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Neuropathological changes in dorsal root ganglia induced by pyridoxine in dogs.

Sumin Yun, Woosuk Kim, Min Soo Kang, Tae Hyeong Kim, Yoonhwan Kim, Jin-Ok Ahn, Jung Hoon Choi, In Koo Hwang, Jin-Young Chung,

BACKGROUND:Pyridoxine (PDX; vitamin B6), is an essential vitamin. PDX deficiency induces various symptoms, and when PDX is misused it acts as a neurotoxicant, inducing severe sensory neuropathy. RESULTS:To assess the possibility of creating a reversible sensory neuropathy model using dogs, 150 mg/kg of PDX was injected subcutaneously into dogs for ... Read more >>

BMC Neurosci (BMC neuroscience)
[2020, 21(1):11]

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Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice.

Francesco De Logu, Simone Li Puma, Lorenzo Landini, Francesca Portelli, Alessandro Innocenti, Daniel Souza Monteiro de Araujo, Malvin N Janal, Riccardo Patacchini, Nigel W Bunnett, Pierangelo Geppetti, Romina Nassini,

Excessive alcohol consumption is associated with spontaneous burning pain, hyperalgesia, and allodynia. Although acetaldehyde has been implicated in the painful alcoholic neuropathy, the mechanism by which the ethanol metabolite causes pain symptoms is unknown. Acute ethanol ingestion caused delayed mechanical allodynia in mice. Inhibition of alcohol dehydrogenase (ADH) or deletion ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2019, 129(12):5424-5441]

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Electron Microscopic and Immunohistochemical Examination of the Effect of 2-Aminoethoxydiphenyl Borate on Optic Nerve Injury in A Rat Model.

Tuba Demirci, Nuray Bilge, Metin Ucar, Ozlem Ozgul Abuc, Hilal Atilay,

Objective:We conducted this study to explore the possible protective effect of 2-aminoethoxydiphenyl borate (2-APB) on experimentally induced optic nerve injury in an acute ischemia-reperfusion (AIR) model. Materials and Methods:A total of 30 Wistar albino rats were randomly divided into sham, AIR, and AIR+treatment (AIR10) groups. In the sham group, AIR ... Read more >>

Eurasian J Med (The Eurasian journal of medicine)
[2020, 52(1):61-66]

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Sirt2-associated transcriptome modifications in cisplatin-induced neuronal injury.

Xin Zhao, Wuying Du, Manchao Zhang, Zainab O Atiq, Fen Xia,

BACKGROUND:Chemotherapy-induced peripheral neuropathy is not only one of the most common causes of dose reduction or discontinuation of cancer treatment, but it can also permanently decrease the quality of life of cancer patients and survivors. Notably, Sirt2 protects many organs from various injuries, including diabetic peripheral neuropathy. As demonstrated previously ... Read more >>

BMC Genomics (BMC genomics)
[2020, 21(1):192]

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Lipidomics dataset of sonication-induced traumatic optic neuropathy in mice.

Ronaldo Nuesi, Ryan A Gallo, Galina Dvoriantchikova, Daniel Pelaez, Sanjoy K Bhattacharya,

Traumatic optic neuropathy (TON) is the loss of vision secondary to trauma. Approximately two weeks after traumatic damage, diffuse retinal ganglion cell loss and axon degeneration of the optic nerve are exhibited [1]. Here we present the changes that occur in the optic nerve lipidome of two-month-old C57BL/6J mice following ... Read more >>

Data Brief (Data in brief)
[2020, 29:105147]

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Current and Emerging Pharmacotherapy for Fibromyalgia.

Roie Tzadok, Jacob N Ablin,

Introduction. Fibromyalgia syndrome (FMS) is a pain disorder with an estimated prevalence of 1-5%. It is associated with a variety of somatic and psychological disorders. Its exact pathogenesis is still unclear but is involved with neural oversensitization and decreased conditioned pain modulation (CPM), combined with cognitive dysfunction, memory impairment, and ... Read more >>

Pain Res Manag (Pain research & management)
[2020, 2020:6541798]

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Antinociceptive and Anti-Inflammatory Effects of Nypa fruticans Wurmb by Suppressing TRPV1 in the Sciatic Neuropathies.

