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Allergic and Environmental Asthma

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Household airborne endotoxin associated with asthma and allergy in elementary school-age children: a case-control study in Kaohsiung, Taiwan.

Yu-Chuan Yen, Chun-Yuh Yang, Tsu-Nai Wang, Pei-Chun Yen, Chi-Kung Ho, Kristina D Mena, Tzu-Chi Lee, Kang-Shin Chen, Yuan-Chung Lin, Pei-Shih Chen,

To evaluate the association between the presence of asthma and allergy, and airborne endotoxin in homes of school-age children in Kaohsiung City, Taiwan, with a case-control study design by matching the age and class exposure. Data collection of home visits included an interviewer-administered questionnaire and air sampling of participants' homes ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2020, :]

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Host-microbiome intestinal interactions during early life: considerations for atopy and asthma development.

Veronika Kuchařová Pettersen, Marie-Claire Arrieta,

PURPOSE OF REVIEW:The body's largest microbial community, the gut microbiome, is in contact with mucosal surfaces populated with epithelial, immune, endocrine and nerve cells, all of which sense and respond to microbial signals. These mutual interactions have led to a functional coevolution between the microbes and human physiology. Examples of ... Read more >>

Curr Opin Allergy Clin Immunol (Current opinion in allergy and clinical immunology)
[2020, 20(2):138-148]

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Obesity May Enhance the Adverse Effects of NO2 Exposure in Urban Schools on Asthma Symptoms in Children.

Perdita Permaul, Jonathan M Gaffin, Carter R Petty, Sachin N Baxi, Peggy S Lai, William J Sheehan, Carlos A Camargo, Diane R Gold, Wanda Phipatanakul,

BACKGROUND:Sparse data address the effects of nitrogen dioxide (NO2) exposure in inner-city schools on obese students with asthma. OBJECTIVE:To evaluate relationships between classroom NO2 exposure and asthma symptoms and morbidity by body mass index (BMI) category. METHODS:The School Inner-City Asthma Study enrolled students aged 4-13 years with asthma from 37 ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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Effects of hypersensitivity disorders and environmental factors on the equine intestinal microbiota.

S Kaiser-Thom, M Hilty, V Gerber,

Background: Recent evidence suggests that an altered intestinal microbiota, specifically a reduction of bacterial diversity or a shift in microbial composition, is associated with the development of hypersensitivity disorders in humans, but this is unknown for horses.Objectives: In this study we hypothesized that horses affected by either Culicoides hypersensitivity or ... Read more >>

Vet Q (The veterinary quarterly)
[2020, :1-15]

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The role of innate immunity in asthma development and protection: Lessons from the environment.

Vadim Pivniouk, Joao Antonio Gimenes Junior, Linnea K Honeker, Donata Vercelli,

Asthma, a complex, chronic disease characterized by airway inflammation, hyperresponsiveness and remodelling, affects over 300 million people worldwide. While the disease is typically associated with exaggerated allergen-induced type 2 immune responses, these responses are strongly influenced by environmental exposures that stimulate innate immune pathways capable of promoting or protecting from ... Read more >>

Clin. Exp. Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2020, 50(3):282-290]

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Symposium report: emerging threats for human health - impact of socioeconomic and climate change on zooanthroponosis in the Republic of Sakha (Yakutia), Russia.

Irene Huber, Katerina Potapova, Elena Ammosova, Wolfgang Beyer, Sergey Blagodatskiy, Roman Desyatkin, Ludwig E Hoelzle, Margarita Ignateva, Ludmila Kokolova, Stefanie Lemke, Mikhail Neustroev, Ayan Nyukkanov, Galina Protodyakonova, Alexander Reshetnikov, Thomas Romig, Vyacheslav Shadrin, Izabella Samoilova, Sergey Semenov, Konstantin Stepanov, Nadezhda Tarabukina, Liliia Vinokurova, Raisa Zakharova, Konstantin Nifontov,

Population growth, socio-cultural and economic changes as well as technological progress have an immediate impact on the environment and human health in particular. Our steadily rising needs of resources increase the pressure on the environment and narrow down untainted habitats for plants and wild animals. Balance and resilience of ecosystems ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1715698]

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Exploratory analysis of plasma cytokine/chemokine levels in 6-year-old children from a birth cohort study.

