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Acute Disseminated Encephalomyelitis

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MicroRNAs as disease progression biomarkers and therapeutic targets in experimental autoimmune encephalomyelitis model of multiple sclerosis.

Bridget Martinez, Philip V Peplow,

Multiple sclerosis is an autoimmune neurodegenerative disease of the central nervous system characterized by pronounced inflammatory infiltrates entering the brain, spinal cord and optic nerve leading to demyelination. Focal demyelination is associated with relapsing-remitting multiple sclerosis, while progressive forms of the disease show axonal degeneration and neuronal loss. The tests ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(10):1831-1837]

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Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014-2019.

Bridget Martinez, Philip V Peplow,

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. The disability caused by inflammatory demyelination clinically dominates the early stages of relapsing-remitting MS and is reversible. Once there is considerable loss of axons, MS patients enter a secondary progressive stage. Disease-modifying drugs currently in use for ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1220-1234]

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CNS-localized myeloid cells capture living invading T cells during neuroinflammation.

Beatrice Wasser, Dirk Luchtman, Julian Löffel, Kerstin Robohm, Katharina Birkner, Albrecht Stroh, Christina Francisca Vogelaar, Frauke Zipp, Stefan Bittner,

To study the role of myeloid cells in the central nervous system (CNS) in the pathogenesis of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), we used intravital microscopy, assessing local cellular interactions in vivo in EAE animals and ex vivo in organotypic hippocampal slice cultures. We ... Read more >>

J. Exp. Med. (The Journal of experimental medicine)
[2020, 217(6):]

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Orexin/hypocretinin in multiple sclerosis and experimental autoimmune encephalomyelitis.

Jean Pierre Pallais, Catherine M Kotz, Milos Stanojlovic,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1039-1040]

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Possible clinical role of MOG antibody testing in children presenting with acute neurological symptoms.

Giulia Musso, Margherita Nosadini, Nicoletta Gallo, Stefano Sartori, Mara Seguso, Mario Plebani,

The differential diagnosis between acquired inflammatory demyelinating syndromes of the central nervous system (CNS), such as multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD) and acute disseminated encephalomyelitis (ADEM) can be very challenging at onset. Apart from cerebrospinal fluid oligoclonal bands and anti-aquaporin-4 antibodies (AQP4-Ab), definite diagnostic biomarkers are lacking. ... Read more >>

Neurol. Sci. (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2020, :]

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NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS.

Cynthia Louis, Fernando Souza-Fonseca-Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks,

Despite increasing recognition of the importance of GM-CSF in autoimmune disease, it remains unclear how GM-CSF is regulated at sites of tissue inflammation. Using GM-CSF fate reporter mice, we show that synovial NK cells produce GM-CSF in autoantibody-mediated inflammatory arthritis. Synovial NK cells promote a neutrophilic inflammatory cell infiltrate, and ... Read more >>

J. Exp. Med. (The Journal of experimental medicine)
[2020, 217(5):]

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The S100B Inhibitor Pentamidine Ameliorates Clinical Score and Neuropathology of Relapsing-Remitting Multiple Sclerosis Mouse Model.

Gabriele Di Sante, Susanna Amadio, Beatrice Sampaolese, Maria Elisabetta Clementi, Mariagrazia Valentini, Cinzia Volonté, Patrizia Casalbore, Francesco Ria, Fabrizio Michetti,

S100B is an astrocytic protein acting either as an intracellular regulator or an extracellular signaling molecule. A direct correlation between increased amount of S100B and demyelination and inflammatory processes has been demonstrated. The aim of this study is to investigate the possible role of a small molecule able to bind ... Read more >>

Cells (Cells)
[2020, 9(3):]

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The therapeutic potential of bilobalide on experimental autoimmune encephalomyelitis (EAE) mice.

Qiang Miao, Xiao-Xue Zhang, Qing-Xian Han, Si-Si Ren, Ruo-Xuan Sui, Jing-Wen Yu, Jing Wang, Qing Wang, Jie-Zhong Yu, Liang Cao, Wei Xiao, Bao-Guo Xiao, Cun-Gen Ma,

Inflammatory demyelination in the central nervous system (CNS) is a hallmark of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Besides MS disease-modifying therapy, targeting myelin sheath protection/regeneration is currently a hot spot in the treatment of MS. Here, we attempt to explore the therapeutic potential of ... Read more >>

Metab Brain Dis (Metabolic brain disease)
[2020, :]

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Viral infections and multiple sclerosis.

Donatella Donati,

The etiology and pathogenesis of MS is likely to involve multiple factors interacting with each other, and the role of infectious and viral agents is still under debate, however a consistent amount of studies suggests that some viruses are associated with the disease. The strongest documentation has come from the ... Read more >>

Drug Discov Today Dis Models (Drug discovery today. Disease models)
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Seizure occurrence in myelin oligodendrocyte glycoprotein antibody-associated disease: A systematic review and meta-analysis.

