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Adipsic Diabetes Insipidus-The Challenging Combination of Polyuria and Adipsia: A Case Report and Review of Literature.

PMID: 31620086 (view PubMed database entry)
DOI: 10.3389/fendo.2019.00630 (read at publisher's website )
PMCID: PMC6759785 (free full text version available)

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Rinkoo Dalan, Hanxin Chin, Jeremy Hoe, Abel Chen, Huiling Tan, Bernhard Otto Boehm, Karen SuiGeok Chua,

Adipsic Diabetes Insipidus is a rare hypothalamic disorder characterized by a loss of thirst in response to hypernatraemia accompanied by diabetes insipidus. These occur secondary to a congregation of defects in the homeostatic mechanisms of water balance. A 27-year old Chinese female presented with Adipsic Diabetes Insipidus after cerebral arteriovenous malformation (AVM) surgery. Initial diagnosis and management was extremely challenging. Long term management required a careful interplay between low dose vasopressin analog treatment and fluids. Detailed charts of medication and sodium balance are described in the case presentation. We performed a literature search of similarly reported cases and describe the possible pathogenesis, etiology, clinical presentation, acute and chronic management, and prognosis.

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2019, 10:630]

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