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Angiogenesis

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Fat grafting and platelet-rich plasma in wound healing: a review of histology from animal studies.

Grant S Nolan, Oliver J Smith, Gavin Jell, Afshin Mosahebi,

Stem cells could form the basis of a novel, autologous treatment for chronic wounds like diabetic foot ulcers. Fat grafts contain adipose-derived stem cells (ADSC) but low survival of cells within the grafts is a major limitation. Platelet-rich plasma (PRP) may increase graft survival. This review examines the histology from ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):80-90]

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Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway.

Shengming Huang, Zhanguo Tan, Jirui Cai, Zhiping Wang, Yuejun Tian,

<h4>Context</h4>Cerebral ischaemia/reperfusion (I/R) injury has a high disability and fatality worldwide. Myrtenol has protective effects on myocardial I/R injury through antioxidant and anti-apoptotic effects.<h4>Objective</h4>This study investigated the effect of myrtenol on cerebral ischaemia/reperfusion (I/R) injury and the underlying mechanism.<h4>Materials and methods</h4>Cerebral I/R injury was induced in adult Sprague-Dawley rats by ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):584-593]

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Tumor-derived exosomal miRNA-141 promote angiogenesis and malignant progression of lung cancer by targeting growth arrest-specific homeobox gene (GAX).

Wulong Wang, Guodai Hong, Siyuan Wang, Wenbin Gao, Ping Wang,

Previous researches have suggested that exosomal miRNA-141 has association with metastatic lung cancer, however, its role and regulatory mechanism require further study. In this study, exosomes were isolated from lung cancer patients and normal human serum and identified. We found that the expression of miRNA-141 was up-regulated in the lung ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):821-831]

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Accelerative effect of topical Zataria multiflora essential oil against infected wound model by modulating inflammation, angiogenesis, and collagen biosynthesis.

Mohammad Reza Farahpour, Sara Sheikh, Elham Kafshdooz, Ali Sonboli,

<h4>Context</h4><i>Zataria multiflora</i> Boiss (Lamiaceae) essential oil (ZME) is believed to be a bactericide herbal medicine and might alleviate negative effects of infection.<h4>Objective</h4>This study evaluates the effects of an ointment prepared from ZME (ZMEO) on infected wounds.<h4>Materials and methods</h4>A full-thickness excisional skin wound was surgically created in each mouse and inoculated ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1-10]

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MAGI1 localizes to mature focal adhesion and modulates endothelial cell adhesion, migration and angiogenesis.

Begoña Alday-Parejo, Kedar Ghimire, Oriana Coquoz, Gioele W Albisetti, Luca Tamò, Jelena Zaric, Jimmy Stalin, Curzio Rüegg,

MAGI1 is an intracellular adaptor protein that stabilizes cell junctions and regulates epithelial and endothelial integrity. Here, we report that that in endothelial cells MAGI1 colocalizes with paxillin, β3-integrin, talin 1, tensin 3 and α-4-actinin at mature focal adhesions and actin stress fibers, and regulates their dynamics. Downregulation of MAGI1 ... Read more >>

Cell Adh Migr (Cell adhesion & migration)
[2021, 15(1):126-139]

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Oral squamous cell carcinoma (OSCC)-derived exosomal MiR-221 targets and regulates phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) to promote human umbilical vein endothelial cells migration and tube formation.

Shuqi He, Wu Zhang, Xian Li, Junjie Wang, Xufeng Chen, Yu Chen, Renfa Lai,

Oral squamous cell carcinoma (OSCC) is the most common tumor of the oral cavity. Studies have shown that exosomal miRNAs from cancer cells play an important role in mediating the cellular environment. The objective was to investigate the effect of OSCC-derived exosomes microRNA-221 (miR-221) in OSCC. We used quantitative real-time ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2164-2174]

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The Inhibitory Effect of Icariin Nanoparticles on Angiogenesis in Pulmonary Fibrosis.

