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Apnea of Prematurity

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Risk factors of obstructive sleep apnea syndrome in children.

Zhifei Xu, Yunxiao Wu, Jun Tai, Guoshuang Feng, Wentong Ge, Li Zheng, Zhe Zhou, Xin Ni,

BACKGROUND:The known risk factors of childhood OSAS include tonsillar and adenoidhypertrophy, obesity, craniofacial anomalies, neuromuscular disorders and African-American (AA) ancestry. Whether other factors such as allergic rhinitis (AR), premature, environmental tobacco smoking (ETS) are associated with OSAS are inconsistent in different studies. Our study enrolled children of a broad age ... Read more >>

J Otolaryngol Head Neck Surg (Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale)
[2020, 49(1):11]

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Caffeine Citrate for Apnea of Prematurity: A Prospective, Open-Label, Single-Arm Study in Chinese Neonates.

Lizhong Du, Xiaomei Tong, Chao Chen, Xirong Gao, Alessandra Gagnatelli, Jingyang Li, Debora Santoro, Sara Nicolardi, Laura Fabbri,

Background: Caffeine citrate has been approved in China for the management of apnea of prematurity. This clinical trial was conducted as a condition of regulatory approval. The aim was to confirm the efficacy of caffeine citrate in the treatment of recurrent intermittent hypoxia and bradycardia in preterm newborns with primary ... Read more >>

Front Pediatr (Frontiers in Pediatrics)
[2020, 8:]

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Immunological outcomes in infants with ROP after dexamethasone and aminophylline.

Larisa Balashova, Svetlana Bykovskaya, Ludmila Korobova, Yulia Kuznetsova, Elena Kantardgy, Vladimir Mukhin, Andrey Popov,

This research aims to improve anaesthesia services given to preterm infants by the use of dexamethasone and aminophylline administrated under sevoflurane, and to analyze its effect on the cell-mediated immunity (CD4+CD25+Foxp3+(Treg) and CD4+CD25highFoxp3+CD127low). We have examined 74 premature babies with retinopathy of prematurity (ROP) at the 3-5 stages during the ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2020, :]

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Anesthesia for Major Surgery in the Neonate.

Calvin C Kuan, Susanna J Shaw,

Perioperative risk of morbidity and mortality for neonates is significantly higher than that for older children and adults. At particular risk are neonates born prematurely, neonates with major or severe congenital heart disease, and neonates with pulmonary hypertension. Presently no consensus exists regarding the safest anesthetic regimen for neonates. Regional ... Read more >>

Anesthesiol Clin (Anesthesiology clinics)
[2020, 38(1):1-18]

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Stopping caffeine in premature neonates: how long does it take for the level of caffeine to fall below the therapeutic range?

Jane Chung, Kim Tran Lopez, Barbara Amendolia, Vishwanath Bhat, Tarek Nakhla, Linda Slater-Myer, Judy Saslow, Zubair H Aghai,

Background: Caffeine is routinely used in preterm infants for apnea of prematurity. Preterm infants are usually monitored for 5 days after discontinuation of caffeine to assess for possible recurrence of apnea. Our objective was to determine if the serum concentration of caffeine decreases to a subtherapeutic level 5 days after its discontinuation.Methods: ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-5]

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Development of the PREMature Infant Index (PREMII™), a clinician-reported outcome measure assessing functional status of extremely preterm infants.

Robert M Ward, Mark A Turner, Ingrid Hansen-Pupp, Jason Higginson, Magdalena Vanya, Emuella Flood, Ethan J Schwartz, Helen A Doll, Adina Tocoian, Alexandra Mangili, Norman Barton, Sujata P Sarda,

Background: Comprehensive measures to evaluate the effectiveness of medical interventions in extremely preterm infants are lacking. Although length of stay is used as an indicator of overall health among preterm infants in clinical studies, it is confounded by nonmedical factors (e.g. parental readiness and availability of home nursing support).Objectives: To ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-10]

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Risk Factors of Respiratory Diseases Among Neonates in Neonatal Intensive Care Unit of Qena University Hospital, Egypt.

