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Two-dimensional diversity: screening human cDNA phage display libraries with a random diversity probe for the display cloning of phosphotyrosine binding domains.

PMID: 15038723 (view PubMed database entry)
DOI: 10.1021/ja039006p (read at publisher's website )

Elizabeth J Videlock, Victor K Chung, Michael A Mohan, Timothy M Strok, David J Austin,

A random phosphopeptide probe (bio-pYZZZ) has been used for the isolation and identification of multiple SH2 domains from human cDNA-displaying phage libraries. In addition, on-phage analysis and quantification of binding affinities for these phage-displayed proteins has shown them to be functional domains, retaining the same characteristics as in their native state.

J. Am. Chem. Soc. (Journal of the American Chemical Society)
[2004, 126(12):3730-3731]

Cited: 5 times

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