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Amyloidosis

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Hypothesis: AA amyloidosis is a factor causing systemic complications after coronavirus disease.

Alexey P Galkin,

The severe course of COVID-19 causes systemic chronic inflammation and thrombosis in a wide variety of organs and tissues. The nature of these inflammations remains a mystery, although they are known to occur against the background of a high level of cytokine production. The high level of cytokines provokes overproduction ... Read more >>

Prion (Prion)
[2021, 15(1):53-55]

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Dismal Prognosis of Acute Allergic Tubulointerstitial Nephritis in Patients with AA Amyloidosis.

Tolga Yildirim, Ebru Gok-Oguz, Neriman Sila Koc, Muge Uzerk-Kibar, Meral Uner, Emine Arzu Saglam, Seref Rahmi Yilmaz, Deniz Ayli, Yunus Erdem,

Patients with AA amyloidosis may present with acute kidney injury that progresses to end-stage kidney disease in a short period of time. Acute allergic tubulointerstitial nephritis (aTIN) is a frequent cause of acute kidney injury in patients with AA amyloidosis. Although aTIN has a favorable prognosis in the general population, ... Read more >>

Nephron (Nephron)
[2021, :1-7]

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LECT-2 amyloidosis: what do we know?

Baldeep Kaur Mann, Janpreet Singh Bhandohal, Everardo Cobos, Chandrika Chitturi, Sabitha Eppanapally,

Amyloidosis is a rare group of diseases characterized by abnormal folding of proteins and extracellular deposition of insoluble fibrils. It can be localized to one organ system or can have systemic involvement. The kidney is the most common organ to be involved in systemic amyloidosis often leading to renal failure ... Read more >>

J Investig Med (Journal of investigative medicine : the official publication of the American Federation for Clinical Research)
[2021, :]

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Daratumumab plus CyBorD for patients with newly diagnosed light chain (AL) amyloidosis.

Foteini Theodorakakou, Meletios A Dimopoulos, Efstathios Kastritis,

Primary systemic immunoglobulin light chain (AL) amyloidosis is caused by a plasma cell clone of, usually low, malignant potential that expresses CD38 molecules on their surface. Treatment of AL amyloidosis is based on the elimination of the plasma cell clone. The combination of cyclophosphamide-bortezomib-dexamethasone (CyBorD) is the most widely used ... Read more >>

Ther Adv Hematol (Therapeutic advances in hematology)
[2021, 12:20406207211058334]

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Outcomes of bortezomib combination chemotherapies in autologous stem cell transplantation-ineligible patients with AL amyloidosis.

Joon Young Hur, Sang Eun Yoon, Darae Kim, Jin-Oh Choi, Ju-Hong Min, Byung Jun Kim, Jung Sun Kim, Jung Eun Lee, Joon Young Choi, Eun-Seok Jeon, Seok Jin Kim, Kihyun Kim,

<h4>Background</h4>Treatment protocols for light chain (AL) amyloidosis have been derived from myeloma treatment. Bortezomib is a key drug used for the treatment of myeloma and AL amyloidosis. We retrospectively investigated the efficacy and toxicity of bortezomib-based chemotherapy in patients with newly diagnosed AL amyloidosis.<h4>Methods</h4>We reviewed the outcomes of newly diagnosed ... Read more >>

Blood Res (Blood research)
[2021, :]

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Early serum free light chain response after high-dose melphalan and stem cell transplantation predicts hematologic response in AL amyloidosis.

Vanessa Fiorini Furtado, Dina Brauneis, Janice Weinberg, Noon Elhassan, J Mark Sloan, Vaishali Sanchorawala,

Bone Marrow Transplant (Bone marrow transplantation)
[2021, :]

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A rare case of intramuscular orbital amyloidosis presenting as progressive esotropia in an adult.

Md Shahid Alam, Prabrisha Banerjee,

Orbital amyloidosis is an uncommon entity. Lacrimal gland, orbital soft tissue and extraocular muscles are the usual sites of involvement. Deposition of amyloid in the extraocular muscle can be either isolated or associated with systemic amyloidosis. We describe a case of a 43-year-old male with isolated amyloid infiltration of the ... Read more >>

Orbit (Orbit (Amsterdam, Netherlands))
[2021, :1-5]

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Current and Emerging Therapies for Hereditary Transthyretin Amyloidosis: Strides Towards a Brighter Future.

