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Full Text Journal Articles about
Altitude Related Disorders

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Apigenin-7-O-β-d-(6″-p-coumaroyl)-glucopyranoside reduces myocardial ischaemia/reperfusion injury in an experimental model via regulating the inflammation response.

Wei Quan, Shanbo Ma, Yanrong Zhu, Qing Shao, Jixing Hou, Xiaoqiang Li,

Context: Traditionally, Clematis tangutica Korsh. (Ranunculaceae) is used as a Tibetan herb for treating indigestion and blood stasis in China. Recently, a flavonoid glycoside, apigenin-7-O-β-d-(6″-p-coumaroyl)-glucopyranoside (APG), was isolated from the whole plant of C. tangutica.Objective: To investigate the cardioprotective effects of APG against myocardial ischaemia/reperfusion injury (MI/RI) and the possible ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):80-88]

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Adaptation to Hypoxia: A Chimera?

Michele Samaja, Giuseppina Milano,

"The Chimera was, according to Greek mythology, a monstrous fire-breathing hybrid creature of Lycia in Asia Minor, composed of the parts of more than one animal [...]. ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(4):]

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Neural network correlates of high-altitude adaptive genetic variants in Tibetans: A pilot, exploratory study.

Zhiyue Guo, Cunxiu Fan, Ting Li, Luobu Gesang, Wu Yin, Ningkai Wang, Xuchu Weng, Qiyong Gong, Jiaxing Zhang, Jinhui Wang,

Although substantial progress has been made in the identification of genetic substrates underlying physiology, neuropsychology, and brain organization, the genotype-phenotype associations remain largely unknown in the context of high-altitude (HA) adaptation. Here, we related HA adaptive genetic variants in three gene loci (EGLN1, EPAS1, and PPARA) to interindividual variance in ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2020, :]

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Diagnostic reference values for sarcopenia in Tibetans in China.

Liping Ye, Youfeng Wen, Ying Chen, Jie Yao, Xin Li, Yingying Liu, Jia Song, Zhengqi Sun,

Sarcopenia is an age-associated disease characterized by loss of muscle mass and function, but the diagnostic cutoff values remain controversial. To investigate the diagnostic cutoff values and incidence of sarcopenia in a plateau population, the limb skeletal muscle mass, gait speed and grip strength of 2318 Tibetan adults were measured ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3067]

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EDN1 gene potentially involved in the development of acute mountain sickness.

Jie Yu, Chuan Liu, Chen Zhang, ShiZhu Bian, Jie Yang, JiHang Zhang, XuBin Gao, YouZhu Qiu, Lan Huang,

Previous investigations have indicated that environmental and genetic factors collectively contribute to the development of acute mountain sickness (AMS), but whether the EDN1 gene is involved in AMS remains to be elucidated. A total of 356 healthy male soldiers who had not traveled to high altitudes in the previous 12 ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5414]

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Characteristics of Cerebral Stroke in the Tibet Autonomous Region of China.

Shuai Zhang, Dong Liu, Dun Zhu Gesang, Ming Lv,

It is well known that cerebrovascular disease has become an important cause of adult death and disability. Strikingly, the Tibet Autonomous Region (TAR) ranks on the top in China for the incidence of stroke. To help explain this phenomenon, we have searched for and analyzed stroke-related literature for the TAR ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e919221]

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Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population.

Yang Shen, Jihang Zhang, Jie Yang, Chuan Liu, Shizhu Bian, Chen Zhang, Jie Yu, Xubin Gao, Lan Huang,

Background:High-altitude headache (HAH) is the most common complication after high-altitude exposure. Hypoxia-inducible factor- (HIF-) related genes have been confirmed to contribute to high-altitude acclimatization. We aim to investigate a possible association between HIF-related genes and HAH in the Chinese Han population. Methods:In total, 580 healthy Chinese Han volunteers were recruited ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:1593068]

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Mild Hypoxia of a Skydiver Making Repeated, Medium-Altitude Aircraft Exits.

Brian S Bradke, Bradford R Everman,

INTRODUCTION: Dramatic increases in parachuting safety over the last three decades have been attributed to advances in technology and training for parachutists. However, very little is known about the physiological condition of skydivers making repeated, medium-altitude aircraft exits without using supplemental oxygen. As in aviation, human error is broadly responsible ... Read more >>

Aerosp Med Hum Perform (Aerospace medicine and human performance)
[2020, 91(2):110-115]

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Sherpas, Coca Leaves, and Planes: High Altitude and Airplane Headache Review with a Case of Post-LASIK Myopic Shift.

Shivang G Joshi, Laszlo L Mechtler,

PURPOSE OF REVIEW:High altitude headache is a common neurological symptom that is associated with ascent to high altitude. It is classified by the International Classification of Headache Disorders, 3rd Edition (ICHD-3) as a disorder of homeostasis. In this article, we review recent clinical and insights into the pathophysiological mechanisms of ... Read more >>

Curr Neurol Neurosci Rep (Current neurology and neuroscience reports)
[2019, 19(12):104]

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Intraocular pressure and axial length changes during altitude acclimatization from Beijing to Lhasa.

