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Antiepileptic Drugs

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7-Acylamino-3H-1,2-benzoxathiepine 2,2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors.

Aleksandrs Pustenko, Alessio Nocentini, Anastasija Balašova, Mikhail Krasavin, Raivis Žalubovskis, Claudiu T Supuran,

A series of 3H-1,2-benzoxathiepine 2,2-dioxides incorporating 7-acylamino moieties were obtained by an original procedure starting from 5-nitrosalicylaldehyde, which was treated with propenylsulfonyl chloride followed by Wittig reaction of the bis-olefin intermediate. The new derivatives, belonging to the homosulfocoumarin chemotype, were assayed as inhibitors of the zinc metalloenzyme carbonic anhydrase (CA, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):650-656]

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Therapeutic Drug Monitoring of Antiepileptic Drugs in Women with Epilepsy Before, During, and After Pregnancy.

Inge J Arfman, Elisabeth A Wammes-van der Heijden, Peter G J Ter Horst, Danielle A Lambrechts, Ilse Wegner, Daan J Touw,

During pregnancy, the pharmacokinetics of an antiepileptic drug is altered because of changes in the clearance capacity and volume of distribution. These changes may have consequences for the frequency of seizures during pregnancy and fetal exposure to antiepileptic drugs. In 2009, a review was published providing guidance for the dosing ... Read more >>

Clin Pharmacokinet (Clinical pharmacokinetics)
[2020, 59(4):427-445]

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Differential Inhibition of Human Nav1.2 Resurgent and Persistent Sodium Currents by Cannabidiol and GS967.

Emily R Mason, Theodore R Cummins,

Many epilepsy patients are refractory to conventional antiepileptic drugs. Resurgent and persistent currents can be enhanced by epilepsy mutations in the Nav1.2 channel, but conventional antiepileptic drugs inhibit normal transient currents through these channels, along with aberrant resurgent and persistent currents that are enhanced by Nav1.2 epilepsy mutations. Pharmacotherapies that ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(7):]

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Association of HIV Infection with Epilepsy and Other Comorbid Conditions.

Dario Cattaneo, Andrea Giacomelli, Davide Minisci, Noemi Astuti, Paola Meraviglia, Cristina Gervasoni,

Here, we aimed to investigate the associations of comorbidities in HIV patients given antiepileptic drugs. HIV patients given antiepileptic drugs for at least 6 months were considered. Comorbidities of the epileptic, HIV-positive patients were stratified according to patients' age and causes of epilepsy. Seventy-four of the 97 HIV patients identified had ... Read more >>

AIDS Behav (AIDS and Behavior)
[2020, 24(4):1051-1055]

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All about pain pharmacology: what pain physicians should know.

Kyung-Hoon Kim, Hyo-Jung Seo, Salahadin Abdi, Billy Huh,

From the perspective of the definition of pain, pain can be divided into emotional and sensory components, which originate from potential and actual tissue damage, respectively. The pharmacologic treatment of the emotional pain component includes antianxiety drugs, antidepressants, and antipsychotics. The anti-anxiety drugs have anti-anxious, sedative, and somnolent effects. The ... Read more >>

Korean J Pain (The Korean journal of pain)
[2020, 33(2):108-120]

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Epilepsy, antiepileptic drugs and dementia.

Ettore Beghi, Massimiliano Beghi,

PURPOSE OF REVIEW:To illustrate the frequency and trends of the comorbidity of epilepsy and dementia and the effects of antiepileptic drugs (AEDs) on cognitive functions. RECENT FINDINGS:Although the mortality and incidence of epilepsy are decreasing overall, they are increasing in the elderly as a result of population growth and increased ... Read more >>

Curr. Opin. Neurol. (Current opinion in neurology)
[2020, 33(2):191-197]

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Anti-Epileptogenic Effects of Antiepileptic Drugs.

