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Outcomes of critically ill patients with acute kidney injury in COVID-19 infection: an observational study.

Rodrigo Bezerra, Flávio Teles, Polyana Bezerra Mendonca, Tedla Damte, Andrew Likaka, Edyniesky Ferrer-Miranda, Jones Oliveira de Albuquerque, José Luiz de Lima Filho,

<h4>Background</h4>Early reports indicate that AKI is common during COVID-19 infection. Different mortality rates of AKI due to SARS-CoV-2 have been reported, based on the degree of organic dysfunction and varying from public to private hospitals. However, there is a lack of data about AKI among critically ill patients with COVID-19.<h4>Methods</h4>We ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):911-918]

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Vinegar-processed Curcuma phaeocaulis promotes anti-angiogenic activity and reduces toxicity in zebrafish and rat models.

Wan Liao, Yi Chen, Zongping Zhu, Jiao Chen, Tianhui Gao, Boonjai Limsila, Yenchit Techadamrongsin, Lei Wang, Jiali Yu, Chaomei Fu, Rui Li,

<h4>Context</h4>Processing with vinegar could enhance the efficacy and reduce the toxicity of <i>Curcuma phaeocaulis</i> Valeton. (Zingiberaceae), a Chinese herbal medicine with anti-inflammatory and antitumor activities.<h4>Objective</h4>This study investigated the vinegar processing effects by evaluating anti-angiogenic effect and toxicity of <i>C. phaeocaulis</i> through zebrafish and rat models.<h4>Materials and methods</h4>Zebrafish embryos (AB and ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):410-417]

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Activation of the β-carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with amines and amino acids.

Andrea Angeli, Linda J Urbański, Vesa P Hytönen, Seppo Parkkila, Claudiu T Supuran,

We report the first activation study of the β-class carbonic anhydrase (CA, EC 4.2.1.1) encoded in the genome of the protozoan pathogen <i>Trichomonas vaginalis</i>, TvaCA1. Among 24 amino acid and amine activators investigated, derivatives incorporating a second carboxylic moiety, such as L-Asp, L- and D-Glu, were devoid of activating effects ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):758-763]

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Effect of amino acids and amines on the activity of the recombinant ι-carbonic anhydrase from the Gram-negative bacterium Burkholderia territorii.

Viviana De Luca, Andrea Petreni, Vincenzo Carginale, Andrea Scaloni, Claudiu T Supuran, Clemente Capasso,

We here report a study on the activation of the ι-class bacterial CA from <i>Burkholderia territorii</i> (BteCAι). This protein was recently characterised as a zinc-dependent enzyme that shows a significant catalytic activity (<i>k</i><sub>cat</sub> 3.0 × 10<sup>5</sup> s<sup>-1</sup>) for the physiological reaction of CO<sub>2</sub> hydration to bicarbonate and protons. Some amino acids and amines, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):1000-1006]

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Activation of carbonic anhydrase isoforms involved in modulation of emotional memory and cognitive disorders with histamine agonists, antagonists and derivatives.

Gustavo Provensi, Alessio Nocentini, Maria Beatrice Passani, Patrizio Blandina, Claudiu T Supuran,

Carbonic anhydrases (CAs, EC 4.2.1.1) activators were shown to be involved in memory enhancement and learning in animal models of cognition. Here we investigated the CA activating effects of a large series of histamine based compounds, including histamine receptors (H<sub>1</sub>R - H<sub>4</sub>R) agonists, antagonists and other derivatives of this autacoid. ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):719-726]

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Hippo signaling pathway in companion animal diseases, an under investigated signaling cascade.

Shaydee J Budel, Marloes M Penning, Louis C Penning,

The Hippo pathway is a highly conserved kinase cascade in mammals with the proteins YAP and TAZ as its most important downstream effectors that shuttle between cytoplasma and nucleus. It has a crucial role in processes such as embryogenesis, organ size control, homeostasis and tissue regeneration, where mechanosensing and/or cell-cell ... Read more >>

Vet Q (The veterinary quarterly)
[2021, 41(1):172-180]

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Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators.