Kiwako Yamamoto-Hanada, Eiryo Kawakami, Mayako Saito-Abe, Miori Sato, Hiroshi Mitsubuchi, Masako Oda, Takahiko Katoh, Masafumi Sanefuji, Shouichi Ohga, Mari Kuwajima, Nathan Mise, Akihiko Ikegami, Fujio Kayama, Ayako Senju, Masayuki Shimono, Koichi Kusuhara, Shin Yamazaki, Shoji F Nakayama, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya,

This study aimed to reveal a new dimension of allergy profiles in the general population by using machine learning to explore complex relationships among various cytokines/chemokines and allergic diseases (asthma and atopic dermatitis; AD). We examined the symptoms related to asthma and AD and the plasma levels of 72 cytokines/chemokines ... Read more >>

Cytokine (Cytokine)
[2020, 130:155051]

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Associations of blood lead levels with asthma and blood eosinophils in U.S. children.

Cheryl R Cornwell, Kathryn B Egan, Hatice S Zahran, Maria C Mirabelli, Joy Hsu, Ginger L Chew,

U.S. children are exposed to lead through lead-based paint, lead-contaminated dust in older homes and through contaminated water, air, soil, or consumer and imported products1,2 . Approximately 24 million housing units have one or more lead-based paint hazards, including 3.6 million homes with children aged ≤6 years1 . Epidemiologic studies ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; a prospective cohort study.

Camilla Jøhnk, Arne Høst, Steffen Husby, Greet Schoeters, Clara Amalie Gade Timmermann, Henriette Boye Kyhl, Iben Have Beck, Anna-Maria Andersson, Hanne Frederiksen, Tina Kold Jensen,

BACKGROUND:Prenatal phthalate exposure has been suggested to alter immune responses and increase the risk of asthma, eczema and rhinitis. However, few studies have examined the effects in prospective cohorts and only one examined rhinitis. We therefore studied associations between maternal urinary concentrations of phthalate metabolites and asthma, eczema and rhinitis ... Read more >>

Environ Health (Environmental health : a global access science source)
[2020, 19(1):32]

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Prevention of Allergic Asthma with Allergen Avoidance Measures and the Role of Exposome.

Gennaro D'Amato, Olga Patricia Monge Ortega, Isabella Annesi-Maesano, Maria D'Amato,

PURPOSE OF REVIEW:It is well known that combination of sensitization and exposure to inhaled environmental allergens is related to both the development and elicitation of symptoms of asthma and that avoidance of allergens would exert beneficial effects in the prevention and control of the disease. Other important factors include the ... Read more >>

Curr Allergy Asthma Rep (Current allergy and asthma reports)
[2020, 20(3):8]

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The synergistic or adjuvant effect of DINP combined with OVA as a possible mechanism to promote an immune response.

Chongyao Li, Peng Song, Fan Lei, Si Lu, Dongting Xu, Guangwei Zheng, Xu Yang, Yang Wu, Ping Ma,

Diisononyl phthalate (DINP) is commonly used as a plasticizer in industrial and consumer product applications. Several studies have suggested a possible link between exposure to DINP and the development of allergic asthma, and the synergistic effect of DINP combined with Ovalbumin (OVA) is a possible way to promote an immune ... Read more >>

Food Chem. Toxicol. (Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association)
[2020, :111275]

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Smoking and snuff use in pregnancy and the risk of asthma and wheeze in pre-schoolchildren-A population-based register study.

Cecilia Lundholm, Anna Gunnerbeck, Brian M D'Onofrio, Henrik Larsson, Göran Pershagen, Catarina Almqvist,

BACKGROUND:Associations between tobacco smoking during pregnancy and offspring asthma have been observed, but the role of nicotine and familial factors remains unclear. OBJECTIVE:To estimate the association between tobacco use in pregnancy, both smoking and Swedish oral moist snuff, and asthma/wheeze in the offspring, how it varies by the child's age ... Read more >>

Clin. Exp. Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2020, :]

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The Frequency of Fast Food Consumption in Relation to Wheeze and Asthma Among Adolescents in Gauteng and North West Provinces, South Africa.

Vusumuzi Nkosi, Funzani Rathogwa-Takalani, Kuku Voyi,

The prevalence of asthma and allergic diseases have been on the rise, especially in developing countries due to life-style changes. The study aimed to investigate the association between the frequency of fast food consumption with wheeze and asthma among adolescents. A previously validated self-completed questionnaire from the International Study of ... Read more >>

Int J Environ Res Public Health (International Journal of Environmental Research and Public Health)
[2020, 17(6):]

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Gender differences in respiratory health outcomes among farming cohorts around the globe: findings from the AGRICOH consortium.