Laura Obici, Roberta Mussinelli,

The past few years have witnessed an unprecedented acceleration in the clinical development of novel therapeutic options for hereditary transthyretin amyloidosis. Recently approved agents and drugs currently under investigation not only represent a major breakthrough in this field but also provide validation of the therapeutic potential of innovative approaches, like ... Read more >>

Neurotherapeutics (Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics)
[2021, :]

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De Novo AL Amyloidosis in Renal Allograft and Anti-CD38 Monoclonal Antibody Treatment.

Despina Fotiou, Chrysanthi Skalioti, George Liapis, Smaragdi Marinaki, Efstathios Kastritis,

Hemasphere (HemaSphere)
[2021, 5(12):e665]

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Guidelines for high dose chemotherapy and stem cell transplantation for systemic AL amyloidosis: EHA-ISA working group guidelines.

Vaishali Sanchorawala, Mario Boccadoro, Morie Gertz, Ute Hegenbart, Efstathios Kastritis, Heather Landau, Peter Mollee, Ashutosh Wechalekar, Giovanni Palladini,

AL amyloidosis is a systemic amyloidosis and is associated with an underlying plasma cell dyscrasia. High dose intravenous melphalan and autologous stem cell transplantation was developed for the treatment of AL amyloidosis in the early 1990s and was prompted by its success in multiple myeloma. This application has evolved significantly ... Read more >>

Amyloid (Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis)
[2021, :1-7]

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Dual-Echo Turbo Spin Echo and 12-Echo Multi Spin Echo Sequences as Equivalent Techniques for Obtaining T2-Relaxometry Data: Application in Symptomatic and Asymptomatic Hereditary Transthyretin Amyloidosis as a Surrogate Disease.

Anysia Poncelet, Markus Weiler, Ute Hegenbart, Georges Sam, Stefan Schönland, Jan C Purrucker, John M Hayes, Ernst Hund, Martin Bendszus, Sabine Heiland, Jennifer Kollmer,

<h4>Objectives</h4>Multi spin echo (MSE) sequences are often used for obtaining T2-relaxometry data as they provide defined echo times (TEs). Due to their time-consuming acquisition, they are frequently replaced by turbo spin echo (TSE) sequences that in turn bear the risk of systematic errors when analyzing small structures or lesions. With ... Read more >>

Invest Radiol (Investigative radiology)
[2021, :]

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Targeted treatments of AL and ATTR amyloidosis.

Pranav Chandrashekar, Anish K Desai, Barry H Trachtenberg,

The therapeutic landscape for cardiac amyloidosis is rapidly evolving. In the last decade, our focus has shifted from dealing with the inevitable complications of continued extracellular infiltration of amyloid fibrils to earlier identification of these patients with prompt initiation of targeted therapy to prevent further deposition. Although much of the ... Read more >>

Heart Fail Rev (Heart failure reviews)
[2021, :]

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Corrigendum to Heybeli C, Bentall A, Wen J, et al. A study from The Mayo Clinic evaluated long-term outcomes of kidney transplantation in patients with immunoglobulin light chain amyloidosis. Kidney Int. 2021;99:707-715.

Cihan Heybeli, Andrew Bentall, Jiqiu Wen, Mariam Priya Alexander, Francis K Buadi, Fernando G Cosio, Patrick G Dean, Angela Dispenzieri, David Dingli, Mireille El Ters, Morie A Gertz, Hatem Amer, Prashant Kapoor, Hasan Khamash, Taxiarchis Kourelis, Shaji Kumar, Elizabeth C Lorenz, Martin Mai, Eli Muchtar, David L Murray, Mikel Prieto, Carrie A Schinstock, Mark D Stegall, Rahma Warsame, Nelson Leung,

Kidney Int (Kidney international)
[2021, 100(6):1348-1349]

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[A rare cause of AA amyloidosis: Hereditary epidermolysis bullosa].