Yuan Wu, Ci Ren Qiong Da, Jiang Liu, Xiaoming Yan,

PURPOSE:To investigate changes in intraocular pressure (IOP) and axial length (AL) on the ascent to high altitude from Beijing to Lhasa. PATIENTS AND METHODS:Twenty volunteers (17 men, 3 women) who had been sent to work in Lhasa, Tibet for more than 6 months were enrolled. One of their journeys from ... Read more >>

PLoS ONE (PloS one)
[2020, 15(1):e0228267]

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A Large Sample Survey of Tibetan People on the Qinghai-Tibet Plateau: Current Situation of Depression and Risk Factors.

Jiazhou Wang, Yueyue Zhou, Yiming Liang, Zhengkui Liu,

BACKGROUND:A depressive state is a negative emotional state characterized by abnormal dejection and unpleasant mood. Long-term depressive symptoms can result in psychological disorders such as depression. However, little is known about the depression status and risk factors of the Tibetan people on the Qinghai-Tibet Plateau. OBJECTIVE:This study explores the depression ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 17(1):]

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Brain functional changes in tibetan with obstructive sleep apnea hypopnea syndrome: A resting state fMRI study.

Dongjie Kang, Zongyuan Qin, Wen Wang, Yun Zheng, Huiying Hu, Yuanyuan Bao, Haihua Bao,

Tibetan is a major ethnic group living on the Qinghai-Tibet Plateau in China. Due to their high-altitude hypoxia environment, sleeping disorder and obstructive sleep apnea hypopnea syndrome (OSAHS) are more prone to occur. In this study, we investigated the brain structural and functional differences between Tibetans OSAHS patients and Tibetans ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(7):e18957]

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Effect of Traditional Chinese Medicine on Long-Term Outcomes of Snakebite in Taiwan.

Teng-I Huang, Ching-Liang Hsieh,

Herein, we review the characteristics of the six predominant venomous snakes in Taiwan and the effects of traditional Chinese medicine on the long-term outcomes of snakebite venom. We electronically searched databases, including PubMed, ClinicalKey, China National Knowledge Infrastructure, National Digital Library of Theses and Dissertations in Taiwan, and Airiti Library, ... Read more >>

Toxins (Basel) (Toxins)
[2020, 12(2):]

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Downregulation of lung miR-203a-3p expression by high-altitude hypoxia enhances VEGF/Notch signaling.

Wei Cai, Sanli Liu, Ziquan Liu, Shike Hou, Qi Lv, Huanhuan Cui, Xue Wang, Yuxin Zhang, Haojun Fan, Hui Ding,

Hypoxia-related microRNAs (miRNAs) are involved in the pathogenesis of various diseases. Because potential variations in miRNA expression mediated by hypoxic lung injury at high altitude remain incompletely characterized, we used a rat model to investigate the biochemical and miRNA changes induced by high-altitude hypoxia. After 24, 48, or 72 h ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(5):4247-4267]

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Retrospective cohort analysis of heart rate variability in patients with high altitude pulmonary hypertension in Tibet.

Zhang Qian, Aili Fan, Dawa, Dawaciren, Binbin Pan,

BACKGROUND:Studies from both humans and animals experiments have offered abundant evidence supporting that mountain sickness is associated with changes in autonomic nervous function (ANF), which can be measured by heart rate variability (HRV). HYPOTHESIS:We aimed to assess changes of ANF in chronic mountain disease by measuring HRV in patients with ... Read more >>

Clin Cardiol (Clinical cardiology)
[2020, 43(3):298-304]

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Hypoxic-inflammatory responses under acute hypoxia: In Vitro experiments and prospective observational expedition trial.

Tobias Kammerer, Valentina Faihs, Nikolai Hulde, Manfred Stangl, Florian Brettner, Markus Rehm, Mareike Horstmann, Julia Kröpfl, Christina Spengler, Simone Kreth, Simon Schäfer,

Induction of hypoxia-inducible-factor-1α (HIF-1α) pathway and HIF-target genes allow adaptation to hypoxia and are associated with reduced incidence of acute mountain sickness (AMS). Little is known about HIF-pathways in conjunction with inflammation or exercise stimuli under acute hypobaric hypoxia in non-acclimatized individuals. We therefore tested the hypotheses that 1) both ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(3):]

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Transient Cerebral Ischemia at High Altitude and Hyper-Responsiveness to Hypoxia.

Jean-Paul Richalet, Philippe Larmignat, Patricia Poignard,

A 36-year-old woman with no medical history participated in a trekking in Ladakh up to 5300 m of altitude. She was well acclimatized and presented no previous sign of acute mountain sickness, high altitude pulmonary edema or high altitude cerebral edema. After an intense effort to catch up with her group, ... Read more >>

High Alt. Med. Biol. (High altitude medicine & biology)
[2020, 21(1):105-108]

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Transcriptome Analysis Unravels Metabolic and Molecular Pathways Related to Fruit Sac Granulation in a Late-Ripening Navel Orange (Citrus sinensis Osbeck).