Mi-Sun Kang, Kyung-Yae Hyun,

Neuropathic pain is generally characterized by sensory abnormalities such as sensory disorders, hyperalgesia, and allodynia. Recent studies have reported that TRPV1 activation is essential for establishing of inflammation in the neuropathy pain models, showing that the expression of this receptor is increased, and contributing to enhanced thermal sensitivity. Nypa fruticans ... Read more >>

Nutrients (Nutrients)
[2020, 12(1):]

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Histologic evaluation of femoral nerve demyelinating and axonal neuropathy in Wistar rats due to alendronate intake: a randomised study.

Papamitsou Theodora, Papakoulas Apostolos, Papaliagkas Vasileios, Karachrysafi Sofia, Dietrich Eva-Maria, Sioga Antonia,

Background:Bisphosphonates (BPs) are forceful inhibitors of osteoclast-mediated bone resorption. Long-term BP use is associated with multiple rare but severe adverse effects. The objective of this study was to investigate the possible effects of BPs in the structure of femoral nerve. Specimens from the femoral nerve of ten female 12-month old ... Read more >>

J Biol Res (Thessalon) (Journal of biological research (Thessalonike, Greece))
[2020, 27:2]

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The proteolytic fraction from Vasconcellea cundinamarcensis accelerates wound healing after corneal chemical burn in rabbits.

Rummenigge Oliveira Silva, Bruna Lopes da Costa, Carolina Nunes da Silva, Thaís Maria da Mata Martins, Lays Fernanda Nunes Dourado, Alfredo Miranda de Goes, Miriam Teresa Lopes, Carlos Edmundo Salas, Armando da Silva-Cunha, Flavia Rodrigues da Silva,

INTRODUCTION:Chemical ocular burns are among the most frequently eye-related injuries, which require immediate and intensive evaluation and care since they may lead to potential complications such as superinfection, corneal perforation, and blindness.Vasconcellea cundinamarcensis, a species from Caricaceae family, contains highly active proteolytic enzymes in its latex that show healing activity ... Read more >>

Burns (Burns : journal of the International Society for Burn Injuries)
[2019, :]

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A Metabolic Insight Into the Neuroprotective Effect of Jin-Mai-Tong (JMT) Decoction on Diabetic Rats With Peripheral Neuropathy Using Untargeted Metabolomics Strategy.

Qian Zhang, Wei Song, Xiaochun Liang, Jun Xie, Yue Shi, Xiaohu Shi, Bintao Qiu, Xiuting Chen,

Jin-Mai-Tong (JMT) decoction is a traditional Chinese compound prescription for treating diabetic peripheral neuropathy (DPN). The aim of this study is to investigate the neuroprotective effect of JMT decoction on diabetic rats with peripheral neuropathy and to elucidate the potential mechanism based on a metabolomics approach. Sprague-Dawley (SD) rats were ... Read more >>

Front Pharmacol (Frontiers in Pharmacology)
[2020, 11:221]

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Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior.

Hui Li, Xiang Ding, Robert Terkeltaub, Hang Lin, Yuqing Zhang, Bin Zhou, Ke He, Kun Li, Zhichen Liu, Jie Wei, Yuanheng Yang, Hui Xie, Chao Zeng, Guanghua Lei,

BACKGROUND:Metformin could activate adenosine monophosphate-activated protein kinase (AMPK) which was postulated as a potential therapeutic target for osteoarthritis. This study aimed to examine the effects of metformin on cartilage and pain in osteoarthritis mouse model. METHODS:Eighty 10-week-old male C57BL/6 mice were randomized to 6 groups: non-operation, sham-operation, destabilization of the ... Read more >>

Arthritis Res. Ther. (Arthritis research & therapy)
[2020, 22(1):34]

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Time in Range, as a Novel Metric of Glycemic Control, Is Reversely Associated with Presence of Diabetic Cardiovascular Autonomic Neuropathy Independent of HbA1c in Chinese Type 2 Diabetes.

Qingyu Guo, Pu Zang, Shaoying Xu, Wenjing Song, Zhen Zhang, Chunyan Liu, Zhanhong Guo, Jing Chen, Bin Lu, Ping Gu, Jiaqing Shao,

Objective:The objective of this study is to investigate the relationship between time in range (TIR), a new metric of continuous glucose monitoring (CGM) and cardiovascular autonomic neuropathy (CAN) in individuals with type 2 diabetes mellitus (T2DM). Methods:A total of 349 individuals with T2DM were enrolled in this study. Evaluating by ... Read more >>

J Diabetes Res (Journal of diabetes research)
[2020, 2020:5817074]

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Nonalcoholic fatty liver disease and alcoholic liver disease: metabolic diseases with systemic manifestations.