Jiahao Wang, Yuying Sun, Xiangtong Tian,

This study investigated icariin (ICA) nanoparticles on angiogenesis in rats with pulmonary fibrosis and its mechanism. First, icariin solid nanoliposomes (ICA-SLN) were prepared. The <i>in vitro</i>release of icariin nanoparticles was determined using a UV-Vis spectrophotometer, after which the plasma concentration of icariin nanoparticles in rats was determined. The bioavailability of ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(11):5429-5435]

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Vinegar-processed Curcuma phaeocaulis promotes anti-angiogenic activity and reduces toxicity in zebrafish and rat models.

Wan Liao, Yi Chen, Zongping Zhu, Jiao Chen, Tianhui Gao, Boonjai Limsila, Yenchit Techadamrongsin, Lei Wang, Jiali Yu, Chaomei Fu, Rui Li,

<h4>Context</h4>Processing with vinegar could enhance the efficacy and reduce the toxicity of <i>Curcuma phaeocaulis</i> Valeton. (Zingiberaceae), a Chinese herbal medicine with anti-inflammatory and antitumor activities.<h4>Objective</h4>This study investigated the vinegar processing effects by evaluating anti-angiogenic effect and toxicity of <i>C. phaeocaulis</i> through zebrafish and rat models.<h4>Materials and methods</h4>Zebrafish embryos (AB and ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):410-417]

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All-trans retinoic acid regulating angiopoietins-1 and alleviating extracellular matrix accumulation in interstitial fibrosis rats.

Zhiqing Zhong, Hong-Yan Li, Hongzhen Zhong, Wenshan Lin, Shujun Lin, Tianbiao Zhou,

All-trans retinoic acid (ATRA) is one of essentially active metabolite of vitamin A, and plays an important role in diverse physiological processes, such as cellular growth and function. Renal interstitial fibrosis (RIF) is a common pathological characteristic of chronic renal disease causing end-stage renal disease currently lacking effective treatment. Low ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):658-663]

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Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer.

Hongjun Guan, Changpeng Sun, Yinfeng Gu, Jinjin Li, Jie Ji, Yongxian Zhu,

Non-small cell lung cancer (NSCLC) is a common malignant tumor, with high morbidity and mortality. Circular RNA (circRNA) circ_0003028 was reported to be upregulated in NSCLC. This study is designed to explore the role and mechanism of circ_0003028 on NSCLC progression. In this work, circ_0003028, microRNA-1298-5p (miR-1298-5p), and glutamic oxaloacetic ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2326-2340]

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Is carbonic anhydrase inhibition useful as a complementary therapy of Covid-19 infection?

Secil Deniz, Tugba Kevser Uysal, Clemente Capasso, Claudiu T Supuran, Ozen Ozensoy Guler,

The ongoing Covid-19 is a contagious disease, and it is characterised by different symptoms such as fever, cough, and shortness of breath. Rising concerns about Covid-19 have severely affected the healthcare system in all countries as the Covid-19 outbreak has developed at a rapid rate all around the globe. Intriguing, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):1230-1235]

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Alterations of long non-coding RNA and mRNA profiles associated with extracellular matrix homeostasis and vascular aging in rats.

Qianqin Li, Zezhou Xiao, Yongsheng Wang, Ximao Liu, Hao Liu, Zhiwen Luo, Shaoyi Zheng,

Vascular aging has been closely associated with various cardiovascular disorders; however, its molecular mechanism remains poorly understood. In our study, RNA sequencing was utilized to explore the expression profiles of long non-coding RNAs (lncRNAs) and mRNAs in the thoracic aortas of young (3 weeks) and old (16 weeks) rats. Functional categorization of ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):832-843]

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Hippo signaling pathway in companion animal diseases, an under investigated signaling cascade.