Li-Ming Wu, Ce Wang, Li-Gang He, Zhi-Jing Wang, Zhu Tong, Fang Song, Jun-Fan Tu, Wen-Ming Qiu, Ji-Hong Liu, Ying-Chun Jiang, Shu-Ang Peng,

Lanelate navel orange (Citrus sinensis Osbeck) is a late-ripening citrus cultivar increasingly planted in China. The physiological disorder juice sac granulation often occurs in the fruit before harvest, but the physiological and molecular mechanisms underlying this disorder remain elusive. In this study, we found that fruit granulation of the late-ripening ... Read more >>

Plants (Basel) (Plants (Basel, Switzerland))
[2020, 9(1):]

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Individual chronic mountain sickness symptom is an early warning sign of cognitive impairment.

Zheng Shanjun, Xie Shenwei, Xiang Bin, Tian Huaijun, Zhou Simin, Li Peng,

OBJECTIVE:To investigate the relationship between various chronic mountain sickness (CMS) symptoms and cognitive performances and identify whether individual CMS symptom can be used as early warning signs of specific cognitive impairment in long-term high altitude migrators. METHODS:A total of 287 workers living at an altitude of 3850 m for 1-5 years ... Read more >>

Physiol. Behav. (Physiology & behavior)
[2020, 214:112748]

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Determinants of Acute Respiratory Infection Among Children in Ethiopia: A Multilevel Analysis from Ethiopian Demographic and Health Survey.

Zelalem Alamrew Anteneh, Hamid Yimam Hassen,

Background:Acute respiratory infection (ARI) is one of the leading public health challenges among children in low- and middle-income countries. Child mortality due to ARI is disproportionately higher in African regions. In Ethiopia, an encouraging progress in the reduction of ARI was observed until 2010, however, since then the national prevalence ... Read more >>

Int J Gen Med (International journal of general medicine)
[2020, 13:17-26]

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DTI Study on Brain Structure and Cognitive Function in Patients with Chronic Mountain Sickness.

Haihua Bao, Ruiyang Li, Mingli He, Dongjie Kang, Lili Zhao,

In chronic mountain sickness (CMS) patients, the structure of the brain, memory and cognition are often irreversibly damaged by chronic hypoxia due to red blood cell overcompensation, elevated haemoglobin and blood stasis. In this study, we aimed to evaluate this damage using diffusion tensor imaging (DTI) and to study the ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):19334]

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Nociception testing during fixed-wing ambulance flights. An interventional pilot study on the effects of flight-related environmental changes on the nociception of healthy volunteers.

Johannes Prottengeier, Stefan Elsner, Andreas Wehrfritz, Andreas Moritz, Joachim Schmidt, Michael Meyer,

BACKGROUND:The effects of environmental changes on the somato-sensory system during long-distance air ambulance flights need to be further investigated. Changes in nociceptive capacity are conceivable in light of previous studies performed under related environmental settings. We used standardized somato-sensory testing to investigate nociception in healthy volunteers during air-ambulance flights. METHODS:Twenty-five ... Read more >>

PLoS ONE (PloS one)
[2020, 15(2):e0217530]

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Efficacy of Shenqi Pollen Capsules for High-Altitude Deacclimatization Syndrome via Suppression of the Reoxygenation Injury and Inflammatory Response.

Binfeng He, Mingdong Hu, Zhihui Liang, Qianli Ma, Yunhai Zi, Zhiwei Dong, Qi Li, Yongjun Luo, Guisheng Qian, Liang Guo, Kexiong Lin, Zhenyu Liu, Guansong Wang,

High-altitude deacclimatization syndrome (HADAS) is involved in hypoxia-reoxygenation injury and inflammatory response, induced a series of symptoms, and has emerged as a severe public health issue. Here, we investigated the mechanism as well as potential means to prevent HADAS using Shenqi pollen capsules (SPCs) in subjects with HADAS in a ... Read more >>

J Immunol Res (Journal of immunology research)
[2019, 2019:4521231]

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Extending the Spectrum of Dysgraphia: A Data Driven Strategy to Estimate Handwriting Quality.

Thibault Asselborn, Mateo Chapatte, Pierre Dillenbourg,

This paper proposes new ways to assess handwriting, a critical skill in any child's school journey. Traditionally, a pen and paper test called the BHK test (Concise Evaluation Scale for Children's Handwriting) is used to assess children's handwriting in French-speaking countries. Any child with a BHK score above a certain ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3140]

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Effects of Acute Normobaric Hypoxia on Memory Interference.

Paul D Loprinzi, Aala'a Matalgah, Lindsay Crawford, Jane J Yu, Zhaowei Kong, Bo Wang, Shijie Liu, Liye Zou,

PURPOSE:Previous research has evaluated the effects of acute hypoxia exposure on cognitive function, notably executive function. No studies, to date, have evaluated the effects of acute hypoxia exposure on memory interference, which was the purpose of this experiment. METHODS:A within-subjects, counterbalanced experimental design was employed, with condition (hypoxia vs. normoxia) ... Read more >>

Brain Sci (Brain sciences)
[2019, 9(11):]

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