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Ackee Fruit Toxicity

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Sub-chronic toxicity study of ethanol stem-bark extract of Blighia sapida (Sapindaceae) in wistar rats.

M B Adekola, J O Areola, N O Omisore, F T Asaolu, S G Ogunleye, O E Apalowo, O O Babalola,

Blighia sapida has been used in the treatment of different pathologies. The study aimed at evaluating the acute and sub-chronic toxicity of ethanol stem-bark extract of B. sapida. The acute toxicity was evaluated by gavage administration at single dose and the extract was also administered at doses of 250, 500 and ... Read more >>

Heliyon (Heliyon)
[2020, 6(2):e02801]

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Evaluation of neurotoxicity and hepatotoxicity effects of acute and sub-acute oral administration of unripe ackee (Blighia sapida) fruit extract.

Abayomi Mayowa Ajayi, Emmanuel Oluseun Ayodele, Benneth Ben-Azu, Adegbuyi Oladele Aderibigbe, Solomon Umukoro,

Ackee (Blighia sapida) is a commonly eaten fruit that is indigenous to West Africa and Jamaica. Ackee poisoning in young children have been reported in parts of Nigeria due to consumption of the unripe fruits. This study was designed to identify potential mechanisms of acute and sub-acute toxicity of unripe ... Read more >>

Toxicol Rep (Toxicology reports)
[2019, 6:656-665]

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Carbohydrates, proteins, fats and other essential components of food from native trees in West Africa.

Anne Mette Lykke, Elie Antoine Padonou,

Native tree foods contribute to food and nutrition security, health and income generation in sub-Saharan Africa. However, the specific contribution of native tree foods to nutrition is poorly documented in science and often not acknowledged in poverty reduction strategies. This review gives an overview on the content of carbohydrates, proteins, ... Read more >>

Heliyon (Heliyon)
[2019, 5(5):e01744]

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Free Radical Scavenging Capacity, Carotenoid Content, and NMR Characterization of Blighia sapida Aril Oil.

Andrea Goldson Barnaby, Jesse Clarke, Dane Warren, Kailesha Duffus,

Blighia sapida aril oil is rich in monounsaturated fatty acids but is however currently not utilized industrially. The oil was characterized utilizing nuclear magnetic resonance (NMR) and Fourier Transform Infrared Spectroscopy (FTIR). A spectrophotometric assay was conducted to determine the free radical scavenging properties and carotenoid content of the oil. ... Read more >>

J Lipids (Journal of lipids)
[2018, 2018:1762342]

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Detection of MCPG metabolites in horses with atypical myopathy.

Mandy Bochnia, Johannes Sander, Joerg Ziegler, Michael Terhardt, Stefanie Sander, Nils Janzen, Jessika-M V Cavalleri, Aleksandra Zuraw, Monika Wensch-Dorendorf, Annette Zeyner,

Atypical myopathy (AM) in horses is caused by ingestion of seeds of the Acer species (Sapindaceae family). Methylenecyclopropylacetyl-CoA (MCPA-CoA), derived from hypoglycin A (HGA), is currently the only active toxin in Acer pseudoplatanus or Acer negundo seeds related to AM outbreaks. However, seeds or arils of various Sapindaceae (e.g., ackee, ... Read more >>

PLoS ONE (PloS one)
[2019, 14(2):e0211698]

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Exploring Antimalarial Herbal Plants across Communities in Uganda Based on Electronic Data.

Denis Okello, Youngmin Kang,

Malaria is one of the most rampant diseases today not only in Uganda but also throughout Africa. Hence, it needs very close attention as it can be severe, causing many deaths, especially due to the rising prevalence of pathogenic resistance to current antimalarial drugs. The majority of the Ugandan population ... Read more >>

Evid Based Complement Alternat Med (Evidence-based Complementary and Alternative Medicine : eCAM)
[2019, 2019:3057180]

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Ethanol Extract of Blighia sapida Stem Bark Show Remarkable Prophylactic Activity in Experimental Plasmodium berghei-Infected Mice.