Khaled A Abdel Baseer, Mostafa Mohamed, Eman A Abd-Elmawgood,

Background:Respiratory diseases in newborns are considered major causes of neonatal morbidity and mortality especially in developing countries. Its causes are diverse and require early detection and management. This study aimed for detection of the prevalence and risk factors of respiratory diseases in addition to outcome among neonates admitted in neonatal ... Read more >>

Ann Glob Health (Annals of global health)
[2020, 86(1):22]

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Clinical Study of Different Modes of Non-invasive Ventilation Treatment in Preterm Infants With Respiratory Distress Syndrome After Extubation.

Fei Ding, Jingling Zhang, Wenya Zhang, Qian Zhao, Zimei Cheng, Yang Wang, Tao Bo, Hui Wu,

Objective: This study aimed to investigate the clinical efficacy and safety of different non-invasive respiratory support methods in preterm infants with respiratory distress syndrome (RDS) after extubation. Methods: From Oct 2017 to 2018, 120 preterm infants were recruited from the NICUs of three hospitals. They were diagnosed with RDS and ... Read more >>

Front Pediatr (Frontiers in Pediatrics)
[2020, 8:63]

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Effect of Earmuffs on Physiological Parameters in Preterm Infants: A Systematic Review.

Serap Ozdemir, Serap Balci,

Noise may cause stress responses such as apnea, hypoxemia, changing in oxygen saturation and augmented oxygen consumption secondary to elevated heart and respiratory rates. Moreover, stress results in increased intracranial pressure, abnormal sleep patterns, hearing impairment, and bronchopulmonary dysplasia, retinopathy of prematurity, intraventricular hemorrhage, periventricular leukomalacia, retardate development and alterations ... Read more >>

Curr Pediatr Rev (Current pediatric reviews)
[2020, :]

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Update on Apneas of Heart Failure With Reduced Ejection Fraction: Emphasis on the Physiology of Treatment: Part 2: Central Sleep Apnea.

Shahrokh Javaheri, Lee K Brown, Rami N Khayat,

Central sleep apnea/Hunter-Cheyne-Stokes breathing (CSA/HCSB) is prevalent in patients with heart failure with reduced ejection fraction (HFrEF). The acute pathobiologic consequences of CSA/HSCB eventually lead to sustained sympathetic overactivity, repeated hospitalization, and premature mortality. A few small randomized controlled trials (RCTs) have shown statistically significant and clinically important reduction in ... Read more >>

Chest (Chest)
[2020, :]

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Perinatal Antecedents of Sleep disturbances in Schoolchildren.

Pablo E Brockmann, Helena Poggi, Alejandro Martinez, Ivonne D Apremont, Rosario Moore, Dale Smith, David Gozal,

STUDY OBJECTIVES:Prematurity has been associated with an increased risk for sleep apnea. However, sleep disturbances in children born preterm have not been extensively investigated. Considering that determinants of sleep may originate early in life, the potential impact of prematurity on sleep disturbances later in life could be important.To establish the ... Read more >>

Sleep (Sleep)
[2020, :]

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Work of Breathing in Premature Neonates: Noninvasive Neurally-Adjusted Ventilatory Assist versus Noninvasive Ventilation.

David N Matlock, Shasha Bai, Michael D Weisner, Norman Comtois, Jennifer Beck, Christer Sinderby, Sherry E Courtney,

BACKGROUND:We tested whether work of breathing in premature newborns estimated by phase angle (θ) by using respiratory inductance plethysmography is decreased during neurally-adjusted ventilatory assist (NAVA) noninvasive ventilation (NIV) versus NIV alone. METHODS:NAVA NIV and NIV were applied in random order while using respiratory inductance plethysmography to measure the phase ... Read more >>

Respir Care (Respiratory care)
[2020, :]

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Obstructive Sleep Apnea as a Predictor of Abnormal Heart Rate Turbulence.

