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Kaempferol suppresses acetaminophen-induced liver damage by upregulation/activation of SIRT1.

Mona Nasser BinMowyna, Nora Abdullah AlFaris,

<h4>Context</h4>Kaempferol, a flavonoid glycoside, has many hepatoprotective effects in several animals due to its antioxidant potential.<h4>Objective</h4>This study evaluated the hepatoprotective effect of kaempferol against acetaminophen (APAP)-induced liver damage and examined whether the protection involved modulation of silent information regulator 1 (SIRT1) signalling.<h4>Materials and methods</h4>Adult male Wistar rats were classified into ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):146-156]

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Hepatoprotective effect of Pandanus odoratissimus seed extracts on paracetamol-induced rats.

Ernawati Sinaga, Ami Fitrayadi, Asrori Asrori, Sri Endarti Rahayu, Suprihatin Suprihatin, Vivitri Dewi Prasasty,

<h4>Context</h4><i>Pandanus odoratissimus</i> Linn. (Pandanaceae) seed extract is known to have antioxidant activities. However, the potential hepatoprotective effect is still unclear.<h4>Objective</h4>To investigate the hepatoprotection aspect of <i>P. odoratissimus</i> methanol extract towards paracetamol-induced rats.<h4>Materials and methods</h4>Thirty male Sprague-Dawley rats were randomly divided into six equal groups: one group served as the healthy ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):31-39]

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Acetaminophen Poisoning.

Angela L Chiew, Nicholas A Buckley,

Acetaminophen is a common medication taken in deliberate self-poisoning and unintentional overdose. It is the commonest cause of severe acute liver injury in Western countries. The optimal management of most acetaminophen poisonings is usually straightforward. Patients who present early should be offered activated charcoal and those at risk of acute ... Read more >>

Crit Care Clin (Critical care clinics)
[2021, 37(3):543-561]

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Prenatal Acetaminophen, Adverse Birth Outcomes, and ADHD: Mediation Analysis in a Prospective Cohort

Brennan Baker, Heather Burris, Tessa Bloomquist, Amélie Boivin, Virginie Gillet, Annie Larouche, Jean-Philippe Bellenger, Jean-Charles Pasquier, Andrea Baccarelli, Larissa Takser,

<h4>Structured Abstract</h4> <h4>Background</h4> Although we previously reported an association of prenatal acetaminophen exposure with more than two-fold increased odds of child ADHD, it is unknown whether prenatal acetaminophen is associated with adverse birth outcomes, and if birth outcomes may mediate the association of prenatal acetaminophen with ADHD. <h4>Methods</h4> This birth ... Read more >>

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Exposure of human fetal kidneys to mild analgesics interferes with early nephrogenesis.

Sabrina Leverrier-Penna, Alain Michel, Laetitia L Lecante, Nathalie Costet, Antonio Suglia, Christèle Desdoits-Lethimonier, Hugoline Boulay, Roselyne Viel, Jonathan M Chemouny, Emmanuelle Becker, Vincent Lavoué, Antoine D Rolland, Nathalie Dejucq-Rainsford, Cécile Vigneau, Séverine Mazaud-Guittot,

Acetaminophen, aspirin, and ibuprofen are mild analgesics commonly used by pregnant women, the sole current recommendation being to avoid ibuprofen from the fifth month of gestation. The nephrotoxicity of these three analgesics is well documented in adults, as is their interference with prostaglandins biosynthesis. Here we investigated the effect of ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21718]

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Variation in Intravenous Acetaminophen Use in Pediatric Hospitals: Priorities for Standardization.

Vanessa Toomey, Adrienne Randolph, Florence Bourgeois, Dionne Graham,

<h4>Objectives</h4>The primary objective was to evaluate hospital variation in intravenous (IV) acetaminophen use across pediatric patient populations. The secondary objective was to identify populations with high use of IV acetaminophen and wide variation in practice to identify priority areas for cost reduction and practice standardization.<h4>Methods</h4>We performed a retrospective study of ... Read more >>

Hosp Pediatr (Hospital pediatrics)
[2021, :]

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Can NSAIDs and Acetaminophen Effectively Replace Opioid Treatment Options for Acute Pain?

Joseph V Pergolizzi, Peter Magnusson, Jo Ann LeQuang, Frank Breve, Robert Taylor, Charles Wollmuth, Giustino Varrassi,

<h4>Introduction</h4>Opioid analgesia for acute painful conditions has come under increasing scrutiny with the public health crisis of opioid overdose, leading clinicians to seek nonopioid alternatives, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (paracetamol).<h4>Areas covered</h4>This perspective evaluates recent clinical trials of nonopioids, opioids, and combination therapy for use in acute ... Read more >>

Expert Opin Pharmacother (Expert opinion on pharmacotherapy)
[2021, :1-8]

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CD36 deficiency ameliorates drug-induced acute liver injury in mice.

