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Longitudinal Cognitive Profiles by Anxiety and Depressive Symptoms in American Older Adults With Subjective Cognitive Decline.

PMID: 34342395 (view PubMed database entry)
DOI: 10.1111/jnu.12692 (read at publisher's website )

Sangwoo Ahn, Michelle A Mathiason, Fang Yu,

<h4>Purpose</h4>The objective of this study was to determine how anxiety and/or depressive symptoms differentially affect specific cognitive domains over time in persons with subjective cognitive decline (SCD).<h4>Design</h4>A longitudinal, observational study was conducted using data from the National Alzheimer's Coordinating Center-Uniform Data Set. Mean follow-up was 4.1 ± 2.4 years.<h4>Methods</h4>Using information from a total of 1401 participants (age 74.0 ± 8.2 years), linear mixed-effects regression models were used to assess longitudinal changes in global cognition, episodic memory, attention, language, and executive function by baseline psychological (anxiety [A] and/or depressive [D]) symptoms in individuals with SCD. Reference was the group having no symptoms (A-/D-).<h4>Findings</h4>The A+/D- group was not associated with any cognitive changes. The A-/D+ group was associated with a greater decline in episodic memory and executive function. The A+/D+ group had a greater decline in attention. Changes in global cognition and language were not predicted by any psychological symptoms.<h4>Conclusions</h4>Depressive symptoms predicted lower episodic memory and executive function.<h4>Clinical relevance</h4>Nurses need to pay attention to depressive symptoms in older adults with SCD because managing depressive symptoms may help protect against cognitive decline more typical of early Alzheimer's dementia.

J Nurs Scholarsh (Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing)
[2021, :]

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