Dominika Urbanik, Paweł Gać, Helena Martynowicz, Małgorzata Poręba, Maciej Podgórski, Marta Negrusz-Kawecka, Grzegorz Mazur, Małgorzata Sobieszczańska, Rafał Poręba,

Obstructive sleep apnea (OSA) causes dysfunction of the autonomic nervous system, but the exact mechanism has not been fully understood. The aim of this study was to analyse the relationship between the incidence and severity of OSA and heart rate turbulence (HRT). Seventy one patients with clinical suspicion of OSA ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 9(1):]

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Reducing Variation in the Management of Apnea of Prematurity in the Intensive Care Nursery.

Katherine Coughlin, Michael Posencheg, Lauren Orfe, Whitney Zachritz, Jaqueline Meadow, Kesi Yang, Lori Christ,

BACKGROUND:Premature infants have bradycardia and/or desaturation events due to apnea of prematurity that resolve as the infants mature. Despite American Academy of Pediatrics guidelines recommending a standard "event-free" period before discharge, length of observation in our Intensive Care Nursery was variable. By June 2018, for infants born <36 weeks' gestation ... Read more >>

Pediatrics (Pediatrics)
[2020, 145(2):]

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Effects of less invasive surfactant administration (LISA) via a gastric tube on the treatment of respiratory distress syndrome in premature infants aged 32 to 36 weeks.

Guang Yang, Mingyan Hei, Zhimin Xue, Yuan Zhao, Xinhua Zhang, Chenghu Wang,

To explore the clinical effects of less invasive surfactant administration (LISA) via a gastric tube on the treatment of respiratory distress syndrome (RDS) in premature infants aged 32 to 36 weeks.A total of 97 premature infants with RDS admitted to the Children's Hospital of Shanxi from February 2017 to January ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(9):e19216]

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Association between adverse perinatal outcomes and sleep disturbances during pregnancy: a systematic review and meta-analysis.

Ziyi Yang, Ziyu Zhu, Chunyi Wang, Fan Zhang, Huan Zeng,

Background: Due to physiological and hormonal factors, sleep disturbances are prevalent in the obstetric population. Multiple studies have evaluated the relationship between sleep disturbances and perinatal outcomes, with inconsistent results. The purpose of this systematic review and meta-analysis was to further assess the overall relationship between four types of sleep ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2020, :1-9]

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[Safety and efficacy of caffeine use started at different time in preterm infants: a multicenter study in Jiangsu Province, China].

Yang Yang, Rui Cheng, Qi Wu, Li-Xing Qiao, Zu-Ming Yang, Hong-Bing Gu, Shan-Yu Jiang, Song-Lin Liu, Shu-Hong Jiang,

OBJECTIVE:To study the efficacy and safety of caffeine used in the early (≤72 hours after birth) and late (>72 hours after birth) stage in preterm infants with a gestational age of ≤31 weeks. METHODS:A retrospective analysis was performed for 640 preterm infants (with a gestational age of ≤31 weeks) who ... Read more >>

Zhongguo Dang Dai Er Ke Za Zhi (Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics)
[2020, 22(2):130-135]

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Effectiveness of nCPAP for moderate preterm infants compared to BiPAP: A Randomized, Controlled Non-Inferiority Trial.

Mi-Ji Lee, Eui Kyung Choi, Kyu Hee Park, Jeonghee Shin, Byung Min Choi,

BACKGROUND:Bilevel positive airway pressure (BiPAP) has recently been used in preterm infants with respiratory distress as an alternative to nasal continuous positive airway pressure (nCPAP) because, theoretically, BiPAP is thought to be more effective than nCPAP. However, the results of some studies comparing nCPAP with BiPAP as the initial respiratory ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2020, 62(1):59-64]

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Improving Sleep for Hospitalized Antepartum Patients: A Non-Randomized Controlled Pilot Study.