Chen Zhang, Xiao Shi, Zhongping Su, Chao Hu, Xianmin Mu, Jinshun Pan, Mengjing Li, Fengmeng Teng, Tao Ling, Ting Zhao, Che Xu, Guozhong Ji, Qiang You,

<h4>Background</h4>Acetaminophen (APAP) overdose causes hepatotoxicity and even acute liver failure. Recent studies indicate that sterile inflammation and innate immune cells may play important roles in damage-induced hepatocytes regeneration and liver repair. The scavenger receptor CD36 has its crucial functions in sterile inflammation. However, the roles of CD36 in APAP induced ... Read more >>

Mol Med (Molecular medicine (Cambridge, Mass.))
[2021, 27(1):57]

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Acetaminophen and ibuprofen in the treatment of pediatric fever: a narrative review.

Ian M Paul, Philip D Walson,

<h4>Objective</h4>A narrative review of randomized, blinded, controlled studies assessing the antipyretic effect of ibuprofen versus acetaminophen or combined or alternating treatment in children was conducted.<h4>Methods</h4>Searches of the PubMed and Embase literature databases were conducted to identify relevant articles. Selected articles were limited to studies published in English that investigated OTC ... Read more >>

Curr Med Res Opin (Current medical research and opinion)
[2021, :1-13]

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Effects of mixed meal tolerance test on gastric emptying, glucose and lipid homeostasis in obese nonhuman primates.

Kamal Albarazanji, Andrea R Nawrocki, Bin Gao, Xiaoli Wang, Yixin Jim Wang, Yong-Fu Xiao,

Meal ingestion elicits a variety of neuronal, physiological and hormonal responses that differ in healthy, obese or diabetic individuals. The mixed meal tolerance test (MMTT) is a well-established method to evaluate pancreatic β-cell reserve and glucose homeostasis in both preclinical and clinical research in response to calorically defined meal. Nonhuman ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):11866]

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Behavioral Problems at Age 11 Years After Prenatal and Postnatal Exposure to Acetaminophen: Parent-Reported and Self-Reported Outcomes.

Kosuke Inoue, Beate Ritz, Andreas Ernst, Wan-Ling Tseng, Yuying Yuan, Qi Meng, Cecilia Høst Ramlau-Hansen, Katrine Strandberg-Larsen, Onyebuchi A Arah, Carsten Obel, Jiong Li, Jørn Olsen, Zeyan Liew,

Several studies have reported associations between prenatal acetaminophen exposure and behavioral outcomes in young children. We aimed to evaluate the associations of prenatal and postnatal exposures to acetaminophen with behavioral problems in children at age 11 years, using behavioral measures reported by parents and children. We studied 40,934 mother-child pairs ... Read more >>

Am J Epidemiol (American journal of epidemiology)
[2021, 190(6):1009-1020]

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Underutilization of Acetaminophen in Older Adult Trauma Patients.

Krista L Haines, Matthew Fuller, Ioana Antonescu, Justin G Vaughan, Karthik Raghunathan, Christopher E Cox, Raquel R Bartz, Tetsu Ohnuma, Suresh Agarwal, Vijay Krishnamoorthy,

<h4>Introduction</h4>Older adults are more vulnerable to opioid-associated morbidity. The purpose of this study was to determine the frequency and timing of acetaminophen and opioid use in the postoperative period.<h4>Methods</h4>Older adult trauma patients (≥65 years) with hip fractures requiring femur or hip fixation were reviewed (Premier Database 2008-2014). We examined rates of ... Read more >>

Am Surg (The American surgeon)
[2021, :31348211023397]

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Hyperammonemia in acetaminophen toxicity.

Ryan T Marino, Alexander M Sidlak,

<h4>Introduction</h4>Acetaminophen-induced hepatotoxicity can result in hyperammonemia, but it is not clear if elevated ammonia concentrations predict encephalopathy.<h4>Methods</h4>We retrospectively studied patients with acetaminophen toxicity at a liver transplant center over 8 years (January 1, 2010-December 31, 2017), who developed hepatotoxicity (AST and/or ALT >1000 IU/L) or hyperammonemia (ammonia > 40 µmol/L). We recorded baseline ... Read more >>

Clin Toxicol (Phila) (Clinical toxicology (Philadelphia, Pa.))
[2021, :1-5]

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The effects of mitochondrial transplantation in acetaminophen-induced liver toxicity in rats.

