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Genetic Mapping of a new Hippo allele, HpoN.1.2, in Drosophila melanogaster.

Jamie L Siders, Kayla L Bieser, Danielle R Hamill, Erika C Acosta, Olivia K Alexander, Humza I Ali, Micah J Anderson, Hayden R Arrasmith, Mustafa Azam, Nikki J Beeman, Hassan Beydoun, Lauren J Bishop, Morgan D Blair, Brianna Bletch, Heather R Bline, Jennifer C Brown, Kelly M Burns, Karina C Calagua, Lexie Chafin, William Ah Christy, Carlyn Ciamacco, Hannah Cizauskas, Caitlyn M Colwell, Abigail R Courtright, Lucero Diaz Alavez, Rayne Is Ecret, Fatima Edriss, Taylor G Ellerbrock, Madison M Ellis, Erica M Extine, Eric Feldman, Luke J Fickenworth, Caroline M Goeller, Alexis S Grogg, Yailine Hernandez, Abigail Hershner, Megan M Jauss, Leyre Jimenez Garcia, Katey E Franks, Ethan T Kazubski, Emily R Landis, Jon Langub, Tia N Lassek, Triet C Le, Julia M Lee, Daniel P Levine, Phoebe J Lightfoot, Natasha Love, Ali Maalhagh-Fard, Colin Maguire, Brynna E McGinnis, Bhargavi V Mehta, Veronica Melendrez, Zimri E Mena, Seth Mendell, Petra Montiel-Garcia, Autumn S Murry, Riley A Newland, Ryan M Nobles, Neha Patel, Yashodhara Patil, Cassidy L Pfister, Victoria Ramage, Mya R Ray, Joseph Rodrigues, Victoria C Rodriquez, Yara Romero, Alexandra M Scott, Nicholas Shaba, Samantha Sieg, Kayla Silva, Sahiba Singh, Aleksandria J Spargo, Savanna J Spitnale, Nicole Sweeden, Logan Tague, Breanna M Tavernini, Kathleen Tran, Liselle Tungol, Kylie A Vestal, Amber Wetherbee, Kayla M Wright, Anthony T Yeager, Rehab Zahid, Jacob D Kagey,

Genetic screens provide a mechanism to identify genes involved with different cellular and organismal processes. Using a Flp/FRT screen in the <i>Drosophila</i> eye we identified mutations that result in alterations and de-regulation of cell growth and division. From this screen a group of undergraduate researchers part of the Fly-CURE consortium ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Methylation of the D2 dopamine receptor affects binding with the human regulatory proteins Par-4 and Calmodulin.

Alexander Bowitch, Ansuman Sahoo, Andrea M Clark, Christiana Ntangka, Krishna K Raut, Paul Gollnick, Michael C Yu, Steven M Pascal, Sarah E Walker, Denise M Ferkey,

MicroPubl Biol (microPublication biology)
[2021, 2021:]

Cited: 0 times

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Pyrogallol induces oxidative stress defects in the fission yeast S. pombe.

Nafees Ahamad, Simmi Anjum, Shakil Ahmed,

Apart from the beneficial roles of pyrogallol in industries, it also tends to produce free radicals that trigger apoptosis in human cells. In this study, we checked the toxic effect of pyrogallol in fission yeast <i>S. pombe</i> cells. We observed that the wild type and <i>wat1/pop3</i> delete cells were unable ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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B.2.16 is a non-lethal modifier of the Dark82 mosaic eye phenotype in Drosophila melanogaster.

Alysia D Vrailas-Mortimer, Nitish Aggarwal, Neha N Ahmed, Ian M Alberts, Masa Alhawasli, Ibrahim A Aljerdi, Brooke M Allen, Ahmad M Alnajar, Michael A Anderson, Ryan Armstong, Chace C Avery, Eric J Avila, Tyra N Baker, Soolmaz Basardeh, Natasha A Bates, Farrah N Beidas, Ashton C Bosler, Deja M Brewer, Ryan S Buenaventura, Natalie Jl Burrell, Alyn P Cabrera-Lopez, Amairani B Cervantes-Gonzalez, Raymond P Cezar, Joselyn Coronel, Corinne Croslyn, Konnor R Damery, Lucero Diaz-Alavez, Nupur P Dixit, Dilcia L Duarte, Amanda R Emke, Katherine English, Audrey A Eshun, Samuel R Esterly, Arnold J Estrada, Mark Feng, Meghan M Freund, Niko Garcia, Charandeep S Ghotra, Haddia Ghyasi, Christa Sa Hale, Luci Hulsman, Lindsey Jamerson, Austin K Jones, Madeline Kuczynski, Takailah N Lacey-Kennedy, Mindy J Lee, Tala Mahjoub, Molly C Mersinger, Alyssa D Muckerheide, David W Myers, Karen Nielsen, Paul J Nosowicz, Jacinda A Nunez, Amy C Ortiz, Tulsi T Patel, Natalie N Perry, W Storm A Poser, Deisy M Puga, Cathrine Quam, Paulina Quintana-Lopez, Piper Rennerfeldt, Nicholas M Reyes, Ian G Rines, Cally Roberts, Daniel B Robinson, Kalina M Rossa, Gloria J Ruhlmann, Jeremy Schmidt, John R Sherwood, Dimyana H Shonoda, Hannah Soellner, Juan C Torrez, Mayukah Velide, Zachary Weinzapfel, Alisa C Ward, Kayla L Bieser, Julie A Merkle, Joyce C Stamm, Richard L Tillett, Jacob D Kagey,

