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Adult outcomes of childhood bronchiectasis.

Dawn Sibanda, Rosalyn Singleton, John Clark, Christine Desnoyers, Ellen Hodges, Gretchen Day, Gregory Redding,

Recent literature has highlighted the importance of transition from paediatric to adult care for children with chronic conditions. Non-cystic fibrosis bronchiectasis is an important cause of respiratory morbidity in low-income countries and in indigenous children from affluent countries; however, there is little information about adult outcomes of childhood bronchiectasis. We ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1731059]

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Australian Group on Antimicrobial Resistance (AGAR) Australian Staphylococcus aureus Sepsis Outcome Programme (ASSOP) Annual Report 2018.

Geoffrey W Coombs, Denise A Daley, Shakeel Mowlaboccus, Yung Thin Lee, Stanley Pang, ,

From 1 January to 31 December 2018, thirty-six institutions around Australia participated in the Australian Staphylococcus aureus Sepsis Outcome Programme (ASSOP). The aim of ASSOP 2018 was to determine the proportion of Staphylococcus aureus bacteraemia (SAB) isolates in Australia that are antimicrobial resistant, with particular emphasis on susceptibility to methicillin, ... Read more >>

Commun Dis Intell (2018) (Communicable diseases intelligence (2018))
[2020, 44:]

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Mortality of Sepsis in Patients With Rheumatoid Arthritis: A Single-Center Retrospective Analysis and Comparison With a Control Group.

Marco Krasselt, Christoph Baerwald, Sirak Petros, Olga Seifert,

INTRODUCTION/BACKGROUND:Patients with rheumatoid arthritis (RA) have a high risk of infections that may require intensive care unit (ICU) admission in case of resulting sepsis. Data regarding the mortality of these patients are very limited. This study investigated clinical characteristics and outcomes of patients with RA admitted to the ICU for ... Read more >>

J Intensive Care Med (Journal of intensive care medicine)
[2020, :885066620917588]

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Melflufen plus dexamethasone in relapsed and refractory multiple myeloma (O-12-M1): a multicentre, international, open-label, phase 1-2 study.

Paul G Richardson, Sara Bringhen, Peter Voorhees, Torben Plesner, Ulf-Henrik Mellqvist, Brandi Reeves, Claudia Paba-Prada, Hanan Zubair, Catriona Byrne, Dharminder Chauhan, Kenneth Anderson, Eva Nordström, Johan Harmenberg, Antonio Palumbo, Pieter Sonneveld,

BACKGROUND:Multiple myeloma is an incurable haematological malignancy, representing over 10% of haematological cancers in the USA. We did a phase 1-2 study of melflufen and dexamethasone in patients with relapsed and refractory multiple myeloma to determine the maximum tolerated dose of melflufen and to investigate its safety and efficacy. METHODS:We ... Read more >>

Lancet Haematol (The Lancet. Haematology)
[2020, :]

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Intravenous calcium Gluconate alleviates Lead-induced abdominal pain, a randomized clinical trial.

Masoud Mayel, Saleh Hamzeh, Salile Shahabi Rabori, Sareh Ghasemirad, Nasim Zamani, Hossein Hassanian-Moghaddam,

BACKGROUND:In 2016, in a lead poisoning outbreak in Iran, physicians reported thousands of opium users who presented to emergency departments (EDs) with intractable severe abdominal pain which did not respond to any narcotic medication. During the same period of time, we investigated the efficacy of intravenous calcium gluconate in alleviating ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):23]

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Sepsis in cancer patients residing in Zimbabwe: spectrum of bacterial and fungal aetiologies and their antimicrobial susceptibility patterns.

Frank Chinowaita, Wendy Chaka, Tinashe K Nyazika, Tendai C Maboreke, Emmanuel Tizauone, Prichard Mapondera, Inam Chitsike, Andrew Z Cakana, Rooyen T Mavenyengwa,

BACKGROUND:Cancer and sepsis comorbidity is a major public health problem in most parts of the world including Zimbabwe. The microbial aetiologies of sepsis and their antibiograms vary with time and locations. Knowledge on local microbial aetiologies of sepsis and their susceptibility patterns is critical in guiding empirical antimicrobial treatment choices. ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2020, 20(1):161]

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Acute pesticide poisoning amongst adolescent girls and women in northern Tanzania.

