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Adult Optic Neuritis

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Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014-2019.

Bridget Martinez, Philip V Peplow,

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. The disability caused by inflammatory demyelination clinically dominates the early stages of relapsing-remitting MS and is reversible. Once there is considerable loss of axons, MS patients enter a secondary progressive stage. Disease-modifying drugs currently in use for ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1220-1234]

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Optic neuritis at the nexus of peripheral autoimmunity and central nervous system demyelination: a nationwide cohort study

Wei-Sheng Lin, Ho-Min Chen, Chih-Chao Yang, Ta-Ching Chen, Jou-Wei Lin, Wang-Tso Lee,

<title>Abstract</title> <p> Background Long-term course of optic neuritis is heterogeneous and varies across populations. We aim to investigate immune-related determinants that predict conversion of optic neuritis (ON) to multiple sclerosis (MS) or neuromyelitis optica (NMO) in a nationwide cohort. Methods We conducted the population-based cohort ... Read more >>

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Matrine protects retinal ganglion cells from apoptosis in experimental optic neuritis

Lin Zhu, Jian Kang, Shu-Qing Liu, Yi-Fan Song, Meng-Ru Wang, Yao-Juan Chu, Ya-Min Shi, Feng-Yan Zhang,

<title>Abstract</title> <p> Background: Inflammatory demyelination and axonal injury of the optic nerve are hallmarks of optic neuritis (ON), which often occurs in multiple sclerosis and is a major cause of visual disturbance in young adults. Although a high dose of corticosteroids can promote visual recovery, it cannot prevent ... Read more >>

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Targeted Kruppel-like factor 4 gene knockout in retinal ganglion cells improves visual function in multiple sclerosis mouse model.

Venu Talla, Rajeshwari Koilkonda,

Axonal demyelination injury and neuronal degeneration are the primary causes of visual disability in multiple sclerosis-linked optic neuritis (MS/optic neuritis) patients. Immunomodulatory therapies targeting inflammation have failed to avert the disease progression and no therapies exist to prevent the neuronal deficits seen in MS to date. Neuroprotective strategies targeting oligodendrocytes ... Read more >>

eNeuro (eNeuro)
[2020, :]

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Triple infection with Cryptococcus, varicella-zoster virus, and Mycobacterium abscessus in a patient with anti-interferon-gamma autoantibodies: a case report.

Pongprueth Rujirachun, Jirath Sangwongwanich, Methee Chayakulkeeree,

BACKGROUND:The most common infection in patients positive for anti-interferon-gamma autoantibodies (anti-IFN-γ AAbs) is disseminated nontuberculous mycobacterial (dNTM) infection. Here, we report a rare case of triple infection caused by Cryptococcus, varicella-zoster virus (VZV), and nontuberculous mycobacterium in a patient with anti-IFN-γ AAbs. CASE PRESENTATION:A 53-year-old Thai man presented with a ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2020, 20(1):232]

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Dramatic efficacy of ofatumumab in refractory pediatric-onset AQP4-IgG neuromyelitis optica spectrum disorder.

Elisabeth Maillart, Florence Renaldo, Caroline Papeix, Kumaran Deiva, Julie Bonheur, Teresa Kwon, Odile Boespflug-Tanguy, David Germanaud, Romain Marignier,

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(3):]

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Randomized control trial of evaluation of Clemastine effects on visual evoked potential, nerve fiber layer and ganglion cell layer complex in patients with optic neuritis.

Mehdi Moghaddasi, Mona Nabovvati, Amin Koushki, Mostafa Soltansanjari, Mahsa Sardarinia, Nafise Mohebi, Seyedhossein Rabani,

OBJECTIVES:Optic neuritis (ON) is the most common cause of optic neuropathy; typically presenting with a unilateral visual loss in young adults, with incidence of 1-5 in 100,000 per year. We evaluated the effect of Clemastine, a first-generation and CNS (central nervous system)-penetrant H1 receptor antagonist on visual evoked potential (VEP), ... Read more >>

Clin Neurol Neurosurg (Clinical neurology and neurosurgery)
[2020, 193:105741]

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Neurological manifestations of autoinflammatory diseases in Chinese adult patients.