Genetic screens have been used to identify genes involved in the regulation of different biological processes. We identified growth mutants in a Flp/FRT screen using the <i>Drosophila melanogaster</i> eye to identify conditional regulators of cell growth and cell division. One mutant identified from this screen, <i>B.2.16</i>, was mapped and characterized ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

Cited: 1 time

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Visualization of binding patterns for five Leucine-rich repeat proteins in the Drosophila embryo.

Namrata Bali, Kai Zinn,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 0 times

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ICD-1/BTF3 antagonizes SKN-1-mediated endoderm specification in Caenorhabditis elegans.

Chee Kiang Ewe, Yamila Torres Cleuren, Geneva Alok, Joel Rothman,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 0 times

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LOC496300 is expressed in the endoderm of developing Xenopus laevis embryos.

Maria Stewart, Kelsey Donahue, Elizabeth Wilke, Emily Shifley,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

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EOR-1 and EOR-2 function in RMED/V neuron specification.

Xun Huang, Yishi Jin,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 2 times

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Genetic mapping of shnE.3.2 in Drosophila melanogaster.

Kayla Bieser, Jamie Sanford, Ken Saville, Katherine Arreola, Zachary Ayres, David Basulto, Serena Benito, Christopher Breen, Julian Brix, Nicole Brown, Krissa Burton, Taree Chadwick, Matthew Chen, Katherine Chu, Beverly Corbett, Zerrick Dill, Meghan Faughender, Ashlynn Hickey, Joshua Julia, Shannon Kelty, Briggette Jobs, Bryce Krason, Brian Lam, Colin McCullough, Bryanna McEwen, Julian McKenzie, Kayla McQuinn, Chloe Moritz, Kristina Myers, Elizabeth Naugle, Ashley Nutter, Danielle O'Conke, Megan O'Grondik, Kriya Patel, Sydney Rudowski, Emma Sberna, Gunner Stall, Tad Steiner, Eda Tanriverdi, Natalie Torres Patarroyo, Virginia Traster, Leo Tsai, Andrew Valenti, Mariela Villegas, Samantha Voors, Kierra Watson, Megan Wright, Jacob Kagey,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 3 times

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Genetic mapping of EgfrL.3.1 in Drosophila melanogaster.

Joyce Stamm, Gnanda Joshi, M A Anderson, Katie Bussing, Colton Houchin, Amber Elinsky, Jacob Flyte, Nadine Husseini, Dominika Jarosz, Chelsea Johnson, Abby Johnson, Christina Jones, Taj Kooner, Daniel Myhre, Thomas Rafaill, Sarah Sayed, Kirby Swan, Jonathan Toma, Jacob Kagey,

MicroPubl Biol (microPublication biology)
[2019, 2019:]

Cited: 4 times

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The mapping of Drosophila melanogaster mutant A.4.4.

Kayla Bieser, Joyce Stamm, Ayala Aldo, Suneil Bhaskara, Makayla Clairborne, Joselyn Coronel Gómez, Ron Dean, Aaron Dowell, Evan Dowell, Mathew Eissa, Ahmad Fawaz, Michael Fouad-Meshriky, Dustin Godoy, Krista Gonzalez, Malak Hachem, Malak Hammoud, Anthony Huffman, Hunter Ingram, Alex Jackman, Bibek Karki, Natalia Khalil, Houda Khalil, Tran Khanh Ha, Arjun Kharel, Izabell Kobylarz, Hunter Lomprey, Adam Lonnberg, Safa Mahbuba, Hend Massarani, Madeline Minster, Krystina Molina, Lynette Molitor, Taylor Murray, Payal Patel, Sydney Pechulis, Architha Raja, Gladys Rastegari, Skylar Reeves, Niveda Sabu, Rafael Salazar, Devan Schulert, Matthew Senopole, Kristen Sportiello, Claudia Torres, Jade Villalobos, Joseph Wu, Stacy Zeigler, Jacob Kagey,

MicroPubl Biol (microPublication biology)
[2018, 2018:]

Cited: 3 times

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Neat1 decreases neuronal apoptosis after oxygen and glucose deprivation.