Shaydee J Budel, Marloes M Penning, Louis C Penning,

The Hippo pathway is a highly conserved kinase cascade in mammals with the proteins YAP and TAZ as its most important downstream effectors that shuttle between cytoplasma and nucleus. It has a crucial role in processes such as embryogenesis, organ size control, homeostasis and tissue regeneration, where mechanosensing and/or cell-cell ... Read more >>

Vet Q (The veterinary quarterly)
[2021, 41(1):172-180]

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A novel imidazolinone metformin-methylglyoxal metabolite promotes endothelial cell angiogenesis via the eNOS/HIF-1α pathway.

Huong Nguyen, Jia Yi Koh, Hainan Li, Argel Islas-Robles, Sai Pranathi Meda Venkata, Jie-Mei Wang, Terrence J Monks,

Peripheral arterial disease (PAD) is one of the major complications of diabetes due to an impairment in angiogenesis. Since there is currently no drug with satisfactory efficacy to enhance blood vessel formation, discovering therapies to improve angiogenesis is critical. An imidazolinone metabolite of the metformin-methylglyoxal scavenging reaction, (E)-1,1-dimethyl-2-(5-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl) guanidine (IMZ), ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21645]

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The interaction of stem cells and vascularity in peripheral nerve regeneration.

Sara Saffari, Tiam M Saffari, Dietmar J O Ulrich, Steven E R Hovius, Alexander Y Shin,

The degree of nerve regeneration after peripheral nerve injury can be altered by the microenvironment at the site of injury. Stem cells and vascularity are postulated to be a part of a complex pathway that enhances peripheral nerve regeneration; however, their interaction remains unexplored. This review aims to summarize current ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(8):1510-1517]

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Effects of Silver Nanoparticles and Silver Nitrate on mRNA and microRNA Expression in Human Hepatocellular Carcinoma Cells (HepG2).

Sheau-Fung Thai, Carlton P Jones, Brian L Robinette, Hongzu Ren, Beena Vallanat, Anna A Fisher, Kirk T Kitchin,

In order to understand toxicity of nano silver, human hepatocellular carcinoma (HepG2) cells were treated either with silver nitrate (AgNO₃) or with nano silver capped with glutathione (Ag-S) at various concentration. Differentially expressed genelists for mRNA and microRNA were obtained through Illumina RNA sequencing and DEseq data analyses. Both treatments ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(11):5414-5428]

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Cutting Edge: Novel Treatment Options Targeting Corneal Neovascularization to Improve High-Risk Corneal Graft Survival.

Claus Cursiefen, Deniz Hos,

<h4>Purpose</h4>Corneal neovascularization is an important risk factor for graft rejection after keratoplasty, although its role in posterior lamellar keratoplasty is not yet well defined. The aim of this work was to describe clinically available approaches that target corneal neovascularization preoperatively to improve graft survival after subsequent penetrating keratoplasty (PK) and ... Read more >>

Cornea (Cornea)
[2021, :]

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Novel piperazine-chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer evaluation.

Marwa F Ahmed, Eman Y Santali, Radwan El-Haggar,

New piperazine-chalcone hybrids and related pyrazoline derivatives have been designed and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors. The National Cancer Institute (NCI) has selected six compounds to evaluate their antiproliferative activity <i>in vitro</i> against 60 human cancer cells lines. Preliminary screening of the examined compounds indicated promising ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):307-318]

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Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats.

Bing Yang, Pang-Bo Wang, Ning Mu, Kang Ma, Shi Wang, Chuan-Yan Yang, Zhong-Bing Huang, Ying Lai, Hua Feng, Guang-Fu Yin, Tu-Nan Chen, Chen-Shi Hu,

The study illustrates that graphene oxide nanosheets can endow materials with continuous electrical conductivity for up to 4 weeks. Conductive nerve scaffolds can bridge a sciatic nerve injury and guide the growth of neurons; however, whether the scaffolds can be used for the repair of spinal cord nerve injuries remains ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(9):1829-1835]

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Angiogenesis and nerve regeneration induced by local administration of plasmid pBud-coVEGF165-coFGF2 into the intact rat sciatic nerve.