Olayinka O Otegbade, Johnson A Ojo, Dolapo I Adefokun, Oyindamola O Abiodun, Bolaji N Thomas, Olusola Ojurongbe,

This work explores the antiplasmodial potential of ethanol extract of Blighia sapida (Lin. Sapindaceae) in chloroquine (CQ)-resistant Plasmodium berghei (ANKA strain)-infected mice. Chloroquine-resistant (ANKA) strain of P berghei was inoculated intraperitoneally into Swiss albino mice. Mice were treated orally for 4 consecutive days, before and after inoculation (prophylactic, suppressive, and ... Read more >>

Drug Target Insights (Drug target insights)
[2017, 11:1177392817728725]

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Screening of Plants Used as Traditional Anticancer Remedies in Mkuranga and Same Districts, Tanzania, Using Brine Shrimp Toxicity Bioassay.

Daniel Z Matata, Olipa D Ngassapa, Francis Machumi, Mainen J Moshi,

Background:Inadequate specialized cancer hospitals and high costs are contributing factors that delay cancer patients from accessing health care services in Tanzania. Consequently, majority of patients are first seen by Traditional Health Practitioners (THPs) before they access specialized services. This study presents ethnomedical information and preliminary evaluation of 25 plant species ... Read more >>

Evid Based Complement Alternat Med (Evidence-based Complementary and Alternative Medicine : eCAM)
[2018, 2018:3034612]

Cited: 0 times

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Newborn foal with atypical myopathy.

Radana Karlíková, Jitka Široká, Marek Mech, David Friedecký, Hana Janečková, Lucie Mádrová, Františka Hrdinová, Zuzana Drábková, Olga Dobešová, Tomáš Adam, Petr Jahn,

The case of atypical myopathy (AM) in newborn Haflinger foal with clinical signs of depression and weakness appearing 6 hours after birth resulting in recumbency 12 hours after birth is described. The foal's dam was diagnosed with AM in the 6th month of gestation based on clinical signs of a ... Read more >>

J. Vet. Intern. Med. (Journal of veterinary internal medicine)
[2018, 32(5):1768-1772]

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Assessment of the potential health risks associated with the aluminium, arsenic, cadmium and lead content in selected fruits and vegetables grown in Jamaica.

Johann M R Antoine, Leslie A Hoo Fung, Charles N Grant,

Thirteen Jamaican-grown food crops - ackee (Blighia sapida), banana (Musa acuminate), cabbage (Brassica oleracea), carrot (Daucus carota), cassava (Manihot esculenta), coco (Xanthosoma sagittifolium), dasheen (Colocasia esculenta), Irish potato (Solanum tuberosum), pumpkin (Cucurbita pepo), sweet pepper (Capsicum annuum), sweet potato (Ipomoea batatas), tomato (Solanum lycopersicum) and turnip (Brassica rapa) - were ... Read more >>

Toxicol Rep (Toxicology Reports)
[2017, 4:181-187]

Cited: 6 times

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A case report of methadone-associated hypoglycemia in an 11-month-old male.

Michael S Toce, Margaret A Stefater, David T Breault, Michele M Burns,

BACKGROUND:Methadone is a synthetic μ-opioid receptor agonist that is used in the management of pain, neonatal abstinence withdrawal syndrome, and opioid dependence. Overdose can cause miosis, respiratory depression, and central nervous system depression. Rarely, hypoglycemia has been reported. We present the case of an 11-month-old male who developed hypoketotic, hyperinsulinemic, ... Read more >>

Clin Toxicol (Phila) (Clinical toxicology (Philadelphia, Pa.))
[2018, 56(1):74-76]

Cited: 2 times

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Ackee Fruit Poisoning in Eight Siblings: Implications for Public Health Awareness.

Oludolapo Sherifat Katibi, Rasaq Olaosebikan, Mohammed Baba Abdulkadir, Taofik Oluwaseun Ogunkunle, Rasheedah Mobolaji Ibraheem, Rukayat Murtala,

Ackee apple fruit is a native fruit to Jamaica and some parts of west Africa. Its toxicity known as "Jamaican vomiting sickness" dates back to the nineteenth century. However, there is a dearth of reported published data on toxicity from Nigeria where it is popularly known in the southwest as ... Read more >>

Am. J. Trop. Med. Hyg. (The American journal of tropical medicine and hygiene)
[2015, 93(5):1122-1123]

Cited: 3 times

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Probable toxic cause for suspected lychee-linked viral encephalitis.

