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Is Tissue Engineering Helping Orthopaedic Care in Trauma?

PMID: 31083143 (view PubMed database entry)
DOI: 10.1097/bot.0000000000001467 (read at publisher's website )

Brett D Crist, J Kent Leach, Mark A Lee,

University of California-Davis Medical Center, Sacramento, CA.

Tissue engineering in orthopaedic trauma is needed. Progress has been made in all areas including regenerating bone, cartilage, soft tissue, and making up for bone defects with scaffolds. Bone regeneration and managing bone defects with scaffolds continue to be successful in the basic science realm with promising results, but currently, these successes are mostly limited to small animal models. Cartilage defects have more clinically available treatment options, but the benefits of "off-the-shelf" allograft options, and scaffolds, have little clinical evidence in the acute fracture setting. Most of the true chondrocyte replacement therapies such as matrix-induced autologous chondrocyte implantation and osteochondral allografts require delayed treatment while cell growth or graft matching occurs. Soft-tissue defects can be managed with tissue engineering for the skin with success, but muscle and nerve defects are still limited to the basic science arena. Although significant gains have been made in all areas for tissue engineering in basic science, and is very promising, this success currently comes with limited translation into clinical availability for the orthopaedic trauma patient.

J Orthop Trauma (Journal of orthopaedic trauma)
[2019, 33 Suppl 6:S12-S19]

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