Alessio Nocentini, Doretta Cuffaro, Lidia Ciccone, Elisabetta Orlandini, Susanna Nencetti, Elisa Nuti, Armando Rossello, Claudiu T Supuran,

The synthesis and carbonic anhydrase (CA; EC 4.2.1.1) activating effects of a series of oxime ether-based amino alcohols towards four human (h) CA isoforms expressed in human brain, hCA I, II, IV and VII, are described. Most investigated amino alcohol derivatives induced a consistent activation of the tested CAs, with ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):48-57]

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Pharmacokinetics of Single Dose Lidocaine and Epinephrine Following Iontophoresis of the Tympanic Membrane in a Double-Blinded Randomized Trial.

Laura J England, Charles A Syms, Christopher York,

<h4>Objective</h4>To evaluate local and systemic safety of bilateral iontophoretic administration of lidocaine with epinephrine or lidocaine alone to the tympanic membrane (TM).<h4>Study design</h4>A randomized, double-blind, two-arm study was conducted at a single center. Healthy adults were randomized to bilateral iontophoretic treatment with 2% lidocaine, 1:100,000 epinephrine, or 2% lidocaine (control). ... Read more >>

Otol Neurotol (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2021, 42(7):1095-1103]

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Specific protein kinase C isoform exerts chronic inhibition on the slowly activating delayed-rectifier potassium current by affecting channel trafficking.

Xiangbo Gou, Tingting Hu, Yu Gou, Chaoqi Li, Ming Yi, Mengran Jia,

The slowly activating delayed rectifier K<sup>+</sup> current (<i>I</i> <sub>Ks</sub>) plays a key role in the repolarization of ventricular action potential in the human heart and is formed by the pore-forming α-subunit encoded by KCNQ1 (Kv7.1) and β-subunit encoded by KCNE1. Evidence suggested that <i>I</i> <sub>Ks</sub> was regulated through protein kinase ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):262-272]

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Prise en charge des allergies alimentaires en milieu scolaire en France : projet d'accueil individualisé et adrénaline.

Guillaume Pouessel, Marion Couvreur, Antoine Deschildre, ,

In Europe, the prevalence of food allergy is estimated at 6-8% of children. Ten to 20% of pediatric food-induced anaphylaxis reactions occur at school. Individual healthcare plans (IHP) for food allergy aim at: identifying children at risk of allergic reactions, reducing the risk of allergen exposure, providing emergency kits containing ... Read more >>

Ann Pharm Fr (Annales pharmaceutiques francaises)
[2021, :]

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Inhibition of catechol-O-methyltransferase by natural pentacyclic triterpenes: structure-activity relationships and kinetic mechanism.

Fang-Yuan Wang, Gui-Lin Wei, Yu-Fan Fan, Dong-Fang Zhao, Ping Wang, Li-Wei Zou, Ling Yang,

Inhibitors of COMT are clinically used for the treatment of Parkinson's disease. Here, we report the first natural pentacyclic triterpenoid-type COMT inhibitors and their structure-activity relationships and inhibition mechanism. The most potent compounds were found to be oleanic acid, betulinic acid and celastrol with IC<sub>50</sub> values of 3.89-5.07 μM, that acted ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):1079-1087]

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An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment.

Linda Eklund, Filip Schagatay, Ellen Tufvesson, Rita Sjöström, Lars Söderström, Helen G Hanstock, Thomas Sandström, Nikolai Stenfors,

Exposure to a cold climate is associated with an increased morbidity and mortality, but the specific mechanisms are largely unknown. People with cardiopulmonary disease and winter endurance athletes are particularly vulnerable. This study aimed to map multiple domains of airway responses to exercise in subzero temperature in healthy individuals.Thirty-one healthy ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2021, 80(1):1897213]

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Norepinephrine affects the interaction of adherent-invasive Escherichia coli with intestinal epithelial cells.

