpiCHO-S™ with Enhanced N-Galactosylation-Sialylation and PEI-Based Transfection.

Xiaotian Zhong, Ashley Schwab, Weijun Ma, Caryl L Meade, Jing Zhou, Aaron M D'Antona, Will Somers, Laura Lin,

Large-scale transient expression in Chinese Hamster Ovary (CHO) cells provides a rapid protein production method with a potential start-to-end alignment advantage for biotherapeutics drug discovery. In this chapter, experimental protocols are illustrated for transient expression of therapeutic glycoproteins with improved galactosylation and sialylation in ExpiCHO-S™ system. To reduce the production ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2022, 2313:143-150]

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Eutrophication leads to the formation of a sulfide-rich deep-water layer in Lake Sevan, Armenia.

Khoren Avetisyan, Natella Mirzoyan, Rayford B Payne, Vardan Hayrapetyan, Alexey Kamyshny,

Lake Sevan is a meso-eutrophic water body, which was severely impacted by anthropogenic level decrease, pollution and eutrophication during the last century. Starting in the 1970s, these processes resulted in the formation of an oxygen-depleted hypolimnion during summer-autumn stratification of the lake. In this work, we demonstrate for the first ... Read more >>

Isotopes Environ Health Stud (Isotopes in environmental and health studies)
[2021, 57(5):535-552]

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Genotypic HIV-1 tropism determination might help to identify people with exhausted treatment options and advanced disease.

Yagai Bouba, Daniele Armenia, Federica Forbici, Ada Bertoli, Vanni Borghi, Roberta Gagliardini, Alessandra Vergori, Stefania Cicalini, Valentina Mazzotta, Vincenzo Malagnino, Miriam Lichtner, Alessandra Latini, Cristina Mussini, Massimo Andreoni, Andrea Antinori, Carlo Federico Perno, Francesca Ceccherini-Silberstein, Maria Mercedes Santoro,

<h4>Objectives</h4>To evaluate HIV-1 tropism in 1382 combined antiretroviral therapy (cART)-experienced patients failing therapy to characterize those with exhausted therapeutic options.<h4>Methods</h4>HIV-1 genotypic tropism was inferred through Geno2Pheno by estimating the false-positive-rate (FPR) values. Cumulative resistance and drug activity were evaluated by Stanford algorithm.<h4>Results</h4>Overall, median (IQR) CD4 count (cells/mm3) nadir and at ... Read more >>

J Antimicrob Chemother (The Journal of antimicrobial chemotherapy)
[2021, :]

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Emergency systems in the Republic of Armenia: country in crisis or land of opportunity.

Sharon A Chekijian,

Eur J Emerg Med (European journal of emergency medicine : official journal of the European Society for Emergency Medicine)
[2021, 28(5):337-338]

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Secretion of a low-molecular-weight species of endogenous GRP94 devoid of the KDEL motif during endoplasmic reticulum stress in Chinese hamster ovary cells.

Andrew Samy, Noriko Yamano-Adachi, Yuichi Koga, Takeshi Omasa,

GRP94 (glucose-regulated protein 94) is a well-studied chaperone with a KDEL (lysine, aspartic acid, glutamic acid, and leucine) motif at its C-terminal, which is responsible for GRP94 localization in the endoplasmic reticulum (ER). GRP94 is upregulated during ER stress to help fold unfolded proteins or direct proteins to ER-associated degradation. ... Read more >>

Traffic (Traffic (Copenhagen, Denmark))
[2021, :]

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Investigating the Structure of Son Bias in Armenia With Novel Measures of Individual Preferences.

Matthias Schief, Sonja Vogt, Charles Efferson,

Sex ratios at birth favoring boys are being documented in a growing number of countries, a pattern indicating that families selectively abort females. Son bias also explains why, in many countries, girls have more siblings and are born at relatively earlier parities compared with their brothers. In this study, we ... Read more >>

Demography (Demography)
[2021, :]

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Poster: MM-219: Outcome of COVID-19 Among Patients with Multiple Myeloma at the Armenian Hematology Center

Lusine Sahakyan, Gayane Grigoryan, Yervand Hakobyan,

Clin Lymphoma Myeloma Leuk (Clinical lymphoma, myeloma & leukemia)
[2021, 21(8):S256-S256]

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Epidemiology of Maxillofacial Injuries in “Heratsi” No 1 University Hospital in Yerevan, Armenia: A Retrospective Study

Lusine Aleksanyan, Anna Yu Poghosyan, Martin Misakyan, Armen Minasyan, Aren Yu Bablumyan, Artashes Tadevosyan, Armen Muradyan,

<h4>Background: </h4> The aim of this study was to perform a retrospective analysis of the prevalence, etiologies, and types of maxillofacial injuries (MFI) and sites of maxillofacial fractures (MFF) and their management in Yerevan, Armenia. <h4>Methods: </h4>: A retrospective cross-sectional study was conducted. Data including age, sex, date of referral, ... Read more >>

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In memory of Margarita Malakyan, a bright person and inquisitive scientist.

