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Severe acute respiratory syndrome coronavirus 2 infection and critically ill children.

PMID: 33938473 (view PubMed database entry)
DOI: 10.1097/mop.0000000000001019 (read at publisher's website )

Rahul Damania, Whitney Moore, Heather C Viamonte, Pradip Kamat, Rajit K Basu,

<h4>Purpose of review</h4>Amidst an ongoing pandemic, the delineation of the pediatric consequence of infection from the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) virus is emerging. This review summarizes available pediatric data and covers the aspects of epidemiology, critical illness with acute infection [coronavirus disease 2019 (COVID-19)], the discovered multi-inflammatory syndrome in children (MIS-C), and management options.<h4>Recent findings</h4>The available data from the source of the initial viral transmission and then through Europe, Africa, and the Western Hemisphere identifies important aspects of the SARS-CoV2 pandemic: 1) Pediatric infection occurs commonly, is likely underestimated, and transmission patterns remain incompletely described, 2) Pediatric patients suffer multiple end-organ injuries but COVID-19 is not the same prevalence in terms of severity as in adults, 3) MIS-C is a novel and life-threatening manifestation of exposure to the virus, 4) Management using a combination of supportive care, standard practice intensive care management, and anti-inflammatory agents is associated with recovery, 5) Long-term sequelae of viral exposure is unknown at this time.<h4>Summary</h4>Emerging evidence suggests pediatric patients are at risk for severe and life-threatening effects of exposure to SARS-CoV2. As the pandemic continues, further research is warranted - particularly as a vaccine is not yet available for use in children.

Curr Opin Pediatr (Current opinion in pediatrics)
[2021, 33(3):286-291]

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