Wenyi Qin, Di Wu, Yi Luo, Mengzhu Zhao, Yi Wang, Xiaochun Shi, Lixin Zhou, Weihong Yu, Yang Sun, Rongrong Wang, Wen Zhang, Mengqi Liu, Min Shen,

OBJECTIVE:Systemic autoinflammatory diseases (SAIDs) are a group of disorders characterized by a dysregulation of innate immune system leading to multi-systemic inflammation. We aim to assess the neurological manifestations of Chinese adult patients with SAIDs. METHODS:Eighty adult patients (≥16 years) were diagnosed as SAIDs from April 2015 to June 2019, at ... Read more >>

Semin. Arthritis Rheum. (Seminars in arthritis and rheumatism)
[2020, :]

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Isolated Area Postrema Syndrome Presenting as Intractable Nausea and Vomiting.

Vasuki Dandu, Suman Siddamreddy, Sreenath Meegada, Vijayadershan Muppidi, Tejo Challa,

Neuromyelitis optica (NMO) is a disease of central nervous system, characterized by demyelination and axonal damage mostly involving optic nerves and spinal cord. Usually these patients present with symptoms related to optic neuritis or myelitis with a typical relapsing course. Some patients present with less common symptoms involving brain stem ... Read more >>

Cureus (Cureus)
[2020, 12(2):e7058]

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Clinical phenotype, radiological features, and treatment of myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG) optic neuritis.

John J Chen, M Tariq Bhatti,

PURPOSE OF REVIEW:To review the clinical characteristics, radiological manifestations and treatment of myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG) optic neuritis. RECENT FINDINGS:Serum antibodies to MOG have recently been found to be a biomarker of MOG-IgG-associated disorder (MOGAD), a demyelinating disease distinct from both multiple sclerosis (MS) and aquaporin-4-IgG neuromyelitis optica ... Read more >>

Curr. Opin. Neurol. (Current opinion in neurology)
[2020, 33(1):47-54]

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Neurological Adverse Effects Associated with anti-TNF Alpha Antibodies in Pediatric Inflammatory Bowel Diseases.

Valérie Bertrand, Nathalie Massy, Bénédicte Pigneur, Stéphanie Coopman, Geneviève Durrieu, Louise Gaboriau, Vincent Langlois, Corinne Gower-Rousseau, Jean-Pierre Hugot, Frank M Ruemmele, ,

OBJECTIVES:neurologic adverse effects (NAE) induced by biotherapies have been reported in the literature mainly in adult patients with inflammatory bowel disease (IBD), rheumatic diseases or psoriasis. There are scant data in children. Aims of this study are to report and describe non-infective NAE associated with anti-TNFα antibodies in pediatric IBD, ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2020, :]

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Multiphasic acute disseminated encephalomyelitis and differential with early onset multiple sclerosis.

Arla Cinderella Stokes Brackett, Otto Jesus Hernández-Fustes, Carlos Arteaga Rodríguez, Olga Judith Hernandez Fustes,

Multiple sclerosis is considered the most frequent demyelinating disorder of the Central Nervous System (CNS) among young adults, yet is very rare before 10 years old. Acute disseminated encephalomyelitis is a monophasic, polysymptomatic disorder that involves the CNS white matter with demyelinating lesions, which usually occurs after systemic viral infections. ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2020, 9(1):61-63]

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A Fulminant Case of Demyelinating Encephalitis With Extensive Cortical Involvement Associated With Anti-MOG Antibodies.

Sonja Hochmeister, Thomas Gattringer, Martin Asslaber, Verena Stangl, Michaela Tanja Haindl, Christian Enzinger, Romana Höftberger,

Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies (MOG-Abs) are commonly associated with clinical presentations as acute disseminated encephalomyelitis (ADEM) in both adults and children and anti-aquaporin 4 antibody-seronegative neuromyelitis optica spectrum disorder (NMOSD) and related syndromes such as optic neuritis, myelitis, and brainstem encephalitis. Most often, the presence of MOG-Abs is associated ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:31]

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Effects of the Positive Threshold and Data Analysis on Human MOG Antibody Detection by Live Flow Cytometry.

