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Adiponectin serum level is an independent and incremental predictor of all-cause mortality after transcatheter aortic valve replacement.

PMID: 35932173 (view PubMed database entry)
DOI: 10.1002/clc.23892 (read at publisher's website )

Jeroen Walpot, Paul van Herck, Valerie Collas, Liene Bossaerts, Caroline M Van de Heyning, Tom Vandendriessche, Hein Heidbuchel, Inez Rodrigus, Christophe De Block, Gary R Small, Johan Bosmans,

<h4>Background</h4>Quantifiable biomarkers may be useful for a better risk and frailty assessment of patients referred for transcatheter aortic valve implantation (TAVI).<h4>Hypothesis</h4>To determine if adiponectin serum concentration predicts all-cause mortality in patients undergoing TAVI.<h4>Methods</h4>77 consecutive patients, undergoing TAVI, were analyzed. The CT axial slices at the level of the fourth lumbar vertebra were used to measure the psoas muscle area, and its low-density muscle fraction (LDM (%)). To assess the operative risk, the STS (Society of Thoracic Surgeons Predicted Risk of Mortality) score, Log. Euroscore, and Euroscore II were determined. A clinical frailty assessment was performed. ELISA kits were used to measure adiponectin serum levels. We searched for a correlation between serum adiponectin concentration and all-cause mortality after TAVI.<h4>Results</h4>The mean age was 80.8 ± 7.4 years. All-cause mortality occurred in 22 patients. The mean follow-up was 1779 days (range: 1572-1825 days). Compared with patients with the lowest adiponectin level, patients in the third tertile had a hazards ratio of all-cause mortality after TAVI of 4.155 (95% CI: 1.364-12.655) (p = .004). In the multivariable model, including STS score, vascular access of TAVI procedure, LDM (%), and adiponectin serum concentration, serum adiponectin level, and LDM(%) were independent predictors of all-cause mortality after TAVI (p = .178, .303, .042, and .017, respectively). Adiponectin level was a predictor of all-cause mortality in females and males (p = .012 and 0.024, respectively).<h4>Conclusion</h4>Adiponectin serum level is an independent and incremental predictor of all-cause mortality in patients undergoing TAVI.

Clin Cardiol (Clinical cardiology)
[2022, :]

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