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Impact of Different Patterns of Organ Failure on Mortality in Acute Necrotizing Pancreatitis.

PMID: 34629457 (view PubMed database entry)
DOI: 10.1097/mpa.0000000000001880 (read at publisher's website )

Anupam K Singh, Jayanta Samanta, Jayendra Shukla, Chhagan Lal Birda, Jahnvi Dhar, Pankaj Gupta, Praveen Kumar-M, Vikas Gupta, Thakur Deen Yadav, Saroj K Sinha, Rakesh Kochhar,

<h4>Objectives</h4>Organ failure (OF) and infected necrosis (IN) are the most important predictors of mortality in necrotizing acute pancreatitis (AP). We studied the relationship between timing (onset and duration) and patterns of OF with mortality and the impact of IN on mortality.<h4>Methods</h4>Consecutive patients with necrotizing AP between January 2017 and February 2020 were analyzed retrospectively for OF and its impact on outcome. Organ failure was divided as single OF, simultaneous multiple OF (SiMOF) and sequential multiple OF (SeMOF). Mortality was compared for timing of onset, total duration and patterns of OF.<h4>Results</h4>Among 300 patients with necrotizing AP, 174 (58%) had OF. Mortality was not associated with onset of OF (P = 0.683) but with duration of OF (P = 0.006). Mortalities for single OF, SiMOF, and SeMOF were 11.8%, 30.4%, and 69.2% respectively (P < 0.001). On Cox proportional hazard analysis, adjusted hazard ratio of risk of mortality for OF with IN versus IN, SiMOF versus single OF and SeMOF versus single OF was 3.183, 2.878, and 8.956, respectively (P = 0.023, <0.030, and <0.001, respectively).<h4>Conclusions</h4>Duration of OF was associated with increased mortality and SeMOF had worse outcome than single OF and SiMOF.

Pancreas (Pancreas)
[2021, 50(7):1030-1036]

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