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Acquired Epileptic Aphasia

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Rasmussen Encephalitis: An Update.

Karla C Cay-Martinez, Richard A Hickman, Guy M McKhann Ii, Frank A Provenzano, Tristan T Sands,

Rasmussen encephalitis (RE) is a rare, devastating, progressive pediatric epilepsy. First described 60 years ago, RE continues to present challenges in diagnosis and management. RE causes a unilateral focal epilepsy in children that typically becomes medically refractory, results in significant hemiparesis, and causes progressive cognitive decline. The etiology is a ... Read more >>

Semin Neurol (Seminars in neurology)
[2020, :]

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Recurrent epileptic seizures following cardiac catheterization with iodixanol: a case report.

Pingping Lei, Weiping He, Quan Shi, Meiying Sun, Zhigang Sun,

BACKGROUND:Contrast-induced encephalopathy (CIE) is a rare complication of cardiac catheterization; clinical manifestations include cortical blindness, seizures and focal neurological deficits. In general, recurrent epileptic seizures following cardiac catheterization with iodixanol occur more rarely than do other complications. CASE PRESENTATION:Here, we report a case of a 76-year-old male patient who experienced ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2020, 20(1):79]

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Comparison of pseudocontinuous arterial spin labeling perfusion MR images and time-of-flight MR angiography in the detection of periictal hyperperfusion.

Noritoshi Shirozu, Takato Morioka, So Tokunaga, Takafumi Shimogawa, Daisuke Inoue, Shoji Arihiro, Ayumi Sakata, Nobutaka Mukae, Sei Haga, Koji Iihara,

Background:Magnetic resonance imaging (MRI), including perfusion MRI with three-dimensional pseudocontinuous arterial spin labeling (ASL) and diffusion-weighted imaging (DWI), are applied in the periictal (including ictal and postictal) detection of circulatory and metabolic consequences associated with epilepsy. Our previous report revealed that periictal hyperperfusion can firstly be detected on ASL, and ... Read more >>

eNeurologicalSci (eNeurologicalSci)
[2020, 19:100233]

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Seizure localization using pre ictal phase-amplitude coupling in intracranial electroencephalography.

Nuria E Cámpora, Camilo J Mininni, Silvia Kochen, Sergio E Lew,

Understanding changes in brain rhythms provides useful information to predict the onset of a seizure and to localize its onset zone in epileptic patients. Brain rhythms dynamics in general, and phase-amplitude coupling in particular, are known to be drastically altered during epileptic seizures. However, the neural processes that take place ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):20022]

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Cefepime-Induced Neurotoxicity Presenting with Nonconvulsive Status Epilepticus Admitted as a Stroke Alert.

John M Cunningham, Katherine V Sachs, Rebecca Allyn,

BACKGROUND Cefepime-induced neurotoxicity has been described in intensive care units (ICUs) and neuro ICU settings, occurring in patients started on cefepime for management of severe infections and sepsis. Most cases occur within 1 to 10 days after starting the drug. We publish a case that occurred on the general medical ... Read more >>

Am J Case Rep (The American journal of case reports)
[2020, 21:e921643]

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Effectiveness and safety of repetitive transcranial magnetic stimulation (rTMS) on aphasia in cerebrovascular accident patients: Protocol of a systematic review and meta-analysis.

Yaling Zheng, Dongling Zhong, Yijie Huang, Mingxing He, Qiwei Xiao, Rongjiang Jin, Juan Li,

BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation approach, might be a promising technique in the management of aphasia after cerebrovascular accidents (CVA). This protocol of systematic review (SR) aims to investigate the effectiveness and safety of rTMS in patients with aphasia after CVA. METHODS:The following databases will be ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(52):e18561]

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GAD65-Ab encephalitis and subtle focal status epilepticus.

Mathilde Goudot, Solène Frismand, Lucie Hopes, Antoine Verger, Bastien Joubert, Jérôme Honnorat, Louise Tyvaert,

AIMS:To delineate common epilepsy features associated with the presence of glutamic acid decarboxylase autoantibodies (GAD65-Ab). METHODS:Three consecutive cases of GAD65-Ab encephalitis patients, followed in our neurological department, were investigated with regards to clinical semiology and EEG. RESULTS:These patients presented new-onset subtle ictal clinical features. Patients 1 and 2 described prolonged ... Read more >>

Epileptic Disord (Epileptic disorders : international epilepsy journal with videotape)
[2019, 21(5):437-442]

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Adolf Meyer: the neuroanatomist and neuropsychiatrist behind Meyer's loop and its significance in neurosurgery.

Olaf E M G Schijns, Peter J Koehler,

Brain (Brain : a journal of neurology)
[2020, 143(3):1039-1044]

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Molecular Aberrations Associated with Seizure Control in Diffuse Astrocytic and Oligodendroglial Tumors.