Peter S Spencer, Valerie S Palmer, Rajarshi Mazumder,

Emerging Infect. Dis. (Emerging infectious diseases)
[2015, 21(5):904-905]

Cited: 4 times

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Quantification of hypoglycin A as butyl ester.

Johannes Sander, Michael Terhardt, Stefanie Sander, Nils Janzen,

L-α-amino-methylenecyclopropyl propionic acid (Hypoglycin A, HGA) has been found to be the toxic compound in fruits of the Sapindaceae family causing acute intoxication when ingested as food or feed. Clinical symptoms are consistent with acquired multiple acyl-CoA dehydrogenase deficiency (MADD). Ultra performance liquid chromatography-tandem mass spectrometry was used to measure ... Read more >>

J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (Journal of chromatography. B, Analytical technologies in the biomedical and life sciences)
[2016, 1029-1030:169-173]

Cited: 2 times

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Hypoglycin A Content in Blood and Urine Discriminates Horses with Atypical Myopathy from Clinically Normal Horses Grazing on the Same Pasture.

M Bochnia, J Ziegler, J Sander, A Uhlig, S Schaefer, S Vollstedt, M Glatter, S Abel, S Recknagel, G F Schusser, M Wensch-Dorendorf, A Zeyner,

Hypoglycin A (HGA) in seeds of Acer spp. is suspected to cause seasonal pasture myopathy in North America and equine atypical myopathy (AM) in Europe, fatal diseases in horses on pasture. In previous studies, this suspicion was substantiated by the correlation of seed HGA content with the concentrations of toxic ... Read more >>

PLoS ONE (PloS one)
[2015, 10(9):e0136785]

Cited: 12 times

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Potential of Traditional Knowledge of Plants in the Management of Arthropods in Livestock Industry with Focus on (Acari) Ticks.

Wycliffe Wanzala,

Antitick plants and related ethnoknowledge/ethnopractices with potential for integrated tick control and management strategies to improve livestock production are reviewed. About 231 plants reviewed showed a variety of bioactive properties, namely, being toxic, repellent, antifeedant, and antiovipositant and ability to immobilize target tick species. These ethnobotanical substances are potentially useful ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2017, 2017:8647919]

Cited: 3 times

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A validated method for quantifying hypoglycin A in whole blood by UHPLC-HRMS/MS.

Jérémy Carlier, Jérôme Guitton, Cécile Moreau, Baptiste Boyer, Fabien Bévalot, Laurent Fanton, Jean Habyarimana, Gilbert Gault, Yvan Gaillard,

Hypoglycin A (HGA) is the toxic principle in ackee (Blighia sapida Koenig), a nutritious and readily available fruit which is a staple of the Jamaican working-class and rural population. The aril of the unripe fruit has high concentrations of HGA, the cause of Jamaican vomiting sickness, which is very often ... Read more >>

J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (Journal of chromatography. B, Analytical technologies in the biomedical and life sciences)
[2015, 978-979:70-77]

Cited: 6 times

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Herbal therapy: A review of emerging pharmacological tools in the management of diabetes mellitus in Africa.

Cromwell Mwiti Kibiti, Anthony Jide Afolayan,

Diabetes mellitus is a chronic physiological glucose metabolic disorder. It has affected millions of people all over the world thereby having a significant impact on quality of life. The management of diabetes includes both nonpharmacological and conventional interventions. Drawbacks in conventional therapy have led to seeking alternative therapy in herbal ... Read more >>

Pharmacogn Mag (Pharmacognosy magazine)
[2015, 11(Suppl 2):S258-74]

Cited: 7 times

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Factors associated with blood lead concentrations of children in Jamaica.

