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Urine Biomarker Assessment of Infant Adherence to Isoniazid Prophylaxis.

PMID: 33055504 (view PubMed database entry)
DOI: 10.1097/inf.0000000000002936 (read at publisher's website )

Sylvia M LaCourse, Daniel Leon, Nuttada Panpradist, Barbra A Richardson, Elizabeth Maleche-Obimbo, Jerphason Mecha, Daniel Matemo, Jaclyn N Escudero, John Kinuthia, Barry Lutz, Grace John-Stewart,

We assessed adherence in an infant tuberculosis prevention trial in Kenya with a urine isoniazid metabolite-detecting dipstick. Ninety-seven infants had 155 assays performed; 77 (49.7%) were found to be positive despite caregiver-reported adherence. Positive assays were associated with maternal secondary education, HIV suppression and no reported missed doses in past 3 days, suggesting caregiver education and self-medication use influenced infant adherence.

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(1):e43-e45]

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