Chun-Hong Shen, Yang Zheng, Meng-Ting Cai, Fan Yang, Wei Fang, Yin-Xi Zhang, Mei-Ping Ding,

OBJECTIVE:Recent reports have suggested that seizures may be a component of the clinical presentation in myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated disease. We aimed to conduct a systematic review and meta-analysis to comprehensively evaluate the occurrence of epileptic seizures in the disease. METHODS:We searched PubMed, MEDLINE and EMBASE for studies reporting ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 42:102057]

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Development of a CD19 PET tracer for detecting B cells in a mouse model of multiple sclerosis

Michelle James, Marc Stevens, Haley Cropper, Katherine Lucot, Aisling Chaney, Kendra Lechtenberg, Isaac Jackson, Marion Buckwalter,

<title>Abstract</title> <p> Background: B cells play a central role in multiple sclerosis (MS) through production of injurious antibodies, secretion of pro-inflammatory cytokines, and antigen presentation. The therapeutic success of monoclonal antibodies (mAbs) targeting B cells in some but not all individuals suffering from MS highlights the need for ... Read more >>

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The Role of Granulocyte-Macrophage Colony-Stimulating Factor in Murine Models of Multiple Sclerosis.

Kelly L Monaghan, Edwin C K Wan,

Multiple sclerosis (MS) is an immune-mediated disease that predominantly impacts the central nervous system (CNS). Animal models have been used to elucidate the underpinnings of MS pathology. One of the most well-studied models of MS is experimental autoimmune encephalomyelitis (EAE). This model was utilized to demonstrate that the cytokine granulocyte-macrophage ... Read more >>

Cells (Cells)
[2020, 9(3):]

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Ic100: A Novel Anti-ASC Monoclonal Antibody Improves Functional Outcomes In An Animal Model Of Multiple Sclerosis

Roberta Brambilla, Robert Keane, Haritha Desu, Melanie Plastini, Placido Illiano, Helen Bramlett, Dietrich, Juan Vaccari,

<title>Abstract</title> <p> Background The inflammasome adaptor apoptosis-associated speck-like protein containing a CARD (ASC) is involved in immune signaling by bridging the interactions between inflammasome sensors and caspase-1. Strong experimental evidence has shown that ASC -/- mice are protected from disease progression in animal models of multiple sclerosis (MS), ... Read more >>

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Anti-GM2 Antibodies in Mycoplasma Pneumoniae-Associated Acute Encephalomyelitis.

Cheng Xia, Hui-Sheng Chen,

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2020, 47(2):258-260]

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En mann i 60-årene med gangvansker, dysartri og lett kognitiv svikt.

Ludmila Nordaa, Elin Bjelland Forsaa, Audun Odland, Soffien Ajmi,

BACKGROUND:Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome is an immune-mediated, treatable and inflammatory CNS disease first reported by Pittock et al. (2010). CASE PRESENTATION:We describe a 66-year-old man with previous history of diabetes, atrial fibrillation and hypertension, who was admitted to hospital with reduced general ... Read more >>

Tidsskr. Nor. Laegeforen. (Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke)
[2020, 140(4):]

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Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation.

Pavan Bhargava, Matthew D Smith, Leah Mische, Emily P Harrington, Kathryn C Fitzgerald, Kyle A Martin, Sol Kim, Arthur Anthony A Reyes, Jaime Gonzalez-Cardona, Christina Volsko, Ajai Tripathi, Sonal Singh, Kesava Varanasi, Hannah-Noelle Lord, Keya R Meyers, Michelle Taylor, Marjan Gharagozloo, Elias S Sotirchos, Bardia Nourbakhsh, Ranjan Dutta, Ellen Mowry, Emmanuelle Waubant, Peter A Calabresi,

Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the CNS. Bile acids are cholesterol metabolites that can signal through receptors on cells throughout the body, including the CNS and immune system. Whether bile acid metabolism is abnormal in MS is unknown. Using global and targeted metabolomic profiling, we identified ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2020, :]

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Novel phloroglucinol derivative Compound 21 protects experimental autoimmune encephalomyelitis rats via inhibiting Th1/Th17 cell infiltration.

Zhe Zhao, Xiu-Qi Bao, Zihong Zhang, Fangyuan Li, Hui Liu, Dan Zhang,

Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammatory infiltration and demyelination in the central nervous system (CNS). Among the factors involved in the immunological mechanisms of MS, T helper 1 (Th1) cells and T helper 17 (Th17) cells play a critical role. Compound 21, a novel phloroglucinol ... Read more >>

Brain Behav. Immun. (Brain, behavior, and immunity)
[2020, :]

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THE action of TH17 cells on blood brain barrier in multiple sclerosis and experimental autoimmune encephalomyelitis.

Rodica Balasa, Laura Barcutean, Adrian Balasa, Anca Motataianu, Corina Roman-Filip, Doina Manu,

Th17 cells, known as a highly pro-inflammatory subtype of Th cells, are involved very early in numerous aspects of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) neuropathology. A crucial event for the formation and accumulation of MS lesions is represented by the disruption of the blood brain barrier (BBB) ... Read more >>

Hum. Immunol. (Human immunology)
[2020, :]

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Deubiquitinating enzymes (DUBs): DoUBle-edged swords in CNS autoimmunity.