Mohammad H Rahbar, Maureen Samms-Vaughan, Aisha S Dickerson, Katherine A Loveland, Manouchehr Ardjomand-Hessabi, Jan Bressler, Sydonnie Shakespeare-Pellington, Megan L Grove, Eric Boerwinkle,

Lead is a heavy metal known to be detrimental to neurologic, physiologic, and behavioral health of children. Previous studies from Jamaica reported that mean lead levels in soil are four times that of lead levels in some other parts of the world. Other studies detected lead levels in fruits and ... Read more >>

J Environ Sci Health A Tox Hazard Subst Environ Eng (Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering)
[2015, 50(6):529-539]

Cited: 1 time

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Improving the management of dysglycemia in children in the developing world.

Hubert Barennes, Eric Pussard,

Improving the availability of point-of-care (POC) diagnostics for glucose is crucial in resource-constrained settings (RCS). Both hypo and hyperglycemia have an appreciable frequency in the tropics and have been associated with increased risk of deaths in pediatrics units. However, causes of dysglycemia, including hyperglycemia, are numerous and insufficiently documented in ... Read more >>

Am. J. Trop. Med. Hyg. (The American journal of tropical medicine and hygiene)
[2015, 92(1):6-8]

Cited: 2 times

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Haiti's food and drinking water: a review of toxicological health risks.

J R Schwartzbord, E Emmanuel, D L Brown,

CONTEXT: The Republic of Haiti is a developing country in the Caribbean region with a history that challenges toxicologists, yet the historical panoply of toxicological hazards in Haiti has received little scholarly attention. OBJECTIVES: The primary objectives of this paper are to review what is known about Haiti's current toxicological ... Read more >>

Clin Toxicol (Phila) (Clinical toxicology (Philadelphia, Pa.))
[2013, 51(9):828-833]

Cited: 8 times

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Alpha-Amylase Inhibition and Antioxidative Capacity of Some Antidiabetic Plants Used by the Traditional Healers in Southeastern Nigeria.

Sunday O Oyedemi, Blessing O Oyedemi, Ifeoma I Ijeh, Princemartins E Ohanyerem, Roger M Coopoosamy, Olayinka A Aiyegoro,

Oxidative stress plays a significant role in the pathogenesis of metabolic syndrome including diabetes mellitus (DM). The inhibition of alpha-amylase is an important therapeutic target in the regulation of postprandial increase of blood glucose in diabetic patients. The present study investigated the alpha-amylase inhibitory and antioxidant potential of selected herbal ... Read more >>

ScientificWorldJournal (The Scientific World Journal)
[2017, 2017:3592491]

Cited: 5 times

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Fat profile of jamaican ackees, oleic Acid content and possible health implications.

A Goldson, D Bremmer, K Nelson, D A Minott,

To re-investigate the composition of ackee oil and unequivocally determine its principal fatty acid components.Oil was extracted from the edible portion of ackees harvested in three different studies (I-III) by several analysts; studies I and II utilized composite samples from several trees while study III consisted of ackees from seven ... Read more >>

West Indian Med J (The West Indian medical journal)
[2014, 63(1):9-12]

Cited: 2 times

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Fulminant hepatic failure attributed to ackee fruit ingestion in a patient with sickle cell trait.

Dianne E Grunes, Irini Scordi-Bello, Matthew Suh, Sander Florman, Jonathan Yao, Maria Isabel Fiel, Swan N Thung,

We report a case of fulminant liver failure resulting in emergent liver transplantation following 3 weeks of nausea, vomiting, and malaise from Jamaican Vomiting Sickness. Jamaican Vomiting Sickness is caused by ingestion of the unripe arils of the Ackee fruit, its seeds and husks. It is characterized by acute gastrointestinal ... Read more >>

Case Rep Transplant (Case reports in transplantation)
[2012, 2012:739238]

Cited: 2 times

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A review of methylene blue treatment for cardiovascular collapse.

Jean C Y Lo, Michael A Darracq, Richard F Clark,

Historically, methylene blue (MB) has been used for multiple purposes, including as an antidote for toxin-induced and hereditary methemoglobinemia, ifosfamide-induced encephalopathy, and ackee fruit and cyanide poisoning; as an aniline dye derivative, antimalarial agent, and antidepressant.Most recently, the use of MB has been advocated as a potential adjunct in the ... Read more >>

J Emerg Med (The Journal of emergency medicine)
[2014, 46(5):670-679]

Cited: 20 times

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