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Expression of serotonin 2A, 2C, 6 and 7 receptor and IL-6 mRNA in experimental toxoplasmic encephalitis in mice.

PMID: 31844757 (view PubMed database entry)
DOI: 10.1016/j.heliyon.2019.e02890 (read at publisher's website )
PMCID: PMC6888730 (free full text version available)

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Hasan Tarik Atmaca,

The neurotropic pathogen <i>Toxoplasma gondii</i> infects about one-third of the human population. Both acute and chronic (latent or life-long) forms of toxoplasmosis are associated with specific neurologic and neuropsychiatric symptoms. In the present study, swiss albino mice were inoculated intraperitoneally with 15-20 tissue cysts of the ME-49 strain of <i>Toxoplasma gondii</i>. The brain samples were collected on the days 10, 20, and 30 for determining the histopathological scores and the number of cysts. Furthermore, a real-time quantitative polymerase chain reaction (RT-PCR) was conducted to find out the gene expression levels of the serotonin 2A receptor (5-HTR2A), serotonin 2C receptor (5-HTR2C), serotonin 6 receptor (5-HTR6), serotonin 7 receptor (5-HTR7), and interleukin-6. The results were compared to the histopathological findings of encephalitic toxoplasmosis. The expression levels were observed to increase for all receptors; however at different time points of infection. This experimental model demonstrates that the expression of serotonin receptors was induced in <i>Toxoplasma gondii</i> infections, displaying unique findings for each of the individual receptors.

Heliyon (Heliyon)
[2019, 5(11):e02890]

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