Kathryn A. Lee, Caryl L. Gay,

Study Objectives:To evaluate feasibility and efficacy of a hospital-based protocol for improving sleep in high- risk antepartum patients.Methods:Sleep measures were compared during 1 week of hospitalization before and after implementing a Sleep Improvement Protocol for Antepartum Patients (SIP-AP). A non-randomized convenience sample of usual care controls was compared to a ... Read more >>

J Clin Sleep Med (Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine)
[0, 13(12):1445-1453]

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Management of Restless Legs Syndrome in Pregnancy and Lactation.

Marjan Jahani Kondori, Bhanu Prakash Kolla, Katherine M Moore, Meghna P Mansukhani,

Restless legs syndrome (RLS) affects about 20% of all pregnant women. RLS symptoms are usually moderate to severe in intensity during pregnancy and can result in insomnia, depression, and other adverse outcomes. Although iron deficiency has been implicated as a potential etiological factor, other mechanisms can also play a role. ... Read more >>

J Prim Care Community Health (Journal of primary care & community health)
[2020, 11:2150132720905950]

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Time-Course Evaluation of Body Mass Index in Japanese Children With Obstructive Sleep Apnea Syndrome After Adenotonsillectomy: A Three-Years Follow-Up Study.

Ken Fukuda, Hiroki Yasudo, Naoki Ohta, Hiroko Narumi, Nozomi Abe, Shunsuke Tarumoto, Hiroshi Yamashita, Kiyoshi Ichihara, Shouichi Ohga, Shunji Hasegawa,

Delayed physical growth is a common complication of pediatric obstructive sleep apnea syndrome (OSAS). Adenotonsillectomy (AT) is the first-line treatment for pediatric OSAS. Only a few studies have performed time-course BMI evaluation in pediatric OSAS patients post-operatively. Thus, we aimed to evaluate the time-course changes in pediatric OSAS patients after ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:22]

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Respiratory failure and death in vulnerable premature children with lower respiratory tract illness.

Gaston Ofman, Brad Pradarelli, Mauricio T Caballero, Alejandra Bianchi, Luciano Alva Grimaldi, Andrea Sancilio, Karina Duenas, Andrea Rodriguez, Fernando Ferrero, Adrian Ferretti, Silvina Coviello, Fausto M Ferolla, Patricio L Acosta, Eduardo Bergel, Romina Libster, Fernando P Polack,

BACKGROUND:Efforts to better understand the risk factors associated with respiratory failure (RF) and fatal LRTI in premature children in developing countries are necessary to elaborate evidenced-based preventive interventions. We aim to characterize the burden of RSV and hMPV LRTI in premature children and determine risk factors for RF and fatal ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2020, :]

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A Survey of Heart Anomaly Detection Using Ambulatory Electrocardiogram (ECG).

Hong Zu Li, Pierre Boulanger,

Cardiovascular diseases (CVDs) are the number one cause of death globally. An estimated 17.9 million people die from CVDs each year, representing 31% of all global deaths. Most cardiac patients require early detection and treatment. Therefore, many products to monitor patient's heart conditions have been introduced on the market. Most ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2020, 20(5):]

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Editorial: Sudden Unexpected Death in Epilepsy: Bio-markers, Mechanisms, Risk Identification and Prevention.

Rainer Surges, Michael R Sperling, Christopher M DeGiorgio,

Front Neurol (Frontiers in neurology)
[2019, 10:1277]

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Monitoring of Infants Discharged Home with Medical Devices.

Pradeep Velumula, Sanket Jani, Neelakanta Kanike, Sanjay Chawla,

Preterm infants and term infants with complex medical conditions are often discharged home with technological support. There is a scarcity of evidence-based guidelines for post-discharge management of these infants at high risk. Common diagnoses necessitating the need for respiratory support and/or monitoring devices include apnea of prematurity and bronchopulmonary dysplasia ... Read more >>

Pediatr Ann (Pediatric annals)
[2020, 49(2):e88-e92]

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