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Pattern of systemic antibiotic use and potential drug interactions: Evaluations through a point prevalence study in Ankara University Hospitals.

PMID: 32927931 (view PubMed database entry)
DOI: 10.3906/sag-2004-164 (read at publisher's website )

İrem Akdemİr Kalkan, GÜle Çinar, Aysel Pehlİvanli, Fatİh Ürkmez, İzel Ezgİ TopaloĞlu, BÜŞra Akyol, Arzu BeŞİkcİ, Alpay Azap, Kemal Osman MemİkoĞlu,

Background/Aim Most of the hospitalized patients are on a number of drugs for comorbidities and/or to prevent nosocomial infections. This necessitates a careful consideration of drug interactions not only to avoid possible toxicities but also to reach the highest efficiency with drug treatment. We aimed to investigate drug interactions related to systemic antibiotic use and compare three different databases to check for drug interactions while characterizing main differences between medical and surgical departments. Materials and Methods This point prevalence study covered data on 927 orders for patients hospitalized June 3-10, 2018 in Ankara University Hospitals. Systemic antibiotic use and related drug interactions were documented by utilizing UptoDate, Drugs and Medscape and compared between departments of medical and surgical sciences. Results The number of orders, drugs or antibiotics per order were not different between medical and surgical sciences departments. A total of 1335 antibiotic-related drug interactions of all levels were reported by one, two or all three databases. UptoDate reported all common and major interactions. Pantoprazole was the most commonly prescribed drug and appeared in 63% of all orders. Among 75 different molecules, ceftriaxone and meropenem were the two most prescribed antibiotics by surgical and medical departments, respectively. Conclusions A dramatic variance existed amongst antibiotics prescribed by different departments. This indicated indicated the requirement for a centralized role of an infectious diseases specialist. Especially for the hospitalized patient, prophylactic coverage with at least one antibiotic brought about a number of drug interactions. A precise evaluation by a clinical pharmacist -currently none on duty- of orders in terms of drug interactions will reduce possible drug-related hazards.

Turk J Med Sci (Turkish journal of medical sciences)
[2020, :]

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