Rim Chaabouni, Meriem Amouri, Chiraz Chaari, Yosra Bouattour, Khadija Sellami, Zouheir Bahloul, Tahiya Boudawara, Hamida Turki,

<h4>Introduction</h4>Recessive dystrophic epidermolysis bullosa is a rare genetic condition characterized by fragile skin and mucous membrane, caused by mutations in the COL7A1 gene. AA amyloidosis is a rare complication of these genodermatosis.<h4>Observations</h4>Two patients with recessive dystrophic epidermolysis bullosa, generalized severe in the first case and generalized intermediate in the second case, ... Read more >>

Nephrol Ther (Nephrologie & therapeutique)
[2021, :]

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Anaesthetic challenges in the spine surgery of a young Asian man with lumbar amyloidosis.

Jabraan Jamil, Chong Yan Tay, Chin Pei Bong, Tat Boon Yeap,

Primary amyloidosis is a rare systemic disorder often associated with multiple organ dysfunction. The most common form, light chain amyloidosis, has an estimated age-adjusted incidence of 5.1-12.8 cases per million person-years. Spine involvement is extremely uncommon. We present the case of a young Asian man with newly diagnosed amyloidosis involving ... Read more >>

BMJ Case Rep (BMJ case reports)
[2021, 14(11):]

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Systemic amyloidosis derived from EFEMP1 in a captive Tsushima leopard cat.

Shinya Miyazaki, Yuki Kobayashi, Fuyuki Kametani, Kyoko Kobayashi, Susumu Iwaide, Tokuma Yanai, Tomoaki Murakami,

In animals, most cases of systemic amyloidosis are of amyloid A type, and the other types of systemic amyloidoses are rare. This study analyzed systemic amyloidosis in a 15-year-old female Tsushima leopard cat. Amyloid deposits strongly positive for Congo red staining were observed in the arterial walls as well as ... Read more >>

Vet Pathol (Veterinary pathology)
[2021, :3009858211048650]

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Primary bladder amyloidosis mimicking bladder cancer complicated by bladder rupture: A case report.

Rayan M Sibira, Ahmed Albakar, Nagy Younes, Issam A Albozom, Khalid Al Rumaihi,

Amyloidosis is related to the extracellular deposition of abnormal protein fibrils in various tissues. It can be either localized to an organ or generalized, affecting multiple systems. Amyloidosis of the urinary bladder is a rare histopathological finding. It is clinically interesting that such cases' clinical, radiological, and even endoscopic presentation ... Read more >>

Clin Case Rep (Clinical case reports)
[2021, 9(11):e05140]

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Family history of plasma cell disorders is associated with improved survival in MGUS, multiple myeloma, and systemic AL amyloidosis.

Alissa Visram, Celine Vachon, Linda B Baughn, Dirk Larson, James Smadbeck, Angela Dispenzieri, Prashant Kapoor, Martha Q Lacy, Morie A Gertz, Francis K Buadi, Suzanne R Hayman, David Dingli, Taxiarchis Kourelis, Wilson Gonsalves, Rahma Warsame, Eli Muchtar, Nelson Leung, Robert A Kyle, S Vincent Rajkumar, Shaji Kumar,

The association between familial plasma cell disorders (PCD) and prognosis in patients with MGUS, multiple myeloma (MM), and systemic light chain (AL) amyloidosis has not been well described. This study retrospectively reviewed outcomes of 25,423 patients (16,744 MGUS, 6194 MM, 2955 AL amyloidosis). Overall, 2.7% of patients reported having a ... Read more >>

Leukemia (Leukemia)
[2021, :]

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Thromboembolism and bleeding in systemic amyloidosis: a review.

Martin Nicol, Virginie Siguret, Giuseppe Vergaro, Alberto Aimo, Michele Emdin, Jean Guillaume Dillinger, Mathilde Baudet, Alain Cohen-Solal, Camille Villesuzanne, Stephanie Harel, Bruno Royer, Bertrand Arnulf, Damien Logeart,

The assessment of both thromboembolic and haemorrhagic risks and their management in systemic amyloidosis have been poorly emphasized so far. This narrative review summarizes main evidence from literature with clinical perspective. The rate of thromboembolic events is as high as 5-10% amyloidosis patients, at least in patients with cardiac involvement, ... Read more >>

ESC Heart Fail (ESC heart failure)
[2021, :]

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Retrospective analysis of autologous stem cell transplantation for AL amyloidosis: A Study from the Multiple Myeloma Working Group of the Japan Society for Hematopoietic Cell Transplantation.