Barbara Miziak, Agnieszka Konarzewska, Marzena Ułamek-Kozioł, Monika Dudra-Jastrzębska, Ryszard Pluta, Stanisław J Czuczwar,

Generally, the prevalence of epilepsy does not exceed 0.9% of the population and approximately 70% of epilepsy patients may be adequately controlled with antiepileptic drugs (AEDs). Moreover, status epilepticus (SE) or even a single seizure may produce neurodegeneration within the brain and SE has been recognized as one of acute ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(7):]

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Drug-Drug Interactions Between Antiretrovirals and Carbamazepine/Oxcarbazepine: A Real-Life Investigation.

Dario Cattaneo, Sara Baldelli, Valeria Cozzi, Marta Fusi, Chiara Atzori, Valeria Micheli, Carlo Filice, Cristina Gervasoni,

BACKGROUND:Carbamazepine and oxcarbazepine are potent modulators of metabolic enzymes. Hence, potential drug-drug interactions (DDIs) may occur between these 2 drugs and antiretrovirals. Here, we aimed to assess the relevance of these drug-drug interactions in real-life clinical settings. METHODS:Patients treated concomitantly with carbamazepine or oxcarbazepine and antiretrovirals for at least 3 ... Read more >>

Ther Drug Monit (Therapeutic drug monitoring)
[2020, 42(2):330-334]

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How do pediatric patients perceive adverse drug events of anticonvulsant drugs? A survey.

Martina Patrizia Neininger, Sarah Woltermann, Sarah Jeschke, Birthe Herziger, Ruth Melinda Müller, Wieland Kiess, Thilo Bertsche, Astrid Bertsche,

Anticonvulsant drugs have a high risk of adverse drug events. Little is known about the perception of those events by pediatric patients. We performed a survey in the neuropediatric departments of two university hospitals. Using a questionnaire, we interviewed patients aged 6-18 years with current anticonvulsant treatment regarding (i) their fears ... Read more >>

Eur. J. Pediatr. (European Journal of Pediatrics)
[2020, :]

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Vitamin D deficiency in pediatric patients using antiepileptic drugs: systematic review with meta-analysis.

Cíntia Junges, Tania Diniz Machado, Paulo Ricardo Santos Nunes Filho, Rudimar Riesgo, Elza Daniel de Mello,

OBJECTIVES:To measure the prevalence of vitamin D deficiency (through the 25-hydroxyvitamin D metabolite) in pediatric patients using antiepileptic drugs. SOURCE OF DATA:Meta-analysis of studies identified through search in the PubMed, Embase, LILACS, and Cochrane Library databases, on February 19, 2019. SUMMARY OF DATA:A total of 748 articles were identified, 29 ... Read more >>

J Pediatr (Rio J) (Jornal de pediatria)
[2020, :]

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Understanding the challenge of comparative effectiveness research in focal epilepsy: A review of network meta-analyses and real-world evidence on antiepileptic drugs.

Solène Thieffry, Pavel Klein, Michel Baulac, Jonathan Plumb, Barbara Pelgrims, Sara Steeves, Simon Borghs,

OBJECTIVE:Head-to-head randomized controlled trials (RCTs) are the gold standard for assessing comparative treatment effects. In the absence of direct comparisons between all possible antiepileptic drugs (AEDs), however, clinical decision-making in focal (partial onset) epilepsy relies on alternative evidence borne from indirect comparisons including network meta-analyses (NMAs) and from real-world evidence ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

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Psychotropic Drug-Associated Pneumonia in Older Adults.

Blair Rajamaki, Sirpa Hartikainen, Anna-Maija Tolppanen,

The use of psychotropic drugs (antipsychotics, benzodiazepines and benzodiazepine-related drugs, and antidepressants) is common, with a prevalence estimates range of 19-29% among community dwelling older adults. These drugs are often prescribed for off-label use, including neuropsychiatric symptoms. The older adult population also has high rates of pneumonia and some of ... Read more >>

Drugs Aging (Drugs & aging)
[2020, 37(4):241-261]

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Different experiences of two PRRT2-associated self-limited familial infantile epilepsy.