Jonathan Fix, Isabella Annesi-Maesano, Isabelle Baldi, Mathilde Boulanger, Soo Cheng, Sandra Cortes, Jean-Charles Dalphin, Mohamed Aqiel Dalvie, Bruno Degano, Jeroen Douwes, Wijnand Eduard, Grethe Elholm, Catterina Ferreccio, Anne-Helen Harding, Mohamed Jeebhay, Kevin M Kelly, Hans Kromhout, Ewan MacFarlane, Cara Nichole Maesano, Diane Catherine Mitchell, Hussein Mwanga, Saloshni Naidoo, Beyene Negatu, Dorothy Ngajilo, Karl-Christian Nordby, Christine G Parks, Marc B Schenker, Aesun Shin, Torben Sisgaard, Malcolm Sim, Thibaud Soumagne, Peter Thorne, Keun-Young Yoo, Jane A Hoppin,

Purpose: Respiratory hazards of farming have been identified for centuries, with little focus on gender differences. We used data from the AGRICOH consortium, a collective of prospective cohorts of agricultural workers, to assess respiratory disease prevalence among adults in 18 cohorts representing over 200,000 farmers, farm workers, and their spouses ... Read more >>

J Agromedicine (Journal of agromedicine)
[2020, :1-12]

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Nasal Allergen Challenge and Environmental Exposure Chamber Challenge: A Randomized Trial Comparing Clinical and Biological Responses to Cat Allergen.

David Larson, Piyush Patel, Anne Marie Salapatek, Peter Couroux, Don Whitehouse, Adela Pina, Jacqueline L Johnson, Michelle L Sever, Srinath Sanda, Julian Poyser, Theresa Allio, Guy W Scadding, Tielin Qin, Mohamed H Shamji, William W Kwok, Eddie A James, Deanna French, Alina Lelic, Mark Larché, Matthew C Altman, Alkis Togias, Stephen R Durham,

BACKGROUND:The direct-instillation nasal allergen challenge (NAC) and the environmental exposure chamber (EEC) are two methods of conducting controlled allergen provocations. The clinical and biological comparability of these methods has not been thoroughly investigated. OBJECTIVE:To compare clinical and immunologic responses to cat allergen in NAC versus EEC. METHODS:Twenty-four participants were randomized ... Read more >>

J. Allergy Clin. Immunol. (The Journal of allergy and clinical immunology)
[2020, :]

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Impact of the Long-Lived Plasma Cells in Patients With Chronic Rhinosinusitis With Nasal Polyps.

Roza Khalmuratova, Hyun Woo Shin,

Allergy Asthma Immunol Res (Allergy, asthma & immunology research)
[2020, 12(2):173-175]

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Clinical symptoms and biomarkers of Bermuda grass-induced allergic rhinitis using the nasal allergen challenge model.

Matthew Rawls, Jenny Thiele, Daniel E Adams, Lisa M Steacy, Anne K Ellis,

BACKGROUND:Bermuda grass is a prevalent allergen that flourishes in tropical climates. Bermuda grass exposure is traditionally believed to be low in Ontario due to the colder environment. However, high rates of Bermuda grass sensitization have been observed in Kingston, Ontario. OBJECTIVE:We sought to investigate whether Bermuda grass allergens can provoke ... Read more >>

Ann. Allergy Asthma Immunol. (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology)
[2020, :]

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Protocol for a prospective multicenter cross-sectional observational study to investigate the role of air pollution on allergic rhinitis prevalence.

Jianmin Liu, Yongkuan Wang, Sisi Liu, Shuwei Cao, Chunyan Xu, Meng Zhang, Shixi Liu,

INTRODUCTION:Allergic rhinitis (AR) is a major chronic inflammatory disease of the respiratory tract. A large number of epidemiological investigations have shown that the prevalence of AR is increasing, resulting in a large social burden. Importantly, the impact of air pollution on health is a widespread concern. We aim to evaluate ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(11):e19497]

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Prevention of baker's asthma.

Mohamed F Jeebhay, Roslynn Baatjies,

PURPOSE OF REVIEW:Baker's allergy and asthma continue to represent an important contributor of occupational asthma globally. This review identified recent studies related to the prevention of baker's allergy and asthma. RECENT FINDINGS:Studies with respect to regulatory exposure standards, workplace control measures aimed at reduction of flour dust exposures, surveillance programmes ... Read more >>

Curr Opin Allergy Clin Immunol (Current opinion in allergy and clinical immunology)
[2020, 20(2):96-102]

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Dietary patterns and asthma among Peruvian children and adolescents.

