Full Text Journal Articles from
Abstract 19450512

Advertisement

Find full text journal articles






Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex.

PMID: 32037398 (view PubMed database entry)
DOI: 10.1038/s12276-020-0380-6 (read at publisher's website )
PMCID: PMC7062731 (free full text version available)

Download PDF Download PDF

Youn-Sang Jung, Jae-Il Park,

Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless, the blockade of Wnt signaling causes side effects such as impairment of tissue homeostasis and regeneration. Recently, several studies have identified cancer-specific Wnt signaling regulators. In this review, we discuss the Wnt inhibitors currently being used in clinical trials and suggest how additional cancer-specific regulators could be utilized to treat Wnt signaling-associated cancer.

Exp Mol Med (Experimental & molecular medicine)
[2020, 52(2):183-191]

Cited: 7 times

AltMetric Statistics


Advertisement

Disclaimer
0.425 s