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Allopurinol

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Repurposing existing drugs: identification of SARS-CoV-2 3C-like protease inhibitors.

Wei-Chung Chiou, Meng-Shiuan Hsu, Yun-Ti Chen, Jinn-Moon Yang, Yeou-Guang Tsay, Hsiu-Chen Huang, Cheng Huang,

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19). Since its emergence, the COVID-19 pandemic has not only distressed medical services but also caused economic upheavals, marking urgent the need for effective therapeutics. The experience of combating SARS-CoV and MERS-CoV has shown that inhibiting the ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):147-153]

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Hyperuricaemia, gout and allopurinol in the CKD Queensland registry.

A Jeyaruban, W Hoy, A Cameron, H Healy, Z Wang, J Zhang, A Mallett,

<h4>Introduction</h4>There is scant data on the role of hyperuricaemia, gout and allopurinol treatment in chronic kidney disease (CKD). Therefore, our aim is to investigate the possible associations between hyperuricaemia, gout, prescription of allopurinol and renal outcomes in patients with CKD.<h4>Methods</h4>The retrospective cohort study involved 1123 Royal Brisbane and Women's Hospital ... Read more >>

J Nephrol (Journal of nephrology)
[2021, :]

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Effects of intensive urate lowering therapy with febuxostat in comparison with allopurinol on pulse wave velocity in patients with gout and increased cardiovascular risk: the FORWARD study.

Giovambattista Desideri, Marek Rajzer, Martijn Gerritsen, Michael T Nurmohamed, Cristina Giannattasio, Anne-Kathrin Tausche, Claudio Borghi,

<h4>Aims</h4>Hyperuricaemia and gout are strongly related with traditional cardiovascular risk factors and vascular damage. This study aimed to assess whether febuxostat and allopurinol could differently influence carotid-femoral pulse wave velocity (cfPWV) in patients with gout and elevated serum uric acid (SUA) levels.<h4>Methods and results</h4>A multi-centre, multinational, phase IV, randomized, parallel-group, ... Read more >>

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2021, :]

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Scientometric analysis of chemotherapy of canine leishmaniasis (2000-2020).

A I Olías-Molero, E Fontán-Matilla, M Cuquerella, J M Alunda,

<h4>Background</h4>Zoonotic visceral leishmaniasis by Leishmania infantum is a first-order pathology in canine veterinary clinics in endemic areas. Moreover, canine infections are considered the main reservoir for human disease; despite their importance in the control of the disease within a One Health approach, no scientometric study has been published. Aims of ... Read more >>

Parasit Vectors (Parasites & vectors)
[2021, 14(1):36]

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Allopurinol-Induced Severe Cutaneous Adverse Drug Reactions: An Analysis of Spontaneous Reports in Malaysia (2000-2018).

Sing Chet Lee, Wee Kee Wo, Hee Sheong Yeoh, Norleen Mohamed Ali, Vidhya Hariraj,

<h4>Introduction</h4>Allopurinol-induced severe cutaneous adverse drug reactions (SCARs) are potentially debilitating and life-threatening reactions, which can cause a financial burden to the healthcare system.<h4>Objectives</h4>We aimed to identify risk factors for allopurinol-induced SCARs and to assess their impact on fatality.<h4>Methods</h4>Adverse drug reaction (ADR) reports with allopurinol as suspected drug were extracted from ... Read more >>

Ther Innov Regul Sci (Therapeutic innovation & regulatory science)
[2021, :]

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Prevalence of Hyperuricemia and the Use of Allopurinol in Older Poles-Results from a Population-Based PolSenior Study.

Mateusz Winder, Aleksander J Owczarek, Małgorzata Mossakowska, Katarzyna Broczek, Tomasz Grodzicki, Łukasz Wierucki, Jerzy Chudek,

<h4>Background</h4>Our study analyzes the frequency and risk factors of hyperuricemia and the use of allopurinol in a representative cohort of the older Polish adult population.<h4>Methods</h4>The analysis was a part of a cross-sectional PolSenior study on aging in Poland. The complete medication data were available in 4873 out of 4979 community ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(2):]

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Real World Evidence of Population Differences in Allopurinol-Related Severe Cutaneous Adverse Reactions in East Asians: A Population-Based Cohort Study.