Oner Ulger, Gokhan Burcin Kubat, Zehra Cicek, Ertugrul Celik, Ozbeyen Atalay, Serpil Suvay, Mehmet Ozler,

<h4>Aims</h4>Acetaminophen (APAP) toxicity is one of the leading causes of acute liver injury-related death and liver failure worldwide. In many studies, mitochondrial dysfunction has been identified as an important cause of damage in APAP toxicity. Therefore, our study aimed to investigate the possible effects of mitochondrial transplantation on liver damage ... Read more >>

Life Sci (Life sciences)
[2021, 279:119669]

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Acetaminophen does not affect cardiac and brain responses to social rejection but seems to attenuate behavioral adaptation in a social judgment task.

Simon Hofman, Matthias J Wieser, Frederik M van der Veen,

The present study examined the effect of Acetaminophen on the painful experience of social rejection by examining brain, cardiac and behavioral measures reflecting different aspects of social feedback processing. Healthy students (<i>N</i> = 72), after ingesting either Acetaminophen or a placebo, performed a social judgment paradigm (SJP), in which they could ... Read more >>

Soc Neurosci (Social neuroscience)
[2021, :1-13]

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Intravenous Acetaminophen Overdose in an Infant With Toxicokinetic Data.

Joshua Trebach, Sarah G Mahonski, Kristina Melchert, Mary Ann Howland, William K Chiang,

<h4>Case report</h4>A 12-month-old (former 24 week gestational age), 8.7 kg male was hospitalized after an uneventful colostomy reversal. In the postoperative unit, the patient unintentionally received 1000 mg IV (114.9 mg/kg) acetaminophen instead of the intended 100 mg IV. Serial acetaminophen concentrations were drawn. The patient received IV Nacetylcysteine and ... Read more >>

J Pharm Pract (Journal of pharmacy practice)
[2021, :8971900211021286]

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Therapeutic liver repopulation by transient acetaminophen selection of gene-modified hepatocytes.

Anne Vonada, Amita Tiyaboonchai, Sean Nygaard, Jeffrey Posey, Alexander Mack Peters, Shelley R Winn, Alessio Cantore, Luigi Naldini, Cary O Harding, Markus Grompe,

Gene therapy by integrating vectors is promising for monogenic liver diseases, especially in children where episomal vectors remain transient. However, reaching the therapeutic threshold with genome-integrating vectors is challenging. Therefore, we developed a method to expand hepatocytes bearing therapeutic transgenes. The common fever medicine acetaminophen becomes hepatotoxic via cytochrome p450 ... Read more >>

Sci Transl Med (Science translational medicine)
[2021, 13(597):]

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An examination of gastrointestinal absorption using the acetaminophen absorption test in critically ill patients with COVID-19: A retrospective cohort study.

Daniel L Southren, Alexa D Nardone, Adeniran A Haastrup, Russel J Roberts, Marvin G Chang, Edward A Bittner,

<h4>Objective</h4>Gastrointestinal (GI) dysfunction is prevalent in critically ill patients with coronavirus disease 2019 (COVID-19). The acetaminophen absorption test (AAT) has been previously described as a direct method for assessment of GI function. Our study determines whether the AAT can be used to assess GI function in critically ill COVID-19 patients, ... Read more >>

Nutr Clin Pract (Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition)
[2021, :]

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Camellia japonica diminishes acetaminophen-induced acute liver failure by attenuating oxidative stress in mice.

Weishun Tian, Jing Zhao, Byung-Kil Choo, In-Shik Kim, Dongchoon Ahn, Hyun-Jin Tae, Md Sadikul Islam, Byung-Yong Park,

This experiment was to explore the possible defensive properties and potential molecular mechanisms of Camellia japonica (CJ) against APAP-stimulated acute liver failure (ALF) in mice. In this study, we investigated the effects of CJ on APAP-induced hepatotoxicity. Mice were orally treated with CJ before or after challenge with APAP. Both ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2021, :]

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Comparison of Monotherapy Versus Combination of Intravenous Ibuprofen and Propacetamol (Acetaminophen) for Reduction of Postoperative Opioid Administration in Children Undergoing Laparoscopic Hernia Repair: A Double-Blind Randomized Controlled Trial.

