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Positron Emission Tomography Can Support the Diagnosis of Dialysis-Related Amyloidosis.

PMID: 31546847 (view PubMed database entry)
DOI: 10.3390/jcm8091494 (read at publisher's website )
PMCID: PMC6781261 (free full text version available)

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Giulia Santagati, Emanuela Cataldo, Valeria Columbano, Antoine Chatrenet, Daniele Penna, Ettore Pelosi, Mammar Hachemi, Lurlinys Gendrot, Louise Nielsen, Francesco Cinquantini, Patrick Saulnier, Vincenzo Arena, Charles Boursot, Giorgina Barbara Piccoli,

BACKGROUND:The improvements in dialysis have not eliminated long-term problems, including dialysis-related amyloidosis (DRA), caused by Beta-2 microglobulin deposition. Several types of scintigraphy have been tested to detect DRA, none entered the clinical practice. Aim of the study was to assess the potential of PET-FDG scan in the diagnosis of DRA. METHODS:Forty-six dialysis patients with at least one PET scan (72 scans) were selected out 162 patients treated in 2016-2018. Subjective global assessment (SGA), malnutrition inflammation score (A), Charlson Comorbidity Index (CCI), were assessed at time of scan; 218 age-matched cases with normal kidney function were selected as controls. PET scans were read in duplicate. Carpal tunnel syndrome was considered a proxy for DRA. A composite "amyloid score" score considered each dialysis year = 1 point; carpal tunnel-DRA = 5 points per site. Logistic regression, ROC curves and a prediction model were built. RESULTS:The prevalence of positive PET was 43.5% in dialysis, 5% in controls (p < 0.0001). PET was positive in 14/15 (93.3%) scans in patients with carpal tunnel. PET sensitivity for detecting DRA was 95% (specificity 64%). Carpal tunnel was related to dialysis vintage and MIS. A positive PET scan was significantly associated with dialysis vintage, MIS and amyloid score. A prediction model to explain PET positivity combined clinical score and MIS, allowing for an AUC of 0.906 (CI: 0.813-0.962; p < 0.001). CONCLUSIONS:PET-FDG may identify DRA, and may be useful in detecting cases in which inflammation favours B2M deposition. This finding, needing large-scale confirmation, could open new perspectives in the study of DRA.

J Clin Med (Journal of clinical medicine)
[2019, 8(9):]

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