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Cell-Based Therapies for the Treatment of Fractures.

PMID: 31083148 (view PubMed database entry)
DOI: 10.1097/bot.0000000000001478 (read at publisher's website )

Joseph Borrelli, Gregory J Della Rocca, Prism Schneider, Hans-Christoph Pape, Paolo Cinelli, Yoram Weil, Amal Khoury, Meir Liebergall, Tracy Watson,

Orthopaedic Trauma Service, The CORE Institute, University of Arizona College of Medicine, Phoenix, AZ.

Ongoing studies investigating fracture healing have uncovered and allowed investigators to gain a better understanding of where the variety of cells, which participate in this process, originate, and how they communicate as well as how they can be enhanced to successfully heal a fracture when the process has slowed or failed completely. This brief review will highlight some of the recent findings regarding the role the immune system in fracture healing and how these cells communicate with each other during the healing process. In addition, two 2 methods that have recently been shown to be promising techniques in supporting fracture when it stalls or reversing the process, when the fracture has failed to heal, will also be described.

J Orthop Trauma (Journal of orthopaedic trauma)
[2019, 33 Suppl 6:S39-S43]

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