Fiona Tea, Deepti Pilli, Sudarshini Ramanathan, Joseph A Lopez, Vera Merheb, Fiona X Z Lee, Alicia Zou, Ganesha Liyanage, Chelsea B Bassett, Selina Thomsen, Stephen W Reddel, Michael H Barnett, David A Brown, Russell C Dale, Fabienne Brilot, ,

Human autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG Ab) have become a useful clinical biomarker for the diagnosis of a spectrum of inflammatory demyelinating disorders. Live cell-based assays that detect MOG Ab against conformational MOG are currently the gold standard. Flow cytometry, in which serum binding to MOG-expressing cells and control ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:119]

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Role of Diffusional Kurtosis Imaging in Differentiating Neuromyelitis Optica-Related and Multiple Sclerosis-Related Acute Optic Neuritis: Comparison With Diffusion-Weighted Imaging.

Ping Lu, Ting Yuan, Xilan Liu, Guohong Tian, Jibin Zhang, Yan Sha,

PURPOSE:The discrimination between neuromyelitis optica (NMO)- and multiple sclerosis (MS)-related acute optic neuritis (ON) after the first presentation is difficult in clinical practice. Through a comparison with diffusion-weighted imaging using readout-segmented echo-planar imaging (RESOLVE-DWI), our aim was to determine the feasibility of diffusional kurtosis imaging (DKI) for differential diagnosis. MATERIALS ... Read more >>

J Comput Assist Tomogr (Journal of computer assisted tomography)
[2020, 44(1):47-52]

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International multicenter examination of MOG antibody assays.

Markus Reindl, Kathrin Schanda, Mark Woodhall, Fiona Tea, Sudarshini Ramanathan, Jessica Sagen, James P Fryer, John Mills, Bianca Teegen, Swantje Mindorf, Nora Ritter, Ulrike Krummrei, Winfried Stöcker, Juliane Eggert, Eoin P Flanagan, Melanie Ramberger, Harald Hegen, Kevin Rostasy, Thomas Berger, Maria Isabel Leite, Jacqueline Palace, Sarosh R Irani, Russell C Dale, Christian Probst, Monika Probst, Fabienne Brilot, Sean J Pittock, Patrick Waters,

OBJECTIVE:To compare the reproducibility of 11 antibody assays for immunoglobulin (Ig) G and IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG and MOG-IgM) from 5 international centers. METHODS:The following samples were analyzed: MOG-IgG clearly positive sera (n = 39), MOG-IgG low positive sera (n = 39), borderline negative sera (n = 13), ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(2):]

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Acute disseminated encephalomyelitis (ADEM) associated with mosquito-borne diseases: Chikungunya virus X yellow fever immunization.

Karolyna Carvalho, Ana Luiza Biancardi, Giovanna Provenzano, Haroldo Moraes,

Acute disseminated encephalomyelitis (ADEM) is a demyelinating autoimmune neuropathic condition characterized by extensive bilateral and confluent lesions in the cerebral white matter and cerebellum. The basal ganglia and gray matter may also be involved. In most cases, the symptoms are preceded by viral infection or vaccination. In this report, we ... Read more >>

Rev. Soc. Bras. Med. Trop. (Revista da Sociedade Brasileira de Medicina Tropical)
[2020, 53:e20190160]

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Diagnosis of Syphilitic Bilateral Papillitis Mimicking Papilloedema.

Alicia Gonzalez-Martinez, Sonia Quintas, Diego Celdrán Vivancos, José Cebrián, José Vivancos,

Syphilis produces myriad nonspecific signs and symptoms. For example, optic disk swelling might be seen in patients with syphilis as a result of cranial hypertension (papilloedema), inflammatory optic neuritis with papillitis, or optic perineuritis. We report a case involving differential diagnosis of syphilitic bilateral papillitis mimicking papilloedema. ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(1):171-173]

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Fingolimod after a first unilateral episode of acute optic neuritis (MOVING) - preliminary results from a randomized, rater-blind, active-controlled, phase 2 trial.