Tsugumichi Sato, Ching-Lan Cheng, Heung-Woo Park, Yea-Huei Kao Yang, Min-Suk Yang, Mizuki Fujita, Yuji Kumagai, Masahiro Tohkin, Yoshiro Saito, Kimie Sai,

Allopurinol-related severe cutaneous adverse reactions (SCARs) are strongly associated with HLA-B*58:01, the allele frequency (AF) of which is largely different among East Asians. However, evidence of population differences in SCAR development and relevance of genetic and/or other risk factors in the real world remain unelucidated. This study aimed to evaluate ... Read more >>

Clin Transl Sci (Clinical and translational science)
[2020, :]

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Gout Pharmacotherapy in Cardiovascular Diseases: A Review of Utility and Outcomes.

Subuhi Kaul, Manasvi Gupta, Dhrubajyoti Bandyopadhyay, Adrija Hajra, Prakash Deedwania, Edward Roddy, Mamas Mamas, Allan Klein, Carl J Lavie, Gregg C Fonarow, Raktim K Ghosh,

Hyperuricemia and gout have been linked to an increased risk for cardiovascular (CV) disease, stroke, hypertension, heart failure, and chronic kidney disease, possibly through a proinflammatory milieu. However, not all the drugs used in gout treatment improve CV outcomes; colchicine has shown improved CV outcomes in patients with recent myocardial ... Read more >>

Am J Cardiovasc Drugs (American journal of cardiovascular drugs : drugs, devices, and other interventions)
[2020, :]

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Reassessing the cardiovascular safety of febuxostat: implications of the FAST study.

Hyon K Choi, Tuhina Neogi, Lisa K Stamp, Robert Terkeltaub, Nicola Dalbeth,

The US FDA-mandated CARES trial, published in 2018, reported increased all-cause and cardiovascular (CV) death in participants randomized to febuxostat compared with allopurinol. The subsequent FDA Drug Safety Communication and Boxed Warning resulted in substantial reductions in febuxostat use in the US. The EMA-mandated Febuxostat versus Allopurinol Streamlined Trial (FAST), ... Read more >>

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2021, :]

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Different chemometric assisted approaches for spectrophotometric quantitative analysis of lesinurad and allopurinol.

Ahmed H Abdelazim, Mohammed Shahin,

Three chemometric assisted spectrophotometric approaches were designed for precise quantitative analysis of lesinurad and allopurinol, in their recently FDA approved combination pharmaceutical dosage form. By utilizing the recorded absorption spectral data of lesinurad and allopurinol mixtures, principle component regression, partial least squares and genetic algorithm partial least squares were developed ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2021, 251:119421]

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Xanthine oxidase inhibitors are associated with reduced risk of cardiovascular disease.

Hirotaka Saito, Kenichi Tanaka, Tsuyoshi Iwasaki, Akira Oda, Shuhei Watanabe, Makoto Kanno, Hiroshi Kimura, Michio Shimabukuro, Koichi Asahi, Tsuyoshi Watanabe, Junichiro James Kazama,

As previous studies have reported finding an association between hyperuricemia and the development of cardiovascular and chronic kidney disease, hyperuricemia is thought to be an independent risk factor for hypertension and diabetic mellitus. However, we have not been able to determine whether the use of xanthine oxidase inhibitors can reduce ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):1380]

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Biopharmaceutical characterization of a novel sustained-release formulation of allopurinol with reduced nephrotoxicity.

Takuya Nihei, Hideyuki Sato, Satomi Onoue,

The present study was aimed to develop a novel sustained-release formulation for allopurinol (ALP/SR) with the use of a pH-sensitive polymer, hydroxypropylmethylcellulose acetate succinate (HPMCAS), to reduce nephrotoxicity. ALP/SR was evaluated in terms of crystallinity, the dissolution profile, pharmacokinetic behavior, and nephrotoxicity in a rat model of nephropathy. Under acidic ... Read more >>

Biopharm Drug Dispos (Biopharmaceutics & drug disposition)
[2021, :]

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Genetic susceptibilities and prediction modeling of carbamazepine and allopurinol-induced severe cutaneous adverse reactions in Vietnamese.