Hime Suzuki, Nobuhiro Mikuni, Shintaro Sugita, Tomoyuki Aoyama, Rintaro Yokoyama, Yuto Suzuki, Rei Enatsu, Yukinori Akiyama, Takeshi Mikami, Masahiko Wanibuchi, Tadashi Hasegawa,

Diffuse astrocytic and oligodendroglial tumors are frequently associated with symptomatic epilepsy, and predictive seizure control is important for the improvement of patient quality of life. To elucidate the factors related to drug resistance of brain tumor-associated epilepsy from a pathological perspective. From January 2012 to October 2017, 36 patients diagnosed ... Read more >>

Neurol. Med. Chir. (Tokyo) (Neurologia medico-chirurgica)
[2020, 60(3):147-155]

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Surgical Technique and Outcome of Extensive Frontal Lobectomy for Treatment of Intracable Non-lesional Frontal Lobe Epilepsy.

Sachiko Hirata, Michiharu Morino, Shunsuke Nakae, Takahiro Matsumoto,

Although extensive frontal lobectomy (eFL) is a common surgical procedure for intractable frontal lobe epilepsy (FLE), there have been very few reports regarding surgical techniques for eFL. This article provides step-by-step descriptions of our surgical technique for non-lesional FLE. Sixteen patients undergoing eFL were included in this study. The goals ... Read more >>

Neurol. Med. Chir. (Tokyo) (Neurologia medico-chirurgica)
[2020, 60(1):17-25]

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PSEN1 variants in Korean patients with clinically suspicious early-onset familial Alzheimer's disease.

Young-Eun Kim, Hanna Cho, Hee Jin Kim, Duk L Na, Sang Won Seo, Chang-Seok Ki,

Pathogenic variants in the PSEN1 gene are known to be the most common cause of early-onset Alzheimer's disease but there are few data on the frequency and spectrum of PSEN1 variants in Korea. In this study, we investigated PSEN1 variants in a consecutive series of clinically suspicious early-onset familial AD ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3480]

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Reduction in seizure frequency with a high-intensity fitness program (CrossFit): A case report.

Mia Liisa van der Kop, Anna Mia Ekström, Ricardo Mario Arida,

Few studies have reported the impact of intensive exercise on seizure susceptibility. Here, we present a case in which a patient developed drug-resistant focal epilepsy after craniotomy for a low-grade glioma. She had a marked reduction in seizure frequency after switching from moderate exercise to a high-intensity exercise program. Psychological ... Read more >>

Epilepsy Behav Rep (Epilepsy & behavior reports)
[2020, 13:100354]

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Comparing Expert and Non-Expert Assessment of Patients Presenting with Neurological Symptoms to the Emergency Department: A Retrospective Observational Study.

Carolin Hoyer, Patrick Stein, Anne Ebert, Hans-Werner Rausch, Simon Nagel, Philipp Eisele, Angelika Alonso, Michael Platten, Kristina Szabo,

Objective:Referrals to neurology in emergency departments (ED) are continuously increasing, currently representing 15% of all admissions. Existing triage systems were developed for general medical populations and have not been validated for patients with neurological symptoms. Methods:To characterize neurological emergencies, we first retrospectively analyzed symptoms, service times and resources of the ... Read more >>

Neuropsychiatr Dis Treat (Neuropsychiatric disease and treatment)
[2020, 16:447-456]

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A case report of sinoatrial arrest caused by temporal lobe epilepsy in subclinical glioblastoma.

Jörg Reifart, Marlene Tschernatsch, Christian W Hamm, Johannes Sperzel, Andreas Hain,

BACKGROUND:Atrial fibrillation with symptomatic bradycardia, higher grade atrioventricular block, and sinus node disease are all common indications for permanent pacemaker implantation. The most frequent causes of sinus node disease treated with pacemaker implantation involve degenerative structural changes of the sinus node; less often, extrinsic causes (such as damage due to ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2020, 20(1):30]

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Analysis of postpartum reversible cerebral vasoconstriction syndrome in China: A case report and literature review.

Lin Liu, Qi Tan, Ruxun Huang, Zongji Hu,

Reversible cerebral vasoconstriction syndrome (RCVS) is a rare clinical syndrome accompanying with severe headache as its main symptom. Postpartum reversible cerebral vasoconstriction syndrome (PPRCVS) refers to RCVS occurring in the puerperium, in which it has a low incidence, and that is easily missed diagnosed and misdiagnosed in clinical practice.By searching ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(45):e17170]

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Intrathecal Infusion of Autologous Adipose-Derived Regenerative Cells in Autoimmune Refractory Epilepsy: Evaluation of Safety and Efficacy.

Elzbieta Szczepanik, Hanna Mierzewska, Dorota Antczak-Marach, Anna Figiel-Dabrowska, Iwona Terczynska, Jolanta Tryfon, Natalia Krzesniak, Bartlomiej Henryk Noszczyk, Ewa Sawicka, Krystyna Domanska-Janik, Anna Sarnowska,

Objective/Purpose. Evaluation of efficacy and safety of autologous adipose-derived regenerative cells (ADRCs) treatment in autoimmune refractory epilepsy. Patients. Six patients with proven or probable autoimmune refractory epilepsy (2 with Rasmussen encephalitis, 2 with antineuronal autoantibodies in serum, and 2 with possible FIRES) were included in the project with approval of ... Read more >>

Stem Cells Int (Stem Cells International)
[2020, 2020:7104243]

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Topological Alterations of the Structural Brain Connectivity Network in Children with Juvenile Neuronal Ceroid Lipofuscinosis.