Elikana Lekei, Aiwerasia V Ngowi, Jones Kapeleka, Leslie London,

BACKGROUND:Acute pesticide poisoning (APP) is reported to affect community health worldwide but its burden in Tanzania is unknown particularly in women. This study examines APP involving adult females and adolescent girls 10 to 19 years in 3 regions of Tanzania which are famous for coffee and vegetable production. METHODS:Over the period ... Read more >>

BMC Public Health (BMC public health)
[2020, 20(1):303]

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Phase I and pharmacokinetic study of the vascular-disrupting agent CKD-516 (NOV120401) in patients with refractory solid tumors.

Hark Kyun Kim, Jeong Won Kang, Young-Whan Park, Jung Young Kim, Minchae Kim, Soo Jin Kim, Se-Mi Kim, Keun Ho Ryu, Seonghae Yoon, Yun Kim, Joo-Youn Cho, Keun Seok Lee, Tak Yun, Kiwon Kim, Mi Hyang Kwak, Tae-Sung Kim, Jinsoo Chung, Joong-Won Park,

We report a phase I pharmacological study of an oral formulation of CKD-516, a vascular-disrupting agent, in patients with refractory solid tumors. Twenty-seven patients (16 in the dose-escalation cohort and 11 in the expansion cohort) received a single daily dose (5-25 mg) of CKD-516 five days per week. Nausea (67%) and ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2020, 8(2):e00568]

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Resatorvid protects against hypoxic-ischemic brain damage in neonatal rats.

Li-Jun Jiang, Zhen-Xing Xu, Ming-Fu Wu, Gai-Qin Dong, Li-Li Zhang, Jun-Yan Gao, Chen-Xi Feng, Xing Feng,

Secondary brain damage caused by hyperactivation of autophagy and inflammatory responses in neurons plays an important role in hypoxic-ischemic brain damage (HIBD). Although previous studies have implicated Toll-like receptor 4 (TLR4) and nuclear factor kappa-B (NF-κB) in the neuroinflammatory response elicited by brain injury, the role and mechanisms of the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1316-1325]

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Descriptive study of adverse drug reactions in a tertiary care pediatric hospital in México from 2014 to 2017.

Olga Morales-Ríos, Carlo Cicero-Oneto, Carlos García-Ruiz, Dina Villanueva-García, Maribelle Hernández-Hernández, Víctor Olivar-López, Rodolfo Norberto Jiménez-Juárez, Luis Jasso-Gutiérrez,

INTRODUCTION:In Pediatrics, adverse drug reactions (ADRs) affect morbidity and mortality. In Mexico, the characteristics of ADRs and suspect drugs have not been described in hospitalized children. OBJECTIVE:To estimate the frequency of ADRs and describe them, as well as suspect drugs, in a tertiary care pediatric hospital in Mexico. METHODS:A total ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0230576]

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A Retrospective Study of Acute Poisoning Cases and Their Management at Emergency Department of Dessie Referral Hospital, Northeast Ethiopia.

Abebe Getie, Yaschilal Muche Belayneh,

Background:Poisoning causes significant patient morbidity and mortality worldwide. It is a common reason for emergency department visits and hospitalizations. Acute poisoning needs immediate effective management to prevent patient mortality or sequela. This study was carried out to determine the pattern of acute poisoning cases and their management at the emergency ... Read more >>

Drug Healthc Patient Saf (Drug, healthcare and patient safety)
[2020, 12:41-48]

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High-dose ulinastatin to prevent late-onset acute renal failure after orthotopic liver transplantation.