Sobieszczańska Beata, Turniak Michał, Olbromski Mateusz, Walczuk Urszula, Marcin Choroszy, Tukiendorf Andrzej, Dzięgiel Piotr,

Norepinephrine (NE), the stress hormone, stimulates many bacterial species' growth and virulence, including <i>Escherichia coli</i>. However, the hormone's impact on the adherent-invasive <i>E. coli</i> (AIEC) implicated in Crohn's disease is poorly understood. In the study, we have investigated the effect of NE on the interaction of six AIEC strains isolated ... Read more >>

Virulence (Virulence)
[2021, 12(1):630-637]

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Local anaesthetics combined with vasoconstrictors in patients with cardiovascular disease undergoing dental procedures: systematic review and meta-analysis.

Caio Chaves Guimaraes, Luciane Cruz Lopes, Cristiane de Cássia Bergamaschi, Juliana Cama Ramacciato, Marcus Tolentino Silva, Jimmy de Oliveira Araújo, Natalia Karol de Andrade, Rogério Heládio Lopes Motta,

<h4>Objectives</h4>There is a lack of evidence about the use of local anaesthetics (LAs) in patients with cardiovascular diseases (CVD) in dental procedures. Thus, this study evaluated the safety of using LA with vasoconstrictor to determine the risk of cardiovascular events in patients with CVD.<h4>Design</h4>Systematic review and meta-analysis.<h4>Methods</h4>We have searched in ... Read more >>

BMJ Open (BMJ open)
[2021, 11(7):e044357]

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The Effect of Epinephrine Dosing Intervals on Outcomes from Pediatric In-Hospital Cardiac Arrest.

Martha F Kienzle, Ryan W Morgan, Jennifer A Faerber, Kathryn Graham, Hannah Katcoff, William P Landis, Alexis A Topjian, Todd J Kilbaugh, Vinay M Nadkarni, Robert A Berg, Robert M Sutton,

<h4>Rationale</h4>Animal studies of cardiac arrest suggest shorter epinephrine dosing intervals than currently recommended (every 3-5 minutes) may be beneficial in select circumstances.<h4>Objectives</h4>To evaluate the association between epinephrine dosing intervals and pediatric cardiac arrest outcomes.<h4>Methods</h4>Single-center retrospective cohort study of children (<18 years of age) who received ≥1 minute of cardiopulmonary resuscitation ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, :]

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Evaluation of targeted bupivacaine, bupivacaine-lidocaine-epinephrine, dexamethasone, and meloxicam for reducing acute postoperative pain in cats undergoing routine ovariohysterectomy.

James Mack Fudge, Bernie Page, Inhyung Lee,

This study compared bupivacaine (BUP), bupivacaine-lidocaine-epinephrine (BLE), dexamethasone (DEX), and meloxicam (MEL) targeted at specific, potentially painful sites for reducing acute postoperative pain in cats undergoing elective ovariohysterectomy. One hundred fifty-one cats were included in a prospective, randomized, double-blinded clinical trial. Anesthesia consisted of a standardized protocol including buprenorphine, ketamine, ... Read more >>

Top Companion Anim Med (Topics in companion animal medicine)
[2021, :100564]

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Hif-1α is not required for the development of cardiac adrenergic control in zebrafish (Danio rerio).

William Joyce, Steve F Perry,

Adrenergic regulation, acting via the sympathetic nervous system, provides a major mechanism to control cardiac function. It has recently been shown that hypoxia inducible factor-1α (Hif-1α) is necessary for normal development of sympathetic innervation and control of cardiac function in the mouse. To investigate whether this may represent a fundamental ... Read more >>

J Exp Zool A Ecol Integr Physiol (Journal of experimental zoology. Part A, Ecological and integrative physiology)
[2021, 335(7):623-631]

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Clinical Management of Infant Anaphylaxis.

Annette Carlisle, Jay Lieberman,

Anaphylaxis is a condition that is likely increasing in prevalence and commonly treated by allergists as well as other first responders and emergency room providers. Although a relatively rare event, anaphylaxis can occur in infants, with the most common cause attributed to foods. Infant anaphylaxis can present with unique diagnostic ... Read more >>

J Asthma Allergy (Journal of asthma and allergy)
[2021, 14:821-827]

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Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release.