T Roine, U Roine, A Tokola, M H Balk, M Mannerkoski, L Åberg, T Lönnqvist, T Autti,

BACKGROUND AND PURPOSE:We used diffusion MR imaging to investigate the structural brain connectivity networks in juvenile neuronal ceroid lipofuscinosis, a neurodegenerative lysosomal storage disease of childhood. Although changes in conventional MR imaging are typically not visually apparent in children aged <10 years, we previously found significant microstructural abnormalities by using ... Read more >>

AJNR Am J Neuroradiol (AJNR. American journal of neuroradiology)
[2019, 40(12):2146-2153]

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Management of toxicities associated with novel immunotherapy agents in acute lymphoblastic leukemia.

Tania Jain, Mark R Litzow,

The advent of novel immunotherapies, such as blinatumomab, inotuzumab, and chimeric antigen receptor (CAR) T cell therapy, has revolutionized the therapeutic landscape in the treatment of relapsed/refractory B cell acute lymphoblastic leukemia, but can be associated with specific toxicities. We review unique toxicities of each of these in this article. ... Read more >>

Ther Adv Hematol (Therapeutic advances in hematology)
[2020, 11:2040620719899897]

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Tuberculous Encephalitis with Aphemia Detected Only by 18F-Fluorodeoxyglucose-Positron Emission Tomography.

Boby Varkey Maramattom, Joe Thomas, Surya Joseph,

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2019, 22(4):527-529]

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Acute isolated aphasia as a challenging symptom in the emergency setting: Predictors of epileptic mimic versus ischemic stroke.

Paola Polverino, Paola Caruso, Mariana Ridolfi, Giovanni Furlanis, Marcello Naccarato, Arianna Sartori, Paolo Manganotti,

INTRODUCTION:Stroke mimics (SM) account for 1% to 41% of all AIS presentation. Seizures are the most frequent cause of mimic, but isolated speech impairment, among adult-onset epilepsy, is quite rare, while aphasia is more often due to an AIS. Prompt AIS/SM recognition is required to establish the most appropriate therapeutic ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2019, 67:129-133]

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Mapping the Effect of Interictal Epileptic Activity Density During Wakefulness on Brain Functioning in Focal Childhood Epilepsies With Centrotemporal Spikes.

Anna Elisabetta Vaudano, Pietro Avanzini, Gaetano Cantalupo, Melissa Filippini, Andrea Ruggieri, Francesca Talami, Elisa Caramaschi, Patrizia Bergonzini, Aglaia Vignoli, Pierangelo Veggiotti, Azzura Guerra, Giuliana Gessaroli, Margherita Santucci, Maria Paola Canevini, Benedetta Piccolo, Francesco Pisani, Giuseppe Gobbi, Bernardo Dalla Bernardina, Stefano Meletti,

Childhood epilepsy with centrotemporal spikes (CECTS) is the most common type of "self-limited focal epilepsies." In its typical presentation, CECTS is a condition reflecting non-lesional cortical hyperexcitability of rolandic regions. The benign evolution of this disorder is challenged by the frequent observation of associated neuropsychological deficits and behavioral impairment. The ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:1316]

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Understanding Childhood Neuroimmune Diseases of the Central Nervous System.

Sara Matricardi, Giovanni Farello, Salvatore Savasta, Alberto Verrotti,

Immune-mediated diseases of the central nervous system (CNS) in childhood are a heterogeneous group of rare conditions sharing the inflammatory involvement of the CNS. This review highlights the growing knowledge of childhood neuroimmune diseases that primarily affect the CNS, outlining the clinical and diagnostic features, the pathobiological mechanisms and genetics, ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:511]

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Hyperglycemia-Induced Aphasia Presenting with Seizure-like Brain Perfusion Findings on Single Photon Emission Computed Tomography.

Chungkun Oh, Seo-Young Lee, Jae-Won Jang,

Dement Neurocogn Disord (Dementia and neurocognitive disorders)
[2019, 18(2):69-72]

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Distinct roles of GRIN2A and GRIN2B variants in neurological conditions.

Scott J Myers, Hongjie Yuan, Jing-Qiong Kang, Francis Chee Kuan Tan, Stephen F Traynelis, Chian-Ming Low,

Rapid advances in sequencing technology have led to an explosive increase in the number of genetic variants identified in patients with neurological disease and have also enabled the assembly of a robust database of variants in healthy individuals. A surprising number of variants in the GRIN genes that encode N-methyl-D-aspartate ... Read more >>

F1000Res (F1000Research)
[2019, 8:]

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A case of near-sudden unexpected death in epilepsy due to ventricular fibrillation.

Myung Ha Seo, Won Young Sung,

Sudden unexpected death in epilepsy (SUDEP) refers to the sudden and unexpected death of an epileptic patient with no other health issues, during normal activity, and for whom no other particular cause of death can be found. The exact cause of SUDEP has not been established yet; however, it is ... Read more >>

Open Access Emerg Med (Open access emergency medicine : OAEM)
[2019, 11:161-166]

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