Dinh van Nguyen, Hieu Chi Chu, Christopher Vidal, Richard B Fulton, Nguyet Nhu Nguyen, Nga Thi Quynh Do, Tu Linh Tran, Thuy Ninh Nguyen, Ha Thi Thu Nguyen, Hanh Hong Chu, Huyen Thi Thanh Thuc, Huong Thi Minh Le, Sheryl van Nunen, Janet Anderson, Suran L Fernando,

<b>Aims:</b> To determine genetic susceptibility markers for carbamazepine (CBZ) and allopurinol-induced severe cutaneous adverse reactions (SCARs) in Vietnamese. <b>Methods:</b> A case control study was performed involving 122 patients with CBZ or allopurinol induced SCARs and 120 drug tolerant controls. <b>Results:</b> <i>HLA-B*58:01</i> was strongly associated with allopurinol-induced SCARs and strongly correlated ... Read more >>

Pharmacogenomics (Pharmacogenomics)
[2020, :]

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Potential of Artesunate in the treatment of visceral leishmaniasis in dogs naturally infected by Leishmania infantum: Efficacy evidence from a randomized field trial.

Hacène Medkour, Idir Bitam, Younes Laidoudi, Ismail Lafri, Abdelaziz Lounas, Hamza Karim Hamidat, Abdeslam Mekroud, Marie Varloud, Bernard Davoust, Oleg Mediannikov,

Leishmaniasis is among the world's most neglected diseases. Dogs are the main reservoirs/hosts of Leishmania infantum, causative agent of both canine and human visceral leishmaniosis. Canine leishmaniasis (CanL) represents a public health problem as one of the most prevalent zoonotic diseases worldwide. Current therapeutics present drawbacks; thus, there is a ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2020, 14(12):e0008947]

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Serum Urate Lowering Therapy Using Allopurinol Improves Serum 25 Hydroxy Vitamin D in Stage 3-5 CKD Patients: A Pilot Study.

AbdelAal Mohammed, Mohamed A Marie, Dina O Abdulazim, Mohammed Hassan, Olfat Shaker, Ghada Ayeldeen, Mona M Salem, Usama A Sharaf El Din, ,

<h4>Background</h4>Recent studies have demonstrated negative associations of serum uric acid (SUA) with serum 25 hydroxy vitamin D (25 [OH] vit D) among CKD patients.<h4>Objective</h4>The aim of the study was to look for the impact of hypouricemic therapy using allopurinol on serum level of 25 (OH) vit D in CKD patients.<h4>Cases ... Read more >>

Nephron (Nephron)
[2020, :1-4]

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A Randomized, Controlled Trial of the Effect of Allopurinol on Left Ventricular Mass Index in Hemodialysis Patients

Elaine Rutherford, Sheila Ireland, Kenneth Mangion, Graham A. Stewart, Mark S. MacGregor, Giles Roditi, Rosemary Woodward, Stephen J. Gandy, J. Graeme Houston, Alan G. Jardine, Petra Rauchhaus, Miles D. Witham, Patrick B. Mark, Allan D. Struthers,

<h4>Introduction</h4> Increased left ventricular mass index (LVMI) is associated with mortality in end-stage renal disease. LVMI regression may improve outcomes. Allopurinol has reduced LVMI in randomized controlled trials in chronic kidney disease, diabetes, and ischemic heart disease. This study investigated whether allopurinol would regress LVMI in hemodialysis patients. <h4>Methods</h4> This ... Read more >>

Kidney Int Rep (Kidney international reports)
[2020, 6(1):146-155]

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Hyperuricemia and progression of chronic kidney disease: to treat or not to treat?

Jürgen Floege, Richard J Johnson,

Kidney Int (Kidney international)
[2021, 99(1):14-16]

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A Randomized, Controlled Trial of the Effect of Allopurinol on Left Ventricular Mass Index in Hemodialysis Patients.

Elaine Rutherford, Sheila Ireland, Kenneth Mangion, Graham A Stewart, Mark S MacGregor, Giles Roditi, Rosemary Woodward, Stephen J Gandy, J Graeme Houston, Alan G Jardine, Petra Rauchhaus, Miles D Witham, Patrick B Mark, Allan D Struthers,

<h4>Introduction</h4>Increased left ventricular mass index (LVMI) is associated with mortality in end-stage renal disease. LVMI regression may improve outcomes. Allopurinol has reduced LVMI in randomized controlled trials in chronic kidney disease, diabetes, and ischemic heart disease. This study investigated whether allopurinol would regress LVMI in hemodialysis patients.<h4>Methods</h4>This was a randomized ... Read more >>

Kidney Int Rep (Kidney international reports)
[2021, 6(1):146-155]

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Serum urate is related to subclinical inflammation in asymptomatic hyperuricaemia.