Hye-Mi Lee, Ji-Hoon Park, Su-Jung Park, Haegi Choi, Jeong-Rim Lee,

<h4>Background</h4>Extensive efforts have been made toward reducing postoperative opioid use in children. In this study, we assessed whether propacetamol, or a nonsteroidal anti-inflammatory drug (NSAID), or their combination could effectively reduce opioid use in children after laparoscopic inguinal hernia repair.<h4>Methods</h4>This randomized, double-blind clinical trial included 159 children aged 6 months ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, 133(1):168-175]

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Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment.

Zhao Shan, Leike Li, Constance Lynn Atkins, Meng Wang, Yankai Wen, Jongmin Jeong, Nicolas F Moreno, Dechun Feng, Xun Gui, Ningyan Zhang, Chun Geun Lee, Jack A Elias, William M Lee, Bin Gao, Fong Wilson Lam, Zhiqiang An, Cynthia Ju,

<b>Background:</b> Hepatic platelet accumulation contributes to acetaminophen (APAP)-induced liver injury (AILI). However, little is known about the molecular pathways involved in platelet recruitment to the liver and whether targeting such pathways could attenuate AILI.<b>Methods:</b> Mice were fasted overnight before <i>i.p.</i> injected with APAP at a dose of 210 mg/kg for ... Read more >>

Elife (eLife)
[2021, 10:]

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No additive effect of acetaminophen when co-ingested with caffeine on cycling performance in well-trained young men.

Søren Jessen, Kasper Eibye, Peter Møller Christensen, Morten Hostrup, Jens Bangsbo,

We investigated the effect of caffeine and acetaminophen on power output during a 6-min performance-test, peripheral fatigue, and muscle protein kinase A (PKA) substrate-phosphorylation. Fourteen men (age(mean±SD): 26±6 years; V̇O<sub>2max</sub>: 63.9±5.0 mL∙min<sup>-1</sup>∙kg<sup>-1</sup>) completed four randomized trials with acetaminophen (1500 mg), caffeine (5 mg∙kgbw<sup>-1</sup>), combined caffeine and acetaminophen (caffeine+acetaminophen) or placebo. ... Read more >>

J Appl Physiol (1985) (Journal of applied physiology (Bethesda, Md. : 1985))
[2021, :]

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Emerging Contaminants in the Northeast Andean Foothills of Amazonia: The Case of Study of the City of Tena, Napo, Ecuador.

Mariana V Capparelli, Isabel Cipriani-Avila, Eliza Jara-Negrete, Sofía Acosta-López, Byron Acosta, Andrés Pérez-González, Jon Molinero, Veronica Pinos-Vélez,

This work is a study on the occurrence of emerging pollutants in the northeast Ecuadorian Amazon. Emerging contaminants (ECs)-caffeine, triclosan, estradiol, acetaminophen, nicotine, and ibuprofen-were quantified by gas chromatography-mass spectrometry in rivers and streams of the Amazon basin near the city of Tena, Ecuador. For that, a total of 16 ... Read more >>

Bull Environ Contam Toxicol (Bulletin of environmental contamination and toxicology)
[2021, :]

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Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.

Anissa A Widjaja, Jinrui Dong, Eleonora Adami, Sivakumar Viswanathan, Benjamin Ng, Leroy S Pakkiri, Sonia P Chothani, Brijesh K Singh, Wei Wen Lim, Jin Zhou, Shamini G Shekeran, Jessie Tan, Sze Yun Lim, Joyce Goh, Mao Wang, Robert Holgate, Arron Hearn, Leanne E Felkin, Paul M Yen, James W Dear, Chester L Drum, Sebastian Schafer, Stuart A Cook,

Acetaminophen (<i>N</i>-acetyl-<i>p</i>-aminophenol; APAP) toxicity is a common cause of liver damage. In the mouse model of APAP-induced liver injury (AILI), interleukin 11 (IL11) is highly up-regulated and administration of recombinant human IL11 (rhIL11) has been shown to be protective. Here, we demonstrate that the beneficial effect of rhIL11 in the ... Read more >>

Sci Transl Med (Science translational medicine)
[2021, 13(597):]

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Analgesia After Cesarean Delivery in the United States 2008-2018: A Retrospective Cohort Study.

Sydney E Reed, Hon Sen Tan, Matthew E Fuller, Vijay Krishnamoorthy, Tetsu Ohnuma, Karthik Raghunathan, Ashraf S Habib,

<h4>Background</h4>Optimizing analgesia after cesarean delivery is a priority and requires balancing adequate pain relief with the risk of analgesics-associated adverse effects. Current recommendations are for use of a multimodal, opioid-sparing analgesic regimen that includes neuraxial morphine combined with scheduled nonsteroidal anti-inflammatory drugs (NSAIDs) and scheduled acetaminophen. Furthermore, recent studies recommend ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2021, :]

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