Qianlei Zhao, Zhenwei Liu, Ying Hu, Shiyu Fang, Feixia Zheng, Xiucui Li, Feng Li, Zhongdong Lin,

To analyze the clinical characteristics and PRRT2 gene mutation of self-limited familial infantile epilepsy and evaluate the treatment responses of different antiepileptic drugs in self-limited familial infantile epilepsy. We reviewed the clinical feature and genetic mutation results and treatment responses of two sibling sisters. They were detected with the PRRT2 ... Read more >>

Acta Neurol Belg (Acta neurologica Belgica)
[2020, :]

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A case of GABRA5-related developmental and epileptic encephalopathy with response to a combination of antiepileptic drugs and a GABAering agent.

Ponghatai Boonsimma, Sirorat Suwannachote, Chureerat Phokaew, Chupong Ittiwut, Kanya Suphapeetiporn, Vorasuk Shotelersuk,

BACKGROUND:GABAA receptors are ligand-gated chloride channels that regulate inhibitory neurotransmission in the central nervous system. Recently, monoallelic de novo mutations in GABRA5 resulting in altered inhibitory synapses were found in three patients with developmental and epileptic encephalopathy. Patient description: We report on a four-year and six-month-old girl with epilepsy and ... Read more >>

Brain Dev. (Brain & development)
[2020, :]

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Second-line anticonvulsants for paediatric convulsive status epilepticus.

Richard E Appleton,

Lancet (Lancet (London, England))
[2020, :]

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Double Crossed: A Case of La Crosse Encephalitis.

Ann Ding, Burton Shen, Sarah Elliott, Khushbu Joshi, Daniel Coghlin, Suzanne McLaughlin,

CASE REPORT:A 10-year-old male with T1DM and recent travel to North Carolina presented to an ED with 1 day of fever, vomiting, and headaches. He was discharged home with the presumptive diagnosis of viral gastroenteritis but returned nine hours later, agitated, and unable to speak. CSF showed pleocytosis. MRI brain ... Read more >>

R I Med J (2013) (Rhode Island medical journal (2013))
[2020, 103(3):59-62]

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[Effectiveness of ketamine in the treatment of refractory and super-refractory status epilepticus in children].

J Wu, Q Wang, S Y Qian, H M Gao, J Liu, J Deng, J S Zeng,

Objective: To investigate the effectiveness of ketamine in the treatment of refractory status epilepticus (RSE) and super refractory status epilepticus (SRSE) in children. Methods: A retrospective study was conducted to collect and analyze the medical data of 18 children with RSE or SRSE who received ketamine in intensive care unit ... Read more >>

Zhonghua Er Ke Za Zhi (Zhonghua er ke za zhi = Chinese journal of pediatrics)
[2020, 58(4):295-300]

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[Treatment of polyneuropathy: autonomic symptoms and pain].

J Sachau, S-C Fabig, S Rehm, R Baron,

BACKGROUND:The treatment of polyneuropathy includes symptomatic therapy of sensory, motor and autonomic dysfunctions. AIM:This article provides an overview of the current treatment recommendations for polyneuropathy, focusing on pain. METHODS:Current treatment guidelines will be discussed based on a literature research. RESULTS:Calcium-channel anticonvulsants gabapentin/pregabalin as well as antidepressants duloxetine and amitriptyline are recommended ... Read more >>

Internist (Berl) (Der Internist)
[2020, 61(3):270-276]

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[Epilepsy in old age].

Kai Siebenbrodt, Adam Strzelczyk, Felix Rosenow,

In an aging society, epilepsy in old age will become a more and more relevant disease. The diagnosis is often difficult because of the frequent occurrence of focal seizures in old age, which are easily overlooked. The diagnosis is often delayed, particularly in older patients who, for example also suffer from ... Read more >>

Nervenarzt (Der Nervenarzt)
[2020, :]

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Clinical and biological assessment of lamotrigine and levetiracetam plasma assays at the Rennes University Hospital.