Christian Albert, Janine Mikolajczak, Anja Liekfeld, Sophie K Piper, Michael Scheel, Hanna G Zimmermann, Claus Nowak, Jan Dörr, Judith Bellmann-Strobl, Claudia Chien, Alexander U Brandt, Friedemann Paul, Olaf Hoffmann,

BACKGROUND:Neuroprotection and promotion of remyelination represent important therapeutic gaps in multiple sclerosis (MS). Acute optic neuritis (ON) is a frequent MS manifestation. Based on the presence and properties of sphingosine-1-phosphate receptors (S1PR) on astrocytes and oligodendrocytes, we hypothesized that remyelination can be enhanced by treatment with fingolimod, a S1PR modulator ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):75]

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Stage IV Small Lymphocytic Lymphoma Presenting with Unilateral Vision Loss.

Christopher Le, Adam Jacob, Devarajan Iyengar, John Dedousis, Antonios Tsompanidis,

Small lymphocytic lymphoma (SLL) is a manifestation of chronic lymphocytic leukemia (CLL) in which malignant B-cell lymphocytes accumulate in the lymph nodes or bone marrow. In this report, we describe the medical course of a patient diagnosed with stage IV small cell lymphocytic lymphoma, who presented to the emergency room ... Read more >>

Case Rep Oncol Med (Case reports in oncological medicine)
[2020, 2020:3752409]

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Novel MT-ND Gene Variants Causing Adult-Onset Mitochondrial Disease and Isolated Complex I Deficiency.

Yi Shiau Ng, Kyle Thompson, Daniela Loher, Sila Hopton, Gavin Falkous, Steven A Hardy, Andrew M Schaefer, Sandip Shaunak, Mark E Roberts, James B Lilleker, Robert W Taylor,

Mitochondrial complex I deficiency is associated with a diverse range of clinical phenotypes and can arise due to either mitochondrial DNA (mtDNA) or nuclear gene defects. We investigated two adult patients who exhibited non-syndromic neurological features and evidence of isolated mitochondrial complex I deficiency in skeletal muscle biopsies. The first ... Read more >>

Front Genet (Frontiers in Genetics)
[2020, 11:24]

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Acute changes in ganglion cell layer thickness in ischemic optic neuropathy compared to optic neuritis using optical coherence tomography.

Peter W MacIntosh, S Vijay Kumar, V R Saravanan, Virna M Shah,

AIM:To elucidate the changes of different ganglion cell layer (GCL) thinning patterns between the optic neuritis (ON) and non-arteritic anterior ischemic optic neuropathy (NAION). METHODS:A prospective, observational study was conducted to evaluate the timing of GCL changes between acute ON and NAION using optical coherence tomography. RESULTS:Thinning on optical coherence ... Read more >>

Int J Ophthalmol (International journal of ophthalmology)
[2020, 13(1):120-123]

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Clinical Course, Imaging Characteristics, and Therapeutic Response in Myelin Oligodendrocyte Glycoprotein Antibody Disease: A Case Series.

Joe James, James Jose, V Abdul Gafoor, B Smita, Neetha Balaram, Aparna Ramachandran,

Myelin oligodendrocyte glycoprotein (MOG) antibody disease is a novel central nervous system autoimmune disorder which forms part of aquaporin 4 (AQP-4) negative, neuromyelitis optica (NMO) spectrum disorder. It has a distinct clinical profile, neuroimaging features and courses from AQP-4 positive NMO and multiple sclerosis. This article is a case series ... Read more >>

J Neurosci Rural Pract (Journal of neurosciences in rural practice)
[2020, 11(1):205-210]

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Seven-year nationwide incidence of optic neuritis requiring intravenous methylprednisolone injection in Korean adults.

Daye Diana Choi, Min-Su Park, Kyung-Ah Park,

Acta Ophthalmol (Acta ophthalmologica)
[2019, :]

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Intracranial Metastases Originating From Pediatric Primary Spinal Cord Glioblastoma Multiforme: A Case Report and Literature Review.

Dengpan Song, Dingkang Xu, Qiang Gao, Peizhu Hu, Fuyou Guo,

Primary spinal cord glioblastoma multiforme (scGBM) is an uncommon entity in pediatrics, and intracranial metastasis originating in spinal cord gliomas is very rare. A 7-year-old female presented with weakness in the limbs, paralysis of the lower limbs and incontinence. The initial MRI of the spinal cord revealed expansion and abnormal ... Read more >>

Front Oncol (Frontiers in Oncology)
[2020, 10:99]

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