Wei-Na Chai, Yi-Fan Wu, Zhi-Min Wu, Yan-Feng Xie, Quan-Hong Shi, Wei Dan, Yan Zhan, Jian-Jun Zhong, Wei Tang, Xiao-Chuan Sun, Li Jiang,

Studies have shown that downregulation of nuclear-enriched autosomal transcript 1 (Neat1) may adversely affect the recovery of nerve function and the increased loss of hippocampal neurons in mice. Whether Neat1 has protective or inhibitory effects on neuronal cell apoptosis after secondary brain injury remains unclear. Therefore, the effects of Neat1 ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):163-169]

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Ghrelin alleviates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.

Xin He, Wei Yuan, Chun-Qing Yang, Lu Zhu, Fei Liu, Juan Feng, Yi-Xue Xue,

Ghrelin is a neuropeptide that has various physiological functions and has been demonstrated to be neuroprotective in a number of neurological disease models. However, the underlying mechanisms of ghrelin in Parkinson's disease remain largely unexplored. The current study aimed to study the effects of ghrelin in a 6-hydroxydopamine (6-OHDA)-induced Parkinson's ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):170-177]

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Inhibition of LncRNA Vof-16 expression promotes nerve regeneration and functional recovery after spinal cord injury.

Xiao-Min Zhang, Li-Ni Zeng, Wan-Yong Yang, Lu Ding, Kang-Zhen Chen, Wen-Jin Fu, Si-Quan Zeng, Yin-Ru Liang, Gan-Hai Chen, Hong-Fu Wu,

Our previous RNA sequencing study showed that the long non-coding RNA ischemia-related factor Vof-16 (lncRNA Vof-16) was upregulated after spinal cord injury, but its precise role in spinal cord injury remains unclear. Bioinformatics predictions have indicated that lncRNA Vof-16 may participate in the pathophysiological processes of inflammation and apoptosis. PC12 ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):217-227]

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Traumatic brain injury induced by exposure to blast overpressure via ear canal.

Yang Ou, Brad A Clifton, Jinghui Li, David Sandlin, Na Li, Li Wu, Chunming Zhang, Tianwen Chen, Jun Huang, Yue Yu, Jerome Allison, Fan Fan, Richard J Roman, James Shaffery, Wu Zhou, Yi Pang, Hong Zhu,

Exposure to explosive shockwave often leads to blast-induced traumatic brain injury in military and civilian populations. Unprotected ears are most often damaged following exposure to blasts. Although there is an association between tympanic membrane perforation and TBI in blast exposure victims, little is known about how and to what extent ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):115-121]

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Ki20227 aggravates apoptosis, inflammatory response, and oxidative stress after focal cerebral ischemia injury.

Cheng Jiang, Ze-Ning Wang, Yu-Chen Kang, Yi Chen, Wei-Xin Lu, Hai-Jun Ren, Bo-Ru Hou,

The survival of microglia depends on the colony-stimulating factor-1 receptor (CSF1R) signaling pathway under physiological conditions. Ki20227 is a highly selective CSF1R inhibitor that has been shown to change the morphology of microglia. However, the effects of Ki20227 on the progression of ischemic stroke are unclear. In this study, male ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):137-143]

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Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis.

Yan Zhou, Lu-Lu Wen, Yan-Fei Li, Kai-Min Wu, Ran-Ran Duan, Yao-Bing Yao, Li-Jun Jing, Zhe Gong, Jun-Fang Teng, Yan-Jie Jia,

Mesenchymal stem cell (MSC) transplantation is a promising treatment strategy for spinal cord injury, but immunological rejection and possible tumor formation limit its application. The therapeutic effects of MSCs mainly depend on their release of soluble paracrine factors. Exosomes are essential for the secretion of these paracrine effectors. Bone marrow ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):194-202]

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Polygalasaponin F protects hippocampal neurons against glutamate-induced cytotoxicity.