Haijin Lv, Xuxia Wei, Xiaomeng Yi, Jianrong Liu, Pinglan Lu, Mi Zhou, Yuling An, Huimin Yi,

Purpose: To compare the efficacy and safety of two distinct doses of ulinastatin on late-onset acute renal failure (LARF) following orthotopic liver transplantation (OLT).Methods: The high-risk recipients that underwent OLT were divided into two groups according to ulinastatin dose: low-dose (LD) ulinastatin group, 0.8 million U/d; high-dose (HD) ulinastatin group, ... Read more >>

Ren Fail (Renal failure)
[2020, 42(1):137-145]

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Different signaling pathways involved in the anti-inflammatory effects of unfractionated heparin on lipopolysaccharide-stimulated human endothelial cells.

Xu Li, Lu Li, Yuequan Shi, Sihan Yu, Xiaochun Ma,

Background:There is a complex interplay between inflammatory response and coagulation in sepsis. Heparin is used as a recognized anticoagulant and possesses multiple biological properties that possibly affect sepsis. This study aimed to determine the possible signaling pathways involved in the anti-inflammatory effects of unfractionated heparin (UFH) on lipopolysaccharide (LPS)-stimulated human ... Read more >>

J Inflamm (Lond) (Journal of inflammation (London, England))
[2020, 17:5]

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Severe sepsis caused by serious gastrointestinal infection in sJIA patients treated with IL-6 receptor antagonist: a case report.

Meng Xu, Congcong Liu, Lishuang Guo, Sirui Yang,

BACKGROUND:Interleukin (IL)-6 plays an essential role in the pathogenesis of systemic juvenile idiopathic arthritis (sJIA). Tocilizumab (TCZ), a kind of biological agent against both membrane and soluble IL-6 receptor, is the only biological agent approved for the treatment of sJIA in China. Infections are the most common adverse events during ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):126]

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Iatrogenic Decompensated Heart Failure.

Patrick Tran, Prithwish Banerjee,

PURPOSE OF REVIEW:To provide an overview of the potential iatrogenic causes of acute decompensated heart failure (AHF) and an evidence-based management strategy to address this. RECENT FINDINGS:As the heart failure (HF) population continues to age and become burdened with greater comorbidities and polypharmacy, patients become more susceptible to the iatrogenic ... Read more >>

Curr Heart Fail Rep (Current heart failure reports)
[2020, 17(2):21-27]

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Anticoagulant therapy for septic coagulopathy and disseminated intravascular coagulation: where do KyberSept and SCARLET leave us?

Christian J Wiedermann,

The use of antithrombin and thrombomodulin to restore impaired anticoagulant pathways in septic coagulopathy has been shown to significantly increase the resolution rate of disseminated intravascular coagulation. In KyberSept and SCARLET, two large, international, randomized controlled trials in patients with sepsis, these anticoagulants have not shown significantly reduced mortality. The ... Read more >>

Acute Med Surg (Acute medicine & surgery)
[2020, 7(1):e477]

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The Effects of Obesity on Outcome in Preclinical Animal Models of Infection and Sepsis: A Systematic Review and Meta-Analysis.

Wanying Xu, Dominique Pepper, Junfeng Sun, Judith Welsh, Xizhong Cui, Peter Q Eichacker,

Background:Clinical studies suggest obesity paradoxically increases survival during bacterial infection and sepsis but decreases it with influenza, but these studies are observational. By contrast, animal studies of obesity in infection can prospectively compare obese versus nonobese controls. We performed a systematic review and meta-analysis of animal investigations to further examine ... Read more >>

J Obes (Journal of obesity)
[2020, 2020:1508764]

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Factors associated with the development of septic shock in patients with candidemia: a post hoc analysis from two prospective cohorts.

Matteo Bassetti, Antonio Vena, Marco Meroi, Celia Cardozo, Guillermo Cuervo, Daniele Roberto Giacobbe, Miguel Salavert, Paloma Merino, Francesca Gioia, Mario Fernández-Ruiz, Luis Eduardo López-Cortés, Benito Almirante, Laura Escolà-Vergé, Miguel Montejo, Manuela Aguilar-Guisado, Pedro Puerta-Alcalde, Mariona Tasias, Alba Ruiz-Gaitán, Fernando González, Mireia Puig-Asensio, Francesc Marco, Javier Pemán, Jesus Fortún, Jose Maria Aguado, Alejandro Soriano, Jordi Carratalá, Carolina Garcia-Vidal, Maricela Valerio, Assunta Sartor, Emilio Bouza, Patricia Muñoz,

BACKGROUND:Almost one third of the patients with candidemia develop septic shock. The understanding why some patients do and others do not develop septic shock is very limited. The objective of this study was to identify variables associated with septic shock development in a large population of patients with candidemia. METHODS:A ... Read more >>

Crit Care (Critical care (London, England))
[2020, 24(1):117]

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Incidence and Lethality of Suicidal Overdoses by Drug Class.