Jing Ruan, Dirk Schlüter, Xu Wang,

Multiple sclerosis (MS) is the most common autoimmune disease of the CNS. The etiology of MS is still unclear but it is widely recognized that both genetic and environmental factors contribute to its pathogenesis. Immune signaling and responses are critically regulated by ubiquitination, a posttranslational modification that is promoted by ... Read more >>

J Neuroinflammation (Journal of neuroinflammation)
[2020, 17(1):102]

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MOG encephalomyelitis: distinct clinical, MRI and CSF features in patients with longitudinal extensive transverse myelitis as first clinical presentation.

Julia Loos, Steffen Pfeuffer, Katrin Pape, Tobias Ruck, Felix Luessi, Annette Spreer, Frauke Zipp, Sven G Meuth, Stefan Bittner,

BACKGROUND:Based on clinical, immunological and histopathological evidence, MOG-IgG-associated encephalomyelitis (MOG-EM) has emerged as a distinct disease entity different from multiple sclerosis (MS) and aquaporin-4-antibody-positive neuromyelitis optica spectrum disorder (NMOSD). MOG-EM is associated with a broader clinical phenotype including optic neuritis, myelitis, brainstem lesions and acute disseminated encephalomyelitis with a substantial ... Read more >>

J. Neurol. (Journal of neurology)
[2020, :]

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Gene Therapy Approaches in an Autoimmune Demyelinating Disease: Multiple Sclerosis.

Md Asiful Islam, Shoumik Kundu, Rosline Hassan,

Multiple sclerosis (MS) is the most common autoimmune demyelinating disease of the central nervous system (CNS). It is a multifactorial disease which develops in an immune-mediated way under the influences of both genetic and environmental factors. Demyelination is observed in the brain and spinal cord leading to neuro-axonal damage in ... Read more >>

Curr Gene Ther (Current gene therapy)
[2020, :]

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Multiphasic acute disseminated encephalomyelitis and differential with early onset multiple sclerosis.

Arla Cinderella Stokes Brackett, Otto Jesus Hernández-Fustes, Carlos Arteaga Rodríguez, Olga Judith Hernandez Fustes,

Multiple sclerosis is considered the most frequent demyelinating disorder of the Central Nervous System (CNS) among young adults, yet is very rare before 10 years old. Acute disseminated encephalomyelitis is a monophasic, polysymptomatic disorder that involves the CNS white matter with demyelinating lesions, which usually occurs after systemic viral infections. ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2020, 9(1):61-63]

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Targeted Krüppel-Like Factor 4 Gene Knock-Out in Retinal Ganglion Cells Improves Visual Function in Multiple Sclerosis Mouse Model.

Venu Talla, Rajeshwari Koilkonda,

Axonal demyelination injury and neuronal degeneration are the primary causes of visual disability in multiple sclerosis (MS)-linked optic neuritis patients. Immunomodulatory therapies targeting inflammation have failed to avert the disease progression and no therapies exist to prevent the neuronal deficits seen in MS to date. Neuroprotective strategies targeting oligodendrocytes and ... Read more >>

eNeuro (eNeuro)
[2020, 7(2):]

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Transplantation of IFN-γ Primed hUCMSCs Significantly Improved Outcomes of Experimental Autoimmune Encephalomyelitis in a Mouse Model.

Xiaoyan Zhou, Xiaoli Liu, Li Liu, Chao Han, Zhaohong Xie, Xiangtian Liu, Yingying Xu, Fan Li, Jianzhong Bi, Chengyun Zheng,

The aim of this study was to investigate potential therapeutic effects of IFN-γ primed human umbilical cord mesenchymal stem cell (IFN-γ-hUCMSCs) transplantation on experimental autoimmune encephalomyelitis (EAE) in mice. In this study, EAE mouse model was established by MOG35-55 immunization method. Outcomes of the EAE mice in terms of body ... Read more >>

Neurochem. Res. (Neurochemical research)
[2020, :]

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Complement-dependent synapse loss and microgliosis in a mouse model of multiple sclerosis.

Jennetta W Hammond, Matthew J Bellizzi, Caroline Ware, Wen Q Qiu, Priyanka Saminathan, Herman Li, Shaopeiwen Luo, Stefanie A Ma, Yuanhao Li, Harris A Gelbard,

Multiple sclerosis (MS) is an inflammatory, neurodegenerative disease of the CNS characterized by both grey and white matter injury. Microglial activation and a reduction in synaptic density are key features of grey matter pathology that can be modeled with MOG35-55 experimental autoimmune encephalomyelitis (EAE). Complement deposition combined with microglial engulfment ... Read more >>

Brain Behav. Immun. (Brain, behavior, and immunity)
[2020, :]

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