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Precision Medicine Applications to Manage Multiply Injured Patients With Orthopaedic Trauma.

PMID: 31083145 (view PubMed database entry)
DOI: 10.1097/bot.0000000000001468 (read at publisher's website )

Todd O McKinley, Felipe A Lisboa, Annamarie D Horan, Greg E Gaski, Samir Mehta,

Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelpha, PA.

Precision medicine offers potential for improved outcomes by tailoring interventions based on patient-specific demographics and disease-specific data. Precision methods are relatively unexplored in trauma patients. New research is being looked at for precision methods to treat patients with large extremity wounds, nonunions, and fractures associated with polytrauma. Precision-based clinical decision tools are being validated to optimize timing for open wound definitive closure. Early patient-specific biomarkers to stratify nonunion risk within 1 week of fracture are being explored. Patient-specific data to stage timing of major fracture interventions in multiply injured patients are being interrogated.

J Orthop Trauma (Journal of orthopaedic trauma)
[2019, 33 Suppl 6:S25-S29]

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