Ted R Miller, David I Swedler, Bruce A Lawrence, Bina Ali, Ian R H Rockett, Nancy N Carlson, Jennifer Leonardo,

Importance:Prior lethality analyses of suicide means have historically treated drug poisoning other than alcohol poisoning as a lumped category. Assessing risk by drug class permits better assessment of prevention opportunities. Objective:To investigate the epidemiology of drug poisoning suicides. Design, Setting, and Participants:This cross-sectional study analyzed censuses of live emergency department ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(3):e200607]

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Poisson poisoning as the mechanism of action of the microtubule-targeting agent colchicine

Hemmat, Braman, Escalante, D.J. Odde,

Abstract Microtubule-directed anti-cancer drugs, such as paclitaxel, vinblastine, and colchicine, disrupt cell mitosis through suppression of microtubule dynamics (“kinetic stabilization”). However, while the molecular mechanisms of paclitaxel and vinblastine act as pseudo- and true-kinetic stabilizers, respectively, the molecular mechanism of colchicine has remained enigmatic since it requires explanation of both ... Read more >>

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Combination of Glutamine and Ulinastatin Treatments Greatly Improves Sepsis Outcomes.

Junyan Wang, Jiahui Zhou, Shuancheng Bai,

Background:Sepsis is one of the most dangerous syndromes, has extremely high mortality, and is caused by the body's extreme responses to an infection. The pathogenesis of sepsis is very complex and remains largely unknown and thus the treatments for sepsis are limited. Here, we evaluated the treatment results of two ... Read more >>

J Inflamm Res (Journal of inflammation research)
[2020, 13:109-115]

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A simple dose of antibiotics: qualitative analysis of sepsis reporting in UK newspapers.

Lynne Rush, Shona Hilton, Lisa McDaid,

BACKGROUND:A recent drive to improve sepsis awareness has been accompanied by prolific media reporting about its management in children. Media reporting is known to influence public understanding of health issues and subsequent health-seeking behaviour. AIM:To examine UK newspaper representations of sepsis in children to better understand how the messages they ... Read more >>

BJGP Open (BJGP open)
[2020, :]

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Prescription of CRRT: a pathway to optimize therapy.

Ayman Karkar, Claudio Ronco,

Severe acute kidney injury (AKI), especially when caused or accompanied by sepsis, is associated with prolonged hospitalization, progression to chronic kidney disease (CKD), financial burden, and high mortality rate. Continuous renal replacement therapy (CRRT) is a predominant form of renal replacement therapy (RRT) in the intensive care unit (ICU) due ... Read more >>

Ann Intensive Care (Annals of intensive care)
[2020, 10(1):32]

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Electrolyte and acid-base disorders in cancer patients and its impact on clinical outcomes: evidence from a real-world study in China.

Yang Li, Xiaohong Chen, Ziyan Shen, Yimei Wang, Jiachang Hu, Jiarui Xu, Bo Shen, Xiaoqiang Ding,

Background: This study aims to delineate the incidence of electrolyte and acid-base disorders (EAD) in cancer patients, to figure out the risk factors of EAD, then to assess the impact of EAD on patients' in-hospital clinical outcomes.Methods: Patients with the diagnosis of malignancies hospitalized during 1 October 2014 and 30 ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):234-243]

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Pharmaceutical care recommendations for antiviral treatments in children with coronavirus disease 2019.

Yan Wang, Li-Qin Zhu,

World J Pediatr (World journal of pediatrics : WJP)
[0, :1-4]

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