Ruslan Masgutov, Alina Zeinalova, Alexey Bogov, Galina Masgutova, Ilnur Salafutdinov, Ekaterina Garanina, Valeriia Syromiatnikova, Kamilla Idrisova, Adelya Mullakhmetova, Dina Andreeva, Liliya Mukhametova, Adilet Kadyrov, Igor Pankov, Albert Rizvanov,

Vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) are well-known growth factors involved in the regeneration of various tissues and organs, including peripheral nerve system. In the present study, we elucidated the local and systemic effects of plasmid construct рBud-coVEGF165-coFGF2 injected into the epineurium of intact rat ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(9):1882-1889]

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Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer.

João Fevereiro, Alexandra G Fraga, Carlos Capela, Ghislain E Sopoh, Ange Dossou, Gilbert Adjimon Ayelo, Maria João Peixoto, Cristina Cunha, Agostinho Carvalho, Fernando Rodrigues, Jorge Pedrosa,

Buruli ulcer (BU) is a devastating skin mycobacterial infection characterized by extensive cell death, which was previously suggested to be mediated by Bcl2-like protein 11 (BIM, encoded by the <i>BCL2L11</i> gene). We here report the association of genetic variants in <i>BCL2L11</i> with ulcerative forms of the disease in a cohort ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):223-225]

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The PFKFB3 Inhibitor AZ67 Inhibits Angiogenesis Independently of Glycolysis Inhibition.

Besa Emini Veseli, Pieter Van Wielendaele, Mirela Delibegovic, Wim Martinet, Guido R Y De Meyer,

Angiogenesis is the process of new blood vessel formation. In this complex orchestrated growth, many factors are included. Lately, focus has shifted to endothelial cell metabolism, particularly to the PFKFB3 protein, a key regulatory enzyme of the glycolytic pathway. A variety of inhibitors of this important target have been studied, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(11):]

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Stem cell therapy for skin regeneration using mesenchymal stem cells derived from the progeroid Werner syndrome-specific iPS cells

Shinichiro Funayama, Hisaya Kato, Hiyori Kaneko, Kentaro Kosaka, Daisuke Sawada, Aki Takada-Watanabe, Takuya Minamizuka, Yusuke Baba, Masaya Koshizaka, Akira Shimamoto, Yasuo Ouchi, Atsushi Iwama, Yusuke Endo, Naoya Takayama, Koji Eto, Yoshiro Maezawa, Koutaro Yokote,

Adult progeria, Werner syndrome (WS), is an autosomal recessive disorder that develops accelerated aging-associated symptoms after puberty. Refractory skin ulcer of limbs, which is one of the symptoms specific to WS, is seriously painful and sometimes results in amputation. In recent years, cell therapy using mesenchymal stem cells (MSCs) has ... Read more >>

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Construction of a Competitive Endogenous RNA Network Associated with Angiogenesis in Ischemic Stroke Using a Bioinformatics Approach

Jia Wang, Xuxiang Zhang, Yibo Xie, Jiachen Li, Xiaokun Wang, chunxiao yang,

Ischemic stroke (IS) is one of the leading causes of death and disability worldwide, and angiogenesis is an important target for its treatment. However, the mechanism of angiogenesis of endogenous RNA (ceRNA) in IS remains poorly understood. This study aims to explore the role of ceRNA in the angiogenesis of ... Read more >>

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Techniques used to assess intussusceptive angiogenesis: A systematic review.

Charis Du Cheyne, Marloes Smeets, Ward De Spiegelaere,

Intussusceptive angiogenesis (IA) is an important physiological form of angiogenesis in which an existing vessel splits in two by the formation of an intraluminal tissue pillar. The presence of these intraluminal pillars form the hallmark of ongoing IA in growing vascular beds. However, their visualization is technically challenging. The goal ... Read more >>

Dev Dyn (Developmental dynamics : an official publication of the American Association of Anatomists)
[2021, :]

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