Rengul Cetin-Atalay, Angelo Y Meliton, David Wu, Parker S Woods, Kaitlyn A Sun, Ying-Jie Peng, Jayasri Nanduri, Xiaoyu Su, Yun Fang, Robert B Hamanaka, Nanduri Prabhakar, Gökhan M Mutlu,

Obstructive sleep apnea (OSA) is a common breathing disorder affecting a significant percentage of the adult population. OSA is an independent risk factor for cardiovascular disease (CVD); however, the underlying mechanisms are not completely understood. Since the severity of hypoxia correlates with some of the cardiovascular effects, intermittent hypoxia (IH) ... Read more >>

Front Physiol (Frontiers in physiology)
[2021, 12:701995]

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Neuroprotective Efficacy of Apple Cider Vinegar on Zinc-High Fat Diet-Induced Mono Amine Oxidase Alteration in Murine Model of AD.

Smriti Tripathi, Papiya Mitra Mazumder,

<h4>Objective</h4>Monoamine Oxidase (MAO), which catalyzes the oxidative deamination of amines present in the brain and peripheral tissues, is involved in the metabolism of monoamines and is vital for cognition. This study was designed to examine the protective effect of Apple Cider Vinegar (ACV) on MAO and amine neurotransmitters such as ... Read more >>

J Am Coll Nutr (Journal of the American College of Nutrition)
[2021, :1-10]

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Efficacy of bolus-dose epinephrine to manage hypotension in the prehospital setting.

Kyle A Weant, David M French,

<h4>Purpose</h4>Hypotension in the Emergency Department (ED) and the prehospital setting has been associated with significant morbidity and mortality. Limited literature exists exploring the utilization of intravenous (IV) bolus-dose epinephrine (BDE) by Emergency Medical Services (EMS).<h4>Methods</h4>A retrospective review evaluated patients transported to an academic medical center who had received IV BDE ... Read more >>

Am J Emerg Med (The American journal of emergency medicine)
[2021, 50:71-75]

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Influence of nitisinone and its metabolites on l-tyrosine metabolism in a model system.

Joanna Płonka, Monika Babiuch, Hanna Barchanska,

Nitisinone (NTBC) is currently used for the treatment of tyrosinemia type 1, a rare disease. It also exhibits potential in the treatment of other orphan diseases as well as nervous system disorders - this is however limited by its side effects. In all living organisms, NTBC inhibits 4-hydroxyphenylpyruvate dioxygenase activity, ... Read more >>

Chemosphere (Chemosphere)
[2021, 286(Pt 1):131592]

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The Psychological Benefits of Scary Play in Three Types of Horror Fans

Coltan Scrivner, Marc Malmdorf Andersen, uffe Schjødt, Mathias Clasen,

<p>Why do people seek out frightening leisure activities such as horror films and haunted attractions, and does the experience benefit them in any way? In this article, we address these questions through two separate studies. In Study 1, we asked American horror fans (n = 256) why they like horror ... Read more >>

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Alpha and beta adrenergic receptors modulate keratinocyte migration.

Hsin-Ya Yang, Pieter Steenhuis, Aaron M Glucksman, Zhanna Gurenko, Thi Dinh La, R Rivkah Isseroff,

Keratinocyte migration into skin wounds is the step of the healing process that correlates with the wound closure rate. Keratinocyte migration, and wound epithelialization are decreased when beta 2-adrenergic receptors (B2AR) are activated by 1 μM epinephrine/adrenaline, resulting in delayed wound healing in human and mouse skin. In the present ... Read more >>

PLoS One (PloS one)
[2021, 16(7):e0253139]

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Effect of epinephrine on the absorption of lidocaine following application to the oral mucosa in rats.

Rui Sasaki, Katsuhisa Sunada,

<h4>Background</h4>We investigated the role of epinephrine in prolonging the localization of lidocaine on the oral mucosa and inhibiting its absorption in the blood of rats.<h4>Methods</h4>We used 7-8-week-old pathogen-free Wistar male rats (n = 128) for our study. We divided them into the control group administered with <sup>14</sup>C-labeled lidocaine hydrochloride gel only and ... Read more >>

BMC Oral Health (BMC oral health)
[2021, 21(1):327]

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