Alexander J Kovalic, George Cholankeril, Sanjaya K Satapathy,

The progression of liver disease is portrayed by several common, overarching signs and symptoms. Classically, these include findings such as spider angiomata, jaundice, palmar erythema, and as cirrhosis decompensates, ascites, variceal hemorrhage (VH), hepatic encephalopathy (HE), and hepatocellular carcinoma (HCC). Aside from these universal hallmarks among cirrhotics, patients with nonalcoholic ... Read more >>

Transl Gastroenterol Hepatol (Translational gastroenterology and hepatology)
[2019, 4:65]

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Risk factors and outcomes of diabetic foot ulcer among diabetes mellitus patients admitted to Nekemte referral hospital, western Ethiopia: Prospective observational study.

Firomsa Bekele, Legese Chelkeba, Ginenus Fekadu, Kumera Bekele,

Objectives:Diabetic foot ulcer is one of the complications of diabetes mellitus. The diabetic patients with foot infections especially gangrene require long-term hospitalization and carry the risk of limb amputation. Despite these challenges, there are a scarce studies done on risk factors and no finding on outcomes of diabetic foot ulcers ... Read more >>

Ann Med Surg (Lond) (Annals of medicine and surgery (2012))
[2020, 51:17-23]

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Central Nervous System Correlates of "Objective" Neuropathy in Alcohol Use Disorder.

Natalie M Zahr, Kilian M Pohl, Adolf Pfefferbaum, Edith V Sullivan,

BACKGROUND:Among the neurological consequences of alcoholism is peripheral neuropathy. Relative to human immunodeficiency virus (HIV) or diabetes-related neuropathies, neuropathy associated with alcohol use disorders (AUD) is understudied. In both the diabetes and HIV literature, emerging evidence supports a central nervous system (CNS) component to peripheral neuropathy. METHODS:In seeking a central ... Read more >>

Alcohol. Clin. Exp. Res. (Alcoholism, clinical and experimental research)
[2019, 43(10):2144-2152]

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Zonisamide enhances neurite outgrowth from adult rat dorsal root ganglion neurons, but not proliferation or migration of Schwann cells.

Shizuka Takaku, Kazunori Sango,

Zonisamide, an anti-epileptic and anti-Parkinson's disease drug, displays neurotrophic activity on cultured motor neurons and facilitates axonal regeneration after peripheral nerve injury in mice, but its underlying mechanisms remain unclear. In this study, zonisamide enhanced neurite outgrowth from cultured adult rat dorsal root ganglion (DRG) neurons in a concentration-dependent manner ... Read more >>

Histochem. Cell Biol. (Histochemistry and cell biology)
[2020, 153(3):177-184]

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Beneficial Effects of SREBP Decoy Oligodeoxynucleotide in an Animal Model of Hyperlipidemia.

Hyun-Jin An, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyemin Gu, Hyun-Ju Kim, Jaechan Leem, Sung Won Youn, Kwan-Kyu Park,

Hyperlipidemia is a chronic disorder that plays an important role in the development of cardiovascular diseases, type II diabetes, atherosclerosis, hypertension, and non-alcoholic fatty liver disease. Hyperlipidemias have created a worldwide health crisis and impose a substantial burden not only on personal health but also on societies and economies. Transcription ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(2):]

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An evaluation of genetic causes and environmental risks for bilateral optic atrophy.

Andrew T Chen, Lauren Brady, Dennis E Bulman, Arun N E Sundaram, Amadeo R Rodriguez, Edward Margolin, John S Waye, Mark A Tarnopolsky,

PURPOSE:To assess the clinical utility of next-generation sequencing (NGS) for the diagnosis of patients with optic atrophy (OA). DESIGN:Retrospective cohort study. METHODS:97 patients were referred to the McMaster University Medical Center (Hamilton, Ontario) for evaluation of bilateral OA. All patients were sent for NGS including a 22 nuclear gene panel ... Read more >>

PLoS ONE (PloS one)
[2019, 14(11):e0225656]

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A phase I/II study of weekly nab-paclitaxel plus cisplatin in chemotherapy-naïve patients with advanced non-small-cell lung cancer.