Mariam Petrosyan, Elina Arakelova, Lyudmila Nersesova, Violetta Ayvazyan, Gohar Tsakanova,

<h4>Purpose</h4>To describe the contribution of Margarita Malakyan to the development of radiation biology in Armenia and how her multidisciplinary collaboration with chemists, physicists and biologists around the world led to the development of radioprotectors and radiosensitizers of different origins.<h4>Conclusion</h4>Margarita Malakyan was a very active and initiative woman, a radiobiologist, whose ... Read more >>

Int J Radiat Biol (International journal of radiation biology)
[2021, :1-9]

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SEM-EDS analysis of ancient bronze artifacts of urartian period from Yegheghnadzor region, Armenia.

Yeghis Keheyan, Giancarlo Lanterna,

The results of the analysis on some fragments of bronze belts and a bowl discovered from southwestern Armenia, Yegheghnadzor archaeological site, are discussed. The samples are dated to the 7-6 BCE from the Urartian period. The artifacts were corroded and a multilayer structure was formed. To study the stratigraphy of ... Read more >>

J Microsc (Journal of microscopy)
[2021, :]

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Evolution of Radioecology in Armenia: A Short Review.

Olga Belyaeva, Nona Movsisyan,

<h4>Purpose</h4>The article generalizes the evolution of radioecological studies conducted by female scientists in Armenia in the period of 1950-2020. Radioecological studies were launched in 1958, prior to the construction of the ANPP and major nuclear disasters.<h4>Conclusion</h4>The obtained results allowed the revealing peculiarities of distribution and accumulation of naturally occurring radioactive ... Read more >>

Int J Radiat Biol (International journal of radiation biology)
[2021, :1-8]

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MM-219: Outcome of COVID-19 Among Patients with Multiple Myeloma at the Armenian Hematology Center

Lusine Sahakyan, Gayane Grigoryan, Yervand Hakobyan,

The effect of COVID-19 on patients with multiple myeloma (MM), the second most common hematological malignancy, is of particularly great concern due to immunosuppression associated with the disease, and at this time remains incompletely understood. The aim of the current study was the analysis of the characteristics of COVID-19 infection ... Read more >>

Clin Lymphoma Myeloma Leuk (Clinical lymphoma, myeloma & leukemia)
[2021, 21(8):S430-S430]

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Multiple myeloma in Armenia during the period 2006-2018: facts and discussion.

Narine Ghazaryan, Samvel Danelyan, Samvel Bardakhchyan, Anahit Saharyan, Lusine Sahakyan,

<h4>Background</h4>It is known that one of the reasons for the increased incidence of hematological malignancies is caused by the growth of multiple myeloma (MM). Worldwide, approximately 159,985 new cases of MM are diagnosed representing 0.9% of all cancer diagnoses and 106,105 patients will die from MM accounting for 1.1% of ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):941]

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N-Glycosylation and enzymatic activity of the rHuPH20 expressed in Chinese hamster ovary cells.

Tao Liu, Yantao Li, Jin Xu, Qingcheng Guo, Dapeng Zhang, Lankun Song, Jun Li, Weizhu Qian, Huaizu Guo, Xinli Zhou, Sheng Hou,

rHuPH20, a neutral pH-active hyaluronidase that degrades glycosaminoglycans under physiologic conditions, has six potential N-glycosylation sites. In this report, the rHuPH20 expressed in Chinese hamster ovary (CHO) cells was analyzed and characterized using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Removal of the N-linked glycans from rHuPH20 with PNGase F shifted ... Read more >>

Anal Biochem (Analytical biochemistry)
[2021, :114380]

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Comparative Y-chromosome analysis among Cypriots in the context of historical events and migrations.

Irene Moutsouri, Anna Keravnou, Panayiotis Manoli, Stefania Bertoncini, Kyriaki Michailidou, Vasilis Christofi, Stavroulla Xenophontos, Marios A Cariolou, Evy Bashiardes,

Y-chromosome analysis provides valuable information regarding the migration patterns of male ancestors, ranging from the Paleolithic age to the modern humans. STR and SNP genotyping analysis provides data regarding the genetic and geographical ancestry of the populations studied. This study focused on the analysis of the Y-chromosome in Maronite Cypriots ... Read more >>

PLoS One (PloS one)
[2021, 16(8):e0255140]

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Corrigendum to "Risk assessment of dietary exposure to potentially toxic trace elements in emerging countries: A pilot study on intake via flour-based products in Yerevan, Armenia"[Food Chem. Toxicol. 146, (December 2020), 111768].

Davit Pipoyan, Astghik Hovhannisyan, Meline Beglaryan, Seda Stepanyan, Alberto Mantovani,

Food Chem Toxicol (Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association)
[2021, 156:112525]

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Right upper quadrant peritonectomy. Answering frequently asked questions.

Artem Stepanyan, Zhirayr Malakyan, Areg Alaverdyan, Hasmik Davtyan, Tatevik Hovhannisyan,

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, 31(9):1305-1306]

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Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture.