Chong Sun, Xin-Cheng Cao, Zhi-Yang Liu, Chao-Lin Ma, Bao-Ming Li,

Excess extracellular glutamate leads to excitotoxicity, which induces neuronal death through the overactivation of N-methyl-D-aspartate receptors (NMDARs). Excitotoxicity is thought to be closely related to various acute and chronic neurological disorders, such as stroke and Alzheimer's disease. Polygalasaponin F (PGSF) is a triterpenoid saponin monomer that can be isolated from ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):178-184]

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The PirB toxin protein from Vibrio parahaemolyticus induces apoptosis in hemocytes of Penaeus vannamei.

Zhou Zheng, Ruiwei Li, Jude Juventus Aweya, Defu Yao, Fan Wang, Shengkang Li, Tran Ngoc Tuan, Yueling Zhang,

Acute hepatopancreatic necrosis disease (AHPND) is a major debilitating disease that causes massive shrimp death resulting in substantial economic losses in shrimp aquaculture. The Pir toxin proteins secreted by a unique strain of <i>Vibrio parahaemolyticus</i> play an essential role in the pathogenesis of AHPND. At present, most studies on the ... Read more >>

Virulence (Virulence)
[2021, 12(1):481-492]

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Yiqi Huoxue Recipe inhibits cardiomyocyte apoptosis caused by heart failure through Keap1/Nrf2/HIF-1α signaling pathway.

Ling Hu, Yanan Xu, Qian Wang, Meijie Liu, Linfeng Meng, Dongyan Yan, Huagang Hu, Minjia Xiao, Zhenzhen Yin, Ying Li, Xiaoping Kang,

Yiqi Huoxue Recipe (YHR) is commonly used in China to treat diseases such as heart failure (HF). It has been reported that YHR can treat HF and has a certain protective effect on myocardial cell damage. The purpose of this study is to determine the cardioprotective effects of YHR on ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):969-978]

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Homeobox A5 activates p53 pathway to inhibit proliferation and promote apoptosis of adrenocortical carcinoma cells by inducing Aldo-Keto reductase family 1 member B10 expression.

Danyan Chen, Zhaonan Shen, Xi Cheng, Qi Wang, Junlin Zhou, Fang Ren, Yue Sun, Hongman Wang, Rongxi Huang,

Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) and Homeobox A5 (HOXA5) are both down-regulated in adrenocortical carcinoma (ACC), and HOXA5 is predicted to bind to the promoter of AKR1B10. We aimed to investigate whether HOXA5 could bind to AKR1B10 to regulate ACC cells proliferation and apoptosis. The expression of AKR1B10 ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1964-1975]

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Rab18 interacted with V-set and immunoglobulin domain-containing 4 (VSIG4) to involve in the apoptosis of glioma and the sensitivity to temozolomide.

Kai Yang, Zhi Wang,

Rab18 and V-set and immunoglobulin domain-containing 4 (VSIG4) were reportedly implicated in the malignant progression of glioma. In this study, their relationship was further explored, accompanied by the investigation into their effects on the sensitivity of temozolomide (TMZ). The proliferation and apoptosis of U87-MG and U251-MG were detected after Rab18 ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1391-1402]

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MicroRNA-362-5p promotes the proliferation and inhibits apoptosis of trophoblast cells via targeting glutathione-disulfide reductase.

Cuihua Zhang, Dan Zhao,

Gestational diabetes mellitus (GDM), a common complication of pregnancy, harms the health of pregnant women and fetuses. MicroRNAs (miRNAs) dysregulation in placenta is involved in GDM. Herein, we explored the roles of miR-362-5p in GDM. After high glucose (HG) treated HTR-8/SVneo cells, CCK-8 and flow cytometry were conducted to assess ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2410-2419]

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Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.

Xia Zhao, Jing Wang, Liying Tang, Pei Li, Jing Ru, Yuzhi Bai,

The study was designed to explore the effects of Withaferin A (WFA) on hyperuricemia-induced kidney injury and its action mechanism. Potassium oxonate (PO) was employed to establish the hyperuricemic mouse model. The pathological changes of renal tissue were evaluated by hematoxylin-eosin and masson trichrome staining. The levels of creatinine, blood ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):589-600]

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miR-34b-5p promotes renal cell inflammation and apoptosis by inhibiting aquaporin-2 in sepsis-induced acute kidney injury.

Caifa Zheng, Dansen Wu, Songjing Shi, Liming Wang,

<h4>Objective</h4>This study was designed to uncover the mechanism of miR-34b-5p-mediated aquaporin-2 (AQP2) in sepsis-induced injury using human renal tubular epithelial cells (HK-2).<h4>Methods</h4>Serum levels of miR-34b-5p, TNF-α, IL-1β, IL-6, serum creatinine (SCr), and blood urea nitrogen (BUN) in septic patients with acute kidney injury (AKI) and healthy controls were detected. Lipopolysaccharide ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):291-301]

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