B Le Daré, A Degremont, E Polard, I Morel, A Biraben, T Gicquel,

INTRODUCTION:Requests for lamotrigine and levetiracetam plasma assays have increased significantly since their development in the biological and forensic toxicology laboratory at the University Hospital of Rennes in 2015. The purpose of this study was to evaluate the follow-up of French National Authority for Health (HAS) guidelines for antiepileptic drug assays ... Read more >>

Rev. Neurol. (Paris) (Revue neurologique)
[2020, :]

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Design, synthesis and docking studies of novel benzopyrone derivatives as anticonvulsants.

Walaa Hamada Abd-Allah, Essam Eldin A Osman, Mostafa Abd-El-Mohsen Anwar, Hanan Naeim Attia, Samir M El Moghazy,

A series of coumarin derivatives 6-8, 9a-h, 11 and 13a, b -16a, b was synthesized and screened for their anticonvulsant profile. Screening of these analogues using the 'gold standard methods' revealed variable anticonvulsant potential with remarkable effects observed particularly in chemically-induced seizure test. Compounds 6, 7, 13b disclosed the highest ... Read more >>

Bioorg. Chem. (Bioorganic chemistry)
[2020, 98:103738]

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Sexual Dysfunction and Mood Stabilizers in Long-Term Stable Patients With Bipolar Disorder.

Ana García-Blanco, María P García-Portilla, Lorena de la Fuente-Tomás, María Batalla, Mónica Sánchez-Autet, Belén Arranz, Gemma Safont, Sergio Arqués, Lorenzo Livianos, Pilar Sierra,

BACKGROUND:In addition to factors intrinsic to bipolar disorder (BD), sexual functioning (SF) can be affected by extrinsic causes, such as psychotropic drugs. However, the effect of mood stabilizers on SF and quality of life (QoL) is an underexplored research area. AIM:To analyze SF in BD outpatients in euthymia for at ... Read more >>

J Sex Med (The journal of sexual medicine)
[2020, :]

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Evaluation of adverse drug reaction profile of antiepileptic drugs in persons with epilepsy: A cross-sectional study.

Sachin Kumar, Sudhir Chandra Sarangi, Manjari Tripathi, Yogendra Kumar Gupta,

INTRODUCTION:Newer antiepileptic drugs (AEDs) are preferred over conventional AEDs with the perception of better safety profile and efficacy though there is a lack of confirmatory evidence. The present study assessed the adverse drug reactions' (ADRs) profile of AEDs prescribed in persons with epilepsy (PWE) as per the System Organ Class ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 105:106947]

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Determination of Perampanel in Dried Plasma Spots: Applicability to Therapeutic Drug Monitoring.

Valentina Franco, Katia Baruffi, Roberto Marchiselli, Francesca Crema, Cinzia Fattore, Andrea Romigi, Valentina De Giorgis, Elena Tartara, Maurizio Elia, Antonio DʼAvolio, Emilio Perucca,

BACKGROUND:Although therapeutic drug monitoring of antiepileptic drugs is typically based on the analysis of plasma samples, alternative matrices, such as dried plasma spots (DPSs), may offer specific advantages. The aims of this work were to (1) develop and validate a bioanalytical method for the quantitative determination of the second-generation antiepileptic ... Read more >>

Ther Drug Monit (Therapeutic drug monitoring)
[2020, 42(2):309-314]

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Effects of Antiepileptic Drug Tapering on Episodic Memory as Measured by Virtual Reality Tests.

Yvonne Höller, Christopher Höhn, Fabian Schwimmbeck, Gaën Plancher, Eugen Trinka,

Antiepileptic drugs impair episodic memory in patients with epilepsy, but this effect has so far only been examined with tests that do not provide first-person experience-an aspect that is crucial for episodic memory. Virtual reality techniques facilitate the development of ecologically valid tests. In the present study, we measure the ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:93]

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