Desirée Luis-Rodríguez, Javier Donate-Correa, Ernesto Martín-Núñez, Carla Ferri, Víctor G Tagua, Atteneri Pérez Castro, Carmen Mora-Fernández, Juan F Navarro-González,

<h4>Objective</h4>Asymptomatic hyperuricaemia (AHU) is associated with inflammatory disorders, including cardiovascular disease. Uric acid (UA) lowering therapies may reduce the risk of appearance or the progression of these comorbidities. In this work, we investigated the relationship between serum UA levels and inflammation in subjects with AHU.<h4>Methods</h4>Serum levels of high-sensitivity CRP (hsCRP), ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2021, 60(1):371-379]

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Effect of a Traditional Chinese Medicine Formula (CoTOL) on Serum Uric Acid and Intestinal Flora in Obese Hyperuricemic Mice Inoculated with Intestinal Bacteria.

Yan Gao, Jing Sun, Yi Zhang, Tiejuan Shao, Haichang Li, Meijiao Wang, Li Zhang, Hua Bian, Chengping Wen, Zhijun Xie, Huiqing Lv,

CoTOL is a traditional Chinese medicine (TCM) formula in clinics for treating gout and hyperuricemia, especially in obese patients with recurrent attacks. However, fewer studies have investigated how CoTOL impacts the intestinal flora in reducing uric acid. In the present, we analyze the bacteria targeted by ingredients of CoTOL and ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2020, 2020:8831937]

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Influence of domperidone supplementation on short-term changes in C-reactive protein and paraoxonase-1 in dogs with leishmaniasis undergoing meglumine antimoniate and allopurinol therapy.

Saverio Paltrinieri, Fabrizio Ibba, Federico Barbè, Gabriele Rossi,

<h4>Background</h4>C-reactive protein (CRP) and paraoxonase 1 (PON1) might increase and decrease in canine leishmaniasis (CanL), , and both can rapidly normalize after therapy. Recently, supplementation of domperidone with conventional therapy , increasing the activity of cells involved in acute phase responses in vitro. This combined therapy has been recommended to ... Read more >>

Vet Clin Pathol (Veterinary clinical pathology)
[2020, :]

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Real-world patterns of pegloticase use for treatment of gout: descriptive multidatabase cohort study.

Sarah K Chen, Jun Liu, Seoyoung C Kim,

<h4>Objective</h4>Pegloticase is used in severe refractory gout or in cases of intolerance to other urate-lowering therapies. We sought to evaluate the patterns of pegloticase use in the USA and the incidence of safety outcomes.<h4>Methods</h4>We conducted a retrospective descriptive study using data from two US commercial insurance claims databases (2010-2018). We ... Read more >>

BMJ Open (BMJ open)
[2020, 10(12):e041167]

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Sugar-induced dysregulation of purine metabolism impacts lifespan.

Claudia Lennicke, Eliano Dos Santos, Helena M Cochemé,

Aging (Albany NY) (Aging)
[2020, 12(24):24479-24480]

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Pancytopenia caused by allopurinol and azathioprine interaction in a heart transplant patient: a case report

Jason Feinman, Brett Rollins, Johanna Contreras, Aditya Parikh, Cameli Matteo, Khan Arif Anis, Nistor Dan Octavian, Camm Christian Fielder, Thomson Ross,

Abstract <h4>Background</h4> Azathioprine is an immunosuppressive now less commonly prescribed after orthotopic heart transplantation. Patients with solid organ transplantation are at increased risk for numerous comorbidities including gout. Co-administration of allopurinol for gout prophylaxis and azathioprine increases the risk for severe myelosuppression due to drug–drug interactions. <h4>Case summary</h4> A 57-year-old ... Read more >>

Eur Heart J Case Rep (European heart journal. Case reports)
[2020, 4(6):1-4]

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Allopurinol shows no benefit in slowing decline in renal function.

Every month, DTB scans sources of information on treatments, disease management and other healthcare topics for key items to bring to our readers' attention and help them keep up to date. To do this, we produce succinct, contextualised summaries of the information concerned. ... Read more >>

Drug Ther Bull (Drug and therapeutics bulletin)
[2020, :]

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