Shin-Ichi Fuchida, Koji Kawamura, Kazutaka Sunami, Nobuhiro Tsukada, Shiro Fujii, Hiroshi Ohkawara, Kensuke Usuki, Atsushi Wake, Shinya Endo, Ken Ishiyama, Yasunori Ueda, Yukinori Nakamura, Toshihiro Miyamoto, Takahiro Fukuda, Tatsuo Ichinohe, Yoshiko Atsuta, Hiroyuki Takamatsu,

<h4>Background</h4>Autologous stem-cell transplantation (ASCT) is the standard of care for eligible patients with light-chain (AL) amyloidosis, but little is known about it in Asian populations.<h4>Objective and study design</h4>To investigate the outcome of and prognostic factors for ASCT, we retrospectively analyzed ASCT cases registered to the Transplant Registry Unified Management Program ... Read more >>

Transplant Cell Ther (Transplantation and cellular therapy)
[2021, :]

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Brain ischemia as a bridge to Alzheimer's disease.

Ryszard Pluta,

Neural Regen Res (Neural regeneration research)
[2022, 17(4):791-792]

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Comparison of the efficacy and safety of intralesional injection of tranexamic acid and the topical application of Kligman combination drug in the treatment of macular amyloidosis.

Mohammadreza Ghassemi, Masoumeh Roohaninasab, Seyed Abolfazl Kamani, Afsaneh Sadeghzadeh-Bazargan, Azadeh Goodarzi,

Macular amyloidosis (MA) is a common form of cutaneous amyloidosis that manifests as dark spots consisting of brown pigments with a rippled pattern on the skin, and the treatment of this condition is highly challenging. The aim of this study was to compare the efficacy and safety of intralesional injection ... Read more >>

Dermatol Ther (Dermatologic therapy)
[2021, :e15213]

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Immunoglobulin Light Chain Amyloidosis Presenting as Inferior Vena Cava Thrombosis.

Anna Axentiev, Marina Rozik, Eliza Slama, Viney Setya,

Immunoglobulin light chain (AL) amyloidosis is a rare disease characterized by the deposition of misfolded extracellular proteins within various body tissues resulting in dysfunction of the cardiac, renal, gastrointestinal, hematologic, and nervous systems, among others. Systemic AL amyloidosis often presents with a constellation of vague symptoms such as fatigue, dyspnea, ... Read more >>

Am Surg (The American surgeon)
[2021, :31348211050834]

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Cardiac Amyloidosis in a Child Presenting with Syncope: The First Reported Case and a Diagnostic Dilemma.

Diana Milagros Torpoco Rivera, Celeste T Williams, Peter P Karpawich,

Cardiac amyloidosis is a rare cause of cardiomyopathy, reported exclusively in adults. We report the first known case presenting in childhood. A 12-year-old boy presented with syncope and diagnosed with ventricular non-compaction by echocardiography. Eventual genetic testing confirmed a TTR gene mutation associated with hereditary transthyretin amyloidosis. ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2021, :]

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Intra-abdominal bleeding caused by amyloid transthyretin amyloidosis in the gastrointestinal tract: a case report.

Shinsei Yumoto, Koichi Doi, Takaaki Higashi, Yoshiya Shimao, Mitsuharu Ueda, Akira Ishihara, Yuki Adachi, Hiroyuki Ishiodori, Shinobu Honda, Hideo Baba,

Diagnosis of gastrointestinal (GI) amyloidosis is often very difficult because of its nonspecific symptoms. However, a few reports have indicated that serious symptoms such as fatal GI bleeding and obstruction or perforation sometimes lead to a diagnosis of GI amyloidosis. A 79-year-old man was transported to our emergency department with ... Read more >>

Clin J Gastroenterol (Clinical journal of gastroenterology)
[2021, :]

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