Yoshihiro Hattori, Yuko Kono, Shoichi Itoh, Takako Inoue, Yoshiko Urata, Yoshitaka Kawa, Rie Tohnai, Toru Kumagai, Kazumi Nishino, Ryuji Uozumi, Satoshi Morita, Shunichi Negoro, Fumio Imamura, Miyako Satouchi,

BACKGROUND:The aim of this study was to evaluate the efficacy and safety of nab-paclitaxel plus cisplatin in chemotherapy-naïve patients with advanced non-small-cell lung cancer (NSCLC). METHODS:Chemotherapy-naïve patients with advanced NSCLC were eligible. In the phase I dose-escalation cohort (3 + 3 design), patients received nab-paclitaxel (80 or 100 mg/m2 given intravenously on days ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):115]

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Tobacco-Alcohol Toxic Optic Neuropathy.

Farah Sunnar Constantin, Monica Irina Ion, Andrei Erol Constantin,

Purpose. To present the case of a 34-year-old man with sudden bilateral decrease of visual acuity, followed by a complete and fast recovery. Material and methods. We reported a case of an apparently healthy 34-year-old patient with sudden and unpainful decrease of visual acuity, presumed of toxic etiology. The patient ... Read more >>

Rom J Ophthalmol (Romanian journal of ophthalmology)
[2019, 63(4):403-405]

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Effect of ropivacaine on peripheral neuropathy in streptozocin diabetes-induced rats through TRPV1-CGRP pathway.

Nanwen Zhang, Haixiang Wei, Weifang Wu, Peimin Lin, Yuan Chen, Zhiwei Liu, Honglin Wang, Yize Bian, Kai Yu, Shan Lin, Yanqi Cui, Renwei Luo, Jianming Lin, Xiaole Chen,

Objective To determine the effect of ropivacaine on peripheral neuropathy in diabetic rats and its possible mechanism. Methods Forty-eight Sprague-Dawley rats were randomly divided into six groups: nondiabetic control group, nondiabetic group A (0.25% ropivacaine), nondiabetic group B (0.75% ropivacaine), diabetic control group (diabetic peripheral neuropathy (DPN) +artificial cerebrospinal fluid), ... Read more >>

Biosci. Rep. (Bioscience reports)
[2019, 39(11):]

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Effect of the combination of high-frequency repetitive magnetic stimulation and neurotropin on injured sciatic nerve regeneration in rats.

Jie Chen, Xian-Ju Zhou, Rong-Bin Sun,

Repetitive magnetic stimulation is effective for treating posttraumatic neuropathies following spinal or axonal injury. Neurotropin is a potential treatment for nerve injuries like demyelinating diseases. This study sought to observe the effects of high-frequency repetitive magnetic stimulation, neurotropin and their combined use in the treatment of peripheral nerve injury in ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(1):145-151]

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Upregulation of large myelin protein zero leads to Charcot-Marie-Tooth disease-like neuropathy in mice.

Yoshinori Otani, Nobuhiko Ohno, Jingjing Cui, Yoshihide Yamaguchi, Hiroko Baba,

Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy mainly caused by gene mutation of peripheral myelin proteins including myelin protein zero (P0, MPZ). Large myelin protein zero (L-MPZ) is an isoform of P0 that contains an extended polypeptide synthesized by translational readthrough at the C-terminus in tetrapods, including humans. The physiological ... Read more >>

Commun Biol (Communications biology)
[2020, 3(1):121]

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Intraorbital Steroid Injection for Active Thyroid Ophthalmopathy.

Abbas Bagheri, Mohammad Abbaszadeh, Shahin Yazdani,

Purpose:To evaluate the effect of orbital steroid injections in patients with active thyroid ophthalmopathy resistant to or dependent on systemic steroids, or with complications related to systemic steroid use. Methods:This prospective non-comparative case series includes 31 eyes of 17 patients with active thyroid ophthalmopathy and clinical activity score (CAS) of ... Read more >>

J Ophthalmic Vis Res (Journal of ophthalmic & vision research)
[2020, 15(1):69-77]

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Modulation of Glycine Receptor-Mediated Pain Signaling in vitro and in vivo by Glucose.

Rama Ashraf Hussein, Marwa Ahmed, Hans-Georg Breitinger, Ulrike Breitinger,

The inhibitory glycine receptor (GlyR) plays an important role in rapid synaptic inhibition in mammalian spinal cord, brainstem, higher brain centers, and is involved in transmission of nociceptive signals. Glucose and related mono- and disaccharides potentiate currents mediated by recombinant α1, α1-β, and α3 GlyRs. Here, we confirmed the specific ... Read more >>

Front Mol Neurosci (Frontiers in molecular neuroscience)
[2019, 12:280]

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