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Efficacy of convalescent plasma according to blood groups in COVID-19 patients.

PMID: 32950044 (view PubMed database entry)
DOI: 10.3906/sag-2007-59 (read at publisher's website )

Tuba HacibekİroĞlu, Yasİn KalpakÇi, Ahmed Cİhad GenÇ, İlhan HacibekİroĞlu, Cenk Sunu, Adem SaricaoĞlu, Yakup Tomak, OĞuz Karabay, Mehmet KÖroĞlu,

Aim In this study, we aim to investigate the efficacy of convalescent plasma (CP) according to blood groups (BGs) in the treatment of critically ill patients diagnosed with COVID-19. Materials and methods: 28 critically ill and laboratory-confirmed COVID-19 patients who were admitted to intensive care unit (ICU) of Sakarya University, Medical Faculty were included in the study. Patients were divided into 2 groups as anti-A Antibody (Ab) containing (BG O and B) and those not containing anti-A Ab (BG A and AB) CP received patients. Results: Among 28 patients, 13 patients received anti-A Ab containing CP (BG; B: 6, O: 7), 15 patients not containing anti-A Ab CP (BG; A: 13, AB: 2). Duration in ICU, the rates of mechanical ventilation (MV) support and vasopressor support, the case fatality rate and discharge rate were lower in patients received CP containing anti-A Ab than not containing anti-A Ab CP. However, only the difference in the rate of MV support achieved statistically significance (p=0.04) Conclusion: In our study, it was observed that the efficiency of CP without anti-A antibody was lower than that of plasma containing anti-A antibody, although it was not statistically significant. This result is thought to be due to the anti-A antibody's ability to block the ACE2 receptor. We believe that this hypothesis should be investigated in controlled studies with higher patient numbers.

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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