Tae Kwang Ha, Dongil Kim, Che Lin Kim, Lise Marie Grav, Gyun Min Lee,

Chinese hamster ovary (CHO) cells are the most widely used mammalian host cells for the commercial production of therapeutic proteins. Fed-batch culture is widely used to produce therapeutic proteins, including monoclonal antibodies, because of its operational simplicity and high product titer. Despite technical advances in the development of culture media ... Read more >>

Biotechnol Adv (Biotechnology advances)
[2021, :107831]

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Improved cultivation of Chinese hamster ovary cells in bioreactor with reciprocal mixing.

Masashi Ueki, Noriyuki Tansho, Makoto Sato, Hisayuki Kanamori, Yoshikazu Kato,

We have constructed a new bioreactor with reciprocal mixing that is better suited for the cultivation of delicate animal cells. In-silico simulation (computational fluid dynamics) suggested both maximum and average shear stresses in the bioreactor with reciprocal mixing to be remarkably lower than in a conventional bioreactor with rotary mixing. ... Read more >>

J Biosci Bioeng (Journal of bioscience and bioengineering)
[2021, :]

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A molecular dynamics study of protein denaturation induced by sulfonate-based surfactants.

Armen H Poghosyan, Aram A Shahinyan, Gayane R Kirakosyan, Naira M Ayvazyan, Yevgeni S Mamasakhlisov, Garegin A Papoian,

Microsecond timescale explicit-solvent atomistic simulations were carried out to investigate how anionic surfactants modulate protein structure and dynamics. We found that lysozyme undergoes near-complete denaturation at the high concentration (> 0.1 M) of sodium pentadecyl sulfonate (SPDS), while only partial denaturation occurs at the concentration slightly below 0.1 M. In large part, protein ... Read more >>

J Mol Model (Journal of molecular modeling)
[2021, 27(9):261]

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Revealing XRF data quality level, comparability with ICP-ES/ICP-MS soil PTE contents and similarities in PTE induced health risk.

Gevorg Tepanosyan, Norik Harutyunyan, Lilit Sahakyan,

Portable X-ray fluorescence spectroscopy (XRF) was recognized as an efficient and promising tools to study the contents of chemical elements in various media including soils under the impact of anthropogenic activities. However, the quality of data and the equality of chemical elements with other common analytical methods such as aqua-regia ... Read more >>

Environ Geochem Health (Environmental geochemistry and health)
[2021, :]

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The Psychosocial Impact of Compounding Humanitarian Crises Caused by War and COVID-19 Informing Future Disaster Response.

Hakob Harutyunyan, Artak Mukhaelyan, Attila J Hertelendy, Amalia Voskanyan, Todd Benham, Fadi Issa, Alex Hart, Gregory R Ciottone,

The coronavirus disease 2019 (COVID-19) pandemic has caused the greatest global loss of life and economic impact due to a respiratory virus since the 1918 influenza pandemic. While health care systems around the world faced the enormous challenges of managing COVID-19 patients, health care workers in the Republic of Armenia ... Read more >>

Prehosp Disaster Med (Prehospital and disaster medicine)
[2021, :1-2]

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The LD50 for Low-Energy Ultrashort-Pulsed Laser Driven Electron Beam Whole-Body Irradiation of Wistar Rats.

Gohar Tsakanova, Elina Arakelova, Violetta Ayvazyan, Zaven Karalyan, Lusine Matevosyan, Arsen Arakelyan, Zohrab Amirkhanyan, Hakob Davtyan, Vitali Khachatryan, Bagrat Grigoryan,

Recently, a new technology of low-energy ultrashort-pulsed electron beam (UPEB) accelerators has been developed opening new directions for radiobiology and biomedical research. The purpose of this study was to reveal the lethal dose, LD50 (lethal dose, 50%) delivered by low-energy UPEB whole-body exposure on an organismal level. Wistar rats were ... Read more >>

Radiat Res (Radiation research)
[2021, :]

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First reported case of a histiocytic sarcoma in an Armenian hamster (Cricetulus migratorius).

Christopher Cheleuitte-Nieves, Sarah V Kitz, Sébastien Monette,

A 14-month-old male Armenian hamster (<i>Cricetulus migratorius</i>) presented with a spontaneous, subcutaneous, firm mass (4.0 × 2.0 × 1.5 cm) on the ventral neck extending towards the cheek pouch causing multifocal small oral ulcerations. This animal was immunized subcutaneously on the dorsal neck for the development of monoclonal antibodies seven months before presentation. The ... Read more >>

Lab Anim (Laboratory animals)
[2021, :236772211033672]

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Visual impairment and associated risk factors in patients with diabetes mellitus in Tavush and Armavir provinces of Armenia.

Aida Giloyan, Diana Muradyan, Vahe Khachadourian,

<h4>Background</h4>Visual impairment (VI) and blindness remain serious public health problems among patients with diabetes. This study assessed the prevalence of VI and its associated risk factors in individuals with diabetes mellitus (DM) in Armenia.<h4>Methods</h4>This cross-sectional study recruited 1287 people with DM. All participants underwent comprehensive ophthalmic examination and responded to ... Read more >>

Int Ophthalmol (International ophthalmology)
[2021, :]

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