Carla E Tarazona-Meza, Corrine Hanson, Suzanne L Pollard, Karina M Romero Rivero, Rocio M Galvez Davila, Sameera Talegawkar, Carlos Rojas, Jessica L Rice, William Checkley, Nadia N Hansel,

BACKGROUND:Asthma is one of the conditions that contributes to the global burden of respiratory diseases and has been previously associated with diet intake. The goal of this study was to determine the relationship between diet, assessed by a developed score, and asthma in Peruvian children. METHODS:This study was a cross ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):63]

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Association of asthma and smoking with lung function impairment in adolescence and early adulthood: the Isle of Wight Birth Cohort Study.

S Hasan Arshad, Claire Hodgekiss, John W Holloway, John W Holloway, Ramesh Kurukulaaratchy, Wilfried Karmaus, Hongmei Zhang, Graham Roberts,

We investigated associations of asthma and smoking with lung function and airway reversibility from childhood to early adulthood.The population-based Isle of Wight Birth Cohort (n=1456) was assessed at birth, and at 1, 2, 4, 10, 18 and 26 years. Asthma was defined as physician diagnosis plus current wheeze and/or treatment. Spirometry ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2020, 55(3):]

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Imbalance of Gut Streptococcus, Clostridium, and Akkermansia Determines the Natural Course of Atopic Dermatitis in Infant.

Yoon Mee Park, So Yeon Lee, Mi Jin Kang, Bong Soo Kim, Min Jung Lee, Sung Su Jung, Ji Sun Yoon, Hyun Ju Cho, Eun Lee, Song I Yang, Ju Hee Seo, Hyo Bin Kim, Dong In Suh, Youn Ho Shin, Kyung Won Kim, Kangmo Ahn, Soo Jong Hong,

PURPOSE:The roles of gut microbiota on the natural course of atopic dermatitis (AD) are not yet fully understood. We investigated whether the composition and function of gut microbiota and short-chain fatty acids (SCFAs) at 6 months of age could affect the natural course of AD up to 24 months in ... Read more >>

Allergy Asthma Immunol Res (Allergy, asthma & immunology research)
[2020, 12(2):322-337]

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Effects of chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) on Th2/Th17-related immune modulation in an atopic dermatitis mouse model.

Han-Na Go, Seung-Hwa Lee, Hyun-Ju Cho, Jae-Rin Ahn, Mi-Jin Kang, So-Yeon Lee, Soo-Jong Hong,

Exposure to chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) has been associated with allergic contact dermatitis and occupational asthma. Despite this association however, no study has investigated the effects of CMIT/MIT exposure on the development of atopic dermatitis (AD). This study was conducted to investigate the influence of epicutaneous exposure to CMIT/MIT on AD in ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4099]

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Biologicals in atopic disease in pregnancy: an EAACI position paper.

Birgit Pfaller, Juan José Yepes-Nuñez, Ioana Agache, Cezmi A Akdis, Mohammad Alsalamah, Sevim Bavbek, Apostolos Bossios, Onur Boyman, Adam Chaker, Susan Chan, Alexia Chatzipetrou, George du Toit, Marek Jutel, Paula Kauppi, Antonios Kolios, Carmen Li, Andrea Matucci, Alanna Marson, Sarah Bendien, Oscar Palomares, Barbara Rogala, Zsolt Szepfalusi, Eva Untersmayr, Alessandra Vultaggio, Thomas Eiwegger,

Biologicals have transformed the management of severe disease phenotypes in asthma, atopic dermatitis, and chronic spontaneous urticaria. As a result, the number of approved biologicals for the treatment of atopic diseases is continuously increasing. Although atopic diseases are among the most common diseases in the reproductive age, investigations, and information ... Read more >>

Allergy (Allergy)
[2020, :]

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Cumulative Lifetime Burden of Cardiovascular Disease From Early Exposure to Air Pollution.

Juyong Brian Kim, Mary Prunicki, Francois Haddad, Christopher Dant, Vanitha Sampath, Rushali Patel, Eric Smith, Cezmi Akdis, John Balmes, Michael P Snyder, Joseph C Wu, Kari C Nadeau,

The disease burden associated with air pollution continues to grow. The World Health Organization (WHO) estimates ≈7 million people worldwide die yearly from exposure to polluted air, half of which-3.3 million-are attributable to cardiovascular disease (CVD), greater than from major modifiable CVD risks including smoking, hypertension, hyperlipidemia, and diabetes mellitus. This serious ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(6):e014944]

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